Oral oncology最新文献

Metastatic colonic adenocarcinoma presenting in the oral cavity: Disease progression over time 在口腔出现的转移性结肠腺癌：疾病随时间的进展

IF 4 2区医学

Oral oncology Pub Date : 2025-06-20 DOI: 10.1016/j.oraloncology.2025.107440

Moisés Willian Aparecido Gonçalves , Gustavo de Souza Vieira , Nádia Cacita , Marcelo Elias Schempf Cattan , Carlos Takahiro Chone , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano

{"title":"Metastatic colonic adenocarcinoma presenting in the oral cavity: Disease progression over time","authors":"Moisés Willian Aparecido Gonçalves , Gustavo de Souza Vieira , Nádia Cacita , Marcelo Elias Schempf Cattan , Carlos Takahiro Chone , Erika Said Abu Egal , Albina Altemani , Fernanda Viviane Mariano","doi":"10.1016/j.oraloncology.2025.107440","DOIUrl":"10.1016/j.oraloncology.2025.107440","url":null,"abstract":"<div><div>A 55-year-old female patient with a history of colonic adenocarcinoma and metastases to the liver, retroperitoneum, lungs, and 11th rib (T3N1M1, clinical stage IVc) was referred for evaluation of a painful lesion in the retromolar trigone. Surgical intervention, chemotherapy, and radiotherapy were mentioned in the medical history for the intestinal condition. Extraoral examination revealed a hardened enlargement on the left hemiface. Intraoral examination showed a vegetative, ulcerative, infiltrative, and bleeding lesion in the left retromolar trigone. Computed tomography demonstrated an expansive lesion with a lytic component and cortical discontinuity in the left ascending mandibular ramus. An incisional biopsy revealed a proliferative epithelial component characterized by irregular tubular structures lined by columnar cells with variable pleomorphism. The tumor cells proved negative for CK7 and positive for CK20, which, combined with diffuse positivity for CDX2, confirmed that the cancer originated primarily in the intestinal epithelium. The Ki-67 index was 90 %. These findings confirmed the diagnosis of metastatic colonic adenocarcinoma to the oral cavity. At the time of the diagnosis of the oral metastasis, 52 months after the initial diagnosis, the patient was already receiving palliative treatment.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107440"},"PeriodicalIF":4.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on, “Mandibular swing approach: 25 years of experience at Istituto Nazionale Tumori of Milan” “下颌旋入法：米兰国立肿瘤研究所25年经验”评论

IF 4 2区医学

Oral oncology Pub Date : 2025-06-19 DOI: 10.1016/j.oraloncology.2025.107442

Gurdeep Gambhir

引用次数: 0

Induction chemotherapy and immunotherapy followed by chemo-radiotherapy in incurable advanced head and neck squamous cell carcinoma: A case-series 无法治愈的晚期头颈部鳞状细胞癌的诱导化疗和免疫治疗后化疗放疗：一个病例系列

IF 4 2区医学

Oral oncology Pub Date : 2025-06-19 DOI: 10.1016/j.oraloncology.2025.107439

Sze Wah Samuel Chan , Zainab Ali Amer Al Maqrashi , Do-Hoon Kim , David Choi , Gregory R. Pond , Adi Kartolo , Brandon M. Meyers

引用次数: 0

Commentary on, “Benefit from adjuvant radiotherapy in early-stage oral cavity and oropharyngeal cancer with solitary ipsilateral lymph node metastasis - A population-based study on German cancer registry data” 评论：“辅助放疗对伴有同侧淋巴结转移的早期口腔和口咽癌的益处——一项基于德国癌症登记数据的人群研究”

IF 4 2区医学

Oral oncology Pub Date : 2025-06-19 DOI: 10.1016/j.oraloncology.2025.107436

Siva Dharshini Rajathirajan

引用次数: 0

Predictive value of three comorbidity indices for survival endpoints in oral squamous cell carcinoma 三个合并症指标对口腔鳞状细胞癌生存终点的预测价值

