Oral oncology最新文献_第9页

The first report of bilateral parapharyngeal lymph node metastasis from papillary thyroid carcinoma: A case report 首次报告甲状腺乳头状癌双侧咽旁淋巴结转移：病例报告

IF 4 2区医学

Oral oncology Pub Date : 2024-08-31 DOI: 10.1016/j.oraloncology.2024.107006

Jingzhu Zhao , Xianhui Ruan , Songfeng Wei , Xiangqian Zheng , Ming Gao

引用次数: 0

Effect analysis of 847 nasopharyngeal carcinoma cases treated with intensity modulated radiation: Experience and suggestions 强度调制放射治疗 847 例鼻咽癌的效果分析：经验与建议

IF 4 2区医学

Oral oncology Pub Date : 2024-08-30 DOI: 10.1016/j.oraloncology.2024.107001

Wen-Jing Yin , Wu Mao , Fang Yang , Meng-Yao Wang , Jin-Quan Liu , Dong-Ping Chen , Li-Ping Zhou , Si-Da Chen , Xi-Zhen Jiang , Yu-Meng Ou , Zheng Wu , Bin Qi

{"title":"Effect analysis of 847 nasopharyngeal carcinoma cases treated with intensity modulated radiation: Experience and suggestions","authors":"Wen-Jing Yin , Wu Mao , Fang Yang , Meng-Yao Wang , Jin-Quan Liu , Dong-Ping Chen , Li-Ping Zhou , Si-Da Chen , Xi-Zhen Jiang , Yu-Meng Ou , Zheng Wu , Bin Qi","doi":"10.1016/j.oraloncology.2024.107001","DOIUrl":"10.1016/j.oraloncology.2024.107001","url":null,"abstract":"<div><h3>Objectives</h3><p>To identify the failure patterns and prognostic factors of nonmetastatic nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era.</p></div><div><h3>Methods</h3><p>Data on 847 patients with newly diagnosed, non-disseminated NPC treated by IMRT between 2012 and 2016 were retrospectively reviewed. Survival outcome, failure patterns and prognosis factors were analyzed.</p></div><div><h3>Results</h3><p>The 5-year local relapse-free survival, nodal relapse-free survival, distant metastasis-free survival, disease-free survival, and overall survival rates were 94.3%, 95.3%, 84.8%, 76.5% and 85.7%, respectively. The major local recurrence sites were the nasopharynx (91.5%, 43/47) and skull base (68.1%, 32/47); 39 patients had in-field failures, four had marginal failures, and four had out-field failures. Level IIb (62.2%, 23/37) was the most frequent regional recurrence site, followed by IIa (35.1%, 13/37) and retropharyngeal region (32.4%, 12/37); 35 cases had in-field failure alone, one had out-field failure alone, and one had both in- and out-field failure. TNM stage was the most significant factor for prognosis prediction. 402 (47.5%) patients had acute adverse events of grade 3 or 4; leukopenia (31.5%) and mucositis (26.7%) was the most common hematological and non-hematological event, respectively. Late complications were slight or moderate damages; xerostomia (647/847, 76.4%) and hearing impairment (422/847, 49.8%) remained the most troublesome.</p></div><div><h3>Conclusion</h3><p>NPC patients treated with IMRT obtained satisfactory survival outcomes. The key failure pattern was distant metastasis. The main pattern of local–regional failure was in-field failure. Screening high risk patients with distant metastases and optimizing radiotherapy targets should be studied.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoinhibitory effects of hypoxia-driven reprogramming of EGR1hi and EGR3 positive B cells in the nasopharyngeal carcinoma microenvironment 鼻咽癌微环境中缺氧驱动的 EGR1hi 和 EGR3 阳性 B 细胞重编程的免疫抑制效应

