Oral oncology最新文献

{"title":"Mandibular swing approach: 25 years of experience at Istituto Nazionale Tumori of Milan","authors":"Marco Guzzo ,&nbsp;Roberto Bianchi ,&nbsp;Sarah Colombo ,&nbsp;Filippo Santamato ,&nbsp;Salvatore Alfieri ,&nbsp;Nicola Alessandro Iacovelli ,&nbsp;Giovanni Felisati ,&nbsp;Laura Gagliardini","doi":"10.1016/j.oraloncology.2025.107405","DOIUrl":"10.1016/j.oraloncology.2025.107405","url":null,"abstract":"<div><div>Between 1997 and 2022, 108 patients underwent the lip-splitting mandibulotomy approach (LSMA) as part of the surgical treatment for oral (49 patients) and oropharyngeal (59) tumors. Seventy-two tumors were primary, and 36 were recurrent/persistent; the most common histology was squamous cell carcinoma (99). Immediate reconstruction of the defect was performed using free flaps (72), pectoralis major musculocutaneous pedicled flaps (32), and local flaps (4).</div><div>Margin status was assessed in all cases; free margins were achieved in 78 patients (72 %), while 30 patients (28 %) had positive or close margins. For primary tumors, margins were free in 76 %, whereas in the recurrent-persistent group the percentage dropped to 64 %.</div><div>Most patients (82) received radiotherapy.</div><div>Fifty patients experienced one or more postoperative complications, most of them in patients who received radiotherapy (41 out of 82 patients, 50 %), compared to 9 out of 26 patients (35 %) who did not undergo radiotherapy.</div><div>Bone-related complications occurred 15 times, all in patients who had undergone radiotherapy; postoperative fistulas were observed in 18 patients, with 7 having received preoperative radiotherapy.</div><div>After an average follow-up of 51 months (range 2–274 months), 54 out of 99 patients (54 %) were alive without disease, while 38 (38 %) died of cancer. The 4-year overall survival rates for patients with oral and oropharyngeal cancers were 47 % and 36 %, respectively.</div><div>In conclusion, LSMA can be recommended in cases of advanced neoplasms, where the best outcomes are achievable only if the tumor can be resected with clear margins and the resulting defect can be effectively reconstructed.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107405"},"PeriodicalIF":4.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on, “Interdisciplinary approaches to diagnosing oral cavity skin cancers: The Dentist’s involvement in detecting dermatological conditions”","authors":"Yunfeng Cao ,&nbsp;Hui Yao","doi":"10.1016/j.oraloncology.2025.107397","DOIUrl":"10.1016/j.oraloncology.2025.107397","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107397"},"PeriodicalIF":4.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Margin analysis of radical tonsillectomy specimens following transoral robotic surgery","authors":"Jane Y. Tong ,&nbsp;Kathryn Brimanson ,&nbsp;Kelly Moyer ,&nbsp;Jeffrey Wolf ,&nbsp;Rodney Taylor ,&nbsp;Michael Kallen ,&nbsp;Hector Mesa ,&nbsp;Kyle M. Hatten","doi":"10.1016/j.oraloncology.2025.107403","DOIUrl":"10.1016/j.oraloncology.2025.107403","url":null,"abstract":"<div><h3>Objectives</h3><div>Interpretation of margin adequacy in patients with squamous cell carcinoma (SCC) of the palatine tonsil treated with transoral robotic surgery (TORS) remains controversial and variable in practice. We describe margin analysis after radical tonsillectomy, including muscle invasion and surgical disruption.</div></div><div><h3>Methods</h3><div>Patients undergoing TORS radical tonsillectomy between January 2017 to December 2023 were retrospectively reviewed. Pathology reports were reviewed for positive, close (&lt;2 mm), or clear margins. Slides were evaluated for likely iatrogenic disruption of the pharyngeal constrictor, defined as the separation of muscle fibers with cautery artifact and evidence of margin ink seepage, as well as for muscle invasion, stratified as absent, partial (within muscle) or complete (beyond muscle).</div></div><div><h3>Results</h3><div>Sixty-six patients with SCC of the palatine tonsil underwent TORS radical tonsillectomy. Fifty-seven (86.4 %) were male. Mean age was 59.7 years. Thirty-one (47.0 %) were pT1, 32 (48.5 %) pT2, and three (4.5 %) pT3. Thirty-six (54.5 %) demonstrated close, 26 (39.4 %) clear, and four (6.1 %) positive margins. All demonstrated muscle disruption. Twenty-seven (40.9 %) demonstrated no muscle invasion, 32 (48.5 %) partial, and seven (10.6 %) complete invasion. Margin status was not significantly associated with muscle invasion. Muscle invasion was associated with T stage (p = 0.049), number of involved lymph nodes (p = 0.043), and adjuvant treatment (p = 0.016). Margin status was significantly associated with PNI (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Surgical muscle disruption was universal during radical tonsillectomy. Muscle invasion (59.1 %) and close margins (54.5 %) also were common. Muscle invasion was associated with T stage, number of involved lymph nodes, and adjuvant treatment, but not margin status, although this requires further study. Clear margins traditionally defined as ≥ 5 mm may not be anatomically feasible for palatine tonsil malignancies.