Oral oncology最新文献

{"title":"Scapula or Fibula?: Prospective data-driven decision criteria for flap selection in mandibular reconstruction planning","authors":"Maharshi Panchal ,&nbsp;Katrina Zaraska ,&nbsp;Thomas D. Milner ,&nbsp;Khanh Linh Tran ,&nbsp;Antony Hodgson ,&nbsp;Sidney Fels ,&nbsp;James Scott Durham ,&nbsp;Eitan Prisman","doi":"10.1016/j.oraloncology.2025.107190","DOIUrl":"10.1016/j.oraloncology.2025.107190","url":null,"abstract":"<div><h3>Objectives</h3><div>The objectives of the study are twofold: 1) to propose a set of criteria for virtually evaluating different types of reconstructions for mandibular defects during surgical planning, and 2) to prospectively apply the criteria to a series of mandibular reconstructions to select the optimal flap.</div></div><div><h3>Materials and Methods</h3><div>Clinically relevant assessment criteria were selected, including volumetric overlap, Haussdorf-95, bony contact, ramus/symphysis angles, and dental implantability. In 2021, 21 consecutive patients undergoing mandibular reconstructions were consented to the study. For each patient, seven virtual reconstructions were created: vertical scapula, horizontal scapula, 1-segment fibula, optimal fibula determined by the Ramer-Douglas-Peucker (RDP) algorithm, RDP + 1 fibula, and RDP-1 fibula. The surgeon selected the optimal reconstruction for each patient based on the objective criteria and clinical considerations.</div></div><div><h3>Results</h3><div>The vertical scapula was selected for 12 cases, the RDP fibula for 6 cases, and the horizontal scapula for 3 cases. For defects involving the symphysis, the horizontal scapula was the frequently selected as its geometry could be leveraged to recreate the symphysis angle. For the remaining defects, the RDP fibula optimizes the bony contact, performs well in volume overlap, and is the most implantable. The vertical scapula minimizes osteotomies while maximizing each criterion but results in low implantability. On average, the chosen reconstruction performed better on all criteria compared to the remaining proposed models.</div></div><div><h3>Conclusion</h3><div>The criteria proposed comprises of measurable and clinically important metrics that can serve as a useful tool for reconstructive surgeons in selecting the optimal flap for mandibular reconstruction.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107190"},"PeriodicalIF":4.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is postoperative adjuvant therapy necessary for pT3N0 oral cavity squamous cell carcinoma?","authors":"Chun-Hung Hua ,&nbsp;Jin-Ching Lin ,&nbsp;Yu-Wen Wen ,&nbsp;Chung-Jan Kang ,&nbsp;Chien-Yu Lin ,&nbsp;Hsiu-Ying Ku ,&nbsp;Kang-Hsing Fan ,&nbsp;Shu-Hang Ng ,&nbsp;Shu-Ru Lee ,&nbsp;Yao-Te Tsai ,&nbsp;Wen-Cheng Chen ,&nbsp;Li-Yu Lee ,&nbsp;Chih-Yen Chien ,&nbsp;Cheng Ping Wang ,&nbsp;Tsung-Ming Che ,&nbsp;Shyuang-Der Terng ,&nbsp;Chi-Ying Tsai ,&nbsp;Hung-Ming Wang ,&nbsp;Chia-Hsun Hsieh ,&nbsp;Chih-Hua Yeh ,&nbsp;Chun-Ta Liao","doi":"10.1016/j.oraloncology.2025.107198","DOIUrl":"10.1016/j.oraloncology.2025.107198","url":null,"abstract":"<div><h3>Background</h3><div>The current NCCN guidelines advocate for the use of adjuvant radiotherapy (RT) or chemoradiotherapy (CRT) in pT3N0 oral cavity squamous cell carcinoma (OCSCC). Here, we sought to evaluate whether postoperative RT/CRT may confer a survival advantage in pT3N0 patients who lack adverse pathological features.</div></div><div><h3>Methods</h3><div>A dataset of 852 pT3N0 OCSCC patients treated between 2018 and 2021 was analyzed. Patients with adverse pathological features (i.e., positive margins, margins &lt;5 mm, lymphovascular invasion, or perineural invasion) were excluded, leaving 235 eligible patients. The cohort was further refined by omitting 12 patients who received surgery plus chemotherapy and two cases who received RT doses &lt;5000 cGy, resulting in two study groups: surgery alone (n = 131) and surgery plus RT/CRT (n = 90).