Oral oncology最新文献

{"title":"Letter to the editor: Burden of oral cancer and associated risk factors at national and state levels: A systematic analysis from the global burden of disease in India, 1990–2021","authors":"Himani","doi":"10.1016/j.oraloncology.2024.107093","DOIUrl":"10.1016/j.oraloncology.2024.107093","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107093"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Salivary DNA methylation derived estimates of biological aging, cellular frequency, and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients","authors":"Diego de Sena Costa de Oliveira, John Lennon Silva Cunha","doi":"10.1016/j.oraloncology.2024.107097","DOIUrl":"10.1016/j.oraloncology.2024.107097","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107097"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of oligometastatic head and neck squamous cell carcinoma: A systematic review","authors":"Jihane Lehyanti ,&nbsp;Caroline Even ,&nbsp;Etienne Fessart ,&nbsp;Cyriaque Wagner-Ballon ,&nbsp;Aurélie Moreira ,&nbsp;Aline Houessinon","doi":"10.1016/j.oraloncology.2024.107085","DOIUrl":"10.1016/j.oraloncology.2024.107085","url":null,"abstract":"<div><div>Head and neck squamous cell carcinoma (HNSCC) is the seventh most common type of cancer worldwide. It is mainly discovered in a locally advanced stage, but it is estimated that 40% of recurrences after the treatment of the primary disease will be in a metastatic form, with one third being oligometastatic. There is no clear consensus regarding the treatment of oligometastatic HNSCC, whether it being local treatment, systemic treatment or a combination of both. We put together a systematic review using the Preferred Reporting Item for Systematic review and Meta-Analysis (PRISMA) method to gather all pertinent articles approaching the therapeutic management of oligometastatic HNSCC, especially in the metachronous setting. Out of 344 articles, 21 articles fit our inclusion criteria and were deemed pertinent to help answer the question of our review. Eight studies included only head and neck cancers (HNC) and the other 13 tackled multiple histologies including HNC. Stereotactic body radiotherapy (SBRT) was the treatment of choice for oligometastatic HNSCC with good local control rates and manageable toxicity. Most included studies were retrospective and not randomized. The association of local treatment and systemic treatment was difficult to assess as treatment protocols were not always standardized. There is crucial need for more prospective randomized trials that compare all treatments and sequences as some patients with a high risk of developing polymetastatic disease could derive benefit form a more intensified approach.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107085"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opinion on “Tumor habitat-based MRI features assessing early response in locally advanced nasopharyngeal carcinoma”","authors":"S. Muthamizh,&nbsp;S. Balachandran,&nbsp;Elangovan Dilipan","doi":"10.1016/j.oraloncology.2024.107095","DOIUrl":"10.1016/j.oraloncology.2024.107095","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107095"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of tongue base mucosectomy in the work-up of squamous cell carcinoma of unknown primary: A Danish national cohort study","authors":"Signe Bergliot Nielsen ,&nbsp;Mikkel Hjordt Holm Larsen ,&nbsp;Hani Ibrahim Channir ,&nbsp;Katalin Kiss ,&nbsp;Benedicte Parm Ulhøi ,&nbsp;Christian Godballe ,&nbsp;Jesper Grau Eriksen ,&nbsp;Niclas Rubek ,&nbsp;Thomas Kjaergaard ,&nbsp;Christian von Buchwald","doi":"10.1016/j.oraloncology.2024.107083","DOIUrl":"10.1016/j.oraloncology.2024.107083","url":null,"abstract":"<div><h3>Introduction</h3><div>Squamous cell carcinoma of unknown primary in the head and neck (HNSCCUP) remains a diagnostic challenge. Tongue base mucosectomy by transoral robotic surgery (TORS-TBM) can increase the diagnostic yield and de-intensify treatment. However, the added value of TORS-TBM as an adjunct to work-up programs for HNSCCUP is unclear. Furthermore, the optimal extent of the procedure and selection criteria remain to be established.