Oral oncology最新文献

{"title":"Tongue base mucosectomy: A case for precision","authors":"Signe Bergliot Nielsen , Mikkel Hjordt Holm Larsen , Hani Ibrahim Channir , Katalin Kiss , Benedicte Parm Ulhøi , Christian Godballe , Jesper Grau Eriksen , Niclas Rubek , Thomas Kjaergaard , Christian von Buchwald","doi":"10.1016/j.oraloncology.2024.107166","DOIUrl":"10.1016/j.oraloncology.2024.107166","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107166"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry","authors":"Zhaohong An ,&nbsp;Xiwei Zhang ,&nbsp;Zhaoyang Wang ,&nbsp;Dilinaer Wusiman ,&nbsp;Xiaohui Zhao ,&nbsp;Lin Li ,&nbsp;Lei Guo ,&nbsp;Minghui Wei ,&nbsp;Wenbin Li ,&nbsp;Changming An","doi":"10.1016/j.oraloncology.2024.107151","DOIUrl":"10.1016/j.oraloncology.2024.107151","url":null,"abstract":"<div><h3>Objective</h3><div>Optimizing clinical decision-making in head and neck squamous cell carcinoma (HNSCC) is challenging due to the ambiguous understanding of the immune cell dynamics and immune checkpoints regulation in the disease after the administration of neoadjuvant immunotherapy (NIT).</div></div><div><h3>Methods</h3><div>HNSCC biopsy samples collected before and after the neoadjuvant treatment are classified into the pathologic response (PR) and the non-pathologic response (NPR) groups according to treatment responses and the expression of immune cells and checkpoints was labeled using multiplex immunohistochemistry (m-IHC).</div></div><div><h3>Results</h3><div>The populations of CD4⁺ T cells, CD8⁺ T cells, regulatory T cells (Treg), PD-1, and PD-L1 were particularly higher in the PR group than the NPR group in pre-treatment tissues, with the p-values of log-transformed positive cell density &lt;0.05. Almost all markers showed a lower expression in the PR patients after treatment, resulting lower post/pre-treatment ratios of positive cell densities in the PR patients relative to the NPR patients. Following treatment, TIM3⁺ T cells and LAG3⁺ T cells exhibited significantly diminished levels in the PR cohort relative to the NPR cohort, with post/pre-treatment expression ratios showing significant differences (P &lt; 0.05). Tumor infiltration lymphocyte analysis revealed that the PR group exhibited a considerably higher average density of CD8⁺ T cells infiltrating in the tumor marginal zone.</div></div><div><h3>Conclusion</h3><div>The presence of T cells demonstrated significant predictive capability for responses to neoadjuvant immunotherapy in HNSCC patients. Furthermore, TIM3⁺ T cells and LAG3⁺ T cells were found to be remarkably lower in the partial response (PR) cohort than in the non-partial response (NPR) cohort post-treatment. This research contributes critical understanding of the physiological changes occurring in immune cell responses.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107151"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Risk factors of lymph node metastasis in the diffuse sclerosing variant of papillary thyroid carcinoma compared with conventional papillary thyroid carcinoma in pediatric populations” [160 (2025) 107120/Article:OO_107120]","authors":"Yanan Liu ,&nbsp;Nantao Fu ,&nbsp;Haitao Liu ,&nbsp;Shanshan Su ,&nbsp;Tingting Yang ,&nbsp;Ping Long ,&nbsp;Wei Zhong ,&nbsp;Xiang Min","doi":"10.1016/j.oraloncology.2024.107135","DOIUrl":"10.1016/j.oraloncology.2024.107135","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107135"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1 testing patterns in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) in the U.S.","authors":"Glenn J. Hanna ,&nbsp;Dandan Zheng ,&nbsp;Wei Gao ,&nbsp;Gleicy M. Hair ,&nbsp;Lei Ai ,&nbsp;Yan Song ,&nbsp;Nati Lerman ,&nbsp;Behzad Bidadi ,&nbsp;Abigail Zion ,&nbsp;Lin Zou ,&nbsp;Yuexin Tang ,&nbsp;Liya Wang ,&nbsp;Sanjay Merchant ,&nbsp;Christopher M. Black","doi":"10.1016/j.oraloncology.2024.107146","DOIUrl":"10.1016/j.oraloncology.2024.107146","url":null,"abstract":"<div><h3>Background</h3><div>Pembrolizumab with/without platinum + 5-FU is approved for the first-line (1L) treatment of R/M HNSCC, and its monotherapy use requires PD-L1 Combined Positive Score (CPS) ≥ 1. We aimed to understand PD-L1 testing patterns and associations with patient characteristics and treatment choice in R/M HNSCC.