Oral oncology最新文献

{"title":"Thyroglossal duct cyst carcinoma: A case report about diagnostic and surgical challenges","authors":"Fatima Shahid ,&nbsp;Ansar Raza Mohsin ,&nbsp;Ummi Aiman Rahman ,&nbsp;Amna Azam Warraich ,&nbsp;Aliza Asif ,&nbsp;Maheen Asif ,&nbsp;Hassan Bin Aziz ,&nbsp;Hafiz Muhammad Asif Maqbool ,&nbsp;Muhammad Nabeel Saddique","doi":"10.1016/j.oraloncology.2026.107890","DOIUrl":"10.1016/j.oraloncology.2026.107890","url":null,"abstract":"<div><h3>Background</h3><div>A thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass, resulting from the incomplete obliteration of the thyroglossal duct during embryogenesis. Although typically presenting in childhood, TGDCs can remain asymptomatic and manifest later in life. Proper diagnosis is crucial to avoid unnecessary interventions and complications.</div></div><div><h3>Case Presentation</h3><div>We report the case of a 26-year-old South Asian male who presented with a painless, fluctuant midline neck swelling that had progressively enlarged over the past few months. Clinical examination revealed a well-defined, mobile mass at the level of the hyoid bone that exhibited upward movement with tongue protrusion, a hallmark feature of TGDC. Ultrasound confirmed a cystic lesion, and fine-needle aspiration ruled out any malignant features. The patient underwent successful surgical excision via the Sistrunk procedure, which involves the removal of the cyst along with the central portion of the hyoid bone to minimize recurrence. Postoperative recovery was uneventful. Histopathology report revealed a unifocal tumor and after MDT’s discussion total thyroidectomy was planned. Patient was asked to follow-up for radiation therapy afterwards.</div></div><div><h3>Conclusion</h3><div>TGDCs can present at any age and should be considered in the evaluation of midline neck masses. A thorough clinical assessment, supported by imaging, is crucial for accurate diagnosis. The Sistrunk procedure remains the gold standard for treatment, significantly reducing the risk of recurrence. In cases with suspicious features or malignancy, total thyroidectomy may be necessary for complete disease management. Early identification and appropriate intervention improve patient outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107890"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does discharge location following head and neck cancer surgery affect quality outcomes?","authors":"Cristina Benites ,&nbsp;Colyn White ,&nbsp;Logesvar Balaguru ,&nbsp;Liu Gonghao ,&nbsp;Ji-Hyun Lee ,&nbsp;Dustin J. Conrad ,&nbsp;Austin Lam ,&nbsp;Peter T. Dziegielewski","doi":"10.1016/j.oraloncology.2026.107879","DOIUrl":"10.1016/j.oraloncology.2026.107879","url":null,"abstract":"<div><h3>Background</h3><div>Discharge (DC) to post-acute care facilities after head and neck cancer (HNC) surgery is common. Studies in various fields of medicine have shown that DC to facilities is associated with clinical outcomes. Evidence specific to HNC surgery is limited.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate how DC, to either home or a facility, impacts outcomes for patients undergoing HNC surgery.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of patients who underwent HNC surgery between January 1, 2014, and January 1, 2023 was performed. Patients were included based on postoperative hospitalization, surgical interventions, and a minimum 30-day follow-up. The primary outcomes were 30-day readmission, 30-day mortality, and postoperative complication severity.</div></div><div><h3>Results</h3><div>Among 1,895 patients (mean age 63 years, 67% female), 1,554 (82%) were DC home and 341 (18%) to a facility. After adjusting for significant variables, DC site was not associated with readmission (OR 0.94, 95% CI 0.63–1.40), mortality (0.6% home vs 1.5% facility, p = 0.2), or complication severity (mild OR 1.3, p = 0.11; severe OR 1.0, p = 0.92). Factors such as dependency in activities of daily living, tracheotomy presence, surgery severity and prolonged hospitalization were found to be significant covariates in the multivariable analysis for both 30-day readmissions and complication severity. Facility patients had more infections or wound dehiscence (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Although DC to a facility was not significantly associated with worsened outcomes in the multivariable analysis, the findings of this study revealed clinically relevant differences in complication rates and readmission.