Oral oncology最新文献

{"title":"Response to recent comments on “Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy”","authors":"Rance B. Tino , Millicent A. Roach , Gabriela D. Fuentes , Anshuman Agrawal , Mohamed Zaid , Dylan J. Cooper , Nimit Bajaj , Ruitao Lin , Lianchun Xiao , Lauren L. Mayo , Lee R. Wiederhold , Shalin J. Shah , Molly K. Tate , Gregory M. Chronowski , Jay P. Reddy , Megan Mezera , Justin M. Mann , Mark Augspurger , Adegbenga O. Otun , Mark S. Chambers , Eugene J. Koay","doi":"10.1016/j.oraloncology.2025.107220","DOIUrl":"10.1016/j.oraloncology.2025.107220","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107220"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia in head and neck cancer patients with evidence of esophageal dysmotility on manometry","authors":"Molly O. Meeker, BS ,&nbsp;Akhil Katragadda ,&nbsp;Mohammad Bilal Alsavaf ,&nbsp;Jack Birkenbeuel ,&nbsp;Zachary Wykoff ,&nbsp;Songzhu Zhao ,&nbsp;Apoorva T. Ramaswamy","doi":"10.1016/j.oraloncology.2025.107219","DOIUrl":"10.1016/j.oraloncology.2025.107219","url":null,"abstract":"<div><h3>Objectives</h3><div>Dysphagia is a well-known complication of head and neck cancer (HNC) treatment that significantly impacts daily life for survivors. This study aims to characterize esophageal dysmotility identified on high resolution manometry (HRM) in HNC survivors with dysphagia.</div></div><div><h3>Methods</h3><div>A retrospective chart review of 30 patients who underwent HRM treated for dysphagia between August 1st 2020 to February 2nd, 2023, was conducted. Patients with dysphagia, at least one HRM, and treated in a HNC dysphagia clinic were included. HRM reports were analyzed using Chicago Classification Version 4.0 (CCV4). EGJ outflow obstruction (EGJOO) was validated using endoscopy or radiographic findings. Data was summarized using mean for continuous variables and frequencies for categorical variables.</div></div><div><h3>Results</h3><div>Of the 30 patients included in our study, 18 (60.0 %) showed evidence of CCV4 dysmotility. The most common subtypes were found to be ineffective motility (n = 6, 33.3 %), followed by EGJOO (n = 5, 27.8 %). Absent contractility and hypercontractile esophagus showed the same frequency (n = 3, 16.7 %), as did achalasia type 1 and type 2 (n = 1, 5.6 %).</div></div><div><h3>Conclusion</h3><div>Oropharyngeal and pharyngoesophageal dysphagia are well recognized causes of dysphagia, while esophageal dysmotility is an understudied cause of dysphagia in the HNC population. In this study of patients undergoing HRM for workup of their dysphagia after HNC, 60% had evidence of a CCV4 motility disorder, with the most common subtypes being ineffective motility and EGJOO. Therefore, HRM, the gold standard of diagnosis for esophageal dysmotility, should be considered in HNC patients who have symptoms suspicious for dysmotility.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107219"},"PeriodicalIF":4.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on sentinel lymph node biopsy in early-stage maxillary cancer","authors":"Xuan Xiao ,&nbsp;Mengmeng Lu ,&nbsp;Tingjiao Liu ,&nbsp;Zhifeng Song","doi":"10.1016/j.oraloncology.2025.107221","DOIUrl":"10.1016/j.oraloncology.2025.107221","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107221"},"PeriodicalIF":4.