</div></div><div><h3>Methods</h3><div>Adults with R/M HNSCC initiating 1L systemic therapy were included from a U.S. nationwide database primarily compromised of community practices (07/01/2019–12/31/2023). PD-L1 testing patterns, treatment sequence, and time gaps related to testing and treatment initiation were summarized. Logistic regression was used to test associations between patient characteristics and PD-L1 testing patterns, and between CPS scores and 1L pembrolizumab monotherapy use.</div></div><div><h3>Results</h3><div>Of 2,207 patients, 32.7 % received PD-L1 testing before 1L therapy initiation, 17.4 % after 1L therapy initiation, and 50.0 % were never tested. Most patients (55.9 %) who tested positive before 1L therapy received pembrolizumab monotherapy while those who tested negative received pembrolizumab + platinum + 5-FU most commonly (31.6 %). Among patients untested before 1L therapy, the most common 1L treatment was pembrolizumab monotherapy (24.3 %). Patients with an ECOG ≥ 2 had higher odds of being tested before 1L therapy (OR: 1.42, p &lt; 0.01). CPS scores were associated with higher odds of receiving 1L pembrolizumab monotherapy (OR: 4.11 and 4.96 for CPS 1–19 and ≥ 20, respectively; both p &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>This study revealed low utilization of PD-L1 testing to guide treatment choice and impactful gaps between specimen collection, the receipt of results, and 1L therapy initiation. There is a need to improve clinician awareness of the importance of PD-L1 testing and an opportunity for updated guidelines on testing.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107146"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From infection to immortality: The role of HPV and telomerase in head and neck cancer","authors":"Silvia Giunco ,&nbsp;Annarosa Del Mistro ,&nbsp;Marzia Morello ,&nbsp;Jacopo Lidonnici ,&nbsp;Helena Frayle ,&nbsp;Silvia Gori ,&nbsp;Anita De Rossi ,&nbsp;Paolo Boscolo-Rizzo","doi":"10.1016/j.oraloncology.2024.107169","DOIUrl":"10.1016/j.oraloncology.2024.107169","url":null,"abstract":"<div><div>Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of malignancies with multifactorial aetiologies. High-risk human papillomavirus (hrHPV) infections, particularly HPV16, and the dysregulation of telomerase activity, specifically through its catalytic subunit, telomerase reverse transcriptase (TERT) are among the key contributors to HNSCC development and progression. HPV promotes oncogenesis via the E6 and E7 oncoproteins, which inactivate tumour suppressors TP53 and RB1, leading to unchecked cellular proliferation. Concurrently, telomerase activation plays a critical role in HNSCC by maintaining telomere length, thus enabling cellular immortality, and facilitating tumour development and progression. The interplay between HPV and telomerase is significant; HPV oncoprotein E6 enhances telomerase activity through multiple regulatory mechanisms, including upregulating TERT expression. Beyond telomere maintenance, TERT influences signalling pathways, cellular metabolism, and the tumour microenvironment, contributing to aggressive tumour behaviour and poor prognosis. This review integrates the roles of HPV and telomerase in HNSCC, focusing on their molecular mechanisms and interactions that drive carcinogenesis and influence disease progression. Understanding the synergistic effects of HPV and TERT in HNSCC may be crucial for risk stratification, prognostic assessment, and the development of novel therapeutic strategies targeting these specific molecular pathways.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107169"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “The effect of time from surgery to commencing adjuvant radiotherapy for patients with head and neck squamous cell carcinoma”","authors":"Sukran Senyurek ,&nbsp;Nulifer Kilic Durankus ,&nbsp;Ugur Selek ,&nbsp;Erkan Topkan","doi":"10.1016/j.oraloncology.2025.107177","DOIUrl":"10.1016/j.oraloncology.2025.107177","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107177"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaplastic thyroid carcinoma in a 43-year-old female confirmed by metastatic lymph node pathology: A case report","authors":"Huanyu Jiang,&nbsp;Lijuan Zhou,&nbsp;Teng Zhao,&nbsp;Gang Zou,&nbsp;Lili Lv,&nbsp;Zhenkun