Oral oncology最新文献

{"title":"Multistate oral carcinogenesis—A prospective cohort study and a parallel case-control study in Taiwan","authors":"Cheng-Ping Wang ,&nbsp;Kelly J. Yu ,&nbsp;Tseng-Cheng Chen ,&nbsp;Ming-shui Tsai ,&nbsp;Chung-Jan Kang ,&nbsp;Chi-Yen Chien ,&nbsp;Eric A. Engels ,&nbsp;Chun-Hung Hua ,&nbsp;Wan-Lun Hsu ,&nbsp;Yih-Leong Chang ,&nbsp;Sanford M. Dawsey ,&nbsp;Nicolas Wentzensen ,&nbsp;Jianxin Shi ,&nbsp;Fangya Mao ,&nbsp;Li C. Cheung ,&nbsp;Hormuzd A. Katki ,&nbsp;Eric Boyd ,&nbsp;Chen-Tu Wu ,&nbsp;J.Silvio Gutkind ,&nbsp;Alfredo Molinolo ,&nbsp;Anil K. Chaturvedi","doi":"10.1016/j.oraloncology.2025.107210","DOIUrl":"10.1016/j.oraloncology.2025.107210","url":null,"abstract":"<div><h3>Background</h3><div>To characterize multistate oral carcinogenesis, we conducted a cohort study of patients with oral precancer and a parallel case-control study of oral cancers and controls in Taiwan.</div></div><div><h3>Methods</h3><div>During 2013–2019, we recruited patients with oral precancer (n = 1998) or invasive oral cancer (n = 768) and hospital-based controls (n = 717). Precancer patients were followed up biannually for up to five years; questionnaire data and biospecimens were collected at multiple timepoints. Precancer natural history (regression/persistence, incidence, progression) was evaluated through follow-up visits and linkages with Taiwan’s Cancer Registry.</div></div><div><h3>Cohort updates</h3><div>Cross-sectionally, 71 % of oral precancers and 62 % of cancers were attributable to betel-quid chewing, smoking, and alcohol. Precancer patients had substantially elevated risk of oral cancer (standardized-incidence-ratio vs. Taiwan general population = 14.1; 95 %CI = 12.0–16.6). Among precancer patients, 156 incident invasive oral cancers occurred (median follow-up = 6.4 years; incidence rate = 1,221/100,000 person-years; annual incidence = 1.2 %; 1-year cumulative-incidence = 1.8 %; 5-year cumulative-incidence = 6.9 %; 10-year cumulative-incidence = 9.5 %). Baseline precancer histopathology strongly predicted risk of progression to oral cancer (5-year cumulative-incidence: no-dysplasia = 5.2 %, mild-dysplasia = 7.1 %, moderate-dysplasia = 32.8 %, severe-dysplasia = 45.9 %). Most oral cancers (88.5 %) were preceded by precancers identified during the study. The study has established a resource of &gt;63,500 biospecimens, including biopsies (n = 6,012), oral cytology (n = 18,422), oral rinses (n = 15,054), saliva (n = 15,066), and blood (n = 8,990). Ongoing investigations are characterizing oral carcinogenesis at the epidemiologic, macroscopic, microscopic, microbiomic, and genomic levels.</div></div><div><h3>Conclusions</h3><div>A majority of oral precancers/cancers in Taiwan are caused by betel-quid chewing, smoking, and alcohol. Patients with oral precancer have substantially elevated risk of site-concordant oral cancer. We highlight our study as a resource to collaboratively address questions regarding oral precancer/cancer natural history and clinical management.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107210"},"PeriodicalIF":4.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry”","authors":"Kohei Okuyama ,&nbsp;Souichi Yanamoto","doi":"10.1016/j.oraloncology.2025.107213","DOIUrl":"10.1016/j.oraloncology.2025.107213","url":null,"abstract":"<div><div>This study in Oral Oncology highlights how neoadjuvant immunotherapy reshapes the tumor immune microenvironment (TIME) in HNSCC, increasing CD8+ T cells and reducing immunosuppressive cells. Using multiplex immunohistochemistry, it offers crucial spatial insights into TIME dynamics, paving the way for biomarker development and personalized therapies. Future research should explore combining this approach with single-cell technologies to elucidate functional immune states, enhancing our understanding of therapeutic responses and informing novel combinatorial treatment strategies.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107213"},"PeriodicalIF":4.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining decision-making in mandibular reconstruction: A critical appraisal of data-driven flap selection criteria","authors":"Carlos M. Ardila ,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.oraloncology.2025.107217","DOIUrl":"10.1016/j.oraloncology.2025.107217","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107217"},"PeriodicalIF":4.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective, efficient palliative radiotherapy for advanced head and neck cancer: Real world data using 25 Gy in 5 fractions","authors":"Muhammad Shahid Iqbal,&nbsp;Nick West,&nbsp;Josef Kovarik,&nbsp;Malcolm Jackson,&nbsp;Rahul Patil,&nbsp;Laura Mackenzie,&nbsp;Maha Zarroug,&nbsp;Laura Gradwell-Nelson,&nbsp;Charles G. Kelly","doi":"10.1016/j.oraloncology.2025.107214","DOIUrl":"10.1016/j.oraloncology.2025.107214","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107214"},"PeriodicalIF":4.