Oral oncology最新文献

{"title":"The use of 3D computer-aided design to optimize photoimmunotherapy catheter placement","authors":"Kelly Bridgham ,&nbsp;Pablo Llerena ,&nbsp;Ayan Kumar ,&nbsp;Eric Mastrolonardo ,&nbsp;Raphael Banoub ,&nbsp;Travis Clark ,&nbsp;Adam Luginbuhl ,&nbsp;David M. Cognetti ,&nbsp;Joseph M. Curry","doi":"10.1016/j.oraloncology.2025.107365","DOIUrl":"10.1016/j.oraloncology.2025.107365","url":null,"abstract":"<div><h3>Background</h3><div>There is limited information regarding how technical aspects of Photoimmunotherapy (PIT) catheter placement influences outcomes. We hypothesize that optimized 3D models of PIT treatment will demonstrate a higher volume of tumor treated compared to 3D models of actual intraoperative catheter placement.</div></div><div><h3>Methods</h3><div>Clinical and radiographic data were obtained for RM-1929 photoimmunotherapy treated patients at a single institution from March 2016 to August 2021. 3D models were rendered to recreate photoimmunotherapy treatments based on intraoperative images. This was compared to an optimized therapy model for each instance of treatment. Comparisons were made between actual and optimized models based on total volume of tumor treated as well as number of cylindrical diffusers placed per treatment.</div></div><div><h3>Results</h3><div>3D models were generated for 9 PIT treatments in 6 patients. Optimized PIT models (N = 9) were matched and compared to actual PIT models (N = 9). Volume of tumor treated was higher for the optimized model compared to the actual treatment (22.6 vs 13.9 cm³, p = 0.004) with a higher percentage of total tumor volume treated (92.1 % vs 69.0 %, p = 0.004). Approximately 2.8 additional LF diffusors were placed per treatment in the optimized plan (8.0 vs. 5.2, p = 0.033).</div></div><div><h3>Conclusion</h3><div>In this post-hoc analysis, we demonstrate the importance of appropriate catheter placement in PIT as well as the feasibility of 3D computer aided design to simulate PIT catheter placement. Optimized 3D models demonstrated a higher volume of tumor treated compared to actual catheter placement. 3D computer aided design may be a useful adjunct to preoperative planning to optimize PIT catheter placement.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107365"},"PeriodicalIF":4.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating Lymph Node Yield, Lymph Node Ratio, and the number of metastatic nodes as prognostic factors in oral cavity squamous cell carcinoma","authors":"Dean Dudkiewicz ,&nbsp;Nir Tsur ,&nbsp;Dan Yaniv ,&nbsp;Esmat Najjar ,&nbsp;Thomas Shpitzer ,&nbsp;Aviram Mizrachi ,&nbsp;Moshe Yehuda ,&nbsp;Gideon Bachar ,&nbsp;Eyal Yosefof","doi":"10.1016/j.oraloncology.2025.107391","DOIUrl":"10.1016/j.oraloncology.2025.107391","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies of Lymph Node Yield (LNY) for neck dissection in Oral Cavity Squamous Cell Carcinoma (OCSCC) have shown LNY of 18 or more lymph nodes to be of prognostic value. This study aims to evaluate the prognostic implications of LNY, number of metastatic nodes, and Lymph Node Ratio (LNR) in clinical N0 OCSCC.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 118 patients who underwent elective neck dissection for OCSCC at Rabin Medical Center (2000–2020). Demographic, clinical, pathological, and surgical data were collected. We examined the prognostic significance of LNY cutoffs (18 and 13), number of positive nodes, and LNR on disease-free and overall survival.</div></div><div><h3>Results</h3><div>The mean LNY was 19.5 ± 11.3 nodes, with a lymph node metastasis rate of 31.3 %. Statistical analysis showed that neither 18 nor 13 lymph nodes had significant prognostic value for recurrence or survival. The mean LNR was 4.52 % ± 11.3 %, with higher LNR values (&gt;3.4 %) significantly associated with increased recurrence (p = 0.003) and reduced survival intervals (p = 0.003). Cox regression analysis further confirmed that both elevated LNR and the presence of more than two metastatic lymph nodes were independently associated with increased mortality.