Oral oncology最新文献

{"title":"Commentary on, “Identification of clinical and pathologic features associated with extranodal extension in patients with HPV-mediated oropharyngeal squamous cell carcinoma”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107394","DOIUrl":"10.1016/j.oraloncology.2025.107394","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107394"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report","authors":"J.A. Rijken ,&nbsp;M. de Ridder ,&nbsp;L.A. Devriese ,&nbsp;G.E. Breimer","doi":"10.1016/j.oraloncology.2025.107392","DOIUrl":"10.1016/j.oraloncology.2025.107392","url":null,"abstract":"<div><div>Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107392"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of hotspot mutations in oral cancer through Ion AmpliSeq™ cancer hotspot panel v.2.0: A circulating DNA fragmentomics approach in the Northeast Indian population","authors":"Denis C Baiju ,&nbsp;Joshua Ravi ,&nbsp;Mridul Sarma ,&nbsp;Muthusamy Sureshan ,&nbsp;Arunachalam Jothi ,&nbsp;Rosy Mondal","doi":"10.1016/j.oraloncology.2025.107387","DOIUrl":"10.1016/j.oraloncology.2025.107387","url":null,"abstract":"<div><div>Oral Squamous Cell Carcinoma (OSCC) is the most commonly diagnosed cancer worldwide, with 90–95% of cases reported to be SCC. The present study aimed to investigate the presence of circulating cell-free tumor DNA (cftDNA) in the patient’s plasma with OSCC and determine the feasibility of liquid biopsies in genomic profiling using deep sequencing-based approach. Mutation analysis of cfDNA will help evaluate the molecular and clinical impacts of the identified somatic alterations during primary staging.</div></div><div><h3>Methods</h3><div>Paired samples from 11 OSCC patients, including cfDNA, tumor tissue, and blood, were submitted for deep sequencing of 50 genes by next-generation sequencing using the Ion Ampliseq Cancer Hotspot Panel v2.</div></div><div><h3>Results</h3><div>We found higher mutational load in cfDNA than in tumor tissue samples, suggesting the potential of cfDNA as a liquid biopsy for monitoring therapeutic responses. The TP53 p.Pro72Arg variant was identified in all the samples, indicating its potential as a diagnostic marker. Molecular dynamics simulations of the p53 protein showed higher fluctuations in the mutant form, potentially affecting protein function. The RB1 p.Ile680Thr pathogenic variant was found in 64% of oral squamous cell carcinoma samples. Recurrently mutated genes, including <em>TP53, KDR, APC, RB1, MET, PIK3CA, CDKN2A, RET</em>, and <em>EGFR</em>, were identified in both tumor tissue and cfDNA samples.</div></div><div><h3>Conclusion</h3><div>The detection of tumor imprints and heterogeneity in cfDNA samples highlights the potential of liquid biopsy as a valuable tool for monitoring therapeutic responses in OSCC. The identification of recurrently mutated genes and pathogenic variants provides insights into potential therapeutic targets.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107387"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “The use of 3D computer-aided design to optimize photoimmunotherapy catheter placement”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107400","DOIUrl":"10.1016/j.oraloncology.2025.107400","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107400"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “The association between health-related quality of life and five-year overall survival among head and neck cancer patients: A prospective cohort study”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2025.107401","DOIUrl":"10.1016/j.oraloncology.2025.107401","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107401"},"PeriodicalIF":4.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of volumetry in sinonasal cancer response assessment to induction chemotherapy, results from two phase II non-randomized controlled prospective multicentric trials: SINTART-1 and SINTART-2","authors":"Paolo Rondi ,&nbsp;Davide Mattavelli ,&nbsp;Vittorio Rampinelli ,&nbsp;Alberto Schreiber ,&nbsp;Ester Orlandi ,&nbsp;Barbara Vischioni ,&nbsp;Nicola A. Iacovelli ,&nbsp;Giuseppina Calareso ,&nbsp;Cristiana Bergamini ,&nbsp;Salvatore Alfieri ,&nbsp;Paolo Castelnuovo ,&nbsp;Paolo Battaglia ,&nbsp;Mario Turri-Zanoni ,&nbsp;Piero Nicolai ,&nbsp;Marco Ferrari ,&nbsp;Lisa Licitra ,&nbsp;Paolo Bossi ,&nbsp;Davide Farina ,&nbsp;Marco Ravanelli ,&nbsp;Carlo Resteghini","doi":"10.1016/j.oraloncology.2025.107388","DOIUrl":"10.1016/j.oraloncology.2025.107388","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to identify the best response criteria in patients with sinonasal cancer undergoing induction chemotherapy (IC).</div></div><div><h3>Material and methods</h3><div>Patients enrolled in SINTART-1 and SINTART-2 were included in this study. Unidimensional diameters (anteroposterior, AP; laterolateral, LL; craniocaudal, CC), maximum axial area (Amax), and volume (V) were performed on MRI by two radiologists. RECIST 1.1 assessment was included as a categorical variable. Variables were evaluated at baseline, after the 1st chemotherapy cycle, and at the best response. Interobserver repeatability was analyzed. Stepwise univariable and multivariable Cox proportional-hazards regression models were used to correlate variables with Disease-Free Survival (DFS) and Overall Survival (OS).</div></div><div><h3>Results</h3><div>60 patients were included in this study. Interobserver correlation coefficient at baseline and after 1st IC cycle was excellent for V (0.916 and 0.928 respectively), CC diameter (0.96 and 0.863), and AP diameter (0.846 and 0.796), good for LL diameter, and moderate for Amax. RECIST 1.1 criteria after the 1st IC cycle and at best response were not associated with OS and DFS. Volume variation after the 1st IC cycle and at best response was significantly associated with OS (p &lt; 0.0001 and p = 0.002) and DFS (p &lt; 0.0001 and p = 0.005). At the multivariable analysis, V variation after the 1st IC cycle and at best response was the only variable significantly associated with OS (p &lt; 0.001 and p = 0.0019) and DFS (p = 0.0004 and p = 0.004).