Oral oncology最新文献

{"title":"Submandibular gland transfer into the temporal fossa in patients with oral squamous cell carcinoma: A viable option to prevent radiation-induced xerostomia","authors":"Tan Mai Nguyen ,&nbsp;Pauline Quilhot ,&nbsp;Isabelle Brochériou ,&nbsp;Guillaume Rougier ,&nbsp;Philippe Maingon ,&nbsp;Chloé Bertolus ,&nbsp;Jean-Philippe Foy","doi":"10.1016/j.oraloncology.2024.107125","DOIUrl":"10.1016/j.oraloncology.2024.107125","url":null,"abstract":"<div><div>Oral squamous cell carcinoma (OSCC) is associated with an important mortality and morbidity related to surgery and radiotherapy. In particular, radiation-induced xerostomia has a major impact on patient’s quality of life. Although intensity-modulated radiation therapy allowed mean dose reduction to the spared submandibular gland (SMG) in patients with head and neck squamous cell carcinoma, xerostomia is still an important sequela for patients treated for an OSCC. SMG surgical transfer into anatomical subsite receiving very low radiation doses is a promising approach to prevent xerostomia. Based on a literature review and data from our institutional cohort, we analyzed the oncological safety of SMG preservation. Then, we discussed the feasibility and relevance of SMG transfer into the temporal fossa, in order to prevent radiation-induced xerostomia in patients with OSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107125"},"PeriodicalIF":4.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards improved speech and swallowing outcomes after hemiglossectomy reconstruction: Impact of neurotization and free flap choice","authors":"Eric L. Wu ,&nbsp;Fendi Obuekwe ,&nbsp;Joshua D. Smith ,&nbsp;Mario G. Solari ,&nbsp;Arturo A. Eguia ,&nbsp;Tonge Enoh ,&nbsp;Anthony Tang ,&nbsp;Marci L. Nilsen ,&nbsp;Jonas T. Johnson ,&nbsp;Seungwon Kim ,&nbsp;Kevin J. Contrera ,&nbsp;Shaum S. Sridharan ,&nbsp;Matthew E. Spector","doi":"10.1016/j.oraloncology.2024.107127","DOIUrl":"10.1016/j.oraloncology.2024.107127","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107127"},"PeriodicalIF":4.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor, “Loss of MACROD2 drives radioresistance but not cisplatin resistance in HPV-positive head and neck cancer.”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2024.107092","DOIUrl":"10.1016/j.oraloncology.2024.107092","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107092"},"PeriodicalIF":4.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of lymph node metastasis in the diffuse sclerosing variant of papillary thyroid carcinoma compared with conventional papillary thyroid carcinoma in pediatric populations","authors":"Yanan Liu ,&nbsp;Nantao Fu ,&nbsp;Haitao Liu ,&nbsp;Shanshan Su ,&nbsp;Tingting Yang ,&nbsp;Ping Long ,&nbsp;Wei Zhong ,&nbsp;Xiang Min","doi":"10.1016/j.oraloncology.2024.107120","DOIUrl":"10.1016/j.oraloncology.2024.107120","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the clinicopathological features and predictors of lymph node metastasis (LNM) in the diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) and compare these findings with conventional papillary thyroid carcinoma (C-PTC) in pediatric populations.</div></div><div><h3>Methods</h3><div>Patients aged 18 years or younger who were preoperatively diagnosed with PTC and underwent thyroidectomy at the First Affiliated Hospitals of Nanchang University from January 2017 to May 2024 were included in this study. Demographic and clinicopathological characteristics were retrospectively analyzed. Univariate and multivariate analyses were performed to identify risk factors for lymph node metastasis. Clinical outcomes, including nerve injury, hypocalcemia, and recurrence, were also recorded and evaluated.