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmented reality in preoperative anterolateral thigh flap perforators positioning: A pilot diagnostic study","authors":"Bin Wei ,&nbsp;Guoxiong Lu ,&nbsp;Zhiqiang Bai ,&nbsp;David O. Osei-Hwedieh ,&nbsp;Yunsheng Chen ,&nbsp;Qunxing Li ,&nbsp;Zhijun Xie ,&nbsp;Peichia Lu ,&nbsp;Jiahao Miao ,&nbsp;Niu Liu ,&nbsp;Jiaying Wu ,&nbsp;Hsinyu Lin ,&nbsp;Fan Wu ,&nbsp;Lizao Zhang ,&nbsp;Siqi Ren ,&nbsp;Yingying Zhu ,&nbsp;Abdo Ahmed Saleh Mohamed ,&nbsp;Eduardo Dias-Ribeiro ,&nbsp;Xinghui Dong ,&nbsp;Kui Jiang ,&nbsp;Song Fan","doi":"10.1016/j.oraloncology.2025.107189","DOIUrl":"10.1016/j.oraloncology.2025.107189","url":null,"abstract":"<div><h3>Background</h3><div>The anterolateral thigh (ALT) flap is the primary choice for healthy and vascularized soft-tissue coverage for appendicular and axial soft tissue reconstruction, especially in the head and neck regions. Nonetheless, there is substantial anatomic variation in ALT perforators that affect flap integrity, survival rates, and donor-site morbidity. Regardless of the ALT flap type, accurate location of perforators can greatly improve surgical success rates and reduce the risk of secondary surgeries. Therefore, we investigated a novel approach for locating perforators.</div></div><div><h3>Method</h3><div>We utilized augmented reality (AR) technology in combination with a self-designed device, <em>Finder</em>, to locate the perforators of the anterolateral thigh (ALT) flap, and compared its accuracy to that of traditional ultrasound localization.</div></div><div><h3>Result</h3><div>In this study, 24 patients underwent ALT flap reconstruction, with all flaps surviving except one case of partial necrosis. Comparing the two positioning methods, Ultrasonic color Doppler (UCD) showed a sensitivity of 81.1 % [95 % confidence interval (CI) 64.3 %–91.4 %] and an AUC of 0.70 (95 % CI 0.55–0.86). AR-Finder demonstrated a higher sensitivity of 97.5 % (95 % CI 85.3 %-99.9 %, p = 0.031) and an AUC of 0.90 (95 % CI 0.80–1.01, p = 0.035). The average distance difference from the actual perforator to virtually determined location was 3.54 ± 2.80 mm (95 % CI 2.58–4.50) for AR-Finder and 9.57 ± 5.84 mm (95 % CI 7.75–11.58) for UCD (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>In this pilot study, AR-Finder demonstrated superior accuracy compared to the UCD method for locating perforators in ALT flaps, providing a new and reliable tool for the design and elevation of ALT flaps.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107189"},"PeriodicalIF":4.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitoxantrone hydrochloride liposome injection for the treatment of Recurrent/Metastatic head and neck squamous cell Carcinoma: A Multicenter, Open-label, Single-arm, phase 1b study","authors":"Hang Yang ,&nbsp;Peng Sun ,&nbsp;Yu Wang ,&nbsp;Xicheng Wang ,&nbsp;Yanyan Liu ,&nbsp;Jiyong Peng ,&nbsp;Hui Zhou ,&nbsp;Yajun Li ,&nbsp;Hong Zhang ,&nbsp;Jianbing Hu ,&nbsp;Bing Zhang ,&nbsp;Shunhuan Lin ,&nbsp;Chunwei Yang ,&nbsp;Weidong Li ,&nbsp;Yanping Liu ,&nbsp;Meng Ji ,&nbsp;Jinghua Zhao ,&nbsp;Jianfei Xue ,&nbsp;Jiajia Huang ,&nbsp;Zhiming Li","doi":"10.1016/j.oraloncology.2025.107211","DOIUrl":"10.1016/j.oraloncology.2025.107211","url":null,"abstract":"<div><h3>Background</h3><div>Mitoxantrone hydrochloride liposomes (PLM60) have been approved for the treatment of relapsed/refractory peripheral T-cell lymphoma (PTCL) in China. This study evaluated the safety and efficacy of PLM60 in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).</div></div><div><h3>Methods</h3><div>Patients with histologically confirmed HNSCC (including nasopharyngeal carcinoma (NPC)) were enrolled. PLM60 was administered at a dose of 20 mg/m² by intravenous infusion every 21 days (one cycle) with a maximum of eight cycles. The primary objective was to determine the safety and the secondary objective was to assess the efficacy of PLM60 in this setting.