</div></div><div><h3>Conclusions</h3><div>Volume variation should be preferred to RECIST 1.1 and other measurements to describe the radiological response to IC in sinonasal cancers.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107388"},"PeriodicalIF":4.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Risk factors of lymph node metastasis in the diffuse sclerosing variant of papillary thyroid carcinoma compared with conventional papillary thyroidcarcinoma in pediatric populations","authors":"Xiaoping Liu ,&nbsp;Shirong Xue","doi":"10.1016/j.oraloncology.2025.107368","DOIUrl":"10.1016/j.oraloncology.2025.107368","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107368"},"PeriodicalIF":4.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “KDM6A, ARID1A and SETD2 loss-of-function mutations as prognostic biomarkers and their association with sites of metastatic progression in locally-advanced, recurrent or metastatic adenoid cystic carcinoma”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107389","DOIUrl":"10.1016/j.oraloncology.2025.107389","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107389"},"PeriodicalIF":4.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of 3D computer-aided design to optimize photoimmunotherapy catheter placement","authors":"Kelly Bridgham ,&nbsp;Pablo Llerena ,&nbsp;Ayan Kumar ,&nbsp;Eric Mastrolonardo ,&nbsp;Raphael Banoub ,&nbsp;Travis Clark ,&nbsp;Adam Luginbuhl ,&nbsp;David M. Cognetti ,&nbsp;Joseph M. Curry","doi":"10.1016/j.oraloncology.2025.107365","DOIUrl":"10.1016/j.oraloncology.2025.107365","url":null,"abstract":"<div><h3>Background</h3><div>There is limited information regarding how technical aspects of Photoimmunotherapy (PIT) catheter placement influences outcomes. We hypothesize that optimized 3D models of PIT treatment will demonstrate a higher volume of tumor treated compared to 3D models of actual intraoperative catheter placement.</div></div><div><h3>Methods</h3><div>Clinical and radiographic data were obtained for RM-1929 photoimmunotherapy treated patients at a single institution from March 2016 to August 2021. 3D models were rendered to recreate photoimmunotherapy treatments based on intraoperative images. This was compared to an optimized therapy model for each instance of treatment. Comparisons were made between actual and optimized models based on total volume of tumor treated as well as number of cylindrical diffusers placed per treatment.</div></div><div><h3>Results</h3><div>3D models were generated for 9 PIT treatments in 6 patients. Optimized PIT models (N = 9) were matched and compared to actual PIT models (N = 9). Volume of tumor treated was higher for the optimized model compared to the actual treatment (22.6 vs 13.9 cm³, p = 0.004) with a higher percentage of total tumor volume treated (92.1 % vs 69.0 %, p = 0.004). Approximately 2.8 additional LF diffusors were placed per treatment in the optimized plan (8.0 vs. 5.2, p = 0.033).</div></div><div><h3>Conclusion</h3><div>In this post-hoc analysis, we demonstrate the importance of appropriate catheter placement in PIT as well as the feasibility of 3D computer aided design to simulate PIT catheter placement. Optimized 3D models demonstrated a higher volume of tumor treated compared to actual catheter placement. 3D computer aided design may be a useful adjunct to preoperative planning to optimize PIT catheter placement.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107365"},"PeriodicalIF":4.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating Lymph Node Yield, Lymph Node Ratio, and the number of metastatic nodes as prognostic factors in oral cavity squamous cell carcinoma","authors":"Dean Dudkiewicz ,&nbsp;Nir Tsur ,&nbsp;Dan Yaniv ,&nbsp;Esmat Najjar ,&nbsp;Thomas Shpitzer ,&nbsp;Aviram Mizrachi ,&nbsp;Moshe Yehuda ,&nbsp;Gideon Bachar ,&nbsp;Eyal Yosefof","doi":"10.1016/j.oraloncology.2025.107391","DOIUrl":"10.1016/j.oraloncology.2025.107391","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies of Lymph Node Yield (LNY) for neck dissection in Oral Cavity Squamous Cell Carcinoma (OCSCC) have shown LNY of 18 or more lymph nodes to be of prognostic value. This study aims to evaluate the prognostic implications of LNY, number of metastatic nodes, and Lymph Node Ratio (LNR) in clinical N0 OCSCC.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 118 patients who underwent elective neck dissection for OCSCC at Rabin Medical Center (2000–2020). Demographic, clinical, pathological, and surgical data were collected. We examined the prognostic significance of LNY cutoffs (18 and 13), number of positive nodes, and LNR on disease-free and overall survival.</div></div><div><h3>Results</h3><div>The mean LNY was 19.5 ± 11.3 nodes, with a lymph node metastasis rate of 31.3 %. Statistical analysis showed that neither 18 nor 13 lymph nodes had significant prognostic value for recurrence or survival. The mean LNR was 4.52 % ± 11.3 %, with higher LNR values (&gt;3.4 %) significantly associated with increased recurrence (p = 0.003) and reduced survival intervals (p = 0.003). Cox regression analysis further confirmed that both elevated LNR and the presence of more than two metastatic lymph nodes were independently associated with increased mortality.</div></div><div><h3>Conclusions</h3><div>Our findings challenge the commonly cited LNY threshold of 18, as no specific LNY cutoff conferred significant survival benefits. Instead, LNR emerged as a superior prognostic marker, correlating strongly with overall survival and locoregional control. Incorporating LNR into prognostic models may enhance risk stratification and guide clinical decision-making in OCSCC management.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107391"},"PeriodicalIF":4.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}