Oral oncology最新文献

{"title":"Predictors of recurrence and survival after salivary gland cancer surgery: A multicenter, retrospective study in northern Japan","authors":"Akira Ohkoshi ,&nbsp;Ryo Ishii ,&nbsp;Kenjiro Higashi ,&nbsp;Tadahisa Shishido ,&nbsp;Satoshi Kano ,&nbsp;Takahiro Kusaka ,&nbsp;Daisuke Matsushita ,&nbsp;Kosuke Murayama ,&nbsp;Yuya Miyakura ,&nbsp;Satoshi Kubota ,&nbsp;Ryosuke Sato ,&nbsp;Shino Godo ,&nbsp;Hiroki Tomizawa ,&nbsp;Satoshi Toyoma ,&nbsp;Ai Tagawa ,&nbsp;Akina Shirotori ,&nbsp;Yukio Katori","doi":"10.1016/j.oraloncology.2024.107131","DOIUrl":"10.1016/j.oraloncology.2024.107131","url":null,"abstract":"<div><h3>Objectives</h3><div>Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery.</div></div><div><h3>Material and Methods</h3><div>A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study. Predictors affecting recurrence and survival were identified by univariate and multivariate Cox regression analyses. Age, sex, primary site, histological type, pathological T status, surgical margin, lymph node metastasis, extranodal extension, and postoperative radiotherapy were the variables evaluated.</div></div><div><h3>Results</h3><div>Multivariate Cox regression analysis showed that increasing age, submandibular cancer, pathological T status 3 or 4, positive surgical margin, and lymph node metastasis, especially with extranodal extension, were independent risk factors for both recurrence and survival. Sublingual cancer was an independent risk factor for recurrence. Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis, and adenoid cystic carcinoma was associated with a good prognosis.</div></div><div><h3>Conclusion</h3><div>Lymph node metastasis with extranodal extension was the most important prognostic factor affecting both recurrence and survival after surgery, adenoid cystic carcinoma was associated with a good prognosis, and postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107131"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma” [Oral Oncol. 47(7) (2011) 601–608]","authors":"Jin Wang ,&nbsp;Hong Chen ,&nbsp;Shuang Fu ,&nbsp;Zhen-Ming Xu ,&nbsp;Kai-Lai Sun ,&nbsp;Wei-Neng Fu","doi":"10.1016/j.oraloncology.2024.107124","DOIUrl":"10.1016/j.oraloncology.2024.107124","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107124"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Time to treatment for head and neck cancer patients decreased during the early phase of the COVID-19 pandemic”","authors":"Lucas Alves da Mota Santana,&nbsp;Marina dos Santos Barreto,&nbsp;Gilmagno Amado Santos,&nbsp;Rajiv Gandhi Gopalsamy,&nbsp;Bernardo Ferreira Brasileiro,&nbsp;Cleverson Luciano Trento,&nbsp;Lysandro Pinto Borges","doi":"10.1016/j.oraloncology.2024.107134","DOIUrl":"10.1016/j.oraloncology.2024.107134","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107134"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical complications and functional outcomes of 3191 jejunal free flaps used for reconstruction of circumferential defects following head and neck cancer resections: A systematic review","authors":"Sarah Mortaja ,&nbsp;Francesca Angela Chiumenti ,&nbsp;Deepak M. Kalaskar ,&nbsp;Raghav C. Dwivedi","doi":"10.1016/j.oraloncology.2024.107130","DOIUrl":"10.1016/j.oraloncology.2024.107130","url":null,"abstract":"<div><div>Pedicled, fasciocutaneous and visceral flaps are all widely adopted for reconstruction after ablative surgery for advanced laryngeal, hypopharyngeal and cervical oesophageal cancers. With multiple options available, the choice depends on type and extent of the defect, patient’s general conditions and institution expertise or preference.</div><div>Since its first description in 1959, the use of jejunal free flap (JFF) has been refined thanks to the introduction of microvascular anastomoses, progressively allowing to achieve low mortality and morbidity rates. Both swallowing and speech outcomes are also positively reported across studies.