Oral oncology最新文献

{"title":"Metastasis to the ciliary body and iris from a parotid carcinoma.","authors":"Suellen Hornos Vieira, André Alexis Corazza Vidoris, Leandro Luongo Matos","doi":"10.1016/j.oraloncology.2024.107098","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2024.107098","url":null,"abstract":"<p><p>Adenoid cystic carcinoma (ACC) of the parotid gland is a relatively rare neoplasm, accounting for 10-15 % of all salivary gland tumors. Metastasis to the uveal region, particularly to the ciliary body and iris, is extremely uncommon, with the first case reported in 2011. This case report describes a 32-year-old woman with a history of ACC of the parotid gland. Despite radical surgery, radiotherapy, and facial nerve reconstruction, the patient developed metastasis to the ciliary body and iris one year after treatment. Ultrasonography revealed a solid iridociliary mass, and radiotherapy was administered. The patient later developed meningeal, hepatic, and bone metastases, leading to her death four years after diagnosis. This report highlights the rarity of uveal metastasis from ACC and the importance of considering metastatic disease in oncology patients presenting with ocular symptoms, as early diagnosis and intervention may improve outcomes and quality of life.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative use of radial artery retrograde forearm flap for oral and maxillofacial reconstruction.","authors":"Hui Peng, Li Y Zhang, Wei Z Zhu, Yu Zhou","doi":"10.1016/j.oraloncology.2024.107084","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2024.107084","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study is to present a novel method of reconstructing oral and maxillofacial defects using the Radial Artery Retrograde Proximal Forearm Flap (RARPFF) and to evaluate the efficacy and safety of the forearm flap for direct closure of the donor site and its effect on hand function in the donor area.</p><p><strong>Methods: </strong>A prospective study of 30 patients who underwent oral and maxillofacial reconstruction with RARPFF between June 2021 and April 2024 was conducted to evaluate the safety and efficacy of the flap and its influence on hand function in the donor area.</p><p><strong>Results: </strong>Flap survival was 93.3 %. The donor site defect in 28 out of 30 patients healed primarily. All donor sites were directly closed without complications such as splitting, tendon exposure, or numbness in the thumb or thenar region. Statistically significant differences were observed in grip strength (MD = 4.56, p < 0.001) and elbow extension (MD = 2.78, p < 0.001) at 3 months, as well as in grip strength (MD = 2.20, p < 0.001) and elbow extension (MD = 1.67, p < 0.001) at 1 year, compared to the contralateral hand. Wrist flexion, extension, radial deviation, ulnar deviation, elbow flexion, pronation, and supination did not exhibit statistically significant differences from the contralateral hand at both 3 months and 1 year. The Michigan Hand Questionnaire (MHQ) revealed a statistically significant difference in aesthetics compared to the contralateral hand (p < 0.001), along with satisfactory overall hand function, activities of daily living (ADL), work performance, pain levels, and patient satisfaction with hand function.</p><p><strong>Conclusions: </strong>The reverse radial artery proximal forearm flap is a dependable and secure technique for head and neck reconstruction. This method can effectively reduce donor site complications while preserving hand function.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we safely de-escalate HPV⁺ oropharyngeal cancers? - A review of current practices and novel approaches.","authors":"Janis Morgenthaler, Maike Trommer, Richard Khor, Morikatsu Wada, Houda Bahig, Adam S Garden, Alesha Thai, Hui Gan, Emmanouil Fokas, Sweet Ping Ng","doi":"10.1016/j.oraloncology.2024.107089","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2024.107089","url":null,"abstract":"<p><p>Oropharyngeal carcinomas linked to high-risk types of human papillomavirus (HPV⁺OPC) as a distinct tumor entity, have a better prognosis than HPV^-OPC. Current treatment approaches do not differentiate between HPV-positive and negative disease, but ongoing studies are exploring de-escalation strategies, aiming to reduce therapy-related morbidity and improve patient quality of life, particularly focusing on reducing