Oral oncology最新文献

{"title":"Comment on \"Does discharge location following head and neck cancer surgery affect quality outcomes?\"","authors":"G Karpagavalli, Ivan Abhishek Prakash, B Ariyalakshmi, P F Regina","doi":"10.1016/j.oraloncology.2026.108182","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2026.108182","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"182 ","pages":"108182"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does osteosarcopenia add prognostic information beyond osteopenia alone in head and neck cancer?","authors":"Chao-Qing Long","doi":"10.1016/j.oraloncology.2026.108190","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2026.108190","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"182 ","pages":"108190"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The double jeopardy effect of socioeconomic barriers on guideline-concordant postoperative radiation in oropharyngeal cancer.","authors":"Sudarshan Ramanan, George Ashji, Nishant Chadha, Yingzhi Wu, Achraf Shamseddine, Yao Yu, Edward Christopher Dee, Nancy Y Lee","doi":"10.1016/j.oraloncology.2026.108187","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2026.108187","url":null,"abstract":"<p><p>Receipt of timely adjuvant radiation after primary surgery for head and neck cancer is a well-established quality benchmark. The social and structural drivers of suboptimal care, however, remain incompletely characterized. Very little work has been done on understanding the combined and interacting effects of social determinants on postoperative radiation therapy (PORT) receipt and timing. Upon examining PORT delivery among intermediate- and high-risk oropharyngeal squamous cell carcinoma patients, we identified that patients who are both uninsured and live far from a treatment center are at the highest risk for not receiving adjuvant radiation therapy. By identifying which specific patient subpopulations are most vulnerable to delayed or omitted treatment, this analysis provides actionable data to guide institutional interventions, optimize resource allocation, and support advocacy efforts aimed at closing equity gaps in head and neck cancer care.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"182 ","pages":"108187"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A phase II clinical trial of paclitaxel-carboplatin as neoadjuvant therapy followed by surgery in patients with locally advanced head and neck squamous cell carcinoma\" [Oral Oncol. 170 (2025) 107745].","authors":"Min Hee Hong, Seoyoung Lee, Chang Gon Kim, Wonrak Son, Jin Woo Park, Sun Och Yoon, Su-Jin Shin, Hyun Jun Hong, Yoon Woo Koh, Jae-Yol Lim, Young Min Park, Chan Woo Wee, Kyung Hwan Kim, Chang Geol Lee, Jun Won Kim, Jinna Kim, Pae Sun Suh, Sung Uk Kuh, Da Hee Kim, Nam Suk Sim, Hye Ryun Kim","doi":"10.1016/j.oraloncology.2026.108114","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2026.108114","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":" ","pages":"108114"},"PeriodicalIF":4.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroglossal duct cyst carcinoma: A case report about diagnostic and surgical challenges","authors":"Fatima Shahid ,&nbsp;Ansar Raza Mohsin ,&nbsp;Ummi Aiman Rahman ,&nbsp;Amna Azam Warraich ,&nbsp;Aliza Asif ,&nbsp;Maheen Asif ,&nbsp;Hassan Bin Aziz ,&nbsp;Hafiz Muhammad Asif Maqbool ,&nbsp;Muhammad Nabeel Saddique","doi":"10.1016/j.oraloncology.2026.107890","DOIUrl":"10.1016/j.oraloncology.2026.107890","url":null,"abstract":"<div><h3>Background</h3><div>A thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass, resulting from the incomplete obliteration of the thyroglossal duct during embryogenesis. Although typically presenting in childhood, TGDCs can remain asymptomatic and manifest later in life. Proper diagnosis is crucial to avoid unnecessary interventions and complications.</div></div><div><h3>Case Presentation</h3><div>We report the case of a 26-year-old South Asian male who presented with a painless, fluctuant midline neck swelling that had progressively enlarged over the past few months. Clinical examination revealed a well-defined, mobile mass at the level of the hyoid bone that exhibited upward movement with tongue protrusion, a hallmark feature of TGDC. Ultrasound confirmed a cystic lesion, and fine-needle aspiration ruled out any malignant features. The patient underwent successful surgical excision via the Sistrunk procedure, which involves the removal of the cyst along with the central portion of the hyoid bone to minimize recurrence. Postoperative recovery was uneventful. Histopathology report revealed a unifocal tumor and after MDT’s discussion total thyroidectomy was planned. Patient was asked to follow-up for radiation therapy afterwards.