Oral oncology最新文献_第8页

Personalized intraoral devices in the era of high-technology head and neck radiotherapy: A resource to be explored 高科技头颈部放射治疗时代的个性化口内设备：有待开发的资源

IF 4 2区医学

Oral oncology Pub Date : 2024-09-09 DOI: 10.1016/j.oraloncology.2024.107013

Breno Amaral Rocha, Mateus Costa Lima, Lucianne Maia Costa, Mayra Mendes Soares Teixeira, Angel da Silva Martinez, Carlos Antônio Lopes Junior, Martinho Campolina Rebello Horta

引用次数: 0

Letter to Editor regarding “Circulating tumor tissue modified viral (TTMV)-HPV DNA in Recurrent, metastatic HPV-driven oropharyngeal cancer” 致编辑的信，内容涉及 "复发性、转移性 HPV 驱动的口咽癌中的循环肿瘤组织修饰病毒 (TTMV)-HPV DNA"。

IF 4 2区医学

Oral oncology Pub Date : 2024-09-08 DOI: 10.1016/j.oraloncology.2024.107020

Sathish Sankar

引用次数: 0

MRI-based deep learning and radiomics for occult cervical lymph node metastasis (OCLNM) prediction 基于磁共振成像深度学习和放射组学的隐匿性宫颈淋巴结转移（OCLNM）预测。

IF 4 2区医学

Oral oncology Pub Date : 2024-09-07 DOI: 10.1016/j.oraloncology.2024.107019

Sesuraj Balasamy , Jayalakshmi Somasundaram , Ashok K. Sundramoorthy

引用次数: 0

Commentary on “Tumor Habitat-Based MRI features assessing early response in locally advanced nasopharyngeal carcinoma” 关于 "基于肿瘤生境的磁共振成像特征评估局部晚期鼻咽癌的早期反应 "的评论。

IF 4 2区医学

Oral oncology Pub Date : 2024-09-07 DOI: 10.1016/j.oraloncology.2024.107018

T. Prithviraj

引用次数: 0

The association of frailty with morbidity and mortality following major mucosal head and neck surgery 头颈部粘膜大手术后体弱与发病率和死亡率的关系。

IF 4 2区医学

Oral oncology Pub Date : 2024-09-07 DOI: 10.1016/j.oraloncology.2024.107021

Eoin F. Cleere, Justin M. Hintze, Claire Doherty, Conrad V.I. Timon, John Kinsella, Paul Lennon, Conall W.R. Fitzgerald

{"title":"The association of frailty with morbidity and mortality following major mucosal head and neck surgery","authors":"Eoin F. Cleere, Justin M. Hintze, Claire Doherty, Conrad V.I. Timon, John Kinsella, Paul Lennon, Conall W.R. Fitzgerald","doi":"10.1016/j.oraloncology.2024.107021","DOIUrl":"10.1016/j.oraloncology.2024.107021","url":null,"abstract":"<div><h3>Objectives</h3><p>Frailty refers to a state of reduced physiological reserve and functional decline. We sought to analyse whether frailty, assessed using the 5-item modified frailty index (5mFI), was associated with increased morbidity and mortality following major mucosal head and neck surgery.</p></div><div><h3>Materials and Methods</h3><p>We performed a retrospective study of patients undergoing major mucosal head and neck surgical resection over a 2-year period. Potential confounding variables were controlled by way of multivariable regression analysis.</p></div><div><h3>Results</h3><p>There were 310 patients included with 77 (24.8 %) classified as frail. Most patients were male (219/310, 70.7 %), had a history of smoking (246/310, 79.4 %) and 151 patients (48.7 %) were older than 65 at time of surgery. Most surgeries related to oral cavity or oropharyngeal subsites (227/310, 73.2 %) and 150 patients (48.4 %) underwent microvascular free tissue reconstruction. On multivariable analysis, frail patients were more likely to suffer adverse outcomes such as a return to theatre (OR 3.47, 95 % CI 1.82–6.62, p < 0.001), a Clavien-Dindo grade IV complication (OR 6.23, 95 % CI 2.55–15.20, p < 0.001) or medical complications, such as respiratory complications (OR 2.61, 95 % CI 1.45–4.69; p = 0.001) or delirium (OR 5.05, 95 % CI 2.46–10.33; p < 0.001). Additionally, hospital length of stay was increased among frail patients (ß 16.46 days, 95 % CI 9.85–23.07 days; p < 0.001). Neither 90-day nor 1-year post-operative mortality was increased in frail patients.</p></div><div><h3>Conclusion</h3><p>Frailty assessed using the 5mFI was associated with greater post-operative morbidity, but not mortality following major mucosal head and neck surgery.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma 通过机器学习从头颈部鳞状细胞癌的超增强相关基因中提取新型预后特征。