</div></div><div><h3>Results</h3><div>Baseline characteristics were comparable between groups, except for a higher proportion of buccal subsite (<em>p</em> = 0.0063) and female patients (<em>p</em> = 0.0495) in the surgery alone group. Kaplan-Meier analyses revealed no significant differences in 4-year disease-specific survival (DSS) (84.2 % <em>versus</em> 85.9 %, <em>p</em> = 0.8834) or overall survival (OS) (75.6 % <em>versus</em> 84.8 %, <em>p</em> = 0.2376). These findings were confirmed by multivariable analyses and remained consistent after propensity score matching (n = 74 per group), with similar survival outcomes between groups (4-year DSS, 90.7 % <em>versus</em> 83.2 %, <em>p</em> = 0.4020; 4-year OS, 87.0 % <em>versus</em> 81.9 %, <em>p</em> = 0.6121)</div></div><div><h3>Conclusions</h3><div>For patients with pT3N0 OCSCC lacking adverse pathological features, the addition of adjuvant RT/CRT does not appear to confer a survival benefit over surgery alone.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107198"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram vs. Depth of invasion for predicting occult lymph node metastasis in cT1-2N0 buccal squamous cell carcinoma","authors":"Na Sun ,&nbsp;Long Huang ,&nbsp;Hong-gang Xiong ,&nbsp;Wei-ming Wang ,&nbsp;Si-qi Hua ,&nbsp;Fei-ya Zhu ,&nbsp;Tong Su","doi":"10.1016/j.oraloncology.2025.107206","DOIUrl":"10.1016/j.oraloncology.2025.107206","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a nomogram prediction model for occult lymph node metastasis (LNM) in patients with cT1-2N0 buccal squamous cell carcinoma (BSCC), then to compare its predictive efficacy against depth of invasion (DOI).</div></div><div><h3>Methods</h3><div>Clinical data were retrieved for patients undergoing primary tumor resection and neck dissection from June 2020 to August 2024. Based on the risk factors screened by Lasso regression, we established four candidate models: logistic regression, random forest, support vector machine, and XGboost. The optimal model was determined by comparing the values of areas under the receiver-operating characteristic curve (AUC), then the nomogram was ultimately plotted accordingly to visualize the results.</div></div><div><h3>Results</h3><div>Two hundred and fifty patients were enrolled. The screened variables include Ki-67, tumor differentiation grade, surgical margin status, perineural invasion, DOI, and smoking. With similar good performance from both the training and test cohorts (AUC, 0.726 vs. 0.782) and good calibration, the logistic regression model performed the best overall, and was thus selected for creating a nomogram. The nomogram was superior to DOI cut-off values of 3 mm and 4 mm in predicting occult LNM, with a higher AUC (0.741 vs. 0.543 and 0.595) and more net benefits. Compared with DOI &lt; 4 mm, at a 9.51 % risk of LNM, the nomogram identified an equivalent number of cases (n = 64) for not undergoing elective neck dissection (END), while successfully reducing 2 false-negative cases (2 vs. 4) with insufficient treatment.</div></div><div><h3>Conclusions</h3><div>The nomogram described here prevails over DOI in predicting occult LNM in early-stage BSCC, and provide effective guidance for END.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107206"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative care utilization among head and neck cancer patients: A population-based analysis","authors":"Talia A. Wenger ,&nbsp;Jaynelle Gao ,&nbsp;Margaret Nurimba ,&nbsp;Peter G. Phung ,&nbsp;Uttam K. Sinha","doi":"10.1016/j.oraloncology.2025.107205","DOIUrl":"10.1016/j.oraloncology.2025.107205","url":null,"abstract":"<div><h3>Purpose</h3><div>Head and neck cancer (HNC) patients face substantial morbidity and mortality. Despite the potential benefits of palliative care (PC) in improving quality of life, many HNC patients do not receive these services. This study aimed to quantify the proportion of HNC patients receiving PC, the timing of PC referrals, and the mental health and clinical outcomes of this population.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using the TriNetX database with de-identified electronic medical records. HNC patients were categorized based on whether they had at least one PC encounter. We examined time to first PC encounter, mortality rates, mental health diagnoses, and access to ACP and supportive care.