Oral oncology最新文献

{"title":"Clinical significance of post-chemoradiotherapy 2-[¹⁸F]FDG PET/CT response in locally advanced nasopharyngeal carcinoma: A real-world study.","authors":"Yiwen Mo, Yuan Wei, Liping Liang, Tingfan Wu, Xinling Li, Ruping Li, Wei Fan, Yingying Hu, Xu Zhang","doi":"10.1016/j.oraloncology.2024.107160","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2024.107160","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prognostic value of post-chemoradiotherapy 2-[¹⁸F]FDG PET/CT in locally advanced nasopharyngeal carcinoma (LANPC) and develop an accurate prognostic model based on the 2-[¹⁸F]FDG PET/CT results.</p><p><strong>Methods: </strong>900 LANPC patients who underwent pretreatment and post-chemoradiotherapy 2-[¹⁸F]FDG PET/CT from May 2014 to August 2022 were included in the study. We divided the patients into two distinct cohorts for the purpose of our study: a training cohort comprising 506 individuals, included from May 2008 to April 2020, and a validation cohort consisting of 394 individuals, included from May 2020 to August 2022. PET/CT were assessed using the improved Deauville score (iDS) system. Cox regression analysis was performed to select candidate variables. A prognostic model was developed by the training cohort, and validated using the independent validation cohort.</p><p><strong>Results: </strong>Age (HR, 2.262(1.488-3.439); p＜0.001), ECOG (HR, 2.450 (1.395-4.301); p = 0.002), post-treatment EBV DNA level (HR, 2.208 (1.289-3.784); p = 0.004) and iDS {[iDS1-2 vs iDS3-4: HR, 3.781 (1.996-7.163); p＜0.001]; [iDS1-2 vs iDS5: HR, 11.707 (5.884-23.295); p＜0.001]}were independent predictors of OS. A 4-factor prognostic model developed and subsequently validated. This innovative model demonstrated excellent discrimination (C-index: 0.862). The calibration curves revealed a close match between the predicted probabilities and the actual outcomes, and decision curve analysis (DCA) confirmed the nomogram's utility for guiding clinical decision-making.</p><p><strong>Conclusion: </strong>Our study validated the predictive value of the iDS system in determining outcome for LANPC. The 4-factor prognostic model, which integrates baseline patient characteristics with iDS, demonstrated good discrimination, agreement, and clinical application potential.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107160"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model.","authors":"Le Yang, Sien Zhang, Jinsong Li, Chongjin Feng, Lijun Zhu, Jingyuan Li, Lisong Lin, Xiaozhi Lv, Kai Su, Xiaomei Lao, Jufeng Chen, Wei Cao, Siyi Li, Hongyi Tang, Xueying Chen, Lizhong Liang, Wei Shang, Zhongyi Cao, Fangsong Qiu, Jun Li, Wenhao Luo, Siyong Gao, Shuqin Wang, Bin Zeng, Wan Duan, Tong Ji, Guiqing Liao, Yujie Liang","doi":"10.1016/j.oraloncology.2024.107165","DOIUrl":"10.1016/j.oraloncology.2024.107165","url":null,"abstract":"<p><strong>Background: </strong>Cervical lymph node metastasis (LNM) is a well-established poor prognosticator of oral squamous cell carcinoma (OSCC), in which occult metastasis is a subtype that makes prediction challenging. Here, we developed and validated a deep learning (DL) model using magnetic resonance imaging (MRI) for the identification of LNM in OSCC patients.</p><p><strong>Methods: </strong>This retrospective diagnostic study developed a three-stage DL model by 45,664 preoperative MRI images from 723 patients in 10 Chinese hospitals between January 2015 and October 2020. It was comprehensively processed from training (8:2), multicenter external validation to reader study. The performance of the DL model was accessed and compared with general and specialized radiologists.</p><p><strong>Results: </strong>LNM was found in 36.51% of all patients, and the occult metastasis rate was 16.45%. The three-stage DL model together with a random forest classifier achieved the performance in identification of LNM with areas under curve (AUC) of 0.97 (0.93-0.99) in training cohort and AUC of 0.81 (0.74-0.86) in external validation cohorts. The models can reduce the occult metastasis rate up to 89.50% and add more benefit in guiding neck dissection in cN0 patients. DL models tied or exceeded average performance relative to both general and specialized radiologists.</p><p><strong>Conclusion: </strong>Our three-stage DL model based on MRI with three-dimensional sequences was beneficial in detecting LNM and reducing the occult metastasis rate of OSCC patients.