IF 4 2区医学

Oral oncology Pub Date : 2024-08-27 DOI: 10.1016/j.oraloncology.2024.106999

Yizhi Ge , Haitao Liu , Wenxuan Huang , Huanfeng Zhu , Dan Zong , Xia He

{"title":"Immunoinhibitory effects of hypoxia-driven reprogramming of EGR1hi and EGR3 positive B cells in the nasopharyngeal carcinoma microenvironment","authors":"Yizhi Ge , Haitao Liu , Wenxuan Huang , Huanfeng Zhu , Dan Zong , Xia He","doi":"10.1016/j.oraloncology.2024.106999","DOIUrl":"10.1016/j.oraloncology.2024.106999","url":null,"abstract":"<div><p>Regulatory B (Breg) cells is a type of immune cell that exhibit immunosuppressive behavior within the tumor microenvironment. However, the differentiation and regulatory mechanisms of these Breg cells remain unexplored. Single-cell transcriptome sequencing analysis of human nasopharyngeal carcinoma (NPC) revealed a significant enrichment of B cell subset characterized by high expression of EGR1 and EGR3 in the tumor microenvironment. Notably, in the hypoxic microenvironment, these B cells induce MAPK pathway activation, subsequently triggering the activation of transcription factors EGR1 and EGR3, which further modulate the expression of immunosuppressive factors like TGFB1 and IL10. In transplant experiments using primary B cells induced under hypoxia and co-transplanted with cancer cells, a significant increase in tumor growth was observed. Mechanism experiments demonstrated that EGR1<sup>hi</sup> and EGR3<sup>+</sup> B cells further activate the maturation and immunosuppressive function of Treg cells through the secretion of IL16 and TNF-α. Hence, this study identifies the key transcription factors EGR1 and EGR3 as essential regulators and elucidates the differentiation of Breg cells under hypoxic conditions.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142075814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on “Platinum/taxane/pembrolizumab vs platinum/5FU/pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma (r/mHNSCC)” 关于 "铂/他沙坦/pembrolizumab 与铂/5FU/pembrolizumab 治疗复发性/转移性头颈部鳞状细胞癌（r/mHNSCC）"的评论

IF 4 2区医学

Oral oncology Pub Date : 2024-08-26 DOI: 10.1016/j.oraloncology.2024.107010

Prithviraj T

引用次数: 0

Current state, challenges, and future perspective of adaptive radiotherapy: A narrative review of nasopharyngeal carcinoma 适应性放射治疗的现状、挑战和未来展望：鼻咽癌综述

IF 4 2区医学

Oral oncology Pub Date : 2024-08-24 DOI: 10.1016/j.oraloncology.2024.107008

Xiate Zhou , Tianchi Shao , Haijian Jia , Liqiao Hou , Xingni Tang , Changhui Yu , Chao Zhou , Suna Zhou , Haihua Yang

{"title":"Current state, challenges, and future perspective of adaptive radiotherapy: A narrative review of nasopharyngeal carcinoma","authors":"Xiate Zhou , Tianchi Shao , Haijian Jia , Liqiao Hou , Xingni Tang , Changhui Yu , Chao Zhou , Suna Zhou , Haihua Yang","doi":"10.1016/j.oraloncology.2024.107008","DOIUrl":"10.1016/j.oraloncology.2024.107008","url":null,"abstract":"<div><p>Patients with nasopharyngeal carcinoma often experience weight loss and tumor regression during the course of radiotherapy that lasts for up to 6–7 weeks. Adaptive radiotherapy is a systematic feedback control approach based on image-guided technology that adjusts these changes and optimizes the radiotherapy plans according to new imaging findings during treatment. There is growing evidence that adaptive radiotherapy can reduce side effects, improve the quality of life, and enhance disease control. However, the routine application of adaptive radiotherapy for nasopharyngeal remains relatively limited. This review discusses the necessity, clinical benefits, and limitations of adaptive radiotherapy, and presents the current state, challenges, and future perspective of adaptive radiotherapy strategies for nasopharyngeal carcinoma.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368837524003269/pdfft?md5=4e9b079495a94dbe375ae0ac3d6b4afd&pid=1-s2.0-S1368837524003269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of antibiotics on PD-1 inhibition in recurrent/metastatic head and neck squamous cell carcinoma 抗生素对复发/转移性头颈部鳞状细胞癌中 PD-1 抑制作用的影响

IF 4 2区医学

Oral oncology Pub Date : 2024-08-24 DOI: 10.1016/j.oraloncology.2024.107003

Helene Knap Rabjerg, Jesper Grau Eriksen, Sebastian Søby

引用次数: 0

DNA Methylation Mediated Epigenetic Silencing of PD-1 and PD-L1: Therapeutic Implications in Oral Cancer. DNA 甲基化介导的 PD-1 和 PD-L1 表观遗传沉默：对口腔癌的治疗意义。

IF 4 2区医学

Oral oncology Pub Date : 2024-08-23 DOI: 10.1016/j.oraloncology.2024.106995

Monisha Prasad

引用次数: 0

Challenges in treating oropharyngeal cancer in the elderly: The role of transoral surgery 治疗老年人口咽癌的挑战：经口手术的作用