</div></div><div><h3>Conclusion</h3><div>TGDCs can present at any age and should be considered in the evaluation of midline neck masses. A thorough clinical assessment, supported by imaging, is crucial for accurate diagnosis. The Sistrunk procedure remains the gold standard for treatment, significantly reducing the risk of recurrence. In cases with suspicious features or malignancy, total thyroidectomy may be necessary for complete disease management. Early identification and appropriate intervention improve patient outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107890"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does discharge location following head and neck cancer surgery affect quality outcomes?","authors":"Cristina Benites ,&nbsp;Colyn White ,&nbsp;Logesvar Balaguru ,&nbsp;Liu Gonghao ,&nbsp;Ji-Hyun Lee ,&nbsp;Dustin J. Conrad ,&nbsp;Austin Lam ,&nbsp;Peter T. Dziegielewski","doi":"10.1016/j.oraloncology.2026.107879","DOIUrl":"10.1016/j.oraloncology.2026.107879","url":null,"abstract":"<div><h3>Background</h3><div>Discharge (DC) to post-acute care facilities after head and neck cancer (HNC) surgery is common. Studies in various fields of medicine have shown that DC to facilities is associated with clinical outcomes. Evidence specific to HNC surgery is limited.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate how DC, to either home or a facility, impacts outcomes for patients undergoing HNC surgery.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of patients who underwent HNC surgery between January 1, 2014, and January 1, 2023 was performed. Patients were included based on postoperative hospitalization, surgical interventions, and a minimum 30-day follow-up. The primary outcomes were 30-day readmission, 30-day mortality, and postoperative complication severity.</div></div><div><h3>Results</h3><div>Among 1,895 patients (mean age 63 years, 67% female), 1,554 (82%) were DC home and 341 (18%) to a facility. After adjusting for significant variables, DC site was not associated with readmission (OR 0.94, 95% CI 0.63–1.40), mortality (0.6% home vs 1.5% facility, p = 0.2), or complication severity (mild OR 1.3, p = 0.11; severe OR 1.0, p = 0.92). Factors such as dependency in activities of daily living, tracheotomy presence, surgery severity and prolonged hospitalization were found to be significant covariates in the multivariable analysis for both 30-day readmissions and complication severity. Facility patients had more infections or wound dehiscence (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Although DC to a facility was not significantly associated with worsened outcomes in the multivariable analysis, the findings of this study revealed clinically relevant differences in complication rates and readmission.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107879"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel method using electronic health record coding to generate a unique, multipurpose database for aerodigestive malignancy surveillance","authors":"Lindsey Mortensen,&nbsp;Alexander Dwyer,&nbsp;Benjamin Palatnik,&nbsp;Beverly R Wuertz,&nbsp;Frank G Ondrey","doi":"10.1016/j.oraloncology.2026.107886","DOIUrl":"10.1016/j.oraloncology.2026.107886","url":null,"abstract":"<div><h3>Background</h3><div>Upper aerodigestive/head and neck cancer affects over 45,000 patients annually in the oral cavity and oropharynx alone. This burden may be reduced through surveillance of patients with oral potentially malignant disorders (OPMD). Here we describe a readily accessible pilot study evaluating a database-generating approach that captures our longstanding Cancer Active Surveillance Program (CASP). Our methods can be applied to other premalignancies and disease conditions to fuel clinically relevant research related to cancer risk, disease progression, interception, and outcomes.</div></div><div><h3>Methods</h3><div>Electronic medical record data from the senior author’s head and neck cancer practice, which harbors a significant primary screening component, was interrogated for 35 International Classification of Disease 9 and 10 codes. These codes represent over 300 unique mucosal lesion descriptors or conditions associated with heightened risk for oral cancer. These data were subject to a proof-of-concept analysis to assess geographic and racial representation in the CASP.</div></div><div><h3>Results</h3><div>Automated extraction from the electronic medical record identified 1576 individuals with OPMDs with lower cost and higher fidelity than manual chart review. CASP patients were overrepresented relative to the state population within urban centers, with underrepresentation in more rural areas. More Black patients and fewer Asian/Pacific Islander patients were seen in CASP relative to our cancer catchment’s demography.</div></div><div><h3>Conclusions</h3><div>Automated medical record queries can identify patients in the catchment area with precancerous or other at-risk conditions for cancer.</div></div><div><h3>Impact</h3><div>This information informs resource utilization to improve inclusivity of underrepresented groups and streamlines identification of potential participants for cancer prevention clinical trials.