Oral oncologyPub Date : 2024-10-01DOI: 10.1016/j.oraloncology.2024.107063
Akashanand , Quazi Syed Zahiruddin , Diptismita Jena , Suhas Ballal , Sanjay Kumar , Mahakshit Bhat , Shilpa Sharma , M. Ravi Kumar , Sarvesh Rustagi , Abhay M. Gaidhane , Lara Jain , Sanjit Sah , Muhammed Shabil
{"title":"Burden of oral cancer and associated risk factors at national and state levels: A systematic analysis from the global burden of disease in India, 1990–2021","authors":"Akashanand , Quazi Syed Zahiruddin , Diptismita Jena , Suhas Ballal , Sanjay Kumar , Mahakshit Bhat , Shilpa Sharma , M. Ravi Kumar , Sarvesh Rustagi , Abhay M. Gaidhane , Lara Jain , Sanjit Sah , Muhammed Shabil","doi":"10.1016/j.oraloncology.2024.107063","DOIUrl":"10.1016/j.oraloncology.2024.107063","url":null,"abstract":"<div><h3>Background</h3><div>Oral cancer is the sixth most prevalent cancer globally, posing a significant health concern, especially in India, where it accounts for one-third of the global cases. Despite high incidence and mortality rates, comprehensive national and regional data on risk factors and trends are scarce.</div></div><div><h3>Methods</h3><div>This study analyzed data from the Global Burden of Disease (GBD) 2021 report, focusing on the age-standardized incidence rate (ASIR), mortality rate (ASMR), disability-adjusted life years (ASDR), and prevalence rate (ASPR) of oral cancer in India from 1990 to 2021. Joinpoint regression analysis was used to assess trends, and ARIMA models were applied to forecast future trends from 2022 to 2031.</div></div><div><h3>Results</h3><div>From 1990 to 2021, India experienced a moderate increase in oral cancer mortality, with ASMR rising from 5.32 to 5.92, reflecting an annual percentage change (APC) of 11.18 %. ASDR increased from 152.94 to 163.61 (APC of 6.98 %), and ASPR showed a marked rise from 15.71 to 25.46 (APC of 62.06 %). The burden varied significantly across states. Gender disparities were observed, with males consistently exhibiting higher incidence and mortality rates. ARIMA forecasts projected an upward trend in oral cancer metrics from 2022 to 2031, with ASIR expected to reach 10.15 per 100,000 and ASPR 29.38 per 100,000 by 2031.</div></div><div><h3>Conclusions</h3><div>The study reveals a persistent and growing burden of oral cancer in India, highlighting the influence of lifestyle and socioeconomic factors. Targeted strategies to mitigate risk behaviors, improve early detection, and address disparities are urgently needed to reduce the disease’s impact.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107063"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-29DOI: 10.1016/j.oraloncology.2024.107041
Katherine Keefe , Hilary C. McCrary , Mei Wei , Bayarmaa Mark , Sarah Drejet , Richard B. Cannon , Luke O. Buchmann , Jason P. Hunt , Mark Dodson , Vikrant Deshmukh , Michael Newman , Marcus M. Monroe , Mia Hashibe
{"title":"Risk of cardiovascular disease among head and neck cancer survivors: A population-based matched cohort study","authors":"Katherine Keefe , Hilary C. McCrary , Mei Wei , Bayarmaa Mark , Sarah Drejet , Richard B. Cannon , Luke O. Buchmann , Jason P. Hunt , Mark Dodson , Vikrant Deshmukh , Michael Newman , Marcus M. Monroe , Mia Hashibe","doi":"10.1016/j.oraloncology.2024.107041","DOIUrl":"10.1016/j.oraloncology.2024.107041","url":null,"abstract":"<div><h3>Background</h3><div>In the United States, approximately 63,000 Americans develop head and neck cancer (HNC) annually. Our study aims were to investigate cardiovascular complications and risk factors for development of CVD among HNC survivors.</div></div><div><h3>Methods</h3><div>Utilizing the Utah Populations Database, a total of 1,901 HNC patients diagnosed and 7,796 birth year, sex, and birth state matched individuals from the general population were identified. Multivariate Cox proportional hazard models were used.</div></div><div><h3>Results</h3><div>Within the first two years after cancer diagnosis, HNC survivors had a higher likelihood of developing cardiovascular disease (CVD). High Charleston Comorbidity Index (CCI) score at baseline (Hazard Ratio (HR) 1.67, 95 % 1.28–2.17), stage II and IV disease (HR 1.80, 95 % 1.29–2.51), age >=65 years old (HR 2.31, 95 % 1.85–2.88), chemotherapy (HR 1.47, 95 % 1.15–1.88) were associated with increased CVD risk.</div></div><div><h3>Conclusions</h3><div>Compared to the general population, HNC survivors were more likely to develop cardiovascular diseases, particularly if they had the following risk factors: older age, stage II or IV cancer, high baseline CCI score, and chemotherapy were risk factors for development of CVD.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107041"},"PeriodicalIF":4.0,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-29DOI: 10.1016/j.oraloncology.2024.107047