</div></div><div><h3>Results</h3><div>Of 304,404 HNC patients, only 22,470 (7.4 %) had at least one PC encounter. The median time from cancer diagnosis to initial PC referral was 318 days. After propensity score matching, the cohorts consisted of 24,916 patients each. Those who received PC had a significantly higher risk of mortality (RR 3.05, 95 % CI 2.97–3.14), depression (RR 1.38, 95 % CI 1.33–1.45), anxiety (RR 1.47, 95 % CI 1.42–1.53), failure to thrive (RR 3.26, 95 % CI 3.03–3.51), and were more likely to engage in advance care planning (RR 4.97, 95 % CI 4.39–5.62) and access supportive care services compared to patients who did not receive PC.</div></div><div><h3>Conclusions</h3><div>PC utilization among HNC patients is low, with patients often waiting nearly a year before their first PC encounter. This delay highlights a significant unmet need for early integrated PC in this population.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107205"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-pathological characterisation of human papillomavirus-associated oral epithelial dysplasia","authors":"Selvam Thavaraj ,&nbsp;Rhonda Henley-Smith ,&nbsp;Harry Gregson-Williams ,&nbsp;Sangeetha Yogarajah ,&nbsp;Edward W. Odell ,&nbsp;Hans Sathasivam","doi":"10.1016/j.oraloncology.2025.107182","DOIUrl":"10.1016/j.oraloncology.2025.107182","url":null,"abstract":"<div><h3>Background</h3><div>Human papillomavirus-associated oral epithelial dysplasia (HPV-OED) has been recently recognised by the World Health Organisation (WHO) as a distinct type of oral epithelial dysplasia. The rarity of HPV-OED, together with gaps in the current understanding of risk factors and clinical behaviour raise the risk of under-recognition and misdiagnosis. To address this, we describe the clinico-pathological features of a consecutive series of HPV-OED from a single institution to provide additional insight into the presentation and behaviour of this disease.</div></div><div><h3>Methods</h3><div>Consecutive cases of HPV-OED were identified over a 20-year period from the pathology routine diagnostic archives of a single centre. Cases with features of viral cytopathic changes in a background of OED underwent HPV-specific testing in addition to p16 immunohistochemistry to confirm HPV positivity.</div></div><div><h3>Results</h3><div>Fifty-three consecutive patients with HPV-OED were identified. The mean age at diagnosis was 55 years-old and there was a strong male predilection (83 %). Most patients were smokers or former smokers, and almost a fifth of individuals were Human Immunodeficiency Virus (HIV)-positive. The latero-ventral tongue was the most common index site. Twenty-eight percent of cases were associated with invasive oral squamous cell carcinoma. There was a statistically significant association between with patient’s HIV status and malignant transformation (p = 0.022).</div></div><div><h3>Conclusions</h3><div>Findings from our cohort of HPV-OED patients suggests that malignant transformation is relatively frequent and associated with the HIV status of patients.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107182"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-eudesmol inhibits cell growth and enhances cell chemosensitivity of NPC through targeting FGF1/FGFR signaling","authors":"Tao Xie ,&nbsp;Yuqi Shu ,&nbsp;Wei Huang ,&nbsp;Anbang Ren ,&nbsp;Jie Lin ,&nbsp;Yujing Tan ,&nbsp;Shufen Zhao ,&nbsp;Junguo Bu","doi":"10.1016/j.oraloncology.2024.107168","DOIUrl":"10.1016/j.oraloncology.2024.107168","url":null,"abstract":"<div><h3>Background</h3><div>Chemoresistance is one of<!--> <!-->the main challenges for advanced NPC<!--> <!-->treatment.<!--> <!-->We previously<!--> <!-->proved LHX2 transcriptionally regulates FGF1 and promotes cancer progression through activating FGF1/FGFR axis,which prompted us to<!--> <!-->explore the potential inhibitors for FGFR to improve the therapy response.</div></div><div><h3>Methods</h3><div>RT-qPCR, immunohistochemistry, western blot assay<!--> <!-->and immunofluorescence<!--> <!-->were applied to verify the gene expression levels. Xenograft<!--> <!-->model as well as lung metastasis model was performed for<!--> <!-->in vitro<!--> <!