late effects from radiotherapy.We performed a literature search for both published and ongoing clinical trials and critically discussed the presented concepts and results. Those include reduction in radiotherapy dose or volume, omission or modification of concomitant chemotherapy/immunotherapy, usage of induction chemotherapy and utilization of advanced molecular and imaging biomarkers and radiomics for selected subgroups of HPV⁺OPC patients. While promising data have been reported from various Phase II trials, evidence from Phase III de-escalation trials has failed to demonstrate improved outcomes. Therefore, further data and an improved risk stratification are required before de-escalated radiation treatments can be recommended outside of clinical trials.The review aims to outline current de-escalation strategies and future possibilities for enhancing patient outcomes in HPV⁺OPC.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do revised resection margins for early-stage oral tongue squamous cell carcinoma require adjuvant therapy?","authors":"Bhargav Ram, Josephine Joy, Shelly Sharma, Shalini Thakur, Anand Subash, Vishal U S Rao","doi":"10.1016/j.oraloncology.2024.107100","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2024.107100","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In reply to “Risk of cardiovascular disease among head and neck cancer survivors: A population-based matched cohort study”","authors":"John Lennon Silva Cunha","doi":"10.1016/j.oraloncology.2024.107096","DOIUrl":"10.1016/j.oraloncology.2024.107096","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Effect analysis of 847 nasopharyngeal carcinoma cases treated with intensity modulated radiation: Experience and suggestions”","authors":"Erkan Topkan ,&nbsp;Efsun Somay ,&nbsp;Duriye Ozturk ,&nbsp;Ugur Selek","doi":"10.1016/j.oraloncology.2024.107099","DOIUrl":"10.1016/j.oraloncology.2024.107099","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of immune function mediated by Gasdermin-E in the immune microenvironment of primary oral squamous cell carcinoma","authors":"Xiangjun Wang ,&nbsp;Xingyu Chen ,&nbsp;Zi Mei","doi":"10.1016/j.oraloncology.2024.107088","DOIUrl":"10.1016/j.oraloncology.2024.107088","url":null,"abstract":"<div><div>In primary oral squamous cell carcinoma (OSCC), the tumor microenvironment (TME) constitutes a highly intricate ecosystem comprised of cellular and acellular elements. The tumor immune microenvironment (TIME) is characterized by the presence of a broad of immune cells, while there is a scarcity of cytotoxic lymphocytes (CTLs) intratumorally. Consequently, the recruitment of a larger cohort of CTLs to infiltrate the tumor core has emerged as a pressing scientific challenge. Gasdermin E (GSDME), as a pivotal effector protein in pyroptosis, plays a significant role in anti-tumor therapy. Here, primary OSCC was induced by <em>Gsdme</em> knockout (KO) mice and wild type (WT) mice of the same strain respectively, using the chemical mutagen 4-Nitroquinoline N-oxide (4-NQO). Through comparative analysis of immune function between the two kinds of mice, intriguing observations have been elucidated, the presence of GSDME was instrumental in augmenting the infiltration of lymphocytes towards the neoplastic site, effectively ameliorating the TIME. Our findings elucidated that the absence of GSDME promotes the development of primary OSCC, accompanied by a notable increase in malignancy. Furthermore, our data delineated a positive inter-relationship between the presence of GSDME and the host organism’s immunological reactivity, which enhances the TIME in primary OSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine plus cisplatin versus docetaxel plus cisplatin and fluorouracil induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: A single center prospective phase II clinical trial","authors":"Kai Shang ,&nbsp;Taotao Li ,&nbsp;Yue Chen ,&nbsp;Xunyan Luo ,&nbsp;Huajing Wu ,&nbsp;Yu Zhou ,&nbsp;Jiayu Song ,&nbsp;Weili Wu ,&nbsp;Yuanyuan Li ,&nbsp;Xiuling Luo ,&nbsp;Xiaoxiao Chen ,&nbsp;Xiuyun Gong ,&nbsp;Chaofen Zhao ,&nbsp;Zhuoling Li ,&nbsp;Lina Liu ,&nbsp;Qianyong He ,&nbsp;Jinhua Long ,&nbsp;Feng Jin","doi":"10.1016/j.oraloncology.2024.107087","DOIUrl":"10.1016/j.oraloncology.2024.107087","url":null,"abstract":"<div><h3>Purpose</h3><div>This prospective clinical trial aims to compare the efficacy and safety of gemcitabine plus cisplatin (GP) versus docetaxel plus cisplatin and fluorouracil (TPF) as induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma (dmNPC).