</div></div><div><h3>Aim</h3><div>The primary aim of the present study was to assess the diagnostic yield of TORS-TBM as a supplement to a standardized work-up program, using the Danish national guidelines as an example. Secondary aims include predictive values of HPV-testing and PET/CT.</div></div><div><h3>Methods</h3><div>This was a national multicenter observational cohort study including all patients diagnosed with HNSCCUP from January 2013 to December 2019, who subsequently underwent TORS-TBM. In most cases HPV status was based on dual testing (p16 and HPV-DNA). Predictive values of PET/CT and HPV status were calculated.</div></div><div><h3>Results</h3><div>A total of 100 consecutive patients underwent TORS-TBM; 93 total TBMs and 7 unilateral TBMs. The primary tumor was detected in 49 % (49/100) of patients. The detection rate was 58 % (47/81) in patients with HPV-associated disease (PPV of HPV status) and 11 % (2/19) in patients with HPV-independent disease. The NPV of HPV status was 89 %. The PPV and NPV of PET/CT was 53 % and 52 %, respectively.</div></div><div><h3>Conclusion</h3><div>Adding total TORS-TBM to the current Danish guideline-based work-up program on HNCCCUP patients with HPV-associated disease significantly improved the diagnostic yield.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107083"},"PeriodicalIF":4.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of intra tumoral HPV-16 viral load in oropharyngeal squamous cell carcinomas","authors":"Agathe Villarmé ,&nbsp;Nathalie Ebran ,&nbsp;Tanguy Pace-Loscos ,&nbsp;Renaud Schiappa ,&nbsp;Audrey Mignot ,&nbsp;Alexandre Bozec ,&nbsp;Anne Sudaka-Bahadoran ,&nbsp;Esma Saada-Bouzid ,&nbsp;Dorian Culié","doi":"10.1016/j.oraloncology.2024.107082","DOIUrl":"10.1016/j.oraloncology.2024.107082","url":null,"abstract":"<div><h3>Objectives</h3><div>The incidence of HPV-induced oropharyngeal squamous cell carcinoma (OSCC) is constantly increasing. Although HPV-related OSCC carry a better prognosis, the majority of patients with an HPV-positive OSCC have other prognostic factors such as tobacco smoking, making therapeutic de-escalating approaches less precise. In this context, our study aims to evaluate the prognostic impact of intra-tumoral HPV-16 viral load (VL) in OSCC.</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective analysis of p16-positive OSCC samples from patients treated between 2012 and 2019. Viral load (VL) was determined using digital droplet Polymerase Chain Reaction (ddPCR) and described according to 3 subgroups: low (&lt;0.9 copies/cell), medium (0.9–85 copies/cell), and high (&gt;85 copies/cell). We assessed the correlation between VL and recurrence-free survival (RFS), specific survival (SS), and overall survival (OS) using the Kaplan-Meier method.</div></div><div><h3>Results</h3><div>In total, 192 patients were included; 148 (77 %) were male. The mean age was 65. HPV-16 was detected in 189/192 samples (98 %). T3-4-stage (p = 0.002), metastasis (p = 0.007), and tobacco consumption (p = 0.01) predicted lower OS. High VL was associated with higher RFS (HR = 0.2, p = 0.01), SS (HR = 0.32, p = 0.02), and OS (HR = 0.39, p = 0.03). After adjusting for tobacco consumption and tumor stage, high VL remained associated with higher RFS (HR = 0.1, 95 %CI [0.04–0.7], p = 0.01) and SS (HR = 0.20, 95 %CI [0.05–0.75], p = 0.01).</div></div><div><h3>Conclusion</h3><div>In our study, high intra-tumoral HPV VL was independently associated with survival. Subject to further validation in independent and prospective cohorts, our findings suggest that HPV VL could help to refine the prognosis of HPV positive OSCC patients.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107082"},"PeriodicalIF":4.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of tumor localization and choice of microvascular flap on posterior airway changes following ablative surgery in primary oral squamous cell carcinoma: A monocentric cross-sectional study","authors":"Lucas M. Ritschl ,&nbsp;Valeriya Sackerer ,&nbsp;Katharina Pippich ,&nbsp;Jakob K. Zink ,&nbsp;Hannes Singer ,&nbsp;Alex Grabenhorst ,&nbsp;Dennis M. Hedderich ,&nbsp;Markus H. Wirth ,&nbsp;Klaus-Dietrich Wolff ,&nbsp;Andreas M. Fichter ,&nbsp;Alexandra V. Behr","doi":"10.1016/j.oraloncology.2024.107080","DOIUrl":"10.1016/j.oraloncology.2024.107080","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to determine the influence of intraoral reconstructions following oral squamous cell carcinoma (OSCC) resection with a free microvascular flap on the posterior airway space (PAS) and to correlate these results with the potential risk of developing an obstructive sleep apnea syndrome (OSAS).