-->assays. Flow cytometry and Tunel staining<!--> <!-->were used to determine the apoptosis of NPC cells.The interaction between β-eudesmol and FGFR1/2 was analyzed by Autodock software.</div></div><div><h3>Results</h3><div> <!-->β-eudesmol inhibited the growth and metastasis<!--> <!-->of NPC<!--> <em>in vivo</em> <!-->and<!--> <!-->in vitro.<!--> <!-->In addition,<!--> <!-->β-eudesmol treatment promoted NPC apoptosis and sensitized NPC to cisplatin. β-eudesmol putatively bound to FGFR and blocked the Akt signaling, STAT3 signaling<!--> <!-->and<!--> <!-->ERK<!--> <!-->signaling,<!--> <!-->which in turn restrained<!--> <!-->ABCC1 transcription.</div></div><div><h3>Conclusion</h3><div> <!-->β-eudesmol suppressed cell growth, metastasis and chemoresistance in NPC through targeting<!--> <!-->FGF1/FGFR signaling, thereby blocking the Akt signaling, STAT3 signaling and<!--> <!-->ERK<!--> <!-->signaling, as well as down-regulating ABCC1 expression. Our findings provided a novel potential drug for NPC treatment.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107168"},"PeriodicalIF":4.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single-cell sequencing-based analysis of a 13-year-old with maxillary sinus NUT carcinoma","authors":"Zhuomiao Ye ,&nbsp;Xin Li ,&nbsp;Fei Xie ,&nbsp;Jie Sun ,&nbsp;Dan Yang ,&nbsp;Chao Deng ,&nbsp;Mingzhu Yin","doi":"10.1016/j.oraloncology.2025.107185","DOIUrl":"10.1016/j.oraloncology.2025.107185","url":null,"abstract":"<div><div>NUT carcinoma is a rare and highly aggressive malignancy, predominantly affecting adolescents and young adults. This tumor demonstrates rapid progression, resistance to conventional anti-cancer treatments, and an extremely poor prognosis. Currently, research on NUT carcinoma is limited, and effective treatment options remain scarce. In this study, we performed single-cell RNA sequencing (scRNA-seq) on tumor tissue from a 13-year-old patient with maxillary sinus NUT carcinoma. The analysis revealed significant heterogeneity among epithelial cells within the tumor microenvironment (TME). Immune cell infiltration was notably low, suggesting that the tumor represents a “cold” immune microenvironment. Subclustering of epithelial cells identified distinct subpopulations characterized by high proliferation, metabolic activity, TGF-Beta-driven invasiveness, and MYC-driven growth and protein secretion. These findings provide critical insights into the tumor’s biology, growth mechanisms, and potential therapeutic vulnerabilities. This study highlights the importance of scRNA-seq in understanding the complexity of NUT carcinoma and underscores the need for personalized treatment approaches, including the potential application of BET inhibitors.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107185"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of recurrent calcifying epithelial odontogenic tumor in an adolescent patient: Case report and review of literature","authors":"Siying Li ,&nbsp;Yingxin Zhang ,&nbsp;Huanyan Dai ,&nbsp;Zhimin Xu","doi":"10.1016/j.oraloncology.2025.107183","DOIUrl":"10.1016/j.oraloncology.2025.107183","url":null,"abstract":"<div><div>Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic epithelial tumor characterized by the presence of amyloid material within the tumor that can undergo calcification. CEOT affects individuals across a broad age range, typically between 20 and 60 years, with an average onset age of 40 years. However, it is extremely rare in children and adolescents. According to the literature, only 31 cases of CEOT in children and adolescents have been reported from 1971 to 2023, accounting for approximately 7 % of all CEOT cases. In the 2022 WHO classification of odontogenic tumors, CEOT is classified as a benign tumor, but it is inherently locally aggressive, capable of invading surrounding normal jawbone tissues, with a recurrence rate of 10–15 %. In this paper, we report a case of a 13-year-old male with a recurrence of CEOT in the mandible 43 months after surgery, covering clinical, imaging, histologic, immunohistochemical, and surgical aspects, and discuss its histopathologic features and treatment options.