</div></div><div><h3>Conclusions</h3><div>Our findings challenge the commonly cited LNY threshold of 18, as no specific LNY cutoff conferred significant survival benefits. Instead, LNR emerged as a superior prognostic marker, correlating strongly with overall survival and locoregional control. Incorporating LNR into prognostic models may enhance risk stratification and guide clinical decision-making in OCSCC management.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107391"},"PeriodicalIF":4.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “Tumor-width-to-tongue-width ratio: A novel predictor of cervical lymph node metastasis and prognosis in squamous cell carcinoma of the tongue”","authors":"Siva Dharshini Rajathirajan","doi":"10.1016/j.oraloncology.2025.107390","DOIUrl":"10.1016/j.oraloncology.2025.107390","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107390"},"PeriodicalIF":4.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary squamous carcinoma of the submandibular gland: a rare case report","authors":"Jiaqi Li ,&nbsp;Yuanyuan Liu ,&nbsp;Dan Lv ,&nbsp;Guangsen Li","doi":"10.1016/j.oraloncology.2025.107386","DOIUrl":"10.1016/j.oraloncology.2025.107386","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107386"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Chitosan-Silver-Lignocaine Sheet: A Breakthrough in Managing PMMC flap dehiscence and Pain”","authors":"Manoj Kumar,&nbsp;Kalyani Bhate,&nbsp;Unnati B. Mehta","doi":"10.1016/j.oraloncology.2025.107385","DOIUrl":"10.1016/j.oraloncology.2025.107385","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107385"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between health-related quality of life and five-year overall survival among head and neck cancer patients: A prospective cohort study","authors":"Irma M. Verdonck-de Leeuw ,&nbsp;Birgit I. Lissenberg-Witte ,&nbsp;Remco de Bree ,&nbsp;Laurien M. Buffart ,&nbsp;Jose Hardillo ,&nbsp;Femke Lamers ,&nbsp;Johannes A. Langendijk ,&nbsp;C.René Leemans ,&nbsp;Robert P. Takes ,&nbsp;Femke Jansen","doi":"10.1016/j.oraloncology.2025.107367","DOIUrl":"10.1016/j.oraloncology.2025.107367","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate associations between health-related quality of life (HRQOL) at baseline (T0), six months after treatment (M6), and change in HRQOL (T0-M6) and five-year overall survival (OS) among head and neck cancer (HNC) patients, after adjusting for potential confounders. Furthermore, we explored whether personal, clinical, physical, psychological, social, lifestyle, HNC-related and biological factors moderate the association.</div></div><div><h3>Methods</h3><div>Data of a prospective multi-center cohort study (NET-QUBIC) was used. In this specific study, patients with HRQOL data at T0 (n = 596), M6 (n = 489), and T0 and M6 (n = 463) were included. HRQOL was operationalized by the EORTC QLQ-C30 global quality of life subscale (QL) and summary score (SumSc). Cox regression analyses investigated associations between HRQOL and OS, adjusted for confounders, and explored which variables moderate the association.</div></div><div><h3>Results</h3><div>Adjusted models showed that higher baseline QL (HR: 0.85 (95% CI: 0.76–0.96)) and SumSc (HR: 0.90 (95% CI: 0.81–0.99)) were associated with longer OS. Adjusted M6 models and adjusted T0-M6 models found no such association. The association between QL and OS was moderated by sex (significant among males) and mean arterial blood pressure (BP) (significant for patients with high BP). The association between SumSc and OS was moderated by coping (significant for patients with no avoidant coping style) and systemic BP (significant for patients with normal BP).