Oral oncology最新文献

{"title":"Re: “Computed tomography radiomics-based cross-sectional detection of mandibular osteoradionecrosis in head and neck cancer survivors” by Kamel et al.","authors":"Efsun Somay , Sibel Bascil , Erkan Topkan , Ugur Selek","doi":"10.1016/j.oraloncology.2025.107457","DOIUrl":"10.1016/j.oraloncology.2025.107457","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107457"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Benefit from adjuvant radiotherapy in early-stage oral cavity and oropharyngeal cancer with solitary ipsilateral lymph node metastasis – A population – based study on German cancer registry data”","authors":"Xinyue Yang , Fan Zhang , Heng Yang","doi":"10.1016/j.oraloncology.2025.107449","DOIUrl":"10.1016/j.oraloncology.2025.107449","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107449"},"PeriodicalIF":4.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous metastasis of oropharyngeal squamous cell carcinoma: A case report","authors":"Ana Letícia Mores ,&nbsp;Caio Augusto Lima de Araujo ,&nbsp;Fabio de Freitas Busnardo ,&nbsp;Leonardo Cardili ,&nbsp;João Guilherme Bertacchi ,&nbsp;Alan Roger Santos-Silva ,&nbsp;Thaís Bianca Brandão ,&nbsp;Ana Carolina Prado-Ribeiro","doi":"10.1016/j.oraloncology.2025.107438","DOIUrl":"10.1016/j.oraloncology.2025.107438","url":null,"abstract":"<div><h3>Background</h3><div>Distant metastasis of head and neck squamous cell carcinoma (HNSCC) most commonly occurs in the lungs, liver, and bones. Cutaneous metastases (CM) from HNSCC are rare, with an incidence ranging from 0.7 % to 2.4 %. These metastases can present as single or multiple nodules, or as erythematous macules in various anatomical sites, often mimicking dermatological conditions. CM is associated with a poor prognosis, with a median survival of 3 to 7 months following diagnosis.</div></div><div><h3>Case Report</h3><div>We report a clinical case of a 57-year-old male with advanced-stage oropharyngeal squamous cell carcinoma who developed CM on his right arm during curative radiotherapy. The lesion, nodular and erythematous, measured approximately 4 x 4 cm and was associated with dorsal pain. Due to the progression of the primary disease to the skull base, palliative treatment was pursued, involving surgical excision of the skin lesions. At the time of surgery, the patient had one lesion on his right arm and two additional lesions on his right dorsal region. The patient passed away 45 days after the diagnosis of CM.</div></div><div><h3>Conclusion</h3><div>The diagnosis and management of CM are challenging. In patients with a history of HNSCC, the emergence of cutaneous lesions warrants prompt incisional biopsy for early diagnosis and appropriate treatment.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107438"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Robotic parotidectomy via retroauricular incision: A safe and feasible approach for benign parotid tumors”","authors":"Lara Góis Floresta ,&nbsp;Lucas Alves da Mota Santana ,&nbsp;Gilmagno Amado Santos ,&nbsp;Rajiv Gandhi Gopalsamy ,&nbsp;Bernardo Ferreira Brasileiro ,&nbsp;Cleverson Luciano Trento ,&nbsp;Lysandro Pinto Borges","doi":"10.1016/j.oraloncology.2025.107458","DOIUrl":"10.1016/j.oraloncology.2025.107458","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107458"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HIV status on overall survival in head and neck cancers by anatomical site and stage: A multi-center cohort study","authors":"Devesh S. Malgave ,&nbsp;Christine M. Hartman ,&nbsp;Jennifer R. Kramer ,&nbsp;Peter A. Richardson ,&nbsp;Efthalia Zafeiropoulou ,&nbsp;Yongquan Dong ,&nbsp;Adovich S. Rivera ,&nbsp;Rulin C. Hechter ,&nbsp;Lori C. Sakoda ,&nbsp;Matthew J. Boyer ,&nbsp;Angela Mazul ,&nbsp;Yvonne M. Mowery ,&nbsp;Donna L. White ,&nbsp;Wendy A. Leyden ,&nbsp;Michael J. Silverberg ,&nbsp;Elizabeth Y. Chiao","doi":"10.1016/j.oraloncology.2025.107446","DOIUrl":"10.1016/j.oraloncology.2025.107446","url":null,"abstract":"<div><h3>Objectives</h3><div>People with human immunodeficiency virus (PWH) are at higher risk for head and neck cancer (HNC) than people without HIV (PWoH), but data on the survival effect of HIV are scarce. The objective is to compare survival for PWH vs. PWoH diagnosed with HNC, stratified by anatomical site and cancer stage.