Jérôme R. Lechien
{"title":"Surgical, Functional, and oncological outcomes of transoral robotic surgery for cT1-T3 supraglottic laryngeal Cancers: A systematic review","authors":"Jérôme R. Lechien","doi":"10.1016/j.oraloncology.2024.107047","DOIUrl":"10.1016/j.oraloncology.2024.107047","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review investigated the surgical, functional, and oncological outcomes of transoral robotic supraglottic laryngectomy (TORS-SGL) for cT1-T3 laryngeal squamous cell carcinoma (LSCC).</div></div><div><h3>Methods</h3><div>Two investigators conducted an updated PubMed, Scopus, and Cochrane Library systematic review for studies investigating the surgical, functional, and oncological outcomes of TORS-SGL using the PRISMA statements. The bias analysis was conducted with the MINORS.</div></div><div><h3>Results</h3><div>Twenty-one studies were included, accounting for 896 patients. TORS-SGL was primarily performed for cT1 (39.1 %), cT2 (46.9 %), and some selected cT3 (7.7 %) LSCCs. Surgical margins were positive in 10.8 % of cases. The mean hospital stay was 8.6 days. Hemorrhage (6.3 %), pneumonia (5.5 %), and aspiration (1.7 %) are the primary complications. The surgical margins were positive in 10.6 % of cases. Feeding tubes, temporary tracheotomy, and definitive percutaneous gastrostomy are found in 65.6 %, 19.7 %, and 5.2 % of patients, respectively. The oral diet is restarted after a mean of 7.2 days. The 5-year OS and DFS of TORS-SGL were estimated to be 78.3 %, and 91.7 %, with 5-year local-relapse-free survival and nodal-relapse-free survival of 90.8 %, and 86.6 %, respectively.</div></div><div><h3>Conclusion</h3><div>The TORS-SGL is a safe, and effective surgical approach for cT1-T3 SGL. The functional and surgical outcomes appear comparable with TOLM-SGL. The oncological outcomes of TORS-SGL could be better than TOLM and open SGLs, but further large cohort-controlled studies are needed to draw reliable conclusions.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107047"},"PeriodicalIF":4.0,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-28DOI: 10.1016/j.oraloncology.2024.107056
Haosen Lian , Yufei Hua , Grace Paka Lubamba , Gaowei Zhang , Mingzhe Bao , Guanru Wang , Guile Zhao , Ning Gao , Bing Yan , Chunjie Li
{"title":"Reconstruction of extensive lower lip defects using vascularized mucosal flap with external skin complex tissue","authors":"Haosen Lian , Yufei Hua , Grace Paka Lubamba , Gaowei Zhang , Mingzhe Bao , Guanru Wang , Guile Zhao , Ning Gao , Bing Yan , Chunjie Li","doi":"10.1016/j.oraloncology.2024.107056","DOIUrl":"10.1016/j.oraloncology.2024.107056","url":null,"abstract":"<div><h3>Background</h3><div>The complexity of lip anatomy and the roles played by the lip make the reconstruction of lip defects more challenging. Adequate reconstruction of lip defects requires adaptation of mucosa, vermilion, and skin features in lip as well as its specific function.</div></div><div><h3>Methods</h3><div>A 59-year-old male with left lower lip cancer underwent en-bloc resection and left selective neck dissection (SND), followed by immediate reconstruction using Facial Artery Myomucosal Island Flap (FAMMIF) with external Skin Complex Tissue.</div></div><div><h3>Results</h3><div>The use of chimeric flap based on FAMMIF and its external skin tissue allowed minimizing the postoperative problem of combination of both aesthetic and functional impairments. The FAMMIF is suitable for the reconstruction of lip mucosa and lip vermilion, while the external skin tissue can be use to replace the external lip skin defect. The patient was satisfied with the treatment outcomes. He is undergoing follow-up without any evidence of recurrence.</div></div><div><h3>Conclusion</h3><div>FAMMIF with external skin complex tissue, as a reconstructive approach selected in our case of lip defect secondary to lip cancer resection, combined the reconstruction of both aesthetics and functions of the lower lip. The technique was found feasible and provided satisfactory postoperative outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107056"},"PeriodicalIF":4.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-27DOI: 10.1016/j.oraloncology.2024.107053