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107403"},"PeriodicalIF":4.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor on, “De-escalated surgery following neoadjuvant chemoimmunotherapy for locally advanced oral squamous cell carcinoma: A retrospective cohort study”","authors":"Renxian Xie","doi":"10.1016/j.oraloncology.2025.107398","DOIUrl":"10.1016/j.oraloncology.2025.107398","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107398"},"PeriodicalIF":4.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The integration of female physiological and social role factors in HRQOL research","authors":"Wanjiao Hao,&nbsp;XiaoPang Ren","doi":"10.1016/j.oraloncology.2025.107393","DOIUrl":"10.1016/j.oraloncology.2025.107393","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107393"},"PeriodicalIF":4.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anlotinib targeted therapy demonstrates efficacy in scalp angiosarcoma with postauricular and cervical lymph node metastases: A rare case report","authors":"Xi Yang ,&nbsp;Xinrui Yu ,&nbsp;Jiazhi He ,&nbsp;Xiaofeng Qu","doi":"10.1016/j.oraloncology.2025.107395","DOIUrl":"10.1016/j.oraloncology.2025.107395","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107395"},"PeriodicalIF":4.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “Identification of clinical and pathologic features associated with extranodal extension in patients with HPV-mediated oropharyngeal squamous cell carcinoma”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107394","DOIUrl":"10.1016/j.oraloncology.2025.107394","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107394"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report","authors":"J.A. Rijken ,&nbsp;M. de Ridder ,&nbsp;L.A. Devriese ,&nbsp;G.E. Breimer","doi":"10.1016/j.oraloncology.2025.107392","DOIUrl":"10.1016/j.oraloncology.2025.107392","url":null,"abstract":"<div><div>Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107392"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of hotspot mutations in oral cancer through Ion AmpliSeq™ cancer hotspot panel v.2.0: A circulating DNA fragmentomics approach in the Northeast Indian population","authors":"Denis C Baiju ,&nbsp;Joshua Ravi ,&nbsp;Mridul Sarma ,&nbsp;Muthusamy Sureshan ,&nbsp;Arunachalam Jothi ,&nbsp;Rosy Mondal","doi":"10.1016/j.oraloncology.2025.107387","DOIUrl":"10.1016/j.oraloncology.2025.107387","url":null,"abstract":"<div><div>Oral Squamous Cell Carcinoma (OSCC) is the most commonly diagnosed cancer worldwide, with 90–95% of cases reported to be SCC. The present study aimed to investigate the presence of circulating cell-free tumor DNA (cftDNA) in the patient’s plasma with OSCC and determine the feasibility of liquid biopsies in genomic profiling using deep sequencing-based approach. Mutation analysis of cfDNA will help evaluate the molecular and clinical impacts of the identified somatic alterations during primary staging.</div></div><div><h3>Methods</h3><div>Paired samples from 11 OSCC patients, including cfDNA, tumor tissue, and blood, were submitted for deep sequencing of 50 genes by next-generation sequencing using the Ion Ampliseq Cancer Hotspot Panel v2.</div></div><div><h3>Results</h3><div>We found higher mutational load in cfDNA than in tumor tissue samples, suggesting the potential of cfDNA as a liquid biopsy for monitoring therapeutic responses. The TP53 p.Pro72Arg variant was identified in all the samples, indicating its potential as a diagnostic marker. Molecular dynamics simulations of the p53 protein showed higher fluctuations in the mutant form, potentially affecting protein function. The RB1 p.Ile680Thr pathogenic variant was found in 64% of oral squamous cell carcinoma samples. Recurrently mutated genes, including <em>TP53, KDR, APC, RB1, MET, PIK3CA, CDKN2A, RET</em>, and <em>EGFR</em>, were identified in both tumor tissue and cfDNA samples.</div></div><div><h3>Conclusion</h3><div>The detection of tumor imprints and heterogeneity in cfDNA samples highlights the potential of liquid biopsy as a valuable tool for monitoring therapeutic responses in OSCC. The identification of recurrently mutated genes and pathogenic variants provides insights into potential therapeutic targets.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107387"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “The use of 3D computer-aided design to optimize photoimmunotherapy catheter placement”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107400","DOIUrl":"10.1016/j.oraloncology.2025.107400","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107400"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}