IF 4 2区医学

Oral oncology Pub Date : 2024-09-07 DOI: 10.1016/j.oraloncology.2024.107016

An Wang , He Xia , Jin Li , Pengfei Diao , Jie Cheng

{"title":"Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma","authors":"An Wang , He Xia , Jin Li , Pengfei Diao , Jie Cheng","doi":"10.1016/j.oraloncology.2024.107016","DOIUrl":"10.1016/j.oraloncology.2024.107016","url":null,"abstract":"<div><p>Dysregulated super-enhancer (SE) results in aberrant transcription that drives cancer initiation and progression. SEs have been demonstrated as novel promising diagnostic/prognostic biomarkers and therapeutic targets across multiple human cancers. Here, we sought to develop a novel prognostic signature derived from SE-associated genes for head and neck squamous cell carcinoma (HNSCC). SE was identified from H3K27ac ChIP-seq datasets in HNSCC cell lines by ROSE algorithm and SE-associated genes were further mapped and functionally annotated. A total number of 133 SE-associated genes with mRNA upregulation and prognostic significance was screened via differentially-expressed genes (DEGs) and Cox regression analyses. These candidates were subjected for prognostic model constructions by machine learning approaches using three independent HNSCC cohorts (TCGA-HNSC dataset as training cohort, GSE41613 and GSE42743 as validation cohorts). Among dozens of prognostic models, the random survival forest algorithm (RSF) stood out with the best performance as evidenced by the highest average concordance index (C-index). A prognostic nomogram integrating this SE-associated gene signature (SEAGS) plus tumor size demonstrated satisfactory predictive power and excellent calibration and discrimination. Moreover, WNT7A from SEARG was validated as a putative oncogene with transcriptional activation by SE to promote malignant phenotypes. Pharmacological disruption of SE functions by BRD4 or EP300 inhibitor significantly impaired tumor growth and diminished WNT7A expression in a HNSCC patient-derived xenograft model. Taken together, our results establish a novel, robust SE-derived prognostic model for HNSCC and suggest the translational potentials of SEs as promising therapeutic targets for HNSCC.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative protective stenting of the carotid artery in severe complex head and neck cancer resection 严重复杂头颈癌切除术中的颈动脉术前保护性支架植入术

IF 4 2区医学

Oral oncology Pub Date : 2024-09-04 DOI: 10.1016/j.oraloncology.2024.107012

Ji Xiaoyu , Pan Baihong , Li Yaozhen, Chen Shen, Sheng Chang, Liu Tinghua, Ouyang Yang