Siva Dharshini Rajathirajan
{"title":"Commentary on “Salivary DNA methylation derived estimates of biological aging, cellular frequency and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2024.107053","DOIUrl":"10.1016/j.oraloncology.2024.107053","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107053"},"PeriodicalIF":4.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-27DOI: 10.1016/j.oraloncology.2024.107046
Jun Young Kim , Younghac Kim , Eun Hye Kim , Man Ki Chung , Han-Sin Jeong , Chung-Hwan Baek , Young-Ik Son , Nayeon Choi
{"title":"Initial negative resection margin versus revised negative resection margin in patients who underwent surgery without adjuvant therapy for early-stage oral tongue squamous cell carcinoma","authors":"Jun Young Kim , Younghac Kim , Eun Hye Kim , Man Ki Chung , Han-Sin Jeong , Chung-Hwan Baek , Young-Ik Son , Nayeon Choi","doi":"10.1016/j.oraloncology.2024.107046","DOIUrl":"10.1016/j.oraloncology.2024.107046","url":null,"abstract":"<div><h3>Background</h3><div>In cases of positive resection margin (RM), re-resection is generally recommended. There has been controversy about the oncologic impact of revised negative RMs after re-resection. The aim of this study was to investigate the oncologic impact of revised negative RM in patients who underwent surgery without adjuvant therapy for early-stage (pT1-2/N0) oral tongue squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with pT1-2 N0 OSCC who did not receive adjuvant therapy (N=441). These patients were classified into an initial negative RM (R0, n = 380) group and a revised negative RM (R1-R0, n = 61) group. Demographic and clinical data (T stage, tumor length, depth of invasion [DOI], lymphovascular invasion [LVI], perineural invasion [PNI], and recurrence) were compared between the R0 and R1-R0 groups.</div></div><div><h3>Results</h3><div>Age, sex, T stage, DOI, LVI, PNI, and SUVmax were not significantly different between the two groups. Local recurrence was more frequent (<em>P</em>=0.045) in the R1-R0 group (13.1 %) than in the R0 group (5.5 %). Local recurrence-free survival was better in the R0 group than in the R1-R0 group (<em>P</em>=0.046). There was no significant difference in overall recurrence or overall survival. On multivariate analysis, initial positive RM was the independent significant risk factor (hazard ratio, 2.249; 95 % confidence interval, 1.025–4.935; <em>P</em>=0.043) for local recurrence.</div></div><div><h3>Conclusion</h3><div>A revised clear RM after initial cut-through margin is a risk factor for local recurrence in early-stage OSCC. Cautious should be considered in early-stage OSCC patients with revised clear RM.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107046"},"PeriodicalIF":4.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-27DOI: 10.1016/j.oraloncology.2024.107049
Wenjiao Lyu , Jing Gong , Lin Zhu , Tingting Xu , Shenglin Huang , Chunying Shen , Cuihong Wang , Xiayun He , Hongmei Ying , Chaosu Hu , Yu Wang , Qinghai Ji , Yajia Gu , Xin Zhou , Xueguan Lu
{"title":"MR radiomics unveils neoadjuvant chemo-responsiveness with insights into selective treatment de-intensification in HPV-positive oropharyngeal carcinoma","authors":"Wenjiao Lyu , Jing Gong , Lin Zhu , Tingting Xu , Shenglin Huang , Chunying Shen , Cuihong Wang , Xiayun He , Hongmei Ying , Chaosu Hu , Yu Wang , Qinghai Ji , Yajia Gu , Xin Zhou , Xueguan Lu","doi":"10.1016/j.oraloncology.2024.107049","DOIUrl":"10.1016/j.oraloncology.2024.107049","url":null,"abstract":"<div><h3>Background</h3><div>Accurate prediction of neoadjuvant chemotherapy (NAC) response allows for NAC-guided personalized treatment de-intensification in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). In this study, we aimed to apply baseline MR radiomic features to predict NAC response to help select NAC-guided de-intensification candidates, and to explore biological underpinnings of response-oriented radiomics.