Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Novel Use of 18-Gauge Angiocatheter to Remove Perfluorocarbon-Silicone Oil Admixture Through Internal Choroidotomy.","authors":"Sohani Amarasekera, Ajay E Kuriyan, Jay Chhablani","doi":"10.3928/23258160-20250217-05","DOIUrl":"10.3928/23258160-20250217-05","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"262-264"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difluprednate for the Treatment of Postoperative Hypotony Following Complicated Retinal Detachment Surgery.","authors":"Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan","doi":"10.3928/23258160-20250127-01","DOIUrl":"10.3928/23258160-20250127-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.</p><p><strong>Patients and methods: </strong>A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.</p><p><strong>Results: </strong>Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, <i>P</i> = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.</p><p><strong>Conclusion: </strong>Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:266-272.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"266-272"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sozinibercept Combination Therapy for Neovascular Age-related Macular Degeneration: Phase 2b Study Subgroup Analysis by Lesion Type.","authors":"Charles C Wykoff, Timothy L Jackson, Clare F Price, Megan E Baldwin, Ian M Leitch, Jason Slakter","doi":"10.3928/23258160-20250108-04","DOIUrl":"10.3928/23258160-20250108-04","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this study was to evaluate the angiographic predictors of response to the anti-vascular endothelial growth factor-C/-D agent, sozinibercept.</p><p><strong>Patients and methods: </strong>Prespecified and post hoc subgroup analyses of a phase 2b, randomized, double-masked, sham-controlled trial of 240 participants with treatment-naïve neovascular age-related macular degeneration, comparing monthly intravitreal sozinibercept 0.5 mg or 2 mg, plus ranibizumab 0.5 mg, versus monthly ranibizumab monotherapy.</p><p><strong>Results: </strong>Visual acuity benefits at week 24 were greatest in participants with occult lesions receiving 2 mg sozinibercept combination therapy (+15.65 [<i>n</i> = 53] letters versus +9.62 [<i>n</i> = 51] with ranibizumab monotherapy; least squares mean difference +6.03; <i>P</i> = 0.0009). A composite analysis of occult and minimally classic lesions excluding retinal angiomatous proliferation (<i>n</i> = 175/240) also favored sozinibercept over control (+16.08 versus +10.34 letters; +5.74; <i>P</i> = 0.0002). Structural outcomes mirrored sozinibercept visual acuity benefits, with less leakage and smaller lesions on multimodal imaging.</p><p><strong>Conclusion: </strong>Angiographic lesion characteristics were found to predict the response to sozinibercept combination therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:287-296.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"287-296"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incomplete RPE and Outer Retinal Atrophy (iRORA) Development in Eyes With Fellow-eye Neovascular Age-related Macular Degeneration.","authors":"Hanna Choi, Giulia Corradetti, Sophiana Lindenberg, Ayesha N Karamat, Deniz Oncel, Henry Liu, Ramya Gnanaraj, Sohaib Fasih-Ahmad, Kenneth M Marion, Kirstie L Baker, Shilpa Gulati, Bradley Foster, Andrew Lam, SriniVas R Sadda, David R Lally","doi":"10.3928/23258160-20250108-01","DOIUrl":"10.3928/23258160-20250108-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The utility of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) in intermediate age-related macular degeneration (iAMD) as a clinical endpoint is not yet elucidated. We aim to understand the time to iRORA development in iAMD.</p><p><strong>Patients and methods: </strong>Eyes with iAMD without iRORA of subjects with fellow-eye neovascular AMD (nAMD) were identified from visits between 2010 and 2019 at a tertiary clinic. Spectral Domain Optical Coherence Tomography 512 × 128mm macular cubes (Cirrus HD-OCT, Zeiss) were assessed for time to first detection of iRORA and complete RPE and Outer retinal atrophy (cRORA) at 24 months. Up to three iRORA lesions were followed. Univariable Cox regressions evaluated baseline OCT characteristics, age, and gender as predictors for iRORA or cRORA development. Baseline OCT characteristics included intraretinal hyperreflective foci (IHRF), subretinal drusenoid deposits (SDD), hyporeflective drusen cores (hDC), and drusen volume measured with semi-automatic segmentation of Bruch's membrane to RPE.