{"title":"Preoperative protective stenting of the carotid artery in severe complex head and neck cancer resection","authors":"Ji Xiaoyu , Pan Baihong , Li Yaozhen, Chen Shen, Sheng Chang, Liu Tinghua, Ouyang Yang","doi":"10.1016/j.oraloncology.2024.107012","DOIUrl":"10.1016/j.oraloncology.2024.107012","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate effects of preoperative protective carotid artery (CA) stenting in complex head and neck cancer (HNC) resection.</p></div><div><h3>Material and methods</h3><p>HNC that encases the CA is complex. Fifty-five patients diagnosed with complex HNC from 2018 to 2021 were enrolled, and were divided into Control group (general complex cases) and carotid artery stent (CAS) group (severe complex cases). All patients underwent standard tumor resection, while patients in the CAS group also underwent preoperative covered CA stenting. Medical information was retrospectively analyzed.</p></div><div><h3>Results</h3><p>CA stenting and tumor resection were successfully performed. Baseline demographics were recorded. CAS and Control groups had similar results for complete tumor resection rate, operation time, and intraoperative blood loss, although the CA was obviously more involved in CAS group than in Control group. However, recurrence rate in the CAS group was significantly lower than Control group, indicating that preoperative CA stent implantation facilitates complete tumor removal. Furthermore, perioperative CA-associated complications including common/internal CA ligation were more frequent in Control group. Overall survival and disease-free survival rate in CAS group and Control group was 87.5% and 69.2%, respectively. Disease-free survival rate in CAS group and Control group was 87.5% and 42.3%, respectively. No postoperative cerebral infarction was observed in either group. Overall hospitalization cost was recorded.</p></div><div><h3>Conclusions</h3><p>Preoperative protective CA stenting facilitates more thorough tumor removal while better preserving the CA during complex HNC resection, reducing the surgical difficulty. Preoperative CA stenting may be a safe and effective therapeutic option for resection of HNC encasing the CA.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of intra-tumoural heterogeneity on liquid biopsy cell-free DNA methylation and copy number in head and neck squamous cell carcinoma 探索肿瘤内异质性对头颈部鳞状细胞癌液体活检无细胞DNA甲基化和拷贝数的影响

IF 4 2区医学

Oral oncology Pub Date : 2024-09-04 DOI: 10.1016/j.oraloncology.2024.107011

Karl Payne , Harini Suriyanarayanan , Jill Brooks , Hisham Mehanna , Paul Nankivell , Deena Gendoo

{"title":"Exploring the impact of intra-tumoural heterogeneity on liquid biopsy cell-free DNA methylation and copy number in head and neck squamous cell carcinoma","authors":"Karl Payne , Harini Suriyanarayanan , Jill Brooks , Hisham Mehanna , Paul Nankivell , Deena Gendoo","doi":"10.1016/j.oraloncology.2024.107011","DOIUrl":"10.1016/j.oraloncology.2024.107011","url":null,"abstract":"<div><p>Liquid biopsy profiling is gaining increasing promise towards biomarker-led identification and disease stratification of tumours, particularly for tumours displaying significant intra-tumoural heterogeneity (ITH). For head and neck squamous cell carcinoma (HNSCC), which display high levels of genetic ITH, identification of epigenetic modifications and methylation signatures has shown multiple uses in stratification of HNSCC for prognosis, treatment, and HPV status. In this study, we investigated the potential of liquid biopsy methylomics and genomic copy number to profile HNSCC. We conducted multi-region sampling of tumour core, tumour margin and normal adjacent mucosa, as well as plasma cell-free DNA (cfDNA) across 9 HNSCC patients. Collectively, our work highlights the prevalence of methylomic ITH in HNSCC, and demonstrates the potential of cfDNA methylation as a tool for ITH assessment and serial sampling.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368837524003294/pdfft?md5=4dab00dbe9961b56c8ece9ddaa452917&pid=1-s2.0-S1368837524003294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xerostomia prediction in patients with nasopharyngeal carcinoma during radiotherapy using segmental dose distribution in dosiomics and radiomics models 利用剂量组学和放射组学模型中的分段剂量分布预测鼻咽癌患者放疗期间的口干症状