</div></div><div><h3>Methods</h3><div>Pre-treatment MR images and clinical data of 131 patients with HPV-positive OPSCC were retrieved from Fudan University Shanghai Cancer Center. Patients were divided into training cohort (n = 47), validation cohort 1 (n = 49) from NAC response-adapted de-intensification trial (IChoice-01, NCT04012502) and real-world validation cohort 2 (n = 35). NAC prediction model using linear support vector machine (SVM) was built and validated. Subsequent nomograms combined radiomics and clinical characteristics were established to predict survival outcomes. RNA-seq and proteomic data were compared to interpret the molecular features underlying radiomic signatures with differential NAC response.</div></div><div><h3>Findings</h3><div>For NAC response prediction, the fusion model with both oropharyngeal and nodal signatures achieved encouraging performance to predict good responders in the training cohort (AUC 0·89, 95% CI, 0·79-0·95) and validation cohort 1 (AUC 0·71, 95% CI, 0·59-0·83). For prognosis prediction, radiomics-based nomograms exhibited satisfactory discriminative ability between low-risk and high-risk patients (PFS, C-index 0·85, 0·76 and 0·83; OS, C-index 0·79, 0·76 and 0·87, respectively) in three cohorts. Expression analysis unveiled NAC poor responders had predominantly enhanced keratinization while good responders were featured by upregulated immune response and oxidative stress.</div></div><div><h3>Interpretation</h3><div>The MR-based radiomic models and prognostic models efficiently discriminate among patients with different NAC response and survival risk, which help candidate selection in HPV-positive OPSCC with regard to personalized treatment de-intensification.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107049"},"PeriodicalIF":4.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-26DOI: 10.1016/j.oraloncology.2024.107045
Ayham Al Afif , Philip Rosen , Jae Gardella , Timothy G. Norwood , Adam Abbas , Lindsay S. Moore , Jessica W. Grayson , Kristine E. Day , Andrew C. Prince , Benjamin J. Greene , William R. Carroll , Sejong Bae
{"title":"Predicting outcomes in head and neck surgery with modified frailty index and surgical apgar scores","authors":"Ayham Al Afif , Philip Rosen , Jae Gardella , Timothy G. Norwood , Adam Abbas , Lindsay S. Moore , Jessica W. Grayson , Kristine E. Day , Andrew C. Prince , Benjamin J. Greene , William R. Carroll , Sejong Bae","doi":"10.1016/j.oraloncology.2024.107045","DOIUrl":"10.1016/j.oraloncology.2024.107045","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the efficacy of the Modified Frailty Index and Modified Surgical Apgar scores in predicting postoperative outcomes in head and neck cancer patients.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed patients who underwent major head and neck surgery between 2012 and 2015. Modified Surgical Apgar, and Frailty Index, scores were calculated on 723 patients. The primary outcome was 30-day complication and/or mortality.</div></div><div><h3>Results</h3><div>The mean Modified Frailty Index was 0.11 ± 0.12, and mean Modified Surgical Apgar score was 6.15 ± 1.67. Both scores were significantly associated with 30-day complication (P<0.05). The Modified Surgical Apgar score was superior to the Modified Frailty Index in predicting complications (Area Under the Curve (AUC) = 0.76; 95 % Confidence Interval (CI), 0.722–0.793; and AUC=0.59; 95 % CI, 0.548–0.633, respectively). Concurrent use of both scoring systems (AUC=0.77) was not superior to individual use. An increase in the mFI from 0.27 to 0.36 was associated with an increase in the risk of complication postoperatively (Odds Ratio (OR) = 3.67; 95 % CI, 1.30–10.34, P=.014). A reduction in the mSAS from 7 to 6 increased the risk of complication following surgery (OR=2.64; 95 % CI, 1.45–4.80; P=.002).</div></div><div><h3>Conclusion</h3><div>Both scores are useful in risk stratifying head and neck cancer patients. The Modified Surgical Apgar score was superior at predicting complications; concurrent use of both scores added minimal benefit.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107045"},"PeriodicalIF":4.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-26DOI: 10.1016/j.oraloncology.2024.107029
Maria Eduarda Pérez-de-Oliveira , Vivian Petersen Wagner , Colin D. Bingle , Pablo Agustin Vargas , Lynne Bingle