</div></div><div><h3>Methods</h3><div>146 dmNPC patients were randomly assigned in a 1:1 ratio to receive 4–6 cycles of GP (GP group) or TPF induction chemotherapy (TPF group) followed by locoregional radiotherapy (LRRT). The primary endpoint was overall survival (OS). Secondary endpoints consisted of progression-free survival（PFS）, objective response rate (ORR), disease control rate (DCR), and treatment-related adverse events (AEs).</div></div><div><h3>Results</h3><div>As of data cutoff (May 31, 2024), the median follow-up time was 60.0 months (IQR 40.3–68.1). There is no significant difference in median OS (35.4 <em>vs</em>. 34.8 months, <em>p</em> = 0.2609) and PFS (15.8 <em>vs</em>. 14.3 months, <em>p</em> = 0.2318) between the GP and TPF groups. No significant differences in ORR (65.8 % <em>vs.</em> 71.2 %, <em>p</em> = 0.476) and DCR (79.5 % <em>vs.</em> 82.2 %, <em>p</em> = 0.674) were observed between GP and TPF group too. Furthermore, the 5-year OS was 40.1 % (95 % CI, 29.6 %-54.2 %) in the GP group, compared with 27.2 % (95 % CI, 17.9 %−41.3 %) in the TPF group（HR = 0.79, 95 % CI, 0.53–1.20). However, the TPF group had higher incidences of grade 3–4 AEs such as neutropenia, leukopenia, nausea, and diarrhea.</div></div><div><h3>Conclusion</h3><div>The study indicates that 4–6 cycles of TPF induction chemotherapy combined with LRRT achieves a therapeutic effect comparable to the GP regimen with controllable safety.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Margin-to-depth ratio as an independent prognostic factor in resected oral cavity squamous cell carcinoma: A nationwide cohort study","authors":"Hanpon Klibngern ,&nbsp;Chung-Jan Kang ,&nbsp;Li-Yu Lee ,&nbsp;Shu-Hang Ng ,&nbsp;Chien-Yu Lin ,&nbsp;Kang-Hsing Fan ,&nbsp;Wen-Cheng Chen ,&nbsp;Jin-Ching Lin ,&nbsp;Yao-Te Tsai ,&nbsp;Shu-Ru Lee ,&nbsp;Chih-Yen Chien ,&nbsp;Chun-Hung Hua ,&nbsp;Cheng-Ping Wang ,&nbsp;Tsung-Ming Chen ,&nbsp;Shyuang-Der Terng ,&nbsp;Chi-Ying Tsai ,&nbsp;Hung-Ming Wang ,&nbsp;Chia-Hsun Hsieh ,&nbsp;Chih-Hua Yeh ,&nbsp;Chih-Hung Lin ,&nbsp;Chun-Ta Liao","doi":"10.1016/j.oraloncology.2024.107102","DOIUrl":"10.1016/j.oraloncology.2024.107102","url":null,"abstract":"<div><h3>Background</h3><div>The prognostic significance of margin-to-depth ratio (MDR) in oral cavity squamous cell carcinoma (OCSCC) remains unclear, particularly in comparison to traditional margin status. We aimed to examine the association between MDR and clinical outcomes in a large Taiwanese cohort.</div></div><div><h3>Methods</h3><div>A total of 18,324 patients with first primary OCSCC were categorized by margin status: positive (1013), &lt;5 mm (8371), and ≥ 5 mm (8940). Disease-specific survival (DSS) and overall survival (OS) served as the main outcome measures.</div></div><div><h3>Results</h3><div>After excluding patients with positive margins (MDR = 0), the optimal MDR cutoff value for DSS and OS was 0.6. Patients with MDR &gt; 0.6 showed significantly better 5-year DSS and OS rates (87 %, 81 %) compared to those with MDR ≤ 0.6 (71 %, 63 %) and MDR = 0 (53 %, 43 %). Multivariable analysis identified MDR ≤ 0.6 as independently associated with both DSS and OS in the entire cohort (hazard ratio [HR] = 1.34/1.32). This finding was consistent in the subgroups with surgical margins &lt; 5 mm (HR = 1.39 for DSS and 1.38 for OS) and margins ≥ 5 mm (HR = 1.21 for both DSS and OS). In subgroups with surgical margins &lt; 5 mm and ≥ 5 mm, an MDR &gt; 0.6 was associated with better survival outcomes.</div></div><div><h3>Conclusions</h3><div>An MDR (cutoff: 0.6) is independently associated with prognosis in OCSCC, offering improved risk stratification compared to margin status alone. While MDR may guide surgical margin modification, further research is needed to determine whether MDR could serve as a postoperative indicator for adjuvant therapy in patients with close or clear margins.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Burden of oral cancer and associated risk factors at national and state levels: A systematic analysis from the global burden of disease in India, 1990–2021","authors":"Himani","doi":"10.1016/j.oraloncology.2024.107093","DOIUrl":"10.1016/j.oraloncology.2024.107093","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}