IF 4 2区医学

Oral oncology Pub Date : 2025-06-18 DOI: 10.1016/j.oraloncology.2025.107443

Huan Liu , Liang Peng , Lirui Zhang, Hao Wang, Lei Xiong, Jinghan Wu, Zhien Feng

{"title":"Predictive value of three comorbidity indices for survival endpoints in oral squamous cell carcinoma","authors":"Huan Liu , Liang Peng , Lirui Zhang, Hao Wang, Lei Xiong, Jinghan Wu, Zhien Feng","doi":"10.1016/j.oraloncology.2025.107443","DOIUrl":"10.1016/j.oraloncology.2025.107443","url":null,"abstract":"<div><h3>Introduction</h3><div>The negative impact of comorbidities on oral cancer prognosis is well known. Few validated comorbidity indices are currently available for clinical management. This study aimed to determine the most relevant index among the Charlson Comorbidity Index (CCI), Age-Adjusted CCI (ACCI), and Adult Comorbidity Evaluation 27 (ACE-27) in terms of survival endpoints in oral cancer.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study investigated the impact of comorbidities and other factors on the prognosis of 674 patients with oral squamous cell carcinoma (OSCC). Comorbidities were assessed in each patient using the CCI, ACCI, and ACE-27. Univariate and multivariate models were used to identify the predictors of survival.</div></div><div><h3>Results</h3><div>Compared to ACE-27 and CCI, severe ACCI was the only meaningful predictor of OSCC (adjusted hazard ratio [AHR] for disease-free survival [DFS]: 1.822, 95 % confidence interval [CI]: 1.237–2.684, P = 0.002; AHR for overall survival [OS]: 2.681, 95 % CI: 1.638–4.389, P < 0.001). More importantly, the ACCI demonstrated excellent prognostic stratification in patients with OSCC undergoing surgery and adjuvant therapy (AHRs for DFS: moderate, 1.692, 95 % CI: 1.013–2.826, P = 0.044; severe, 2.545, 95 % CI: 1.283–5.049, P = 0.008; AHRs for OS: moderate, 2.004, 95 % CI: 1.078–3.725, P = 0.028; severe, 3.086, 95 % CI: 1.397–6.817, P = 0.005).</div></div><div><h3>Conclusion</h3><div>The ACCI is an essential predictor of OSCC prognosis. We suggest that the ACCI be included in the routine clinical evaluation system, especially to evaluate the comorbidity and prognosis of patients with OSCC undergoing surgery combined with adjuvant therapy.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107443"},"PeriodicalIF":4.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on, “Prevalence of oral human papillomavirus infection among adult men and women in Taiwan (PILLOT).” 台湾成年男女口腔人乳头瘤病毒感染流行情况（PILLOT）评论。

IF 4 2区医学

Oral oncology Pub Date : 2025-06-18 DOI: 10.1016/j.oraloncology.2025.107437

Siva Dharshini Rajathirajan

引用次数: 0

When histology tells a different story: salivary duct carcinoma in disguise 但组织学告诉我们的是另一种情况：变相的唾液管癌