{"title":"Disruption of oncogenic pathways in mucoepidermoid carcinoma: CREB inhibitor 666.15 as a potential therapeutic agent","authors":"Maria Eduarda Pérez-de-Oliveira , Vivian Petersen Wagner , Colin D. Bingle , Pablo Agustin Vargas , Lynne Bingle","doi":"10.1016/j.oraloncology.2024.107029","DOIUrl":"10.1016/j.oraloncology.2024.107029","url":null,"abstract":"<div><div><strong>Objectives:</strong> Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour with around 50 % of cases carrying the CRTC1-MAML2 translocation. The CREB pathway has been associated with the transforming activity of this translocation. The aim of this study was to determine the effects of CREB inhibition on MEC cell behaviour <em>in vitro</em>. <strong>Material and Methods:</strong> Two translocation-positive (UM-HMC-2 and H292) and one translocation-negative (H253) MEC cell lines were treated with 666.15, a CREB inhibitor. Drug IC50 doses were determined for each cell line. Clonogenic and spheroid assays were used to assess survival, including percentage of cancer stem cells, and transwell and scratch assays evaluated invasive and migratory capacities, respectively. Immunofluorescence staining was used to determine E-cadherin expression. <strong>Results:</strong> CREB inhibition significantly reduced the number of surviving colonies and spheroids and delayed cell invasion in all cell lines, but this was more significant in the fusion positive, UM-HMC-2 cells. The expression of E-cadherin was significantly higher in treated UM-HMC-2 and H292 cells. <strong>Conclusion:</strong> CREB inhibition with 666.15 impaired key MEC oncogenic behaviours associated with metastasis and drug resistance, including cell invasion and survival.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107029"},"PeriodicalIF":4.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral oncologyPub Date : 2024-09-25DOI: 10.1016/j.oraloncology.2024.107044
Kajal Mahto , Gaurav Kumar Goldar , Akash Varshney , Manu Malhotra , Madhu Priya , Amit Kumar , Bhinyaram , Ashok Singh , Abhishek Bhardwaj , G. Vetrivel , Subrata Nag , Amit Kumar Tyagi
{"title":"Achieving negative superficial resection margins with NBI and white light in carcinoma oral cavity: Could it be a norm?","authors":"Kajal Mahto , Gaurav Kumar Goldar , Akash Varshney , Manu Malhotra , Madhu Priya , Amit Kumar , Bhinyaram , Ashok Singh , Abhishek Bhardwaj , G. Vetrivel , Subrata Nag , Amit Kumar Tyagi","doi":"10.1016/j.oraloncology.2024.107044","DOIUrl":"10.1016/j.oraloncology.2024.107044","url":null,"abstract":"<div><h3>Introduction</h3><div>In India, oral cavity cancer rates are the highest, largely due to tobacco and areca nut use. The primary goal of oncologic surgery is complete tumor resection with adequate margins, yet no accepted guidelines exist margin identification. NBI enhances mucosal lesion detection and may improve margin assessment in OSCC.</div></div><div><h3>Aims</h3><div>This study aims to evaluate the proportion of negative superficial resection margins using NBI and to compare these results with margins assessed using white light (WL) examination.</div></div><div><h3>Materials and Methods</h3><div>The study at AIIMS, Rishikesh, included 38 patients with T1-T3 biopsy-proven OSCC. Surgical margins were marked using WL and NBI. Histopathology classified margins as clear (>5mm), close (1–5 mm), or involved. Sensitivity, specificity, and predictive values of NBI were calculated.</div></div><div><h3>Results</h3><div>The average NBI examination duration was 227 s. Negative margins were achieved in 68.42 % (>5mm) and 78.94 % (>3mm) of NBI cases, compared to 71.05 % and 84.21 % for WL. NBI had a sensitivity of 12.50 %, specificity of 96.67 %, and overall accuracy of 78.95 %.</div></div><div><h3>Discussion</h3><div>NBI showed high specificity but low sensitivity. This could be due to the smaller number of patients in NBI positive group. In the present study, the single positive margin identified with NBI could also have been detected with the combined approach of white light and palpation, ensuring that no positive margins were missed.</div></div><div><h3>Conclusion</h3><div>NBI can complement WL for margin assessment in oral SCC but requires a long learning curve and a dedicated team. Integrating NBI into standard protocols could improve surgical outcomes and reduce recurrence.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107044"},"PeriodicalIF":4.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}