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107165"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of a dormant malignancy in long-standing tongue ulceration.","authors":"Aparna Ganesan, Vineeth Kumar, Balasubramanian Krishnan","doi":"10.1016/j.oraloncology.2025.107173","DOIUrl":"10.1016/j.oraloncology.2025.107173","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107173"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating tumor DNA determines induction chemotherapy response in HPV associated oropharyngeal squamous cell carcinoma: A pilot study.","authors":"Zachary M Huttinger, Emile Gogineni, Sujith Baliga, Dukagjin M Blakaj, Priyanka Bhateja, Marcelo Bonomi, Stephen Y Kang, Matthew O Old, Nolan B Seim, Kyle K VanKoevering, Amit Agrawal, Enver Ozer, James W Rocco, Catherine T Haring","doi":"10.1016/j.oraloncology.2025.107179","DOIUrl":"10.1016/j.oraloncology.2025.107179","url":null,"abstract":"<p><strong>Background: </strong>Induction chemotherapy (IC) followed by chemoradiation (CRT) is one treatment approach for patients with locoregionally advanced oropharyngeal squamous cell carcinoma (OPSCC) associated with human papillomavirus (HPV). This pilot study aimed to assess whether a circulating tumor (ct) DNA assay outperforms PET-CT in assessing treatment response in patients with HPV + OPSCC treated with induction chemotherapy (IC) followed by chemoradiation (CRT).</p><p><strong>Materials and methods: </strong>Patients treated with IC and definitive CRT for HPV + OPSCC were included. HPV ctDNA and PET-CT were performed pre-treatment, 2-3 weeks after IC and 3 months after CRT. CtDNA levels were correlated with tumor volumes. Post-IC and post- CRT ctDNA levels were correlated post-induction and post-treatment imaging responses.</p><p><strong>Results: </strong>Seventeen patients were included. Baseline ctDNA levels correlated with volume of primary tumor (R2 = 0.33, p = 0.02), but did not correlate with nodal volumes (R2 = 0.01, p = 0.7) or total disease burden (R2 = 0.02, p = 0.6). After IC, 5.9 % (1/17) of patients had complete response by PET- CT, whereas 52.9 % (9/17) had complete molecular response by ctDNA testing. After completion of CRT, 76.5 % (13/17) patients had complete clinical response to treatment. Of patients who had ctDNA clearance after IC, 88.9 % (8/9) remained disease free after definitive CRT, whereas one had progressive disease diagnosed by both imaging and ctDNA. HPV ctDNA clearance after IC predicted disease control after CRT more strongly than PET-CT IC response (61.5 % (8/13) vs 7.7 % (1/13), p = 0.01).</p><p><strong>Conclusions: </strong>HPV ctDNA clearance following IC outperforms standard imaging in assessing response and may help identify patients with favorable prognosis.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107179"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undifferentiated small round cell sarcoma of the parapharyngeal space in a 4.5-year-old patient:A rare case report.","authors":"Lei Wang, Xinmei Kang","doi":"10.1016/j.oraloncology.2025.107184","DOIUrl":"10.1016/j.oraloncology.2025.107184","url":null,"abstract":"<p><p>This case report describes a 4.5-year-old girl diagnosed with a rare Undifferentiated Small Round Cell Sarcoma (USRCS) originating in the parapharyngeal space with multiple lung metastases. Diagnostic workups, including imaging, immunohistochemistry, and genetic sequencing, identified the tumor as an unclassified subtype of USRCS. The patient was treated with the Ewing sarcoma chemotherapy regimen, alternating between VDC (vincristine + doxorubicin + cyclophosphamide) and IE (ifosfamide + etoposide), in combination with bevacizumab. The tumor achieved complete remission, and no recurrence has been observed during follow-up.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107184"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of benign parotid gland tumors: From functional surgery to personalized surgery.","authors":"Hao Lu, Shengwen Liu, Wenya Zhu, Wanlin Xu, Wenjun Yang","doi":"10.1016/j.oraloncology.2025.107172","DOIUrl":"https://doi.org/10.1016/j.oraloncology.2025.107172","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107172"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omitting elective neck dissection in cT1/2N0 oral squamous cell carcinoma with sentinel lymph node metastasis: A prospective study.","authors":"Qigen Fang, Junhui Yuan, Xu Zhang, Liyuan Dai, Ruihua Luo, Tao Huang","doi":"10.1016/j.oraloncology.2024.107149","DOIUrl":"10.1016/j.oraloncology.2024.107149","url":null,"abstract":"<p><strong>Objective: </strong>To examine the distribution of non-sentinel lymph nodes (SLNs) and to determine the feasibility of omitting elective neck dissection (END) in cases of cT1/2N0 oral cancer presenting with SLN metastasis.