IF 4 2区医学

Oral oncology Pub Date : 2024-09-02 DOI: 10.1016/j.oraloncology.2024.107000

Xushi ZHANG , Wanjia ZHENG , Sijuan HUANG , Haojiang LI , Zhisheng BI , Xin YANG

{"title":"Xerostomia prediction in patients with nasopharyngeal carcinoma during radiotherapy using segmental dose distribution in dosiomics and radiomics models","authors":"Xushi ZHANG , Wanjia ZHENG , Sijuan HUANG , Haojiang LI , Zhisheng BI , Xin YANG","doi":"10.1016/j.oraloncology.2024.107000","DOIUrl":"10.1016/j.oraloncology.2024.107000","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to integrate radiomics and dosiomics features to develop a predictive model for xerostomia (XM) in nasopharyngeal carcinoma after radiotherapy. It explores the influence of distinct feature extraction methods and dose ranges on the performance.</p></div><div><h3>Materials and methods</h3><p>Data from 363 patients with nasopharyngeal carcinoma were retrospectively analyzed. We pioneered a dose-segmentation strategy, where the overall dose distribution (OD) was divided into four segmental dose distributions (SDs) at intervals of 15 Gy. Features were extracted using manual definition and deep learning, applying OD or SD and integrating radiomics and dosiomics, yielding corresponding feature scores (manually defined radiomics, MDR; manually defined dosiomics, MDD; deep learning-based radiomics, DLR; deep learning-based dosiomics, DLD). Subsequently, 18 models were developed by combining features and model types (random forest and support vector machine).</p></div><div><h3>Results and conclusion</h3><p>Under OD, O(DLR_DLD) demonstrated exceptional performance, with an optimal area under the curve (AUC) of 0.81 and an average AUC of 0.71. Within SD, S(DLR_DLD) surpassed the other models, achieving an optimal AUC of 0.90 and an average AUC of 0.85. Therefore, the integration of dosiomics into radiomics can augment predictive efficacy. The dose-segmentation strategy can facilitate the extraction of more profound information. This indicates that ScoreDLR and ScoreMDR were negatively associated with XM, whereas ScoreDLD, derived from SD exceeding 15 Gy, displayed a positive association with XM. For feature extraction, deep learning was superior to manual definition.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival, Surgical, and functional outcomes of transoral laser microsurgery for cT1-T3 supraglottic laryngeal Cancers: A systematic review 经口激光显微手术治疗 cT1-T3 声门上型喉癌的生存、手术和功能效果：系统综述

IF 4 2区医学

Oral oncology Pub Date : 2024-09-01 DOI: 10.1016/j.oraloncology.2024.107009

Jerome R. Lechien , Stéphane Hans

{"title":"Survival, Surgical, and functional outcomes of transoral laser microsurgery for cT1-T3 supraglottic laryngeal Cancers: A systematic review","authors":"Jerome R. Lechien , Stéphane Hans","doi":"10.1016/j.oraloncology.2024.107009","DOIUrl":"10.1016/j.oraloncology.2024.107009","url":null,"abstract":"<div><h3>Background</h3><p>This review aimed to investigate the surgical, functional, and oncological outcomes of transoral laser microsurgery supraglottic laryngectomy (TOLM-SGL) for cT1-T3 laryngeal cancers.</p></div><div><h3>Methods</h3><p>PubMed, Scopus, and Cochrane Library were searched by two independent investigators for studies investigating the surgical, functional, and oncological outcomes of TOLM-SGL using the PRISMA statements. A bias analysis was carried out with MINORS.</p></div><div><h3>Results</h3><p>Twenty-four studies were included (937 patients), including 206 (25.9 %) cT1, 467 (58.7 %) cT2, and 123 (15.4 %) cT3 cases. Most patients were cN0 (63.9 %). The mean hospital stay of TOLM was 10.1 days. Aspiration (5.5 %), and bleeding (5.3 %) were the most prevalent complications. The laryngeal preservation rate was 93.7 %. Temporary tracheotomy was performed in 18.0 % of patients, with a mean time of decannulation of 6.8 days. A feeding tube was placed in 59.9 % of patients. The oral diet restarted after 6.4 days. Definitive gastrostomy was necessary in 2.4 % of cases. The 5-year OS and DFS were 70.1 % and 82.0 %, respectively. Distant metastasis, local, and regional recurrence occurred in 4.6 %, 11.6 %, and 5.1 % of patients. There was an important heterogeneity between studies for inclusion criteria, patient profiles, TOLM indications, and details of surgical, functional, and oncological outcomes.</p></div><div><h3>Conclusion</h3><p>TOLM supraglottic laryngectomy is a safe, and effective procedure associated with adequate functional, surgical, and oncological outcomes. Future studies are needed to define the place of TOLM in advanced LSCC; the role and timing of concomitant bilateral neck dissection, the indications of tracheotomy and feeding tube.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0