Microscopic findings in oral squamous cell carcinoma with cystic spaces and clear cells mimicking mucoepidermoid carcinoma: A detailed case report

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-02-28 DOI:10.1016/j.oraloncology.2025.107230

Moisés Willian Aparecido Gonçalves , Iara Vieira Ferreira , Maria Clara Falcão Ribeiro-de-Assis , Carlos Takahiro Chone , Natália Vital Gonçalves , Albina Altemani , Fernanda Viviane Mariano

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引用次数: 0

Abstract

A 62-year-old male was referred for management of oral squamous cell carcinoma (OSCC), previously diagnosed in another service. The patient complained of persistent oral discomfort for 10 months, reported being a social drinker, and denied smoking. Intraoral examination revealed a vegetating, hardened lesion, measuring 3.0 cm, in transition between the retromolar trigone, soft palate, and buccal mucosa. Microscopic examination of the incisional biopsy performed previously revealed malignant epithelial cells proliferate and invade the surrounding stroma as islands and cords of epithelial cells, with the presence of cystic spaces and clear cells, resembling mucoepidermoid carcinoma (MEC). The histological findings led to a diagnosis of MEC or OSCC. Based on the correlation between the morphological, immunohistochemical, and histochemical findings, the diagnosis of OSCC with cystic spaces and clear cells was supported. The patient was referred for further therapeutic intervention. Recognizing the histological variants of OSCC is important, due to the similarity with other neoplasms.

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.