Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107532
Gnanaprakash Jeyaraj
{"title":"Commentary on, “Effects of diagnostic delays in head and neck cancer patients presenting to the emergency department”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2025.107532","DOIUrl":"10.1016/j.oraloncology.2025.107532","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107532"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107526
Jatinder Pal Singh Chawla , Gundeep Kaur Madan
{"title":"Comment on “Current status of circulating tumour DNA and circulating cell alterations in HPV-associated head and neck cancer”","authors":"Jatinder Pal Singh Chawla , Gundeep Kaur Madan","doi":"10.1016/j.oraloncology.2025.107526","DOIUrl":"10.1016/j.oraloncology.2025.107526","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107526"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107514
Rong Sun , Deqi Kong
{"title":"Toward comprehensive optimization of larynx-preserving strategies in MI-LSCC","authors":"Rong Sun , Deqi Kong","doi":"10.1016/j.oraloncology.2025.107514","DOIUrl":"10.1016/j.oraloncology.2025.107514","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107514"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107523
Oreste Gallo, Letizia Flammia
{"title":"What does margin mean in laryngeal surgery?","authors":"Oreste Gallo, Letizia Flammia","doi":"10.1016/j.oraloncology.2025.107523","DOIUrl":"10.1016/j.oraloncology.2025.107523","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107523"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107450
Deping Li , Yibin Wang
{"title":"Comment on: Neoadjuvant chemoradiation for patients with resectable locally advanced oral cavity squamous cell carcinoma: Results of the prospective INVERT clinical trial","authors":"Deping Li , Yibin Wang","doi":"10.1016/j.oraloncology.2025.107450","DOIUrl":"10.1016/j.oraloncology.2025.107450","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107450"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107529
Aravinth Annamalai
{"title":"Comments on, “Mandibular swing approach: 25 years of experience at Istituto Nazionale Tumori of Milan”","authors":"Aravinth Annamalai","doi":"10.1016/j.oraloncology.2025.107529","DOIUrl":"10.1016/j.oraloncology.2025.107529","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107529"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107513
Liya Zhu , Xiuli Jing , Byeong-Cheol Ahn
{"title":"Turning tumor microenvironmental foes to friends: A new opportunity for thyroid cancer therapy and redifferentiation","authors":"Liya Zhu , Xiuli Jing , Byeong-Cheol Ahn","doi":"10.1016/j.oraloncology.2025.107513","DOIUrl":"10.1016/j.oraloncology.2025.107513","url":null,"abstract":"<div><div>Cancer cells engage in dynamic crosstalk with their microenvironment (TME), critically influencing tumor progression, metastasis, immune evasion, and therapeutic resistance. Thyroid cancer (TC) exhibits characteristic tumor heterogeneity, together with secreted factors (cytokines, chemokines, extracellular vesicles) and the extracellular matrix, these elements constitute the TME. In addition, TC-TME interactions drive key pathological processes including differentiation status across histological subtypes—from differentiated (DTC) to aggressive variants(poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC)). A hallmark of malignancy, metabolic reprogramming not only fuels uncontrolled proliferation but also actively remodels the TME through mechanisms including immune modulation, angiogenesis regulation, and stromal reprogramming. At the same time, immunotherapy represents a promising therapeutic frontier for treatment-refractory cases such as radioiodine-resistant DTC (RR-DTC), PDTC, and ATC. Emerging evidence reveals distinct mutational signatures that correlate with TME remodeling, suggesting potential diagnostic and prognostic biomarkers. While current redifferentiation approaches primarily target cancer cells with limited success, novel strategies focusing on TME modulation—particularly targeting tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and tumor-associated mast cells (TAMCs)—show therapeutic potential. Deciphering these intricate metabolic adaptations and their bidirectional interactions with the TME represents a pivotal opportunity for developing precision therapies and enhancing treatment efficacy in the clinical oncology of TC. This review synthesizes current knowledge on TME-directed therapies in TC and highlights the urgent need to elucidate metabolic reprogramming and other factors within the TME to develop innovative treatment paradigms targeting both cancer cells and TC-associated immune cells.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107513"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-22DOI: 10.1016/j.oraloncology.2025.107515
Yu Lin , Luyao Liu , Dong Shen , Ling Zhang , Qin Zhang , Xuewen Liu , Dongsheng Chen , Yiqian Liu , Yongqian Shu
{"title":"Illustrating potential actionable drug targets of head and neck tumors based on comprehensive genomic landscape of 386 samples","authors":"Yu Lin , Luyao Liu , Dong Shen , Ling Zhang , Qin Zhang , Xuewen Liu , Dongsheng Chen , Yiqian Liu , Yongqian Shu","doi":"10.1016/j.oraloncology.2025.107515","DOIUrl":"10.1016/j.oraloncology.2025.107515","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107515"},"PeriodicalIF":4.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2025-07-21DOI: 10.1016/j.oraloncology.2025.107525
Shashank Dokania, Parth Aphale, Himanshu Shekhar
{"title":"Comment on “Clinical outcomes for unresectable anaplastic thyroid cancer treated with radiation: Impacts of radiation intent and the percentage of life spent receiving treatment”","authors":"Shashank Dokania, Parth Aphale, Himanshu Shekhar","doi":"10.1016/j.oraloncology.2025.107525","DOIUrl":"10.1016/j.oraloncology.2025.107525","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"168 ","pages":"Article 107525"},"PeriodicalIF":4.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}