</div></div><div><h3>Conclusion</h3><div>Higher HRQOL at baseline (how patients enter the cancer trajectory) was associated with longer OS, but (change in) HRQOL at 6 months (how they overcome cancer treatment) was not. This knowledge is important to personalize treatment plans.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107367"},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of clinical and pathologic features associated with extranodal extension in patients with HPV-mediated oropharyngeal squamous cell carcinoma","authors":"Brennan Olson ,&nbsp;Aaron Bogan ,&nbsp;Chadi N Abdel-Halim ,&nbsp;Danelle Rolle-McFarland ,&nbsp;Jeffrey Graves ,&nbsp;Tissiana Vallecillo ,&nbsp;Daniel J. Ma ,&nbsp;Michelle A. Neben-Wittich ,&nbsp;Scott C. Lester ,&nbsp;Mauricio Gamez ,&nbsp;Adam Holtzmann ,&nbsp;Homan Mohammadi ,&nbsp;Joaquin Garcia ,&nbsp;Ashish Chintakuntlawar ,&nbsp;Katharine A. Price ,&nbsp;Harry E. Fuentes Bayne ,&nbsp;Jean Claude M. Rwigema ,&nbsp;Samir H. Patel ,&nbsp;Lisa A. McGee ,&nbsp;Samip Patel ,&nbsp;David M. Routman","doi":"10.1016/j.oraloncology.2025.107308","DOIUrl":"10.1016/j.oraloncology.2025.107308","url":null,"abstract":"<div><h3>Background</h3><div>Extranodal extension (ENE) is an important prognostic factor that is not ascertainable prior to surgical resection of involved lymph node(s) or may not be available in patients with prior excisional biopsies.</div></div><div><h3>Methods</h3><div>This study involved a retrospective analysis of 900 patients diagnosed with HPV(+)OPSCC and treated with primary surgery at a single tertiary care center. Patient demographics, comorbidities, and pathologic characteristics of disease were collected and analyzed. Pathology reports were reviewed to identify ENE. Univariate and multivariate logistic regression models were used to identify factors associated with odds of ENE.</div></div><div><h3>Results</h3><div>ENE was identified in 506/900 (56.2 %) patients. On univariate analysis, increased Adult Comorbidity Evaluation – 27 (p = 0.013), pathologic T-stage (p = 0.012), pathologic N-stage (p &lt; 0.001), count of involved nodes (p &lt; 0.001), size of largest involved node (p &lt; 0.001), and perineural invasion (p = 0.001) were found to be positively associated with increased odds of ENE. On multivariate analysis, count of involved nodes (p &lt; 0.001), size of largest involved node (p &lt; 0.001), and perineural invasion (p = 0.021) were positively associated with increased odds of ENE. Although PNI improved the model’s predictive performance statistically, its exclusion produced similar results. Both predictive models have been made publicly available (<span><span>https://rtools.mayo.edu/prime_ene_prediction/</span><svg><path></path></svg></span>).</div></div><div><h3>Conclusion</h3><div>Increased count of involved lymph nodes, size of largest involved lymph node, and presence of perineural invasion in patients with HPV(+)OPSCC are strongly associated with increased odds of ENE. These data suggest that ENE presence can be reliably predicted using the number and size of involved nodes. Such a predictive model could prove a useful tool in informing treatment strategies for HPV(+)OPSCC patients prior to surgical resection of involved lymph node(s) and those without sufficient pathologic ENE data from prior excisional biopsies.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107308"},"PeriodicalIF":4.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to “Adjuvant treatment in elderly patients undergoing transoral surgery for HPV-related oropharyngeal cancer”","authors":"Jingmin You","doi":"10.1016/j.oraloncology.2025.107345","DOIUrl":"10.1016/j.oraloncology.2025.107345","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107345"},"PeriodicalIF":4.