</div></div><div><h3>Results</h3><div>A total of 45 patients with a median age of 50 years were enrolled (26 NPC and 19 non-NPC). Eleven patients completed the planned regimen. The most common hematological adverse events (AEs) were anemia (64.4 %), decreased white blood cell count (55.6 %), and decreased lymphocyte count (46.7 %). The most common non-hematologic AE was skin hyperpigmentation (37.8 %). Grade ≥ 3 AEs occurred in 30 patients (80.0 %), and most were hematologic. Four patients reported AEs leading to death, with two cases assessed as possibly related to the study drug. Of the 37 patients evaluable for efficacy, the overall objective response rate (ORR) was 24.3 % (95 % CI: 11.8–41.2 %) and the disease control rate was 62.2 % (95 % CI: 44.8–77.5 %). The proportion of patients with an overall response was higher in the NPC group (7/25, ORR: 28.0 %) than in the non-NPC group (2/12, ORR: 16.7 %).</div></div><div><h3>Conclusions</h3><div>PLM60 has demonstrated manageable safety and evidence of efficacy in patients with recurrent/metastatic HNSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107211"},"PeriodicalIF":4.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced osteosarcoma in the head and neck region: Case report and literature review","authors":"Iara Vieira Ferreira ,&nbsp;Marcelo Elias Schempf Cattan ,&nbsp;Carlos Takahiro Chone ,&nbsp;Arthur Antolini ,&nbsp;Erika Said Abu Egal ,&nbsp;Albina Altemani ,&nbsp;Fernanda Viviane Mariano","doi":"10.1016/j.oraloncology.2025.107216","DOIUrl":"10.1016/j.oraloncology.2025.107216","url":null,"abstract":"<div><div>Radiation-induced sarcoma (RIS) is a rare but highly aggressive complication of radiotherapy, especially in the head and neck region (RIS-HN). This report describes a case of radiation-induced osteosarcoma (RIOS) in a 32-year-old woman with a history of craniopharyngioma treated with surgery and radiotherapy 13 years prior. The patient exhibited symptoms including epistaxis, diplopia, and ptosis of the right eyelid. Imaging revealed a large, inoperable tumor in the area that had received prior radiotherapy. A biopsy confirmed the diagnosis of osteosarcoma, and the patient initiated palliative chemotherapy. Unfortunately, the treatment was unsuccessful, and the patient passed away. A review of 148 RIOS cases published in the last 25 years in the literature shows that the maxilla and mandible are the most affected sites (68.86 %), with an average latency of 11.79 years. The most common primary tumor was nasopharyngeal carcinoma, treated with an average radiation dose of 61.69 Gy. The prognosis remains poor, with 72.3 % of patients dying within an average of 23 months of follow-up. This study highlights the clinical and pathological characteristics of RIOS, the importance of long-term monitoring of irradiated patients to detect and treat these tumors early, with the aim of improving patient outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107216"},"PeriodicalIF":4.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multistate oral carcinogenesis—A prospective cohort study and a parallel case-control study in Taiwan","authors":"Cheng-Ping Wang ,&nbsp;Kelly J. Yu ,&nbsp;Tseng-Cheng Chen ,&nbsp;Ming-shui Tsai ,&nbsp;Chung-Jan Kang ,&nbsp;Chi-Yen Chien ,&nbsp;Eric A. Engels ,&nbsp;Chun-Hung Hua ,&nbsp;Wan-Lun Hsu ,&nbsp;Yih-Leong Chang ,&nbsp;Sanford M. Dawsey ,&nbsp;Nicolas Wentzensen ,&nbsp;Jianxin Shi ,&nbsp;Fangya Mao ,&nbsp;Li C. Cheung ,&nbsp;Hormuzd A. Katki ,&nbsp;Eric Boyd ,&nbsp;Chen-Tu Wu ,&nbsp;J.Silvio Gutkind ,&nbsp;Alfredo Molinolo ,&nbsp;Anil K. Chaturvedi","doi":"10.1016/j.oraloncology.2025.107210","DOIUrl":"10.1016/j.oraloncology.2025.107210","url":null,"abstract":"<div><h3>Background</h3><div>To characterize multistate oral carcinogenesis, we conducted a cohort study of patients with oral precancer and a parallel case-control study of oral cancers and controls in Taiwan.</div></div><div><h3>Methods</h3><div>During 2013–2019, we recruited patients with oral precancer (n = 1998) or invasive oral cancer (n = 768) and hospital-based controls (n = 717). Precancer patients were followed up biannually for up to five years; questionnaire data and biospecimens were collected at multiple timepoints. Precancer natural history (regression/persistence, incidence, progression) was evaluated through follow-up visits and linkages with Taiwan’s Cancer Registry.