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic significance of the lateral margin in buccal cancer","authors":"Muthuswamy Dhiwakar ,&nbsp;Sneha Kamalakkannan ,&nbsp;Deeksha Dhiwakar ,&nbsp;Nithyanand Chidambaranathan ,&nbsp;Rajeshwari Muthusamy ,&nbsp;Pirabu Sakthivel ,&nbsp;Firoz Rajan","doi":"10.1016/j.oraloncology.2025.107212","DOIUrl":"10.1016/j.oraloncology.2025.107212","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the specific oncologic significance of the lateral margin (LM)- the marginal plane closest to skin- in resected buccal cancer.</div></div><div><h3>Materials and methods</h3><div>216 consecutive, treatment naïve patients undergoing primary surgery for buccal cancer were included. Cheek skin was resected based on clinical features of skin or subcutaneous involvement or proximity to oral commissure. Main outcomes were 1) frequency of LM ≤1 mm in relation to other (anterior, posterior, superior and inferior) margins and 2) association of LM ≤1 mm with LRFS and DFS. Secondary outcomes were rate of LM ≤1 mm and size of LM with and without skin resection.</div></div><div><h3>Results</h3><div>A total of 67 (31 %) patients had one or more margin ≤1 mm, of which LM comprised 36 (54 %). LM ≤1 mm was disproportionately highest among the five marginal planes (p &lt; 0.001) and was independently associated with LRFS and DFS. Both associations held in sensitivity analysis wherein patients with co-existent margin ≤1 mm at any of the other four marginal planes underwent group-wise exclusion. Skin resection and preservation was performed in 61 (28 %) and 155 (72 %) patients respectively. The latter had a higher rate of LM ≤1 mm and smaller LM size (both p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This cohort study of buccal cancer shows that LM is most prone for ≤1 mm size. LM ≤1 mm predicts worse LRFS and DFS independent of other margins and risk factors. As skin preservation is associated with a higher rate of LM ≤1 mm, surgeons must lower the threshold to encompass more tissue laterally, including skin where appropriate.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107212"},"PeriodicalIF":4.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143213242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of testing for the diagnosis of human papillomavirus (HPV) status in head and neck squamous cell carcinoma: Where from and where to?","authors":"Aabida Khan ,&nbsp;Melendhran Pillay ,&nbsp;Rishan Bipath ,&nbsp;Mpumelelo Msimang ,&nbsp;Jason Harry ,&nbsp;Andile Lindokuhle Sibiya ,&nbsp;Nokukhanya Msomi","doi":"10.1016/j.oraloncology.2025.107208","DOIUrl":"10.1016/j.oraloncology.2025.107208","url":null,"abstract":"<div><div>Human papillomavirus (HPV) is causally associated with head and neck squamous cell carcinomas with the strongest association in the oropharynx. HPV-associated oropharyngeal carcinomas have a different pathogenesis with distinct clinical features and better prognosis than HPV-negative oropharyngeal carcinomas which impacts staging and prognosis. It is, therefore, of clinical significance to accurately determine the HPV status, particularly in oropharyngeal carcinomas. In this review, the different test methods that are used for characterizing HPV status in head and neck squamous cell carcinomas, both conventional methods (p16 immunohistochemistry, HPV DNA in-situ hybridization, HPV DNA PCR, HPV E6/E7 mRNA RT-PCR, HPV RNA in-situ hybridization) as well as emerging novel approaches (HPV circulating tumour DNA, HPV16 E6 antibodies, oral HPV DNA/mRNA PCR), are discussed. Currently, a combined testing approach is favoured, using a sequential strategy of screening with p16 immunohistochemistry and confirming with HPV DNA PCR. HPV RNA in-situ hybridization could potentially serve as a single test owing to its good sensitivity and specificity. The use of liquid biopsies is gaining momentum with HPV circulating tumour DNA as the frontrunner in demonstrating promising clinical utility for early detection in HPV-associated oropharyngeal carcinomas. HPV16 E6 antibodies and oral HPV DNA PCR has potential utility as adjunct tests to aid diagnosis. In this rapidly evolving HPV testing landscape, we as clinicians and laboratorians must evolve and advocate for access to cost-effective accurate HPV testing globally.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107208"},"PeriodicalIF":4.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between microvascular free-flap arterial anastomosis caliber and risk for development of osteoradionecrosis","authors":"Krishna S. Hanubal ,&nbsp;Logesvar Balaguru ,&nbsp;David Rengifo ,&nbsp;Alexander Simko ,&nbsp;Zhanna Galochkina ,&nbsp;Reordan DeJesus ,&nbsp;Zhongyue Zhang ,&nbsp;Cristina Benites ,&nbsp;Ji-Hyun Lee ,&nbsp;Dustin Conrad ,&nbsp;William Mendenhall ,&nbsp;Peter T. Dziegielewski","doi":"10.1016/j.oraloncology.2024.107137","DOIUrl":"10.1016/j.oraloncology.2024.107137","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoradionecrosis (ORN) following radiation therapy (RT) is a serious complication for patients undergoing head and neck cancer treatment. Recent literature has found an association between ipsilateral external carotid artery (ECA) diameter and the development of ORN. This study evaluates microvascular free-flap arterial anastomosis diameter and the development of ORN.