IF 4 2区医学

Oral oncology Pub Date : 2025-06-18 DOI: 10.1016/j.oraloncology.2025.107433

Rasla P C , Akshay Trimukhe , Ajoy Roychoudhury , Varun Surya

{"title":"When histology tells a different story: salivary duct carcinoma in disguise","authors":"Rasla P C , Akshay Trimukhe , Ajoy Roychoudhury , Varun Surya","doi":"10.1016/j.oraloncology.2025.107433","DOIUrl":"10.1016/j.oraloncology.2025.107433","url":null,"abstract":"<div><div>Salivary duct carcinoma (SDC) is a rare, high-grade malignancy known for its aggressive clinical behaviour and histological resemblance to ductal carcinoma of the breast. It predominantly arises in the major salivary glands and typically affects older males. This case report highlights an unusual presentation of SDC originating from the minor salivary glands of the buccal mucosa in a 52-year-old male with a notable history of chronic tobacco use. The patient presented with a painless intraoral mass that was rapidly increasing in size and was initially presumed to be carcinoma of the buccal mucosa. Histopathological analysis revealed solid nests and islands of malignant epithelial cells with areas of comedonecrosis, displaying architectural patterns characteristic of SDC. Immunohistochemically, the tumor cells showed CK7 positivity and were negative for CK20 and myoepithelial markers, confirming the diagnosis. This rare case underscores the importance of considering SDC in the differential diagnosis of aggressive intraoral neoplasms, especially in atypical locations such as the minor salivary glands.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107433"},"PeriodicalIF":4.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMARCB1-deficient sinonasal carcinoma with oral involvement: A potential mimicker of salivary-type carcinomas 伴有口腔病变的smarcb1缺陷鼻窦癌：一种潜在的唾液型癌模仿者

IF 4 2区医学

Oral oncology Pub Date : 2025-06-18 DOI: 10.1016/j.oraloncology.2025.107435

Bruno Tavares Sedassari , Marcelo Fonseca Celin , Fernanda Mombrini Pigatti

{"title":"SMARCB1-deficient sinonasal carcinoma with oral involvement: A potential mimicker of salivary-type carcinomas","authors":"Bruno Tavares Sedassari , Marcelo Fonseca Celin , Fernanda Mombrini Pigatti","doi":"10.1016/j.oraloncology.2025.107435","DOIUrl":"10.1016/j.oraloncology.2025.107435","url":null,"abstract":"<div><div>SMARCB1-deficient sinonasal carcinoma is a rare sinonasal malignancy characterized by loss if INI1 expression on immunohistochemistry due to biallelic loss of <em>SMARCB1</em> gene. Oral involvement is a an exceedingly unusual event. We present a 59-year-old woman with a destructive swelling covered by an ulcerated mucosa in the left posterior hard palate and alveolar ridge. Computed tomography scan demonstrated a tumor filling the left maxillary sinus with extension to the inferior nasal turbinate, alveolar process, and adjacent soft tissues. A biopsy performed from the oral aspect of the lesion revealed a basaloid tumor with rhabdoid/plasmacytoid cells, features that overlap with salivary-type carcinomas. Immunohistochemical analysis showed neoplastic cells positive to AE1/AE3 and p63, but negative to 34βE12, p16, chromogranin, synaptophysin, NUT, CD99, myogenin, smooth muscle actin, HMB45, S100 protein, androgen receptor, and TTF1. INI1 was also negative in neoplastic cells, but its expression was retained in stromal cells. The final diagnosis of SMARCB1-deficient sinonasal carcinoma was established. In conclusion, SMARCB1-deficient sinonasal carcinoma may infiltrate the oral cavity mimicking salivary-type carcinomas. A correlation of clinical, radiological, microscopical, and immunohistochemical aspects, the latter mainly represented by INI1 negativity, is mandatory to reach the appropriate diagnosis.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107435"},"PeriodicalIF":4.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of virtual reality on education, surgical planning, and interdisciplinary collaboration for clinicians in head and neck oncology 探讨虚拟现实对头颈部肿瘤临床医生的教育、手术计划和跨学科合作的影响

IF 4 2区医学

Oral oncology Pub Date : 2025-06-18 DOI: 10.1016/j.oraloncology.2025.107444

Antoine Dubray-Vautrin , Maria Lesnik , Joey Martin , Olivier Choussy , Nathalie Badois