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107183"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD271high cancer stem cells regulate macrophage polarization in head and neck squamous cell carcinoma","authors":"Lifan Chen ,&nbsp;Ruihua Fang ,&nbsp;Zhimou Cai,&nbsp;Bixue Huang,&nbsp;Jinhong Zhang,&nbsp;Yun Li,&nbsp;Yi Chen,&nbsp;Zhenglin Xu,&nbsp;Wenbin Lei,&nbsp;Minjuan Zhang","doi":"10.1016/j.oraloncology.2025.107181","DOIUrl":"10.1016/j.oraloncology.2025.107181","url":null,"abstract":"<div><h3>Purpose</h3><div>Cancer stem cells (CSCs) are considered key drivers of progression in head and neck squamous cell carcinoma (HNSCC). Our single-cell RNA sequencing (scRNA-seq) analysis revealed predominant expression of CD271 in CSCs, however, its role as a CSC marker in HNSCC requires further elucidation. We investigated the stemness characteristics of CD271^high HNSCC cells and their interactions with the tumor immune microenvironment.</div></div><div><h3>Methods</h3><div>scRNA-seq data from hypopharyngeal squamous cell carcinoma (HPSCC) tissues were analyzed to identify expression profile of CSCs. Overall survival was compared between CD271^high and CD271^low patients based on immunostaining of HPSCC samples. The stemness of CD271^high HNSCC cells was evaluated via an in vivo limiting dilution assay. In a C57BL/6 mice model, the percentage of immune cells and macrophage subtypes were analyzed by flow cytometry. The role of CD271 in macrophage polarization was further examined by in vitro coculture of CD271^high cells with CD14⁺ monocytes. Gene expressions were analyzed by qPCR.</div></div><div><h3>Results</h3><div>CD271 is predominantly expressed in CSCs identified by scRNA-seq analysis. CD271 enhances HNSCC cell proliferation and is negatively correlated with patient prognosis in HPSCC. CD271 knockdown suppressed HNSCC tumor growth and regulated macrophage polarization within the TME. CD271^high cells exhibited stemness features and enhanced tumor growth in vivo.</div></div><div><h3>Conclusions</h3><div>CD271^high HNSCC cells exhibit CSC characteristics and regulate macrophage polarization. Targeting CD271 may improve the immunosuppressive TME to inhibit tumor growth. Combining CD271-targeting agents with other therapies presents a promising strategy that may enhance therapeutic efficacy and prognosis in HNSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107181"},"PeriodicalIF":4.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of synchronous bilateral/contralateral tonsil carcinoma: A systematic review and meta-analysis","authors":"Alex Charlton ,&nbsp;Zahir Mughal ,&nbsp;Florida Sharin ,&nbsp;Raguwinder Bindy Sahota ,&nbsp;Mohammed Shaji Mansuri ,&nbsp;Manish Mair","doi":"10.1016/j.oraloncology.2025.107180","DOIUrl":"10.1016/j.oraloncology.2025.107180","url":null,"abstract":"<div><div>The purpose of this systematic review and <em>meta</em>-analysis was to identify the prevalence of synchronous contralateral tonsil carcinoma (SCTC) amongst patients with tonsil carcinoma or head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Thirteen retrospective studies, comprising 2623 patients, were analysed, revealing an overall pooled SCTC prevalence of 4%, rising to 10% in HNSCCUP cases. HPV/p16 positivity was associated with SCTC prevalence of 3%, while HPV/p16 negativity was greater at 8%. Clinical or imaging evaluations often missed SCTC preoperatively, emphasising the importance of contralateral tonsillectomy. Morbidity varied among patients undergoing contralateral tonsillectomy.</div><div>The prevalence of SCTC is significant in cases of HNSCCUP and tonsil malignancy, emphasising the importance of informed discussions regarding contralateral tonsillectomy. Tailored approaches considering individual patient and tumour characteristics are crucial, with contralateral tonsillectomy generally warranted in HNSCCUP. Further research, including prospective studies with standardised protocols, is needed to improve the understanding and management of SCTC, specifically the clinical significance of occult SCTC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107180"},"PeriodicalIF":4.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}