Yu","doi":"10.1016/j.oraloncology.2025.107192","DOIUrl":"10.1016/j.oraloncology.2025.107192","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107192"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do we recognize oral oncology with accuracy? AI-driven models serve in the diagnosis of oral squamous cell carcinoma","authors":"Jiayi Chen","doi":"10.1016/j.oraloncology.2025.107194","DOIUrl":"10.1016/j.oraloncology.2025.107194","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107194"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of extracranial schwannoma in the masticator space removed by endoscopic assisted transoral approach (EATA)","authors":"Giovanni Motta ,&nbsp;Pasquale Puzone ,&nbsp;Gino Latini ,&nbsp;Arianna Di Stadio ,&nbsp;Luca D’Ascanio","doi":"10.1016/j.oraloncology.2024.107164","DOIUrl":"10.1016/j.oraloncology.2024.107164","url":null,"abstract":"<div><h3>Background</h3><div>Extracranial schwannomas, particularly those arising from the masticator space, are rare entities. Given the challenges in pre-operative diagnosis and the potential for misdiagnosis, accurate localization and differential diagnosis are crucial for optimal surgical planning.</div></div><div><h3>Case Report</h3><div>A 42-year-old woman underwent a head and neck MRI for unrelated reasons and was incidentally found to have a mass in the left masticator space. Radiological findings were suggestive of a schwannoma. An endoscopic-assisted transoral approach was adopted for the resection of the lesion. Histopathological examination confirmed the diagnosis of schwannoma. The patient had an uneventful postoperative recovery.</div></div><div><h3>Conclusion</h3><div>This case report highlights the feasibility of an endoscopic-assisted transoral approach for the resection of rare masticator space schwannomas. This minimally invasive technique offers potential benefits in terms of reduced morbidity and improved cosmetic outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107164"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and oncological outcomes of transoral laser versus robotic surgery in supraglottic squamous cell carcinoma","authors":"Charlotte Loubieres ,&nbsp;Robin Baudouin ,&nbsp;Marta Circiu ,&nbsp;Florent Couineau ,&nbsp;Lise Crevier-Buchman ,&nbsp;Tiffany Rigal ,&nbsp;Clémence Forges ,&nbsp;Aude Julien-Laferriere ,&nbsp;Grégoire Vialatte De Pemille ,&nbsp;Jérôme R. Lechien ,&nbsp;Stéphane Hans","doi":"10.1016/j.oraloncology.2025.107178","DOIUrl":"10.1016/j.oraloncology.2025.107178","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the surgical, functional and oncological outcomes of Transoral Laser Microsurgery (TLM) and Transoral Robotic Surgery (TORS) for the treatment of supraglottic squamous cell carcinoma.</div><div>Study Design:</div><div>Retrospective case series with prospective data.</div><div>Settings:</div><div>Tertiary Academic Medical Center.</div></div><div><h3>Methods</h3><div>A chart-review analysis, with prospective follow-up was performed on 122 patients treated for a supraglottic squamous cell carcinoma with either TLM or TORS between 2003 and 2019. Patients were grouped according to the surgical technique used. Clinical, surgical, functional and oncological outcomes were compared, including local and regional controls, DFS, and OS, and postoperative complications.</div></div><div><h3>Results</h3><div>A total of 122 patients, including 47 treated with TLM and 75 with TORS. Negative margins were observed in n = 12/47 (25.5 %) of TLM cases and n = 4/75 (5.3 %) of TORS cases (<em>p</em> &lt; 0.05). There was no significant difference between the two techniques in terms of 5-year local and regional control, however a significant difference was found in disease-free survival and overall survival. The functional laryngeal preservation rate was 97.8 % in the TLM group and 100 % in the TORS group.</div></div><div><h3>Conclusion</h3><div>Both techniques appear to be safe and effective, though TORS shows superiority in achieving negative margins compared to TLM. Therefore, the choice of technique should be tailored to available resources, surgical team preferences, and experience, while also considering the learning curves associated with each approach.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107178"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}