</div></div><div><h3>Materials and methods</h3><div>Only primary OSCC cases of the tongue or floor of the mouth which were operated and reconstructed. The PAS displayed in computed tomography (CT) scans at three time points were analyzed: t₀ = preoperative, t₁ = first postoperative CT, and t₂ = most recent situation. The following three PAS parameters were calculated: minimum cross-sectional area (minCSA), mean cross-sectional area (meanCSA), and volume.</div></div><div><h3>Results</h3><div>MinCSA increased from t₀ to t₂: t₀ = 86.9 cm² (0.0 – 251.8), t₁ = 106.6 cm² (1.0 – 483.4), and t₂ = 124.8 cm² (0.5 – 395.6). MeanCSA increased from t₀ to t₂: t₀ = 225.1 cm² (79.0 – 500.2), t₁ = 247.8 cm² (102.8 – 674.3), and t₂ = 272.2 cm² (92.2 – 668.4). The volume increased from t₀ to t₂: t₀ = 21.5 cm³ (8.0 – 63.2), t₁ = 24.1 cm³ (9.6 – 67.3), and t₂ = 26.9 cm³ (6.2 – 67.4).</div></div><div><h3>Conclusions</h3><div>Posterior airway space PAS values became higher than preoperatively. In particular, flap type had a significant influence on the three PAS parameters.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107080"},"PeriodicalIF":4.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral squamous cell carcinomas drive monocytes into immunosuppressive CD25+CD163+CD206+ macrophages","authors":"Hector F. Pelaez-Prestel ,&nbsp;Fernando Gonzalez-Martin ,&nbsp;Alvaro Ras-Carmona ,&nbsp;Almudena Rocha ,&nbsp;Carlos Cabañas ,&nbsp;Esther M. Lafuente ,&nbsp;Pedro A. Reche","doi":"10.1016/j.oraloncology.2024.107078","DOIUrl":"10.1016/j.oraloncology.2024.107078","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) are major cellular components in the tumor microenvironment of oral squamous cell carcinomas (OSCCs). Most of these TAMs derive from circulating monocytes that differentiate <em>in situ.</em> In this work, we show that cell culture media (CM) derived from two OSCC cell lines, H413 and TR146, promote monocyte differentiation into M2 macrophages, characterized by a high expression of CD163, CD206 and a low expression of CD11c, CD86 and HLA-DR. Monocyte-derived macrophages (moMΦ) differentiated by CM from H413 cells (H413-CM) were also unable to activate allogeneic T cells, and inhibited T cell activation and proliferation induced by CD3/CD28 stimulation. By culturing monocytes with fractionated H413-CM, we found that soluble proteins mediated CD163⁺CD206⁺ moMΦ differentiation, discarding a role for small metabolites and extracellular vesicles. Differential proteomic analyses on H413-CM fractions revealed the presence of several proteins, including the complement factor H or plasminogen activator inhibitor 1, as potential candidates to induce CD163⁺CD206⁺ moMΦ differentiation. Finally, RNAseq transcriptomic analyses of H413-CM conditioned moMΦ, identified a expression profile signature involving cytokines and cytokine receptors, which surprisingly included <em>IL2RA</em> (encoding CD25). CD25 enhanced expression was confirmed on H143-CM moMΦ. Collectively, these data indicate that the CM from OSCC cell lines promotes the differentiation of functionally immunosuppressive macrophages resembling TAMs, and contributes to the understanding of how OSCCs create an immunosuppressive cellular environment that favors tumor growth.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107078"},"PeriodicalIF":4.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutational landscape of Japanese patients with oral squamous cell carcinoma from comprehensive genomic profiling tests","authors":"Norihisa Ichimura ,&nbsp;Yusuke Urata ,&nbsp;Takeru Kobayashi ,&nbsp;Ryo Ebata ,&nbsp;Hiroya Matsumoto ,&nbsp;Hideharu Hibi","doi":"10.1016/j.oraloncology.2024.107079","DOIUrl":"10.1016/j.oraloncology.2024.107079","url":null,"abstract":"<div><h3>Objectives</h3><div>Oral squamous cell carcinoma (OSCC) is the most common subtype of head and neck squamous cell carcinoma (HNSCC). Treatment options for OSCC are currently limited owing to the lack of identified therapeutic targets. In this study, we aimed to analyze the genomic profiles of Japanese patients with OSCC and compare them to those of patients with HNSCC to identify potential therapeutic targets.