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucinous adenocarcinoma of the base of the tongue: A case report","authors":"João Paulo Gonçalves de Paiva ,&nbsp;Daniela Giraldo Roldán ,&nbsp;Helder Domiciano Dantas Martins ,&nbsp;Paulo Rogério Ferreti Bonan ,&nbsp;Pablo Agustin Vargas","doi":"10.1016/j.oraloncology.2025.107369","DOIUrl":"10.1016/j.oraloncology.2025.107369","url":null,"abstract":"<div><div>A 50-year-old male patient presented with a nodular lesion at the right base of the tongue. An incisional biopsy was performed, and the histopathological evaluation revealed an ill-defined multicystic papillary proliferation of mucin-producing cells. Immunohistochemically, tumor cells were positive for CK7 and negative for CK20, p40, p63, SOX10, SMA, and calponin. The Ki67 proliferation index accounted for about 27%. Based on the diagnosis of papillary-type salivary gland mucinous adenocarcinoma (MAd), the patient underwent surgical excision. During a 7-month follow-up period, no recurrence or metastasis was observed. We also conducted a literature review of 56 cases of MAd published in the English language, summarizing the clinical, demographic, histopathological, and prognostic features of the tumor.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107369"},"PeriodicalIF":4.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KDM6A, ARID1A and SETD2 loss-of-function mutations as prognostic biomarkers and their association with sites of metastatic progression in locally-advanced, recurrent or metastatic adenoid cystic carcinoma","authors":"Sam Rack ,&nbsp;Karan Patel ,&nbsp;Emily Heathcote ,&nbsp;Hitesh Mistry ,&nbsp;Guy Betts ,&nbsp;Kevin Harrington ,&nbsp;Robert Metcalf","doi":"10.1016/j.oraloncology.2025.107229","DOIUrl":"10.1016/j.oraloncology.2025.107229","url":null,"abstract":"<div><h3>Objectives</h3><div>Recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) is typically slow growing however, some patients have more rapid progression. We sought to classify mutations in chromatin regulating genes in ACC to determine the impact of chromatin regulatory disfunction on clinical outcomes.</div></div><div><h3>Materials and methods</h3><div>Matched clinical-genomic data from 271 pts with non-resectable or R/M ACC were included in this study. 132 pts were recruited locally. 139 ACC pts were included from cBioPortal for analysis. Mutations were classified as pathogenic using standardised bioinformatic pipelines. Analyses was performed to determine the impact of one or more mutations on overall survival from recurrence (OSr) and site of metastases.</div></div><div><h3>Results</h3><div>KDM6A mutations were seen in 12 % of patients, followed by ARID1A 9 %, EP300 6 %, CREBBP 5 %, KMT2D 5 %, SETD2 2.6 %, an KMT2C 1.8 %. While 15 % of patients harboured activating NOTCH1/2 mutations, which co-occurred with mutations in KDM6A, ARID1A, and CREBBP. NOTCH activation (8.4 v 2.3 years, p= &lt;0.005), KDM6A (6.6 v 4.6 years, p = 0.008) and SETD2 (5.9 v 3.8 years, p = 0.04) mutations were associated with worse OSr. In NOTCH wild-type patients, median OSr for KDM6A 9.2 v 4.8 years (p = 0.07) and SETD2 was 9.8 v 3.2 years (p = 0.04). KDM6A (OR 4.5, 95 % CI 1.7–13.2, p = 0.002) mutations were significantly associated with bone metastasises and ARID1A mutations were associated with bone (OR 3.5, 95 % CI 1.2–11.8, p = 0.025) and liver (OR 3.0, 95 % CI 1.0–9.1, p = 0.053) in NOTCH wild-type patients.</div></div><div><h3>Conclusions</h3><div>ARID1A, KDM6A and SETD2 loss of function mutations negatively impact clinical outcomes in R/M-ACC irrespective of NOTCH status.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"166 ","pages":"Article 107229"},"PeriodicalIF":4.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}