Thyroid volumes after intensity‐modulated radiotherapy as predictors of radiation‐induced hypothyroidism in nasopharyngeal carcinoma: A retrospective study

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-03-11 DOI:10.1016/j.oraloncology.2025.107223

Zhe Dong , Gao-Yuan Wang , Guan-Jie Qin, Dong-Yu Dai, Wen-Fei Li, Ling-Long Tang, Cheng Xu, Jun Ma

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引用次数: 0

Abstract

Purpose

This study aimed to investigate the ability of thyroid volumes after intensity-modulated radiotherapy (IMRT) to predict the incidence of radiation‐induced hypothyroidism/primary hypothyroidism (HT)/(PHT) in nasopharyngeal carcinoma (NPC) patients.

Methods and materials

404 NPC patients were retrospectively enrolled from January 2015 to January 2019. Thyroid volumes were calculated based on magnetic resonance imaging. Volume of thyroid after IMRT within 3 months was defined as Vt-after. Least absolute shrinkage and selection operator (LASSO) regression, random forest analysis, and multivariate Cox proportional hazards were performed to identify optimal predictors of PHT. Then, these predictors were employed to construct the risk stratification using the recursive partitioning analysis (RPA).

Results

A smaller Vt-after was significantly associated with a higher risk of HT/PHT (hazard ratio (HR): 2.046, p < 0.001; HR: 3.214, p < 0.001; respectively). Vt-after and thyroid volumes at 1, 2, and 3 years after IMRT demonstrated superior predictive ability compared to the thyroid volume before IMRT for predicting PHT within the subsequent 2-year period. The combination of Vt-after and thyroid volume spared from 45 Gy (VS45), both of which were independent factors for predicting PHT, was incorporated into the RPA risk stratification called PRA-VS45. The PRA-VS45 emerged as a highly discriminative tool, with an area under the curve (AUC) of 0.716 on predicting PHT at 5 years.

Conclusions

This study identified thyroid volumes after IMRT as valuable parameters to predict radiation‐related PHT in NPC patients. The PRA-VS45 has the potential to be clinical applications for predicting PHT.

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.