Oral oncology最新文献

{"title":"Letter to the editor: Stroke risk after head and neck cancer diagnosis and treatment in a Real-World clinical cohort","authors":"Cunxi Zou","doi":"10.1016/j.oraloncology.2025.107705","DOIUrl":"10.1016/j.oraloncology.2025.107705","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"172 ","pages":"Article 107705"},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative pembrolizumab and the changing paradigm of adjuvant therapy in head and neck squamous cell carcinoma: the case of T1-2, pN1","authors":"Giancarlo Tirelli, Paolo Boscolo-Rizzo","doi":"10.1016/j.oraloncology.2025.107770","DOIUrl":"10.1016/j.oraloncology.2025.107770","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107770"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: A phase II clinical trial of paclitaxel-carboplatin as neoadjuvant therapy followed by surgery in patients with locally advanced head and neck squamous cell carcinoma","authors":"Min Li, Yingchun Zhou, Ming Cai","doi":"10.1016/j.oraloncology.2025.107784","DOIUrl":"10.1016/j.oraloncology.2025.107784","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107784"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145518017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and surgical complexity outperform preoperative Geriatric-8 for 30-day major complications in older head and neck cancer","authors":"Araceli Diez-Fraile , Lies Pottel , Philippe Lamoral , Tom De Backer , Christophe Spaas , Raf Van Hoeyweghen , Tom Vauterin , Catherine Dick , Johan Abeloos , Joke De Ceulaer","doi":"10.1016/j.oraloncology.2025.107774","DOIUrl":"10.1016/j.oraloncology.2025.107774","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107774"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the comment on “Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancers","authors":"Annu Singh , Teeradon Treechairusame , Edward Christopher Dee , Joseph M. Huryn , Cherry L. Estilo , Nancy Y. Lee","doi":"10.1016/j.oraloncology.2025.107775","DOIUrl":"10.1016/j.oraloncology.2025.107775","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107775"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating CD103+ intratumoral immune cell abundance and PD-L1 CPS in primary tumors versus lymph nodes in Human papillomavirus associated oropharyngeal Cancer","authors":"Chia Yuen Chong ,&nbsp;Richard J. Young ,&nbsp;Annette M. Lim ,&nbsp;Angela Pizzolla ,&nbsp;Christopher M. Angel ,&nbsp;Mathias Bressel ,&nbsp;Matthew Magarey ,&nbsp;Benjamin Dixon ,&nbsp;Benjamin Solomon ,&nbsp;Danny Rischin","doi":"10.1016/j.oraloncology.2025.107792","DOIUrl":"10.1016/j.oraloncology.2025.107792","url":null,"abstract":"<div><h3>Background</h3><div>CD103⁺ intratumoral immune cell (ITIC) abundance in Human Papillomavirus associated Oropharyngeal Cancer (HPVOPC) primary tumors in patients treated with chemoradiation conveys an excellent prognosis, but data is lacking for nodal expression and surgical cohorts. High programmed death-ligand 1 (PD-L1) expression predicts immunotherapy response, but its prognostic significance and correlation with CD103⁺ expression in HPVOPC is unknown.</div></div><div><h3>Methods</h3><div>Immunohistochemistry to evaluate CD103⁺ ITIC abundance &gt; 30 % and PD-L1 Combined Positive Score (CPS) &gt; 20 % in primary tumors and lymph nodes in 114 surgically treated HPVOPC patients. Findings were correlated with clinicopathological and outcome data.</div></div><div><h3>Results</h3><div>High CD103⁺ ITIC abundance (&gt;30 %) in 14.5 % of primary tumors (16/110) and 14.3 % (11/77) of lymph nodes. High PD-L1 CPS (&gt;20 %) in 38.3 % (41/107) of primaries, and 36.3 % (28/77) of nodes. Discordant rates between primaries and nodes for CD103⁺ ITIC and PD-L1 CPS were 15 % and 29 % respectively. 5-year failure free survival (FFS) was 100 % and 83 % in patients with high and low CD103⁺ ITIC abundance primary tumors, (95 % CI: 72–91; <em>p</em> = 0.161). 5-year FFS was 98 % and 79 % (<em>p</em> = 0.033) in patients with high and low PD-L1 CPS primary tumors. Lymph node CD103⁺ ITIC abundance and PD-L1 CPS did not appear to be prognostic for survival.</div></div><div><h3>Conclusions</h3><div>This study highlights the discordance in CD103⁺ ITIC and PD-L1 expression between primaries and nodes, favorable results in high CD103⁺ ITIC abundance HPVOPC in a surgical cohort consistent with outcomes in chemoradiation cohorts, and promising results suggesting that high PD-L1 CPS in HPVOPC also identifies patients with an excellent prognosis.