</div><div>A systematic review of English literature on JFF in H&amp;N cancer reconstruction published after 2000 was carried out on Medline and Embase. Thirty-six studies were included in the analysis with a total of 3191 JFF reconstructions. Primary outcomes were surgical complications and functional outcomes (quality of speech and oral alimentation). A cumulative review was created pooling complication rates reported in single studies, and overall rates were obtained for fistulas (11.39%), strictures (14.17%), total and partial flap failure (4.79 and 6.15% respectively) and perioperative mortality (3.1%). Functional outcomes were variably reported, with different qualitative and quantitative assessment methods showing overall positive results. When reported, we’ve included impact of adjuvant radiotherapy and the ability of JFF to tolerate it has been widely confirmed. Above results have also been compared with same outcomes registered for different flaps.</div><div>Overall, studies over the past 20 years demonstrate good clinical and functional outcomes, proving JFF to be a reliable and safe method for reconstructing circumferential pharyngoesophageal defects.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107130"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting macrophage migration inhibitory factor to inhibit T cell immunosuppression in the tumor microenvironment and improve cancer outcomes in head and neck squamous cell carcinoma","authors":"S. Hasan Pracha ,&nbsp;Suvekshya Shrestha ,&nbsp;Nathan Ryan ,&nbsp;Puja Upadhaya ,&nbsp;Felipe F. Lamenza ,&nbsp;Sushmitha Jagadeesha ,&nbsp;Pete Jordanides ,&nbsp;Peyton Roth ,&nbsp;Anna Springer ,&nbsp;Steve Oghumu","doi":"10.1016/j.oraloncology.2024.107126","DOIUrl":"10.1016/j.oraloncology.2024.107126","url":null,"abstract":"<div><div>Head and neck squamous cell carcinoma (HNSCC) is the 7th most common cancer globally with a 40–50 % survival rate. Although macrophage migration inhibitory factor (MIF) is overexpressed in most solid tumors and promotes tumor growth and invasion, the therapeutic potential of MIF inhibition in HNSCC is yet to be explored. In this study, we investigated the efficacy of CPSI-1306, a small-molecule MIF inhibitor, on HNSCC cell growth and cancer associated signaling pathways <em>in vitro</em>, as well as its impact on T cells in the HNSCC tumor microenvironment <em>in vivo</em>. CPSI-1306 did not reduce HNSCC cell proliferation <em>in vitro</em>, and mildly decreased VEGF and EGFR expression. However, CPSI-1306 significantly reduced tumor development in two orthotopic mouse oral cancer (MOC-2 and MOC-1) HNSCC models. Interestingly, CPSI-1306 treatment increased T cell infiltration to the tumor microenvironment and completely abrogated immunosuppressive checkpoint markers TIGIT, TIM3, and CTLA-4, but not PD-1 on tumor infiltrating CD8⁺ T cells. This was accompanied by increased CD8⁺ T cell expression of antitumoral cytokines IFN-γ and TNF-α in the draining lymph nodes and Granzyme B in the tumor microenvironment of CPSI-1306 treated tumor bearing mice. Our studies demonstrate that the small molecule MIF inhibitor CPSI-1306 potently inhibits T cell immunosuppression in the tumor microenvironment and reduces tumor growth in HNSCC. These studies open a novel therapeutic option for modulating anti-tumoral T cell immunity to improve HNSCC outcomes by targeting MIF.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107126"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic gastrostomy tube during chemoradiation for head and neck cancer decreases weight loss but increases rate of tube use beyond six months","authors":"Neil D. Almeida ,&nbsp;Han Yu ,&nbsp;Austin J. Iovoli ,&nbsp;Mengyu Fang ,&nbsp;Tyler V. Schrand ,&nbsp;Abigail Pepin ,&nbsp;Vishal Gupta ,&nbsp;Kimberly E. Wooten ,&nbsp;Michael R. Markiewicz ,&nbsp;Ryan P. McSpadden ,&nbsp;Wesley L. Hicks Jr ,&nbsp;Mark K. Farrugia ,&nbsp;Anurag K. Singh","doi":"10.1016/j.oraloncology.2024.107136","DOIUrl":"10.1016/j.oraloncology.2024.107136","url":null,"abstract":"<div><h3>Importance</h3><div>The role of prophylactic percutaneous endoscopic gastrostomy (PEG) tube placement in head and neck cancer (HNC) patients treated with chemoradiation remains controversial and varies by center.