</div></div><div><h3>Materials and methods</h3><div>We extracted the clinical and genomic information of patients with OSCC (n = 242) and those with other HNSCC (n = 402) who underwent comprehensive genomic profiling tests under the National Health Insurance between June 2019 and April 2024 from the Center for Cancer Genomics and Therapeutics database.</div></div><div><h3>Results</h3><div>The most frequent genomic alterations identified in OSCC were <em>TP53</em> (85.5 %), followed by <em>TERT</em> (62.4 %), <em>CDKN2A</em> (41.3 %), <em>FGF19</em> (24.9 %), and <em>CCND1</em> (23.6 %). <em>FGF19</em> and <em>CCND1</em> were co-amplified, and <em>CDKN2A</em> and <em>CDKN2B</em> were co-deleted. The frequencies of <em>TERT</em>, <em>HRAS,</em> and <em>CASP8</em> alterations were the highest in OSCC among all HNSCC subtypes. The frequency of <em>EGFR</em> alterations was substantially higher in adolescent and young adults than older patients with OSCC. Genes associated with genomic integrity and the RTK-RAS pathway were frequently altered in OSCC.</div></div><div><h3>Conclusion</h3><div>This study analyzed the genomic profiles of patients with OSCC in Japan and the genetic differences between OSCC and other HNSCC subtypes. This analysis offers insights into the development of personalized therapeutics for OSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107079"},"PeriodicalIF":4.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study","authors":"Valentine Poissonnet ,&nbsp;Emilien Chabrillac ,&nbsp;Emmanuelle Uro-Coste ,&nbsp;Virginie Woisard ,&nbsp;Antoine Moya-Plana ,&nbsp;Florent Espitalier ,&nbsp;Joel Castelli ,&nbsp;Thibault Dedieu ,&nbsp;Sébastien Salas ,&nbsp;Renaud Garrel ,&nbsp;Robin Baudouin ,&nbsp;Gilles Poissonnet ,&nbsp;Claire Castain ,&nbsp;Jonathan Barbut ,&nbsp;Haitham Mirghani ,&nbsp;Diane Evrard ,&nbsp;Olivier Bouchain ,&nbsp;Jean Paul Marie ,&nbsp;Hélène Orliac ,&nbsp;Philippe Ceruse ,&nbsp;Sébastien Vergez","doi":"10.1016/j.oraloncology.2024.107072","DOIUrl":"10.1016/j.oraloncology.2024.107072","url":null,"abstract":"<div><h3>Introduction</h3><div>Salivary carcinomas of the tongue represent a therapeutic challenge as their radical excision is particularly mutilating. We aimed to study the oncologic and functional outcomes of advanced stages salivary carcinomas of the tongue.</div></div><div><h3>Materials and methods</h3><div>This retrospective multicentric study, based on the French national network on rare head and neck cancers (REFCOR), included all patients with a T3-T4 salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018.</div></div><div><h3>Results</h3><div>In total, 47 patients were included, of which 44.7 % underwent surgery. Histologies were mostly adenoid cystic carcinomas (61.7 %), followed by other adenocarcinomas (27.7 %) and mucoepidermoid carcinomas (10.6 %). Median follow-up duration was 63.9 months. In multivariable analysis, surgery was significantly associated with better Recurrence-Free Survival (HR = 0.23, 95 %CI [0.09;0.55]) and Local/Regional Recurrence-Free Survival (HR = 0.31, 95 %CI [0.10;0.95]). The rate of distant metastasis at the end of follow-up was 61.9 % in the surgical group and 57.7 % in the non-surgical group. The Distant Metastasis Free Survival was 54.9 % [38.3;68.7], without statistical difference between both groups. There were similar rates of definitive gastrostomies but the rate of normal oral diet at the last follow-up seemed higher in the surgery group (38.1 % vs 15.4 %).</div></div><div><h3>Conclusion</h3><div>Radical surgery in that population mainly aims to improve local/regional control, which may result in better long-term swallowing functions. About half of these tumors may be associated with occult distant metastasis at initial presentation. More studies are warranted to establish the role of postoperative RT and non-surgical treatment with concurrent CRT.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107072"},"PeriodicalIF":4.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}