</div></div><div><h3>Materials and Methods</h3><div>The multi-institutional U.S.-based retrospective analysis included HNC patients (296 PWH and 29,875 PWoH) diagnosed between 2008 and 2020. Statistical analysis reported 5-year overall survival and hazard ratios (HR) for all-cause mortality by HIV infection and CD4 counts for oropharyngeal cancer (OPC), oral cavity cancer (OC), and laryngeal and hypopharyngeal cancers (LHPC); with additional analysis stratified by HPV status and stage (I–IVB).</div></div><div><h3>Results</h3><div>Compared with PWoH, PWH were likely younger (median [IQR], 60[54–65] vs. 64[59–70] years; p &lt; 0.001), male (98 % vs. 93 %; p = 0.003), black (39 % vs. 13 %; p &lt; 0.001); and HPV+ tumors (25 % vs. 21 %; p = 0.041). The Kaplan–Meier mean survival in years for PWH versus PWoH were 3.41 vs. 3.78 for OPC, 3.78 vs. 3.40 for OC, and 3.50 vs. 3.44 for LHPC. In adjusted analysis, HIV-infection was associated with 43 % higher hazard of death for OPC (HR: 1.43 [95 % CI, 1.08–1.90]) but not associated with OC (HR: 0.74 [0.40–1.12]) and LHPC (HR: 0.98 [0.72–1.34]). For HPV-stratified analysis, higher hazards for both HPV+ (45 %) and HPV- (70 %) tumors. Similar trends were observed in stage-stratified and CD-based analyses.</div></div><div><h3>Conclusion and Relevance</h3><div>HIV’s association with poorer survival in OPC warrants further research to understand the factors contributing to this survival gap.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107446"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of methylation capture sequencing workflow in formalin fixed tissue from oral squamous cell carcinoma patients","authors":"Minh Phuong Dong ,&nbsp;Kesava Asam ,&nbsp;Carissa M. Thomas ,&nbsp;Nicholas F. Callahan ,&nbsp;Paul C. Walker ,&nbsp;Khanh K. Nguyen ,&nbsp;Yi Ye ,&nbsp;Ke Xu ,&nbsp;Bradley E. Aouizerat ,&nbsp;Chi T. Viet","doi":"10.1016/j.oraloncology.2025.107462","DOIUrl":"10.1016/j.oraloncology.2025.107462","url":null,"abstract":"<div><h3>Background</h3><div>Oral squamous cell carcinoma (OSCC) is typically diagnosed at advanced stages, resulting in poor survival rates. Epigenetic alterations, especially DNA methylation, are important early and key contributors to OSCC pathogenesis, but comprehensive epigenetic analysis has traditionally been confounded by cancer tissue availability, with fresh-frozen tissues being the gold standard but difficult to obtain.</div></div><div><h3>Methods</h3><div>This study established and optimized a new workflow for the use of methylation capture sequencing (MC-seq) to analyze DNA methylation profiles in formalin-fixed paraffin-embedded (FFPE) tissues. Twelve OSCC patients were randomly selected from a prospective, multi-institutional study. Paired fresh-frozen and FFPE tissues were collected and processed for DNA extraction and MC-seq. Data were pre-processed using Bismark and methylKit pipelines. Methylation concordance between FFPE and fresh-frozen samples was assessed by comparing β-value correlation.</div></div><div><h3>Results</h3><div>DNA from FFPE and fresh-frozen OSCC samples showed minimal differences in fragmentation, with FFPE achieving high mapping efficiency (average 71.6%) and retaining an average of about 5 million CpG sites at 10× depth. The distributions of CpG in the methylome region, including promoter, exonic, intronic, and intergenic regions, showed similar patterns between sample types. Additionally, the methylation levels of all matched CpG sites in our 12-gene prognostic panel showed a strong correlation (r ≥ 0.97) between FFPE and fresh-frozen samples.