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107792"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145569573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer stage documentation and accuracy: Single-center retrospective study on oropharyngeal cancers","authors":"Elif Baran ,&nbsp;Melissa Lee ,&nbsp;Pabiththa Kamalraj ,&nbsp;Irene Karam ,&nbsp;Ian Poon ,&nbsp;Andrew Bayley ,&nbsp;Kevin M. Higgins ,&nbsp;Danny J. Enepekides ,&nbsp;Kelvin K.W. Chan ,&nbsp;Ambika Parmar ,&nbsp;Martin Smoragiewicz ,&nbsp;Antoine Eskander","doi":"10.1016/j.oraloncology.2025.107795","DOIUrl":"10.1016/j.oraloncology.2025.107795","url":null,"abstract":"<div><h3>Objective</h3><div>The objectives were to (1) conduct an electronic health records (EHRs) review of oropharyngeal cancer patients, (2) determine EHR stage documentation rates, and (3) compare staging accuracy within EHRs and by Cancer Center Coders.</div></div><div><h3>Methods</h3><div>Retrospective analysis of oropharyngeal cancer patients seen between January 1, 2010, and August 1, 2020, at a tertiary care center. Two experts reviewed EHRs to determine tumour (T), nodal (N), metastatic (M) and overall cancer stages. EHR staging documentation was abstracted and accuracy was reported in comparison to expert staging. Cancer Center Coders independently captured cancer staging, and accuracy was reported in comparison to expert staging.</div></div><div><h3>Results</h3><div>803 patients were included. EHR stage documentation rates were 80 %, 78 %, 16 %, and 16 % for T, N, M, and overall stage, respectively. Average annual concordance (SD) between expert review and Cancer Center Coders were 65.6 %(5.0), 67.0 %(5.4), 90.7 %(4.9), 65.8 %(11.9) for T, N, M and overall stage, respectively. Concordance (SD) between expert review and EHR stage were 65.6%(8.6), 58.5 %(7.8), 9.3 %(3.8) and 13.6 %(7.5) for T, N, M and overall stage, respectively. In a sub-cohort of patients with only chart-documented staging, concordance (SD) rates were 80.9 %(5.4), 74.1 %(5.6), 58.0 %(16.3) and 78.2 %(15.0) for T, N, M and overall cancer stages.</div></div><div><h3>Conclusion</h3><div>EHR stage documentation rates were good for T and N stages, however poor for M and overall cancer stages. Staging accuracy was moderate-to-good when comparing staging from expert reviews to staging by Cancer Center Coders and clinicians. Quality improvement interventions may improve accuracy and frequency of HNC staging, thus improving patient outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107795"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-surgery billing in head and neck free-flap reconstruction: trends and reimbursement patterns under medicare","authors":"Daniel Gilmore ,&nbsp;Nolan B. Seim ,&nbsp;Lauren E. Miller","doi":"10.1016/j.oraloncology.2025.107763","DOIUrl":"10.1016/j.oraloncology.2025.107763","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107763"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The low evidence to treat elderly patients with head and neck cancer","authors":"Beatriz Bertin ,&nbsp;Luiz Paulo Kowalski ,&nbsp;Leandro Luongo Matos","doi":"10.1016/j.oraloncology.2025.107764","DOIUrl":"10.1016/j.oraloncology.2025.107764","url":null,"abstract":"<div><div>Treatment of head and neck cancer in older patients is particularly complex, as they are more prone to side effects and treatment-related toxicity due to age-related physiological changes. Nevertheless, they should still receive care based on the best available standards and protocols, since alternative approaches may increase the risk of treatment failure and mortality. The core issue lies in the lack of evidence-based protocols tailored to the specific needs of older patients, as most clinical trials seam to focus on younger populations. The objective of this study was to determine the rate of patients over 65 years of age included in clinical trials of treatments for head and neck cancer. In this context, the study aims to shed light on the proportion of clinical evidence that can be safely extrapolated to the treatment of older patients with head and neck cancer. To achieve this, we analyzed the age distribution of patients enrolled in clinical trials cited by the National Comprehensive Cancer Network (NCCN) in the NCCN Guidelines Version 2.2025: Head and Neck Cancers. Less than one-fourth of patients enrolled in the NCCN-referenced clinical trials were over 65 years of age, reinforcing concerns about the applicability of current protocols to this population. To address this gap, the most effective strategy is to promote the generation and dissemination of evidence-based data that actively includes older adults worldwide.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107764"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: “Patterns of care in de‑novo oligo‑metastatic and oligo‑recurrent head and neck cancers: A HNCIG survey” (Oral oncology)","authors":"Nengjun Xiang ,&nbsp;Wentao Li","doi":"10.1016/j.oraloncology.2025.107749","DOIUrl":"10.1016/j.oraloncology.2025.107749","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"171 ","pages":"Article 107749"},"PeriodicalIF":3.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}