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107879"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel method using electronic health record coding to generate a unique, multipurpose database for aerodigestive malignancy surveillance","authors":"Lindsey Mortensen,&nbsp;Alexander Dwyer,&nbsp;Benjamin Palatnik,&nbsp;Beverly R Wuertz,&nbsp;Frank G Ondrey","doi":"10.1016/j.oraloncology.2026.107886","DOIUrl":"10.1016/j.oraloncology.2026.107886","url":null,"abstract":"<div><h3>Background</h3><div>Upper aerodigestive/head and neck cancer affects over 45,000 patients annually in the oral cavity and oropharynx alone. This burden may be reduced through surveillance of patients with oral potentially malignant disorders (OPMD). Here we describe a readily accessible pilot study evaluating a database-generating approach that captures our longstanding Cancer Active Surveillance Program (CASP). Our methods can be applied to other premalignancies and disease conditions to fuel clinically relevant research related to cancer risk, disease progression, interception, and outcomes.</div></div><div><h3>Methods</h3><div>Electronic medical record data from the senior author’s head and neck cancer practice, which harbors a significant primary screening component, was interrogated for 35 International Classification of Disease 9 and 10 codes. These codes represent over 300 unique mucosal lesion descriptors or conditions associated with heightened risk for oral cancer. These data were subject to a proof-of-concept analysis to assess geographic and racial representation in the CASP.</div></div><div><h3>Results</h3><div>Automated extraction from the electronic medical record identified 1576 individuals with OPMDs with lower cost and higher fidelity than manual chart review. CASP patients were overrepresented relative to the state population within urban centers, with underrepresentation in more rural areas. More Black patients and fewer Asian/Pacific Islander patients were seen in CASP relative to our cancer catchment’s demography.</div></div><div><h3>Conclusions</h3><div>Automated medical record queries can identify patients in the catchment area with precancerous or other at-risk conditions for cancer.</div></div><div><h3>Impact</h3><div>This information informs resource utilization to improve inclusivity of underrepresented groups and streamlines identification of potential participants for cancer prevention clinical trials.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107886"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “My letter: Do we recognize oral oncology with accuracy? AI-driven models serve in the diagnosis of oral squamous cell carcinoma”","authors":"Jiayi Chen","doi":"10.1016/j.oraloncology.2026.107889","DOIUrl":"10.1016/j.oraloncology.2026.107889","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"175 ","pages":"Article 107889"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of frozen section for HPV-Associated squamous cell carcinoma of unknown primary","authors":"Sindhura Sridhar ,&nbsp;Annie Moroco ,&nbsp;Shravan Gowrishankar ,&nbsp;Mitra Mehrad ,&nbsp;Kim Ely ,&nbsp;James S. Lewis ,&nbsp;Madalina Tuluc ,&nbsp;Stacey Gargano ,&nbsp;Melanie Hicks ,&nbsp;Kyle Mannion ,&nbsp;Arielle G. Thal ,&nbsp;Adam J. Luginbuhl ,&nbsp;Joseph M. Curry ,&nbsp;David M. Cognetti ,&nbsp;Michael C. Topf","doi":"10.1016/j.oraloncology.2026.107861","DOIUrl":"10.1016/j.oraloncology.2026.107861","url":null,"abstract":"<div><h3>Introduction</h3><div>Current guidelines for the management of metastatic squamous cell carcinoma of unknown primary (SCCUP) recommend submission of suspicious primary sites for frozen section analysis (FSA). This study aims to investigate the diagnostic accuracy of FSA for identification of HPV-associated SCCUP.