IF 4 2区医学

Oral oncology Pub Date : 2024-08-23 DOI: 10.1016/j.oraloncology.2024.106996

Andrea Costantino, Bruce Haughey, Uthman Alamoudi, Jeffery Scott Magnuson

引用次数: 0

Secretory carcinoma of the minor salivary gland: An in-depth case report 小唾液腺分泌性癌：深度病例报告

IF 4 2区医学

Oral oncology Pub Date : 2024-08-22 DOI: 10.1016/j.oraloncology.2024.107005

Reydson Alcides de Lima-Souza , Iara Vieira Ferreira , Carlos Takahiro Chone , Erika Said Abu Egal , Alena Skálová , Albina Altemani , Fernanda Viviane Mariano

{"title":"Secretory carcinoma of the minor salivary gland: An in-depth case report","authors":"Reydson Alcides de Lima-Souza , Iara Vieira Ferreira , Carlos Takahiro Chone , Erika Said Abu Egal , Alena Skálová , Albina Altemani , Fernanda Viviane Mariano","doi":"10.1016/j.oraloncology.2024.107005","DOIUrl":"10.1016/j.oraloncology.2024.107005","url":null,"abstract":"<div><p>A 56-year-old female was referred to our service for management of a malignant salivary gland neoplasm with compromised margins that had been biopsied previously at another service. The patient reported a twenty-year history of a lesion in the oral cavity with progressive and exuberant growth over the past two years, associated with local pain and dyspnea. Physical examination revealed an erythematous, ulcerated, and hemorrhagic lesion measuring approximately 3 cm on the left soft palate and tonsillar pillar. Computed tomography revealed an expansile lesion in the topography of the left soft palate, growing predominantly toward the lumen of the nasopharynx and partially invading the left wall of this region. The patient underwent surgery and histopathologic examination revealed an infiltrative and aggressive epithelial neoplasia with large vacuolated and eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. The neoplastic cells were arranged in a solid, microcystic, tubular, and follicular pattern with eosinophilic luminal secretion. Mitotic figures were frequent and all margins were affected by the neoplasia. Morphologic and immunohistochemical features supported the diagnosis of secretory carcinoma, and the patient is currently being followed for further therapeutic intervention.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative dosimetric analysis of normal brain tissue in patients with Nasopharyngeal carcinoma at different stages after radiation therapy 鼻咽癌患者放疗后不同阶段正常脑组织的剂量比较分析

IF 4 2区医学

Oral oncology Pub Date : 2024-08-22 DOI: 10.1016/j.oraloncology.2024.106998

Fenglei Du , Kainan Shao , Yiwei Yang , Xue Bai , Yonghong Hua , Guoping Shan

{"title":"Comparative dosimetric analysis of normal brain tissue in patients with Nasopharyngeal carcinoma at different stages after radiation therapy","authors":"Fenglei Du , Kainan Shao , Yiwei Yang , Xue Bai , Yonghong Hua , Guoping Shan","doi":"10.1016/j.oraloncology.2024.106998","DOIUrl":"10.1016/j.oraloncology.2024.106998","url":null,"abstract":"<div><h3>Introduction</h3><p>Radiotherapy (RT) is the main treatment for patients with nasopharyngeal carcinoma (NPC). NPC patients at different stages have varying levels of damage to normal brain tissue after RT. No study has yet thoroughly analyzed the variations in radiation dosages in the brain for different stages of NPC patients treated with RT. This study aims to examine these variations.</p></div><div><h3>Methods</h3><p>1446 NPC patients’ CT and RTdose data were retrospectively reviewed. Analysis of the radiation dosage was executed on these 803 patients. The RTdose images for several patient groups were averaged after registering each patient’s RTdose data to the CT brain template created in our earlier study. The voxel-based (VB) analysis was used to examine the dose variations in the brains of three groups of NPC patients: the early-stage group, the stage III group, and the stage IV group.</p></div><div><h3>Results</h3><p>As the disease progresses from early to advanced stages, the intensity and volume of radiation in the brain increase. The normal brain tissue accepted a substantially larger dosage in more advanced NPC patients. Differences in brain regions between stage III and early-stage patients were minimal compared to any other two groups. Brain regions exhibited substantial variations between the stage IV group and all other patient groups were broadly distributed.</p></div><div><h3>Conclusion</h3><p>Our findings highlight the critical role of NPC staging in the therapeutic strategy, emphasizing the heterogeneity of radiation-induced tissue damage across disease stages and implying the need to develop stage-specific RT plans.</p></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0