</div></div><div><h3>Results</h3><div>A total of 119 children were enrolled in this study, with a median age of 15.6 years. Of these, 89 (74.8 %) were female, and 18 (15.1 %) were diagnosed with DSV-PTC. Central lymph node metastasis (CLNM) was observed in 94 (79 %) patients, while 60 (50.4 %) had lateral lymph node metastasis (LLNM). DSV-PTC was associated with a higher incidence of CLNM and LLNM compared to C-PTC (p = 0.039, p &lt; 0.001). Multifocality and bilateral tumors were also more common in DSV-PTC (<em>p</em> &lt; 0.001). Cox regression analysis identified tumor size as an independent predictive factor for CLNM in pediatric C-PTC patients. Tumor size, ETE and the presence of CLNM were independent predictive factors for LLNM. After a mean follow-up of 32.8 months, no patient died from the disease, but four C-PTC patients (4.0 %) developed local recurrences, which were managed surgically. Lung metastasis occurred in 2 (11.1 %)</div><div>DSV-PTC and 1(1.0 %)C-PTC patients, respectively. Permanent injuries included one case of unilateral recurrent laryngeal nerve(RLN) injury and two cases of bilateral RLN injury. Four patients (4.0 %) experienced temporary hypocalcemia, which resolved after 6 months of calcium therapy.</div></div><div><h3>Conclusions</h3><div>DSV-PTC presents unique characteristics of lymph node metastasis and may be more aggressive than conventional PTC in pediatric populations. The presence of CLNM, tumor size and ETE were identified as independent predictors of LLNM in pediatric patients with conventional PTC. Evaluating these prognostic factors may help in customizing individualized surgical approaches for children, thereby reducing unnecessary surgical complications.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107120"},"PeriodicalIF":4.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction chemotherapy for locally advanced nasopharyngeal carcinoma: Efficacy and safety of the TPC regimen compared to GP and TPF","authors":"Chang Yan ,&nbsp;Runzhi Wang ,&nbsp;Chaojun Zhang ,&nbsp;Guoxiang Lin ,&nbsp;Youqing Du ,&nbsp;Meiwen Chen ,&nbsp;Fushuang Liu ,&nbsp;Ling Li ,&nbsp;Song Qu ,&nbsp;XiaoDong Zhu","doi":"10.1016/j.oraloncology.2024.107119","DOIUrl":"10.1016/j.oraloncology.2024.107119","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Gemcitabine plus cisplatin (GP) and docetaxel plus cisplatin plus fluorouracil (TPF) are induction chemotherapy (IC) regimens for locally advanced nasopharyngeal carcinoma (LA-NPC). The oral convenience of capecitabine presents its potential as a fluorouracil substitute in the TPF regimen, which has yet to be thoroughly investigated. This study aims to compare the efficacy and safety of the docetaxel, cisplatin, and capecitabine (TPC) with GP and TPF in LA-NPC.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on newly diagnosed stage III-IVa nasopharyngeal carcinoma patients who received GP, TPC, or TPF induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) between February 2019 and December 2021. A comparison of the prognostic outcomes and associated adverse reactions among patients receiving different IC regimens. Multivariate Cox regression was applied to analyze independent prognostic factors, and subgroup survival analyses were conducted based on these factors.</div></div><div><h3>Results</h3><div>A total of 291 LA-NPC patients were included, with 70 receiving TPC, 119 receiving GP, and 102 receiving TPF. Kaplan-Meier survival analysis indicated no significant differences in OS, PFS, LRFS, and DMFS among the 3 groups. Multivariate Cox regression identified T classification and clinical stage as independent prognostic factors. Subgroup analyses revealed no significant differences in OS and PFS between the 3 groups across T1-2 and T3-4 classifications or III and IVa stages.The TPC group exhibited lower incidence rates of treatment-related acute toxicity reactions, including grade 3–4 toxicities.</div></div><div><h3>Conclusion</h3><div>The TPC induction chemotherapy regimen demonstrates comparable efficacy to GP and TPF, while maintaining a favorable safety profile.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107119"},"PeriodicalIF":4.