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of patients with biopsy-proven p16-positive SCCUP who underwent diagnostic operation at two tertiary care institutions was performed. Sensitivity, specificity, PPV, and NPV of diagnostic FSA were assessed.</div></div><div><h3>Results</h3><div>77 patients were included in analysis. 66 patients underwent definitive TORS (diagnostic TORS operation with subsequent neck dissection after identification of the occult primary tumor), 7 patients underwent diagnostic TORS (TORS to identify occult primary tumor, no neck dissection), and 4 patients underwent direct laryngoscopy and biopsy only. Primary tumors were identified in 63 patients (82%) with a mean tumor size of 1.1 cm. There was no significant difference in size between patients whose tumor was identified on FSA (mean 1.1 cm) and on permanent only (mean 0.9 cm) (p = 0.26). The sensitivity, specificity, PPV, and NPV of FSA for SCCUP was 86%, 100%, 100%, and 86%, respectively. Diagnostic frozen specimens included 52 direct laryngoscopy biopsies and 69 TORS excisions. In the biopsies, sensitivity was 100% and NPV was 100%, whereas in the TORS-excised specimens, sensitivity was 77% and NPV was 77%.</div></div><div><h3>Conclusions</h3><div>In this case series of 77 patients with SCCUP, the sensitivity and NPV of FSA for identification of the primary tumor was over 85%. FSA is valuable during diagnostic operation for SCCUP.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107861"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary management of the clinically N0 neck in oral squamous cell carcinoma","authors":"Makoto Adachi ,&nbsp;Shinsuke Ohta ,&nbsp;Ayaka Ishii ,&nbsp;Masayuki Motohashi","doi":"10.1016/j.oraloncology.2025.107839","DOIUrl":"10.1016/j.oraloncology.2025.107839","url":null,"abstract":"<div><h3>Background</h3><div>The management of the clinically negative neck (N0) in oral squamous cell carcinoma (OSCC) remains a challenging clinical dilemma. Although imaging techniques have advanced, occult metastases are present in approximately 20–30% of patients with early-stage oral cancer and clinically negative necks.</div></div><div><h3>Objective</h3><div>This review examines current evidence on optimal strategies for managing the N0 neck in oral cancer patients.</div></div><div><h3>Methods</h3><div>We discuss diagnostic modalities for detecting occult metastases, including clinical examination, conventional imaging (ultrasonography, computed tomography, magnetic resonance imaging), functional imaging (positron emission tomography), and sentinel lymph node biopsy. The review evaluates the main management approaches---elective neck dissection, watchful waiting, and sentinel lymph node biopsy---analyzing current evidence from randomized controlled trials and <em>meta</em>-analyses.</div></div><div><h3>Results</h3><div>We examine patient and tumor factors that influence decision-making, including tumor thickness, location, differentiation, and pattern of invasion. Special considerations for specific subsites and clinical scenarios are discussed.</div></div><div><h3>Conclusions</h3><div>Finally, we explore emerging technologies and future directions in the management of the N0 neck, including molecular biomarkers, liquid biopsy techniques, and personalized approaches to treatment. This review provides evidence-based recommendations to support clinical decision-making for managing patients with oral cancer and clinically negative necks.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107839"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of secondary ameloblastic carcinoma of the mandible and a comparative review of primary and secondary subtypes","authors":"Xin Wei ,&nbsp;Jiayu Shen ,&nbsp;Ce Shi ,&nbsp;Shichen Zhang ,&nbsp;Huanyan Dai ,&nbsp;Zhiyan Wu ,&nbsp;Xi Li ,&nbsp;Zhimin Xu ,&nbsp;Bing Han","doi":"10.1016/j.oraloncology.2026.107848","DOIUrl":"10.1016/j.oraloncology.2026.107848","url":null,"abstract":"<div><h3>Background</h3><div>Ameloblastic carcinoma is an extremely rare malignant odontogenic epithelial tumor, which can be categorized into primary ameloblastic carcinoma and secondary ameloblastic carcinoma. The secondary type typically arises from a pre-existing, histologically confirmed benign ameloblastoma. Owing to the scarcity of clinical reports, the epidemiology, treatment, and prognosis of ameloblastic carcinoma remain poorly understood.