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that FFPE samples are reliable for methylation capture sequencing, offering a new, scalable and reliable alternative to fresh-frozen samples for large-scale OSCC research.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107462"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive sinonasal malignancy: A comparative perspective on SMARCB1-deficient carcinoma and adenoid cystic carcinoma","authors":"Servet Elçin Alpat","doi":"10.1016/j.oraloncology.2025.107455","DOIUrl":"10.1016/j.oraloncology.2025.107455","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107455"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alk-positive anaplastic large cell Lymphoma: First documented case of primary mandibular involvement in a 12-Year-Old male","authors":"Akshay Trimukhe ,&nbsp;Asit Ranjan Mridha ,&nbsp;Rahul Yadav ,&nbsp;Deepika Mishra ,&nbsp;P.C. Rasla ,&nbsp;Varun Surya","doi":"10.1016/j.oraloncology.2025.107452","DOIUrl":"10.1016/j.oraloncology.2025.107452","url":null,"abstract":"<div><div>Anaplastic large cell lymphoma (ALCL), ALK-positive, is a rare subtype of peripheral T-cell lymphoma, most commonly affecting lymph nodes and soft tissues in children and young adults. Primary bone involvement is uncommon, and mandibular localization is exceptionally rare. We present the first reported case of ALK-positive ALCL presenting as a primary bone lymphoma of the mandible in a 12-year-old male. The patient reported with a diffuse, progressively enlarging swelling on the right side of the face. Imaging revealed an ill-defined, FDG-avid (SUV max 13.5) destructive lesion involving the right mandibular body, with no evidence of disease elsewhere. Histopathological examination showed a high-grade malignant neoplasm composed of cohesive sheets of large atypical cells with marked cytoplasmic clearing, nuclear pleomorphism, prominent nucleoli, and atypical mitoses, accompanied by bone destruction and a mixed inflammatory infiltrate. Due to the undifferentiated morphology, an extensive immunohistochemical panel was applied. The tumor was negative for epithelial, B-cell, plasma cell, melanocytic, and myogenic markers, but positive for CD45, CD3, CD30, ALK, and EMA, confirming a diagnosis of ALK-positive ALCL of T-cell lineage. Bone marrow aspiration and biopsy showed no evidence of infiltration, establishing the mandible as the primary site. The patient was treated with Brentuximab Vedotin in combination with the R-CHOP regimen and showed an excellent clinical response with gradual resolution of swelling. This case highlights the diagnostic complexity of undifferentiated mandibular tumors in pediatric patients and emphasizes the importance of integrating morphology, immunophenotyping, and systemic evaluation to identify rare presentations of peripheral T-cell lymphomas.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107452"},"PeriodicalIF":4.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Enhancing early detection of HPV associated oropharyngeal cancer: a comparative study of NGS, ddPCR, and qPCR.","authors":"Subramani Abilaji, Jayaraman Narenkumar","doi":"10.1016/j.oraloncology.2025.107461","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2025.107461","url":null,"abstract":"<p><p>Human papillomavirus (HPV) is a key etiological agent in oropharyngeal cancer (OPC), underscoring the need for sensitive and accurate detection methods. The recent study, \"Comparison of Next Generation Sequencing, Droplet Digital PCR, and Quantitative Real-Time PCR for the Earlier Detection and Quantification of HPV in