{"title":"Exploring the impact of virtual reality on education, surgical planning, and interdisciplinary collaboration for clinicians in head and neck oncology","authors":"Antoine Dubray-Vautrin , Maria Lesnik , Joey Martin , Olivier Choussy , Nathalie Badois","doi":"10.1016/j.oraloncology.2025.107444","DOIUrl":"10.1016/j.oraloncology.2025.107444","url":null,"abstract":"<div><div>Virtual reality (VR) technologies are transforming the landscape of oncology, particularly in the education and surgical planning of head and neck cancers. We conducted a narrative literature review using Scopus®, PubMed® to identify relevant studies enhancing surgical training, therapeutic planning, and interdisciplinary collaboration. Our findings reveal that VR provides immersive learning environments that significantly improve surgical skill development, including hand-eye coordination in procedures like ear surgeries. Moreover, VR facilitates the visualization of complex anatomical structures and vascular anatomy, aiding in preoperative tumor contouring and flap design for reconstructive surgery. The integration of VR with 3D printing allows for the creation of patient-specific models, enhancing preoperative planning by accurately representing tumors and surrounding tissues. Additionally, VR enhances collaborative decision-making in tumor boards by enabling multidisciplinary teams to visualize medical images in a shared virtual space. Despite its potential, further research is needed to assess the full impact of VR technologies on surgical outcomes and educational efficacy in head and neck oncology decision making. This review underscores the importance of continued exploration into VR applications to optimize patient care and improve training methodologies in surgical practices.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107444"},"PeriodicalIF":4.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transoral endoscopic thyroidectomy vestibular approach for pT1b papillary thyroid carcinoma: surgical and oncological outcomes 经口内窥镜甲状腺切除术前庭入路治疗pT1b乳头状甲状腺癌：手术和肿瘤结果

IF 4 2区医学

Oral oncology Pub Date : 2025-06-17 DOI: 10.1016/j.oraloncology.2025.107406

Duy Quoc Ngo , Du Sy Truong , Duong The Le , Thang Manh Hoang

{"title":"Transoral endoscopic thyroidectomy vestibular approach for pT1b papillary thyroid carcinoma: surgical and oncological outcomes","authors":"Duy Quoc Ngo , Du Sy Truong , Duong The Le , Thang Manh Hoang","doi":"10.1016/j.oraloncology.2025.107406","DOIUrl":"10.1016/j.oraloncology.2025.107406","url":null,"abstract":"<div><h3>Objectives</h3><div>Evidence regarding efficacy and oncological safety of Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) for papillary thyroid carcinoma (PTC) with tumor size 1–2 cm remains limited. This study evaluates the surgical and oncological outcomes of TOETVA in patients with pT1b PTC.</div></div><div><h3>Methods</h3><div>We conducted a cohort study of 50 consecutive patients with pT1b PTC who underwent TOETVA between January 2019 and December 2024 at Our Hospital. Clinical characteristics, surgical outcomes, and long-term oncological results were evaluated. All procedures were performed by a single experienced endoscopic surgeon. Patients were followed for recurrence and complications.</div></div><div><h3>Results</h3><div>The cohort comprised predominantly female patients (96 %) with mean age 30.5 ± 7.1 years. Mean tumor size was 17 ± 4.6 mm. Lobectomy with isthmusectomy and central neck dissection was performed in 44 patients (88 %) with mean operative time of 85.4 ± 7.5 min, while total thyroidectomy with central neck dissection was performed in 6 patients (12 %) with mean operative time of 122.5 ± 5.2 min. Occult central lymph node metastases were identified in 15 patients (30 %). Mean lymph node yield was 4.2 ± 2.2 nodes. Temporary mental nerve injury occurred in 2 patients (4.0 %) and temporary recurrent laryngeal nerve palsy in 2 patients (4.0 %), all resolving within 3 months. No permanent complications were observed. During mean follow-up of 29.6 months (range 2.4–64.4), no recurrences were detected, and all patients reported satisfactory cosmetic outcomes.</div></div><div><h3>Conclusions</h3><div>TOETVA represents a safe and effective approach for managing pT1b PTC, demonstrating excellent surgical outcomes and patient satisfaction with minimal complications.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107406"},"PeriodicalIF":4.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0