</div></div><div><h3>Objective</h3><div>To evaluate the impact of prophylactic PEG tube placement in patients undergoing chemoradiation for HNC PEG tube use for more than 6 months and weight loss.</div></div><div><h3>Design, Setting, and Participants</h3><div>This single-institution retrospective study included 502 patients with head and neck cancer.</div></div><div><h3>Exposures</h3><div>Concurrent Chemoradiation (CCRT) and prophylactic PEG tube placement.</div></div><div><h3>Main Outcomes and Measures</h3><div>Univariate analyses were performed to determine risk factors for long term PEG tube and weight loss. Outcomes that were significantly associated with prophylactic PEG were selected for a multivariate analysis. The Kaplan-Meier method was used to estimate survival and the time to PEG removal, with comparisons between groups analyzed by log-rank tests. The global health status score from the EORTC QLQ30 was utilized to assess impact on quality of life.</div></div><div><h3>Results</h3><div>Significantly higher weight loss was seen with the following variables: 1) omitting prophylactic PEG tube (p &lt; 0.00001), 2) younger age (p = 0.0032), and 3) adjuvant CCRT (p = 0.0005). There was significantly higher risk of feeding tube duration longer than 6 months in those who: received prophylactic PEG tube (p &lt; 0.0001) and were older than the median age of 60.8 years (p = 0.0165) on multivariate analysis. Prophylactic PEG tube was not associated with improved global health status, overall survival, or progression-free survival on univariate analysis.</div></div><div><h3>Conclusions and Relevance</h3><div>Prophylactic feeding tubes significantly decreased weight loss during treatment. Prophylactic PEG tube and older than median age was significantly associated with higher risk of feeding tube duration longer than 6 months.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107136"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 10 %-rule debate: A fresh perspective on sentinel lymph node biopsy in OSCC","authors":"Carlos M. Ardila,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.oraloncology.2024.107141","DOIUrl":"10.1016/j.oraloncology.2024.107141","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107141"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal profiling uncovers tertiary lymphoid structures as a critical determinant of immunotherapy response and prognosis in nasopharyngeal carcinoma","authors":"Hui Li ,&nbsp;Liming Lou ,&nbsp;Juan Du ,&nbsp;Mei Li ,&nbsp;Xianhui Wen ,&nbsp;Yuan Zhang ,&nbsp;Songran Liu ,&nbsp;Zi-Qi Zheng ,&nbsp;Xu Liu","doi":"10.1016/j.oraloncology.2024.107129","DOIUrl":"10.1016/j.oraloncology.2024.107129","url":null,"abstract":"<div><div>Nasopharyngeal carcinoma (NPC), historically termed ‘lymphoepithelioma-like carcinoma’ due to its rich lymphocyte infiltration, benefit from PD-1 blockade treatment. However, a comprehensive understanding of its tumor microenvironment (TME) remains elusive, hindering the identification of effective biomarkers for immunotherapy. We leveraged multimodal profiling data, including gene expression, immunohistochemistry, and multiplex immunohistochemistry, from three independent cohorts of NPC patients with a total of 327 patients to dissect the TME in NPC. Unsupervised hierarchical clustering of TME cell populations in the discovery cohort revealed two novel subtypes with distinct prognosis: ‘Immune Inflamed’ and ‘Immune Deficient’. Intriguingly, the most significant differences between the two subtypes were the abundance of B cells and tertiary lymphoid structures (TLS), with a nearly two-fold increase in TLS presence in the Immune Inflamed subtype. The prognostic significance of TLS was confirmed in three independent NPC cohorts, surpassing the prognostic value of individual immune cell subsets. Mechanistically, TLS enhanced anti-tumor immunity by increasing T and B cell receptor repertoire diversity, promoting infiltration of plasma