HPV-Positive Oropharyngeal Cancer\", offers a valuable comparative analysis of three prominent molecular techniques. Next Generation Sequencing (NGS) provides comprehensive viral genotyping and detection of integration sites but is limited by cost and complexity. Droplet Digital PCR (ddPCR) enables absolute quantification and detects low viral loads with high precision, making it ideal for clinical monitoring, despite higher costs. Quantitative Real-Time PCR (qPCR), while cost-effective and rapid, offers relative quantification and lower sensitivity at low viral loads. The authors present a clear and balanced comparison, highlighting the strengths and limitations of each method. This work significantly contributes to advancing early diagnosis and individualized treatment strategies in HPV-related OPC. Future research integrating these techniques may further enhance diagnostic sensitivity and clinical utility. I commend the authors and Oral Oncology for publishing such impactful and clinically relevant research.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":" ","pages":"107461"},"PeriodicalIF":4.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical and clinical performance validation of HPV-SEQ, a novel NGS-based liquid biopsy platform for detection and quantification of human papilloma virus circulating tumor DNA","authors":"Samaneh Eickelschulte ,&nbsp;Anna Starus ,&nbsp;David H. Murray ,&nbsp;Kirsten A. Keyser ,&nbsp;Oliver Schauer ,&nbsp;Simon Guellert ,&nbsp;Emily Lauren Gramiccioni ,&nbsp;Johannes Fredebohm ,&nbsp;Frederick Jones ,&nbsp;Harry Quon ,&nbsp;Carmen Kut ,&nbsp;Yilin Cao ,&nbsp;Carole Fakhry ,&nbsp;Tanguy Seiwert ,&nbsp;Yuxuan Miao ,&nbsp;Mark W. Lingen ,&nbsp;Alexander T. Pearson ,&nbsp;Everett E. Vokes ,&nbsp;Ari J. Rosenberg ,&nbsp;Nishant Agrawal ,&nbsp;Evgeny Izumchenko","doi":"10.1016/j.oraloncology.2025.107445","DOIUrl":"10.1016/j.oraloncology.2025.107445","url":null,"abstract":"<div><h3>Background</h3><div>Human papillomavirus (HPV) is the primary causative driver of oropharyngeal squamous cell carcinoma (OPSCC). Accurate detection of HPV-DNA is critical for risk stratification and management of OPSCC. However, assays designed to detect HPV in primary tumors do not allow monitoring of HPV-DNA over time, whereas commercially available droplet digital PCR-based methods for assessment of circulating cell free (cf)HPV-DNA in plasma remain suboptimal, hindering adaptation into clinical practice. We have developed HPV-SEQ, a novel next-generation-sequencing (NGS) based method for detection and quantification of HPV16/18 DNA in plasma of patients with OPSCC.</div></div><div><h3>Methods</h3><div>The assay uses primers targeting the L1 gene of HPV16 and HPV18 viral genomes and strain specific calibrators at a defined concentration to determine the ratio of native HPV to a known standard, enabling accurate reporting of patient-derived HPV16/18 viral load in a sample. This study was conducted using two different patient populations in addition to healthy donors and contrived material. All experiments were performed to fulfill several applicable analytical, performance and validation guidelines.</div></div><div><h3>Results</h3><div>A thorough analytical characterization and clinical validation of this platform demonstrates that HPV-SEQ detects cfHPV-DNA with exceptional limit of quantification and high precision, providing a foundation for integrating this platform into clinical settings.</div></div><div><h3>Conclusions</h3><div>This ultra-sensitive HPV profiling method with optimal analytical performance may represent a significant advancement in risk stratification, treatment management, and post-treatment surveillance for patients with OPSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107445"},"PeriodicalIF":4.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}