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107886"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “My letter: Do we recognize oral oncology with accuracy? AI-driven models serve in the diagnosis of oral squamous cell carcinoma”","authors":"Jiayi Chen","doi":"10.1016/j.oraloncology.2026.107889","DOIUrl":"10.1016/j.oraloncology.2026.107889","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107889"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary management of the clinically N0 neck in oral squamous cell carcinoma","authors":"Makoto Adachi ,&nbsp;Shinsuke Ohta ,&nbsp;Ayaka Ishii ,&nbsp;Masayuki Motohashi","doi":"10.1016/j.oraloncology.2025.107839","DOIUrl":"10.1016/j.oraloncology.2025.107839","url":null,"abstract":"<div><h3>Background</h3><div>The management of the clinically negative neck (N0) in oral squamous cell carcinoma (OSCC) remains a challenging clinical dilemma. Although imaging techniques have advanced, occult metastases are present in approximately 20–30% of patients with early-stage oral cancer and clinically negative necks.</div></div><div><h3>Objective</h3><div>This review examines current evidence on optimal strategies for managing the N0 neck in oral cancer patients.</div></div><div><h3>Methods</h3><div>We discuss diagnostic modalities for detecting occult metastases, including clinical examination, conventional imaging (ultrasonography, computed tomography, magnetic resonance imaging), functional imaging (positron emission tomography), and sentinel lymph node biopsy. The review evaluates the main management approaches---elective neck dissection, watchful waiting, and sentinel lymph node biopsy---analyzing current evidence from randomized controlled trials and <em>meta</em>-analyses.</div></div><div><h3>Results</h3><div>We examine patient and tumor factors that influence decision-making, including tumor thickness, location, differentiation, and pattern of invasion. Special considerations for specific subsites and clinical scenarios are discussed.</div></div><div><h3>Conclusions</h3><div>Finally, we explore emerging technologies and future directions in the management of the N0 neck, including molecular biomarkers, liquid biopsy techniques, and personalized approaches to treatment. This review provides evidence-based recommendations to support clinical decision-making for managing patients with oral cancer and clinically negative necks.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107839"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of frozen section for HPV-Associated squamous cell carcinoma of unknown primary","authors":"Sindhura Sridhar ,&nbsp;Annie Moroco ,&nbsp;Shravan Gowrishankar ,&nbsp;Mitra Mehrad ,&nbsp;Kim Ely ,&nbsp;James S. Lewis ,&nbsp;Madalina Tuluc ,&nbsp;Stacey Gargano ,&nbsp;Melanie Hicks ,&nbsp;Kyle Mannion ,&nbsp;Arielle G. Thal ,&nbsp;Adam J. Luginbuhl ,&nbsp;Joseph M. Curry ,&nbsp;David M. Cognetti ,&nbsp;Michael C. Topf","doi":"10.1016/j.oraloncology.2026.107861","DOIUrl":"10.1016/j.oraloncology.2026.107861","url":null,"abstract":"<div><h3>Introduction</h3><div>Current guidelines for the management of metastatic squamous cell carcinoma of unknown primary (SCCUP) recommend submission of suspicious primary sites for frozen section analysis (FSA). This study aims to investigate the diagnostic accuracy of FSA for identification of HPV-associated SCCUP.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of patients with biopsy-proven p16-positive SCCUP who underwent diagnostic operation at two tertiary care institutions was performed. Sensitivity, specificity, PPV, and NPV of diagnostic FSA were assessed.</div></div><div><h3>Results</h3><div>77 patients were included in analysis. 66 patients underwent definitive TORS (diagnostic TORS operation with subsequent neck dissection after identification of the occult primary tumor), 7 patients underwent diagnostic TORS (TORS to identify occult primary tumor, no neck dissection), and 4 patients underwent direct laryngoscopy and biopsy only. Primary tumors were identified in 63 patients (82%) with a mean tumor size of 1.1 cm. There was no significant difference in size between patients whose tumor was identified on FSA (mean 1.1 cm) and on permanent only (mean 0.9 cm) (p = 0.26). The sensitivity, specificity, PPV, and NPV of FSA for SCCUP was 86%, 100%, 100%, and 86%, respectively. Diagnostic frozen specimens included 52 direct laryngoscopy biopsies and 69 TORS excisions. In the biopsies, sensitivity was 100% and NPV was 100%, whereas in the TORS-excised specimens, sensitivity was 77% and NPV was 77%.</div></div><div><h3>Conclusions</h3><div>In this case series of 77 patients with SCCUP, the sensitivity and NPV of FSA for identification of the primary tumor was over 85%. FSA is valuable during diagnostic operation for SCCUP.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107861"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}