cells, macrophages, and natural killer cells, and consequently increasing antibody-dependent cell-mediated cytotoxicity and antibody-dependent phagocytosis. Finally, TLS status robustly predicted prognosis in a cohort of NPC patients treated with PD-1 blockade, and its prognostic value was consistent across a pan-cancer immunotherapy cohort of 10 tumors and 1158 patients, although with context-specific effects depending on cancer type and immunotherapy modality. In conclusion, this study provides compelling evidence that TLS is a robust indicator of overall immune response within TME and have great potential to guide individualized immunotherapy.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107129"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering molecular relapse and intra-tumor heterogeneity in non-metastatic resectable head and neck squamous cell carcinoma using circulating tumor DNA","authors":"Grégoire Marret ,&nbsp;Constance Lamy ,&nbsp;Sophie Vacher ,&nbsp;Luc Cabel ,&nbsp;Mathieu Séné ,&nbsp;Ladidi Ahmanache ,&nbsp;Laura Courtois ,&nbsp;Zakhia El Beaino ,&nbsp;Jerzy Klijanienko ,&nbsp;Charlotte Martinat ,&nbsp;Nicolas Servant ,&nbsp;Choumouss Kamoun ,&nbsp;Maral Halladjian ,&nbsp;Thierry Bronzini ,&nbsp;Cédric Balsat ,&nbsp;Jean-François Laes ,&nbsp;Aubray Prévot ,&nbsp;Sébastien Sauvage ,&nbsp;Maxime Lienard ,&nbsp;Emmanuel Martin ,&nbsp;Maud Kamal","doi":"10.1016/j.oraloncology.2024.107111","DOIUrl":"10.1016/j.oraloncology.2024.107111","url":null,"abstract":"<div><h3>Objectives</h3><div>Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genetic intra-tumor heterogeneity (ITH), which may hinder precision medicine strategies that depend on results from single tumor-biopsy specimens. Treatment response assessment relies on radiologic imaging, which cannot detect minimal residual disease (MRD). We assessed the relevance of circulating tumor DNA (ctDNA) as a biomarker for ITH and MRD in HNSCC.</div></div><div><h3>Materials and methods</h3><div>We recruited 41 non-metastatic resectable HNSCC patients treated with upfront curative-intent surgery in the prospective biobanking SCANDARE study (NCT03017573). Thirty-one patients (76 %) showed recurrent disease at a median follow-up of 41 months. Targeted next-generation sequencing was performed on resected tumor tissues, as well as on serial blood samples obtained at surgery, within 14 weeks after surgery, at six months and at recurrence.</div></div><div><h3>Results</h3><div>ctDNA was detected in 21/41 patients at surgery (sensitivity: 51 %; 95 % CI, 35–67 %) and 15/22 patients at recurrence (sensitivity: 68 %; 95 % confidence interval [CI], 45–86 %). Among patients with mutations identified in longitudinal plasma samples, additional mutations missed in tumor tissues were reported in 3/21 patients (14 %), while emerging mutations were reported in 9/21 patients (43 %). In the postoperative surveillance setting, ctDNA-based MRD detection anticipated clinical recurrence with a median lead-time of 9.9 months (interquartile range, 8.0–14.5 months) in 17/27 patients (63 %). When detected within 14 weeks after surgery, MRD correlated with disease recurrence after adjusting for classical prognostic variables (HR = 3.0; 95 % CI, 1.1–7.9; <em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>ctDNA detection is a useful biomarker for ITH and MRD in resectable HNSCC patients.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107111"},"PeriodicalIF":4.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous adenoid cystic carcinoma in the submandibular gland and tongue: A rare case report","authors":"Flávia Sirotheau Corrêa Pontes ,&nbsp;Emilie Christina Teixeira de Barros ,&nbsp;Thaís da Silva Fonseca ,&nbsp;Igor Mesquita Lameira ,&nbsp;Anderson Maurício Paiva e Costa ,&nbsp;Douglas Fabrício da Silva Farias ,&nbsp;Hélder Antônio Rebelo Pontes","doi":"10.1016/j.oraloncology.2024.107128","DOIUrl":"10.1016/j.oraloncology.2024.107128","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107128"},"PeriodicalIF":4.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}