Oral oncology最新文献

{"title":"A Warthin tumor-like lesion with a Warthin tumor immunophenotype","authors":"Nikolaos Katsoulas , Ioannis G. Koutlas , Konstantinos I. Tosios","doi":"10.1016/j.oraloncology.2025.107728","DOIUrl":"10.1016/j.oraloncology.2025.107728","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107728"},"PeriodicalIF":3.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Whole-exome sequencing reveals the mutational landscape of head and neck lymphoepithelioma-like carcinoma","authors":"Thangapandi Marudhupandi","doi":"10.1016/j.oraloncology.2025.107740","DOIUrl":"10.1016/j.oraloncology.2025.107740","url":null,"abstract":"<div><div>The recent article by Zhang et al. titled “Whole-exome sequencing reveals the mutational landscape of head and neck lymphoepithelioma-like carcinoma” makes a significant contribution to understanding this rare cancer. Using whole-exome sequencing, the authors identified frequently mutated genes, potential driver mutations, and candidate treatments, offering valuable insights into the molecular basis of HNLEC. Importantly, they identified links between specific gene alterations and patient outcomes, as well as druggable pathways, through DGIdb analysis. Although limited by sample size, this pioneering study provides a genomic foundation that can guide future research. Larger multi-institutional studies, functional testing of candidate driver genes, and the incorporation of viral and immune profiling will be the next steps in turning these findings into clinical applications. This work provides a strong base for advancing precision oncology in HNLEC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107740"},"PeriodicalIF":3.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged transoral surgery in synchronous HPV-related oropharyngeal cancer","authors":"Samih J. Nassif ,&nbsp;Erin Longstreth ,&nbsp;Gregory S. Weinstein ,&nbsp;Shravan Kandula ,&nbsp;Andrea Costantino ,&nbsp;Bruce H. Haughey","doi":"10.1016/j.oraloncology.2025.107738","DOIUrl":"10.1016/j.oraloncology.2025.107738","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107738"},"PeriodicalIF":3.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor subtype classification tool for HPV-associated head and neck cancers","authors":"Shiting Li ,&nbsp;Bailey F. Garb ,&nbsp;Tingting Qin ,&nbsp;Sarah E. Soppe ,&nbsp;Elizabeth Lopez ,&nbsp;Snehal Patil ,&nbsp;Nisha J. D’Silva ,&nbsp;Laura S. Rozek ,&nbsp;Maureen A. Sartor","doi":"10.1016/j.oraloncology.2025.107726","DOIUrl":"10.1016/j.oraloncology.2025.107726","url":null,"abstract":"<div><h3>Background</h3><div>Molecular subtypes of HPV-associated Head and Neck Squamous Cell Carcinoma (HNSCC), named IMU (immune strong) and KRT (highly keratinized), are well-recognized due to distinct molecular features, tumor microenvironments, clinical outcomes, and potentially differing optimal treatment strategies. Currently, no standardized method exists to subtype a new HPV + HNSCC tumor. Our paper introduces a machine learning-based classifier and webtool to reliably subtype HPV + HNSCC tumors using the IMU/KRT paradigm and highlights the importance of subtype in HPV + HNSCC.</div></div><div><h3>Methods</h3><div>We conducted RNA-seq on 67 HNSCC tumors from University of Michigan Health. Combining this with three publicly available datasets, we utilized a total of 229 HPV + HNSCC RNA-seq samples. The classifier was trained and tested using 84 subtype-labeled HPV + RNA-seq samples and validated with the remaining samples. We also tested the association of 37 clinicodemographic and molecular variables with subtype.</div></div><div><h3>Results</h3><div>The classifier achieved 100% accuracy in the test set. Validation on two additional cohorts demonstrated successful separation by known features of the subtypes. Investigation of the relationship between subtype and the molecular and clinicodemographic variables revealed 21 significant associations, both confirming previous findings and revealing novel subtype associations.</div></div><div><h3>Conclusions</h3><div>This study provides a reliable classifier for subtyping HPV + HNSCC tumors as either IMU or KRT based on bulk RNA-seq data and improves our understanding of the HPV + HNSCC subtypes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107726"},"PeriodicalIF":3.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the pathological staging of the oral squamous cell carcinoma based on microscopic hyperspectral imaging","authors":"Yingchun Zhou,&nbsp;Min Li,&nbsp;Ming Cai","doi":"10.1016/j.oraloncology.2025.107739","DOIUrl":"10.1016/j.oraloncology.2025.107739","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107739"},"PeriodicalIF":3.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of care in de-novo oligo-metastatic and oligo-recurrent head and neck cancers: A Head and Neck Cancer International Group (HNCIG) Survey.","authors":"Monali Swain ,&nbsp;Sarbani Ghosh-Laskar ,&nbsp;Lachlan McDowell ,&nbsp;Christina Henson ,&nbsp;Pierluigi Bonomo ,&nbsp;Sadhana Kannan ,&nbsp;Timothy Malouff ,&nbsp;Akihiro Homma ,&nbsp;Alexander Rühle ,&nbsp;Anna Lee ,&nbsp;Francesca Caparrotti ,&nbsp;James Bates ,&nbsp;Jorgen Johansen ,&nbsp;Juliette Thariat ,&nbsp;Marco Ferrari ,&nbsp;Miguel Mayo-Yáñez ,&nbsp;Sarah Hamilton ,&nbsp;Sue S. Yom ,&nbsp;Hisham Mehanna ,&nbsp;Petr Szturz","doi":"10.1016/j.oraloncology.2025.107647","DOIUrl":"10.1016/j.oraloncology.2025.107647","url":null,"abstract":"<div><h3>Background</h3><div>The current survey was conducted among head and neck cancer physicians across the globe to understand the patterns of care and practice for de-novo oligo-metastatic (OM) and oligo-recurrent (OR) head and neck cancer (HNC).</div></div><div><h3>Material and methods</h3><div>An 18-item survey questionnaire was designed and distributed through the member organizations of the Young Investigator Subcommittee of the HNCIG. The responses were presented as a proportion of the total response for a particular survey item.