</div></div><div><h3>Methods</h3><div>We report and analyze a case of a 49-year-old male with secondary ameloblastic carcinoma of the mandible. Based on preoperative pathological examination indicating squamous cell carcinoma, the patient underwent right mandibular resection, cervical lymph node dissection, and anterolateral femoral flap repair. Postoperatively, the diagnosis of secondary ameloblastic carcinoma was confirmed pathologically. No signs of metastasis or recurrence were observed during the 2-year follow-up. Additionally, we systematically reviewed the literature on the clinical details, treatment, and outcomes of ameloblastic carcinoma from 2000 to 2022, including five cases from our hospital.</div></div><div><h3>Results</h3><div>A total of 35 cases of primary ameloblastic carcinoma and 45 cases of secondary ameloblastic carcinoma were identified. Both types predominantly occur in males, primarily in the mandible, and are mainly treated with surgery. However, they present at different ages. The primary type is characterized by a short disease course and a favorable prognosis, whereas the secondary type usually has a history of ameloblastoma and a poor prognosis.</div></div><div><h3>Conclusion</h3><div>Our study is one of the few in the literature to highlight a high incidence of secondary ameloblastic carcinoma, suggesting that clinicians should be vigilant for malignant transformation in benign ameloblastomas. We hope this research provides valuable insights for clinical management and a theoretical basis for future studies on the pathogenesis of ameloblastic carcinoma.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107848"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refinement of N category in version-nine of AJCC/UICC TNM staging system for nasopharyngeal carcinoma based on the international consensus recommendations for diagnosing extranodal extension","authors":"Jing Zhong ,&nbsp;Hongye Chen ,&nbsp;Zhiwei Yan ,&nbsp;Hanchuan Xu ,&nbsp;Peng Shi ,&nbsp;Peide Zhu ,&nbsp;Yahan Zheng ,&nbsp;Youping Xiao ,&nbsp;Dechun Zheng ,&nbsp;Caizhu Pan ,&nbsp;Yunbin Chen ,&nbsp;Shaojun Lin ,&nbsp;Jianji Pan ,&nbsp;Qiaojuan Guo","doi":"10.1016/j.oraloncology.2026.107866","DOIUrl":"10.1016/j.oraloncology.2026.107866","url":null,"abstract":"<div><h3>Objectives</h3><div>To ascertain the prognostic value of grade 2 imaging extranodal extension (G2 iENE), also called matted nodes (MNs), in nasopharyngeal carcinoma (NPC) based on the 9th-version of AJCC/UICC TNM staging system (TNM-9) and the Head and Neck Cancer International Group (HNCIG)’s criteria for diagnosing iENE, and propose future refinement of the TNM-9 N category.</div></div><div><h3>Materials and methods</h3><div>Non-metastatic NPC patients treated between 2017 and 2018 were screened. MRI data were reviewed for re-staging according to the TNM-9 and iENE status per the HNCIG-criteria. Five-year overall survival (OS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS) were analyzed. Recursive partitioning analysis (RPA) based on the ordinal N category of TNM-9 and the G2 iENE status were performed to propose a refined N category.</div></div><div><h3>Results</h3><div>Totally, 1334 patients were included, with 462 (34.6%) patients presenting with G2 iENE at baseline. Besides N Category, G2 iENE also showed independent prognostic value for OS (HR: 1.453, P = 0.042), PFS (HR: 1.293, P = 0.057) and DMFS (HR: 1.363, P = 0.042). The RPA-N category was then derived: RPA-N0 (N0), RPA-N1 (N1 without G2 iENE), RPA-N2 (N1 with G2 iENE and N2) and RPA-N3 (N3). The RPA-N classification had a lower Akaike information criterion (AIC) and higher C-index for all endpoints, and performed better in hazard consistency, hazard discrimination, sample size balance and outcome prediction when compared to TNM-9.</div></div><div><h3>Conclusions</h3><div>G2 iENE, based on the HNCIG-criteria, constitute an independent adverse prognostic factor for NPC based on the TNM-9. The RPA-N category, which integrated N category of TNM-9 and G2 iENE, demonstrated better performance than N category in TNM-9, further validation in multicenter cohorts is warranted.