</p><p><strong>Results: </strong>In 101 eyes of 101 subjects (64% female; median 81 years old), 28.70% (<i>n</i> = 30) developed iRORA whereas 2.97% (<i>n</i> = 3) developed cRORA without iRORA at 24 months. Median (range) time to first iRORA or cRORA was 20 (12 to 24) months. The presence of baseline IHRF was associated with increased risk of iRORA development at month 24 (HR = 2.28, 95% CI: 1.14 to 4.56; <i>P</i> value = 0.019).</p><p><strong>Conclusion: </strong>In subjects with fellow-eye nAMD, approximately one third of iAMD eyes developed iRORA at 24 months. Intraretinal hyperreflective foci was associated with a two-fold increased risk in iRORA development. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:274-279.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"274-279"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Visual Response After Lapse in Treatment Among Patients With Neovascular Age-related Macular Degeneration.","authors":"Jovana Hanna, Jonathan Markle, Christopher Maatouk, Nikhil Das, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20250128-01","DOIUrl":"10.3928/23258160-20250128-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to analyze baseline predictors of visual response in patients with neovascular age-related macular degeneration (nAMD) who have undergone lapses in treatment with anti-VEGF therapy. The mainstay treatment option for nAMD is intravitreal vascular endothelial growth factor inhibitor (anti-VEGF) therapy. Given the chronic nature of nAMD, patients who undergo lapses in treatment with these agents can have progression of their disease.</p><p><strong>Patients and methods: </strong>This retrospective, comprehensive chart review included 261 adults aged 18 years or older who were diagnosed with nAMD between January 2012 and June 2020 and had undergone at least one anti-VEGF injection prior to an unintended lapse in follow-up of 3 months or greater. Following exclusion criteria, in which individuals were not administered an anti-VEGF injection at the pre-lapse visit, a total of 163 patients were analyzed. Patients were separated into \"vision loss\" and \"stable vision\" categories and classified based on degree of vision loss. A stepwise backward logistic regression was used to analyze baseline medical and ophthalmic factors between each group to determine which factors were more likely to be associated with more significant vision loss.</p><p><strong>Results: </strong>Out of 261 nAMD patients reviewed, 163 patients were investigated in the main analysis. Higher cube volume (1.24 ± 0.24, <i>P</i> = 0.22), and lapse length (2.89 ± 0.056, <i>P</i> = 0.004) increased the likelihood of vision loss, while lack of smoking history (-2.07 ± 0.46, <i>P</i> = 0.038) decreased the likelihood. The two groups were significantly different in post-lapse ophthalmologic continuous variables, including cube volume (9.69 ± 0.98 and 10.2 ± 1.39 in the stable vision and unstable vision groups, respectively, <i>P</i> = 0.01) and cube average thickness (269 ± 27.3 and 282 ± 38.4 in the stable vision and unstable vision groups, respectively, <i>P</i> = 0.02). The main model had an area under the curve (AUC) of 58% and predictive accuracy of 78.1%.</p><p><strong>Conclusion: </strong>The calculated AUC was not high enough to establish reliable predictability in this study. However, additional factors may need to be considered for greater predictability. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:280-285.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"280-285"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Cenegermin-Bkbj Dramatically Resolves Neurotrophic Keratitis Associated With Pars Plana Vitrectomy.","authors":"Anny M S Cheng, Shaden H Yassin, Shailesh K Gupta, Kakarla V Chalam","doi":"10.3928/23258160-20250124-01","DOIUrl":"10.3928/23258160-20250124-01","url":null,"abstract":"<p><p>Neurotrophic keratitis (NK) may occur secondary to pars plana vitrectomy (PPV). A subset of patients with very severe NK corneal defects may require therapy escalation, and Cenegermin-Bkbj, a recombinant human nerve growth factor, represents a novel treatment option. This case report presents the successful treatment of refractory NK using Cenegermin-Bkbj in a patient after undergoing multiple PPV surgeries. A 60-year-old woman with recurrent retinal detachments in the right eye after receiving the third PPV developed persistent irritation, photophobia, and worsening visual acuity due to iatrogenic NK despite lubrication, bandage contact lens, preservative-free artificial tears, restasis, and right lower lid punctal cautery over 6 weeks. She received daily topical Cenegermin-Bkbj for 8 weeks to achieve complete corneal reepithelialization, restoration of corneal sensation, and visual acuity improvement from hand motion to 20/80. She remained symptom-free at the 8-week follow-up. This case highlights the importance of early recognition, tailored management, and the potential efficacy of Cenegermin-Bkbj in treating NK arising after retinal procedures. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:309-311.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"309-311"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Giant Choroidal Cavern in a Case of Rod-Cone Dystrophy: A Rare Presentation.","authors":"Rajul Shah, Udit Ajmani, Sameera Nayak, Niroj Kumar Sahoo, P Srinivas Rao, Brijesh Takkar","doi":"10.3928/23258160-20241216-02","DOIUrl":"10.3928/23258160-20241216-02","url":null,"abstract":"<p><p>This report presents a case of a 22-year-old woman with bilateral giant choroidal caverns (CCs) in rod-cone dystrophy. Her best-corrected visual acuity was 20/80 in the right eye and 20/50 in the left eye. Fundus examination showed optic nerve pallor, narrowed blood vessels, and diffuse pigmentary changes. Fundus autofluorescence showed a central area of reduced autofluorescence surrounded by stippled autofluorescence. An electroretinogram showed decreased amplitude of both scotopic and photopic waves, consistent with a diagnosis of rod-cone dystrophy (retinitis pigmentosa). Optical coherence tomography revealed large CC and foveal atrophy in each eye. A giant CC alongside rod-cone dystrophy is a distinctive feature. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:241-243.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"241-243"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Retinal Blood Flow Parameters in Sickle Cell Disease at Steady State and Healthy Subjects Using Doppler Optical Coherence Tomography.","authors":"Hernan A Rios, Sofia Ahsanuddin, Oscar Otero-Marquez, Luis Duran Muncharaz, Kana Minamide, Jordan Bellis, Elizabeth Stidham, Toco Y P Chui, Masahiro Akiba, Jeffrey A Glassberg, Richard B Rosen","doi":"10.3928/23258160-20241114-03","DOIUrl":"10.3928/23258160-20241114-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Sickle cell disease (SCD) is a vascular disease that may affect the retina. This study aimed to evaluate differences in average velocity (AV, mm/s), blood flow (BF, μL/min) and vessel diameter (VD, μm) from the temporal retinal arcades in SCD compared to healthy eyes using Doppler optical coherence tomography (DOCT).</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted between 2021 and 2023. The DOCT scan was located at the superior and inferior temporal vessel arcades of all subjects. Differences between the two groups were assessed.</p><p><strong>Results: </strong>Thirty-nine healthy eyes and 36 SCD eyes were imaged. The median of AV, BF, and VD were 1.4, 2.5, and 1.3 times higher in SCD eyes compared to healthy eyes in the superotemporal arteries (<i>P</i> = 0.002, <i>P</i> = 5.0 × 10^-3, <i>P</i> = 4.0 × 10^-6, respectively). Similar findings were observed for superotemporal veins and inferotemporal veins.</p><p><strong>Conclusion: </strong>Eyes with SCD eyes exhibited significantly elevated retinal vascular flow parameters compared to healthy eyes. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:220-227.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"220-227"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy for Subretinal Fluid Associated With Choroidal Nevus.","authors":"Jose Pena, Hidayet Sener, Carol L Shields","doi":"10.3928/23258160-20241216-04","DOIUrl":"10.3928/23258160-20241216-04","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"254-255"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Intravitreal Aflibercept 8 mg in Eyes With Neovascular Age-Related Macular Degeneration Previously Treated With Faricimab.","authors":"Bita Momenaei, Yoshihiro Yonekawa, Paige Abril, Rachel McCullough, Ashkan M Abbey","doi":"10.3928/23258160-20241205-01","DOIUrl":"10.3928/23258160-20241205-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.</p><p><strong>Results: </strong>The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (<i>P</i> = 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (<i>P</i> = 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (<i>P</i> < 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (<i>P</i> = 0.029 and 0.004), respectively.</p><p><strong>Conclusions: </strong>Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:206-211.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"206-211"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}