</div></div><div><h3>Materials and Methods</h3><div>Sixty-six patients underwent fibular free-flap reconstruction followed by RT between 2012–2019 at the University of Florida. Anastomosis and ECA diameters pre- and post-RT were measured from computed tomography images. Multivariate regression analysis identified significant factors in the development of ORN.</div></div><div><h3>Results</h3><div>Incidence of ORN was 33.3 % (N = 22/66). Mean post-RT anastomosis diameters were 2.3 and 2.2 for the ORN group and no-ORN group, respectively (<em>p</em> = 0.548). Mean post-RT ipsilateral ECA diameters were 4.7 and 4.2 for the ORN group and no-ORN groups, respectively (<em>p</em> = 0.040). The change in pre-RT versus post-RT ipsilateral ECA diameters was different in patients with RT dose above and below 55 Gy (<em>p</em> = 0.041). Neither post-RT anastomosis (OR = 1.78, 95% CI: 0.43, 8.65, <em>p</em> = 0.434), nor ECA (OR = 1.44, 95% CI: 0.78, 2.83, <em>p</em> = 0.250) diameters were associated with development of ORN while controlling RT dose (OR = 1.15, 95% CI: 1.04, 1.28, <em>p</em> = 0.006), post-operative fistula (OR = 9.11, 95% CI: 1.65, 93.7, <em>p =</em> 0.010), and post-operative infection (OR = 3.48. 95% CI = 1.01, 12.7, <em>p =</em> 0.048), and CCI (OR = 0.61, 95 % CI: 0.36, 0.96, <em>p</em> = 0.031).</div></div><div><h3>Conclusion</h3><div>A higher degree of narrowing in ipsilateral ECA following RT may be linked to development of ORN. RT doses ≥ 55 Gy were associated with a high risk of ORN.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107137"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between radiological, macroscopic and microscopic depth of invasion in oral squamous cell carcinoma: A prospective study using contrast-enhanced computed tomography","authors":"P.S. Gopinath Thilak ,&nbsp;Tanaya Mande ,&nbsp;Vinay Kumar J. Rajendra ,&nbsp;H.L. Kishan Prasad ,&nbsp;Padmaraj J. Hegde","doi":"10.1016/j.oraloncology.2024.107159","DOIUrl":"10.1016/j.oraloncology.2024.107159","url":null,"abstract":"<div><h3>Background</h3><div>Depth of invasion (DOI) significantly influences prognosis and treatment strategies in oral squamous cell carcinoma (OSCC). Accurate preoperative imaging, such as contrast-enhanced computed tomography (CECT), alongside postoperative histopathological evaluations, aids in determining DOI. This study evaluates the correlation between radiological DOI (rDOI), macroscopic DOI (PDOI), and microscopic DOI (pDOI) in OSCC.</div></div><div><h3>Methods</h3><div>This study included 54 OSCC patients from April 2022 to November 2023. rDOI was assessed using preoperative CECT, while PDOI and pDOI were measured through histopathological examination of resected specimens. Spearman correlation analysis and Bland-Altman plots assessed agreement between DOI measurements, with statistical significance set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Strong correlations were found between rDOI and PDOI (r = 0.713), rDOI and pDOI (r = 0.688), and PDOI and pDOI (r = 0.897, p &lt; 0.001 for all). CECT overestimated DOI in T1 and T2 lesions, particularly in ulcerative tumors. Bland-Altman analysis showed mean differences of 1.86 mm (rDOI-PDOI) and 3.3 mm (rDOI-pDOI). Higher correlations were observed in the presence of perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion 5 (WPOI 5), with r values up to 0.948 (rDOI-PDOI) and 0.980 (PDOI-pDOI).</div></div><div><h3>Conclusion</h3><div>While rDOI correlates strongly with pathological DOI, overestimations in smaller and ulcerative lesions necessitate cautious interpretation. Pathological risk factors, including PNI, LVI, and WPOI 5, were associated with greater DOI and enhanced agreement between radiological and pathological assessments. Overall, CECT is a reliable tool for preoperative evaluation of DOI.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107159"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can margin-to-depth ratio guide as an independent prognostic factor for adjuvant therapy?","authors":"Bhargav Ram,&nbsp;Puvvula Praneetha,&nbsp;Kanakarajulu Bhavya,&nbsp;Shalini Thakur,&nbsp;Anand Subash,&nbsp;Vishal US Rao","doi":"10.1016/j.oraloncology.2025.107176","DOIUrl":"10.1016/j.oraloncology.2025.107176","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107176"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy","authors":"Zi Yin,&nbsp;Huzi Zhao,&nbsp;Changqing Zhu,&nbsp;Juan Fang","doi":"10.1016/j.oraloncology.2025.107195","DOIUrl":"10.1016/j.oraloncology.2025.107195","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"161 ","pages":"Article 107195"},"PeriodicalIF":4.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}