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107866"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “A pilot study of a digital workflow for navigated tumor bed marking to reduce clinical target volume during adjuvant radiotherapy for oral squamous cell carcinoma”","authors":"Jenefar Sudarson","doi":"10.1016/j.oraloncology.2026.107884","DOIUrl":"10.1016/j.oraloncology.2026.107884","url":null,"abstract":"<div><div>The accurate identification of the Clinical Target Volume (CTV) remains a challenge in providing postoperative adjuvant radiation therapy for patients with OSCC, due to postoperative changes in anatomy, along with the inability to define the exact location of the CTV during surgery. Holdorf et al. report on a pilot study assessing the utility of a digital navigation intraoperatively to identify and outline the tumor bed to improve planning of postoperative radiation therapy. Using navigated margins traced on imaging postoperatively, the authors demonstrate a reduction in CTV volume compared with traditional planning. They noted a mean reduction in CTV of 25.71%. Most importantly, the navigated method preserved the anatomic integrity of the CTV. This commentary discusses defining the CTV, including reducing the risk of irradiating healthy tissue while maintaining oncologic safety. This study supports integrating surgical navigation into approach for cancer care and provides evidence for further studies evaluating the long-term oncologic and radiation-related side effects. These data mark progress toward providing individualized adjuvant radiation therapy for patients with head and neck cancer.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107884"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma of the parotid Gland: A Population-Based study of incidence and treatment outcomes in 1018 patients","authors":"K. Sandström ,&nbsp;L. Farnebo ,&nbsp;A. Hafström ,&nbsp;A. Westerborn ,&nbsp;M. Olin ,&nbsp;E. Hammerlid ,&nbsp;L. Hammarstedt-Nordenvall ,&nbsp;M. Gebre-Medhin ,&nbsp;B. Granström ,&nbsp;T. Andersson-Säll ,&nbsp;G. Laurell","doi":"10.1016/j.oraloncology.2026.107863","DOIUrl":"10.1016/j.oraloncology.2026.107863","url":null,"abstract":"<div><h3>Intro</h3><div>Population-based studies predominantly focused on carcinoma of the parotid gland (CPG) are rare. The study aims were to analyze the incidence of CPG and to assess treatment outcomes in relation to histopathology, preoperative diagnosis and adjuvant radiotherapy.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on data from the Swedish Head and Neck Cancer Register (SweHNCR), including 1,018 patients diagnosed with CPG between 2008 and 2019.</div></div><div><h3>Results</h3><div>The age-adjusted incidence remained stable with a mean of 0.9 (range 0.65–1.08) cases per 100,000 person-years (ASR-Europe). Curative treatment was administered to 90 % of the patients, with a recurrence rate of 9 % within 3 years. The highest recurrence rates were observed in patients with salivary duct carcinoma and adenocarcinoma, while patients with acinic cell and mucoepidermoid carcinomas had lower recurrence rates. For stage I–II tumors, the 5-year relative survival was unaffected by whether the malignant diagnosis was known preoperatively. Male sex, increasing age, stage III–IV disease, and a World Health Organization/ Eastern Cooperative Oncology Group (WHO/ECOG) performance status 2–4 was independently associated with increased overall mortality risk, whereas the timing of adjuvant radiotherapy was not.</div></div><div><h3>Conclusion</h3><div>This study contributes to establishing the incidence and treatment outcomes of CPG in Sweden and highlights the diverse histopathological diagnoses of these tumors. Notably, unknown malignancy at the time of surgery did not impact survival in early-stage disease, and the timing of postoperative radiotherapy was not associated with overall survival.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"174 ","pages":"Article 107863"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}