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed diagnosis to treatment interval (DTI) in head & neck cancers – A systematic review and meta-analysis","authors":"Noémie Villemure-Poliquin ,&nbsp;Rui Fu ,&nbsp;Karolina Gaebe ,&nbsp;Jin Kwon ,&nbsp;Marc Cohen ,&nbsp;Marianne Ruel ,&nbsp;Kennedy Ayoo ,&nbsp;Andrew Bailey ,&nbsp;Madette Galapin ,&nbsp;Julie Hallet ,&nbsp;Antoine Eskander","doi":"10.1016/j.oraloncology.2024.107106","DOIUrl":"10.1016/j.oraloncology.2024.107106","url":null,"abstract":"<div><h3>Introduction</h3><div>Delayed diagnosis to treatment interval (DTI) in head and neck cancers (HNC) can significantly impact patient outcomes. The need for multimodal treatment in HNC may cause delays in initiation of treatment. This systematic review aims to provide a comprehensive understanding of the consequences of delayed DTI on both oncologic and QoL outcomes, proposing a new quality benchmark along the treatment continuum of HNC patients.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, Embase, CENTRAL, Web of Science, and CINAHL databases for trials and cohort studies evaluating the impact of delayed DTI in patients with HNC. Outcomes included overall survival (OS), disease-free survival (DFS), locoregional (LRR) and local recurrences (LR) and distant metastasis.</div></div><div><h3>Results</h3><div>Our search strategy initially identified 10,779 titles and abstracts, of which 63 articles met inclusion criteria for a total of 873,718 patients. The pooled analysis showed that treatment initiation within 30 days improved OS by 9 % compared to longer intervals (aHR: 1.09 [1.06–1.13]; I² = 80 %), with no significant associations found for DFS, LRR, LR, or distant metastasis.</div></div><div><h3>Conclusion</h3><div>While adherence to a 30-day DTI may be associated with improved survival in some HNC patients, significant heterogeneity in the data limits the generalizability of this finding. Further research with more refined analyses, including adjustments for treatment modality and cancer stage, is necessary. Additionally, gaps remain in the literature, particularly in the methodological limitations related to DTI classification.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107106"},"PeriodicalIF":4.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical reflections on the clinical implementation of 3D-Printed oral stents for radiotherapy patients","authors":"Carlos M. Ardila ,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.oraloncology.2024.107112","DOIUrl":"10.1016/j.oraloncology.2024.107112","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107112"},"PeriodicalIF":4.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma","authors":"Roosmarijn S. Tellman ,&nbsp;Dominique N.V. Donders ,&nbsp;Rutger Mahieu ,&nbsp;Ellen M. Van Cann ,&nbsp;Robert J.J. van Es ,&nbsp;Gerben E. Breimer ,&nbsp;Bart de Keizer ,&nbsp;Remco de Bree","doi":"10.1016/j.oraloncology.2024.107110","DOIUrl":"10.1016/j.oraloncology.2024.107110","url":null,"abstract":"<div><h3>Background</h3><div>Sentinel lymph node biopsy (SLNB) has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). The 10%-rule, used to define sentinel lymph nodes (SLN) intraoperatively, states that an SLN is defined by gamma counts that are at least 10% of the hottest harvested lymph node (LN). However, this intraoperative rule has not yet been adequately evaluated for early-stage OSCC. This study aims to evaluate the 10%-rule intraoperatively and explore possibilities for redefining this criterion.</div></div><div><h3>Methods</h3><div>A single center retrospective study was performed between 2014 and 2023. Patients (n = 66) with clinically node-negative OSCC (cT1-3N0) and positive SLNB were included in this study. Radioactivity of all harvested LNs were measured ex-vivo. Metastatic LNs were assessed for complying with the 10 %-rule. The accuracy of alternative thresholds was evaluated. If multiple positive SLNs on one side of the neck were found, the hottest positive SLN on that side was considered the LN accountable for upstaging the corresponding neck side from N0 to N+.</div></div><div><h3>Results</h3><div>A total of 233 LNs were harvested, of which 98 contained metastases and 190 met the 10%-rule. Of these metastatic LNs, 70 were accountable for upstaging the side of the neck. The 10%-rule correctly staged 69 of 70 metastatic sides of the neck. By increasing the intraoperative cut-off point to 20%, 68 of 70 metastatic sides of the neck were correctly staged and 18 LNs (172 vs. 190) were not defined as SLN. Applying the 10%-rule to each side of the neck increased detection of one metastatic LN. However, this LN was not accountable for upstaging that side of the neck.