</p><p><strong>Methods: </strong>A prospective cohort of patients with cT1/2N0 oral cancer underwent SLN biopsy using a γ-probe alongside methylene blue staining, followed by subsequent END. The primary outcome variable was non-SLN metastasis, with its predictors evaluated through logistic regression analysis.</p><p><strong>Results: </strong>A total of 200 patients with detectable SLNs were analyzed. Logistic regression revealed a significant odds ratio of 4.28 [95 % confidence interval: 2.11-14.56] for predicting non-SLN metastasis when comparing a depth of invasion greater than 4.0 mm to a DOI of 4.0 mm or less. Among the six cases of non-SLN metastasis, three patients with negative SLN biopsy results exhibited metastasis; one was found in ipsilateral level V and two in contralateral level Ib. In contrast, all three patients with positive SLN biopsy results had a DOI surpassing 4.0 mm, presenting with at least two positive SLNs. Non-SLN metastasis was detected in ipsilateral level III for one patient and at level IV for two others.</p><p><strong>Conclusion: </strong>END may be judiciously omitted in cases where only one positive SLN is identified in early-stage oral cancer with a depth of invasion of ≤ 4.0 mm.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107149"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ctDNA from liquid biopsy in predicting survival outcomes in HPV-negative head and neck cancer: A meta-analysis.","authors":"Nivedita Kaorey, Kyle Dickinson, Venkata Ramana Agnihotram, Anthony Zeitouni, Nader Sadeghi, Julia V Burnier","doi":"10.1016/j.oraloncology.2024.107148","DOIUrl":"10.1016/j.oraloncology.2024.107148","url":null,"abstract":"<p><p>The incidence of head and neck cancer (HNC) is on the rise, making it a significant clinical challenge. Human papillomavirus (HPV)-related and HPV-negative HNC exhibit distinct etiopathogenesis and prognoses, requiring targeted approaches for effective management. Conventional tissue biopsies are essential for confirming the diagnosis and locating solid tumors. However, they have limitations in detecting microscopic disease, tracking treatment response, and capturing the dynamic heterogeneity of the mutational profile within the tumor. Liquid biopsy using circulating tumor DNA (ctDNA) analysis has emerged as a promising non-invasive tool to overcome the drawbacks of conventional biopsy for comprehensive molecular profiling. This meta-analysis aims to colligate available evidence on the clinical utility of ctDNA analysis in predicting survival outcomes, specifically in HPV-negative HNC. Our systematic search of six electronic databases identified eight publications (N = 886 patients) meeting the inclusion criteria. The included studies reported data from HPV-negative HNC patients, employing ctDNA analysis to report survival outcomes. Our findings reveal a significant association between mutation or methylation in ctDNA and worsened survival outcomes in HPV-negative HNC cases. The presence of ctDNA mutations in TP53 and methylation of SEPT9 and SHOX2 was linked to reduced overall survival, disease-free survival, and progression-free survival. Subgroup analyses demonstrated consistent associations across different survival outcomes, ctDNA detection methods, and blood collection tubes used. Our study underscores the need for future research endeavors prioritizing larger, well-designed prospective studies with standardized methodologies to further elucidate the role of ctDNA analysis in guiding personalized treatment approaches and optimizing patient care in this specific HNC cohort.</p>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107148"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on, \"Development of a prediction model for tube feeding dependence in HPV-associated oropharyngeal cancer patients undergoing chemoradiotherapy\".","authors":"Shuang Xu, Fengfeng Qin, Wenjian Hu","doi":"10.1016/j.oraloncology.2025.107186","DOIUrl":"10.1016/j.oraloncology.2025.107186","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107186"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous papillary and medullary thyroid carcinoma with distinct genetic mutations: A case report.","authors":"Huanyu Jiang, Lijuan Zhou, Gang Zou, Haidong Zhang, Zhenkun Yu","doi":"10.1016/j.oraloncology.2025.107191","DOIUrl":"10.1016/j.oraloncology.2025.107191","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"107191"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}