</div></div><div><h3>Cohort updates</h3><div>Cross-sectionally, 71 % of oral precancers and 62 % of cancers were attributable to betel-quid chewing, smoking, and alcohol. Precancer patients had substantially elevated risk of oral cancer (standardized-incidence-ratio vs. Taiwan general population = 14.1; 95 %CI = 12.0–16.6). Among precancer patients, 156 incident invasive oral cancers occurred (median follow-up = 6.4 years; incidence rate = 1,221/100,000 person-years; annual incidence = 1.2 %; 1-year cumulative-incidence = 1.8 %; 5-year cumulative-incidence = 6.9 %; 10-year cumulative-incidence = 9.5 %). Baseline precancer histopathology strongly predicted risk of progression to oral cancer (5-year cumulative-incidence: no-dysplasia = 5.2 %, mild-dysplasia = 7.1 %, moderate-dysplasia = 32.8 %, severe-dysplasia = 45.9 %). Most oral cancers (88.5 %) were preceded by precancers identified during the study. The study has established a resource of &gt;63,500 biospecimens, including biopsies (n = 6,012), oral cytology (n = 18,422), oral rinses (n = 15,054), saliva (n = 15,066), and blood (n = 8,990). Ongoing investigations are characterizing oral carcinogenesis at the epidemiologic, macroscopic, microscopic, microbiomic, and genomic levels.</div></div><div><h3>Conclusions</h3><div>A majority of oral precancers/cancers in Taiwan are caused by betel-quid chewing, smoking, and alcohol. Patients with oral precancer have substantially elevated risk of site-concordant oral cancer. We highlight our study as a resource to collaboratively address questions regarding oral precancer/cancer natural history and clinical management.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107210"},"PeriodicalIF":4.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry”","authors":"Kohei Okuyama ,&nbsp;Souichi Yanamoto","doi":"10.1016/j.oraloncology.2025.107213","DOIUrl":"10.1016/j.oraloncology.2025.107213","url":null,"abstract":"<div><div>This study in Oral Oncology highlights how neoadjuvant immunotherapy reshapes the tumor immune microenvironment (TIME) in HNSCC, increasing CD8+ T cells and reducing immunosuppressive cells. Using multiplex immunohistochemistry, it offers crucial spatial insights into TIME dynamics, paving the way for biomarker development and personalized therapies. Future research should explore combining this approach with single-cell technologies to elucidate functional immune states, enhancing our understanding of therapeutic responses and informing novel combinatorial treatment strategies.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107213"},"PeriodicalIF":4.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining decision-making in mandibular reconstruction: A critical appraisal of data-driven flap selection criteria","authors":"Carlos M. Ardila ,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.oraloncology.2025.107217","DOIUrl":"10.1016/j.oraloncology.2025.107217","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107217"},"PeriodicalIF":4.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective, efficient palliative radiotherapy for advanced head and neck cancer: Real world data using 25 Gy in 5 fractions","authors":"Muhammad Shahid Iqbal,&nbsp;Nick West,&nbsp;Josef Kovarik,&nbsp;Malcolm Jackson,&nbsp;Rahul Patil,&nbsp;Laura Mackenzie,&nbsp;Maha Zarroug,&nbsp;Laura Gradwell-Nelson,&nbsp;Charles G. Kelly","doi":"10.1016/j.oraloncology.2025.107214","DOIUrl":"10.1016/j.oraloncology.2025.107214","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107214"},"PeriodicalIF":4.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}