</div></div><div><h3>Conclusion</h3><div>The 10%-rule in SLNB applies to patients with OSCC and effectively identifies metastatic SLNs intraoperatively. Applying the 10%-rule per neck side must be considered. Increasing the threshold percentage is not advisable.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107110"},"PeriodicalIF":4.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional reconstruction of lip defects","authors":"Pai Pang,&nbsp;Xiaomeng Xue,&nbsp;Zhongfei Xu,&nbsp;Weiyi Duan,&nbsp;Fayu Liu,&nbsp;Xuexin Tan,&nbsp;Enjiao Zhang,&nbsp;Zhongzheng Qi ,&nbsp;Changfu Sun","doi":"10.1016/j.oraloncology.2024.107055","DOIUrl":"10.1016/j.oraloncology.2024.107055","url":null,"abstract":"<div><div>The lip is a crucial structure in the oral and maxillofacial region, serving vital physiological functions such as speech, swallowing, chewing, and expression. Due to the complexity of lip anatomy, function, and the various types of defects, the functional restoration and reconstruction of lip defects remain complex and challenging tasks. In this article, we summarize several methods for functional restoration and reconstruction of lip defects using local flaps that carry the depressor anguli oris muscle, as well as some free flaps. We also introduce methods for repairing extensive defects in the oral and maxillofacial region that are accompanied by lip defects using combinations of various tissue flaps.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107055"},"PeriodicalIF":4.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we ready to use ultrasounds in the clinical assessment of depth of invasion and tumor thickness in oral squamous cell carcinoma? Results from a systematic review, meta-analysis and trial sequential analysis","authors":"Fariba Esperouz ,&nbsp;Vito Carlo Alberto Caponio ,&nbsp;Andrea Santarelli ,&nbsp;Andrea Ballini ,&nbsp;Lorenzo Lo Muzio ,&nbsp;Domenico Ciavarella ,&nbsp;Lucio Lo Russo","doi":"10.1016/j.oraloncology.2024.107104","DOIUrl":"10.1016/j.oraloncology.2024.107104","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the accuracy of ultrasound in the quantification of tumor thickness (TT) and depth of invasion (DOI) of oral potentially malignant disorders and oral squamous cell carcinoma.</div></div><div><h3>Materials and methods</h3><div>A systematic review search was conducted in PubMed, Scopus, and Web of Science to answer the PICO question: “What is the correlation and the mean difference between ultrasound and histopathological assessment of tumor thickness and depth of invasion in patients with oral squamous cell carcinoma and oral potentially malignant disorders? The risk of bias was assessed, meta-analysis and trial sequential analysis was conducted on the available quantitative data, followed by trial sequential analysis.</div></div><div><h3>Results</h3><div>Of 2089 results, 48 studies were considered suitable for inclusion.</div><div>Meta-analysis showed a low heterogeneity for tumor thickness mean difference (I² = 0.00 %) with an overall standardized mean difference (SMD) of 0.13 (95 % CI: −0.07 to 0.33, p = 0.214). Tumor thickness correlation showed high heterogeneity (I² = 93.41 %). For depth of invasion, the mean difference had moderate heterogeneity (I² = 8.98 %) with an overall SMD of 0.27 (95 % CI: 0.06 to 0.48, p = 0.013). However, correlation analysis showed moderate heterogeneity (I² = 56.22 %). Trial sequential analysis confirmed the tumor thickness results but indicated more studies are required for depth of invasion to meet the required information size.</div></div><div><h3>Conclusion</h3><div>There were no statistically significant differences between the results of ultrasound and histological examination, the clinical use of this device cannot yet be confirmed.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107104"},"PeriodicalIF":4.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}