</div></div><div><h3>Results</h3><div>A total of 204 responses were obtained with an overall response rate of 15.6 % (204/1307). The incidence of OM disease was reported to be &lt; 10 % by 81.9 % of respondents with a higher incidence of oligo-recurrent disease (up to 20 %). Performance status and extent of disease are absolute essential factors for decision-making. In suitable patients, the majority of respondents (67.4 %) would like to treat with a combination of systemic and local therapy both to primary and metastatic site. For oligo-recurrent HNC, 63.7 % of respondents would treat with both systemic and metastatic directed therapy (MDT) with 27 % would consider MDT alone. Surgery and stereotactic body radiotherapy (SBRT) remain the choice of MDT for lung and liver metastasis. The majority of the respondents use SBRT in &gt; 50 % of their patients.</div></div><div><h3>Conclusion</h3><div>The current approach to <em>de-novo</em> OM and oligo-recurrent HNC varies in this global survey, but a significant proportion of respondents support radical intent treatment in select cases. Multicentre retrospective and prospective studies as well as international consensus statement are essential prerequisites for developing future clinical guidelines.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107647"},"PeriodicalIF":3.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Head and neck lymphedema after radiotherapy—Prevalence, changes and associated factors—a prospective observational cohort study”","authors":"Linyi Jiang","doi":"10.1016/j.oraloncology.2025.107737","DOIUrl":"10.1016/j.oraloncology.2025.107737","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107737"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic evolution of a metastatic oral squamous cell carcinoma: a case report, molecular analysis, and review of the literature","authors":"Benjamin Palatnik ,&nbsp;David Kazadi ,&nbsp;Ashok Jethwa ,&nbsp;Andrew Nelson ,&nbsp;Naomi Fujioka","doi":"10.1016/j.oraloncology.2025.107734","DOIUrl":"10.1016/j.oraloncology.2025.107734","url":null,"abstract":"<div><h3>Background</h3><div>Metastasis to the peritoneum is a rare but aggressive manifestation of squamous cell carcinoma of the head and neck (SCCHN). The specific drivers of metastasis in SCCHN remain unclear. We describe a case of recurrent, metastatic SCCHN and explore the potential role of acquired genomic alterations on the disease course.</div></div><div><h3>Methods</h3><div>Mutational profiling of serial tumor specimens was conducted. Identified mutations were compared to TCGA SCCHN data.</div></div><div><h3>Results</h3><div>Tumor specimens showed the progressive accumulation of mutations in <em>TP53</em>, <em>NOTCH1</em>, <em>APC</em>, and <em>SMAD4</em>.</div></div><div><h3>Conclusion</h3><div>This case provides insight into potential metastatic drivers in SCCHN, particularly <em>SMAD4</em> and the TGF-b pathway, which are integral in controlling epithelial cell proliferation and dedifferentiation.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107734"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Prospective study of algorithm-based chemoradioselection to optimize treatment intensity for advanced head and neck cancer","authors":"Thangapandi Marudhupandi","doi":"10.1016/j.oraloncology.2025.107731","DOIUrl":"10.1016/j.oraloncology.2025.107731","url":null,"abstract":"<div><div>The new prospective study by Hongo et al. on algorithm-based chemoradioselection (CRS) for advanced head and neck cancer signifies a crucial advancement in optimizing treatment intensity while reconciling oncological outcomes with organ preservation. The authors utilized CRS to provide a viable approach for patient stratification and therapeutic personalization, thus minimizing overtreatment while maintaining sufficient tumor control. This novel method addresses the enduring issue of tailoring multimodal treatment for advanced cases, where both effectiveness and quality of life are crucial. The study emphasizes the clinical significance of evidence-based algorithms in enhancing therapeutic decision-making. Future investigations incorporating molecular biomarkers, artificial intelligence, and validation within extensive, multi-institutional cohorts will improve the precision and applicability of CRS, thereby strengthening its potential to establish itself as a standard tool in head and neck oncology.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107731"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma","authors":"Thangapandi Marudhupandi","doi":"10.1016/j.oraloncology.2025.107730","DOIUrl":"10.1016/j.oraloncology.2025.107730","url":null,"abstract":"<div><div>The article by Wang et al., titled “Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma,” offers an innovative contribution to the field of oncology. By combining super-enhancer biology with advanced machine learning algorithms, the authors successfully created a prognostic gene signature (SEAGS) that showed strong predictive performance across multiple independent cohorts. Additionally, the study identified WNT7A as a new super-enhancer-driven oncogene, highlighting the importance of epigenetic regulation in head and neck squamous cell carcinoma (HNSCC) and underscoring the potential clinical impact of these findings. This research not only advances biomarker discovery but also paves the way for new therapeutic strategies targeting super-enhancers. Future studies involving single-cell epigenomics, multi-omics data integration, and validation in prospective clinical trials are recommended to bolster the prognostic value and therapeutic use of SEAGS in precision oncology.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"170 ","pages":"Article 107730"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}