Ophthalmic surgery, lasers & imaging retina最新文献

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Ocular Anesthesia Techniques in Intravitreal Therapy: A Comparative Review. 眼麻醉技术在玻璃体内的应用:比较回顾。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 DOI: 10.3928/23258160-20260409-03
Eric W Lai, Timothy Lee, Dhruv P Patel, Seenu M Hariprasad, Sidney A Schechet
{"title":"Ocular Anesthesia Techniques in Intravitreal Therapy: A Comparative Review.","authors":"Eric W Lai, Timothy Lee, Dhruv P Patel, Seenu M Hariprasad, Sidney A Schechet","doi":"10.3928/23258160-20260409-03","DOIUrl":"https://doi.org/10.3928/23258160-20260409-03","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 5","pages":"282-286"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Risk Factors Associated With the Development of Neovascular Glaucoma Following a Diagnosis of Proliferative Diabetic Retinopathy or Retinal Vein Occlusion. 诊断为增殖性糖尿病视网膜病变或视网膜静脉闭塞后发生新生血管性青光眼的发病率和危险因素
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 Epub Date: 2026-04-15 DOI: 10.3928/23258160-20260311-01
Param Bhatter, Priya S Eppel, Sonia B Kim, Rishi P Singh, David C Kaelber, Katherine E Talcott
{"title":"Incidence and Risk Factors Associated With the Development of Neovascular Glaucoma Following a Diagnosis of Proliferative Diabetic Retinopathy or Retinal Vein Occlusion.","authors":"Param Bhatter, Priya S Eppel, Sonia B Kim, Rishi P Singh, David C Kaelber, Katherine E Talcott","doi":"10.3928/23258160-20260311-01","DOIUrl":"10.3928/23258160-20260311-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to evaluate cumulative incidence and risk factors for neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR), central retinal vein occlusion (CRVO), or branch retinal vein occlusion (BRVO).</p><p><strong>Patients and methods: </strong>A retrospective cohort study using an aggregated, de-identified electronic health record platform (TriNetX), with data from 60+ health care organizations, identified patients with ICD-10 encounter diagnoses for PDR, CRVO, or BRVO and subsequent NVG. NVG cumulative incidence was calculated at 1 day, 1 month, and 3 months post-diagnosis. Risk factors were evaluated after propensity score matching. Incidence (%), relative risk, and 95% CI were reported.</p><p><strong>Results: </strong>Neovascular glaucoma developed in 8.8% of PDR (<i>n</i> = 14,937), 11.6% of CRVO (<i>n</i> = 6,302), and 4.4% of BRVO (<i>n</i> = 2,253) cases. Risk was significantly higher for male patients, age ≥ 70, Black or Hispanic, or with primary open angle glaucoma, hypertension, or diabetes mellitus.</p><p><strong>Conclusion: </strong>Neovascular glaucoma is a common early complication of retinal vascular disease. Several demographic and systemic factors may warrant closer monitoring to prevent vision loss.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"294-300"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Systemic Methotrexate on Preventing Proliferative Vitreoretinopathy Following Retinal Detachment Repair. 甲氨蝶呤在预防视网膜脱离修复后增殖性玻璃体视网膜病变中的作用。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 DOI: 10.3928/23258160-20260413-01
Negin Yavari, Amer F Alsoudi, Karen M Wai, Euna Koo, Chase A Ludwig, Andrea L Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy
{"title":"The Role of Systemic Methotrexate on Preventing Proliferative Vitreoretinopathy Following Retinal Detachment Repair.","authors":"Negin Yavari, Amer F Alsoudi, Karen M Wai, Euna Koo, Chase A Ludwig, Andrea L Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy","doi":"10.3928/23258160-20260413-01","DOIUrl":"10.3928/23258160-20260413-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to evaluate the association between systemic methotrexate (MTX) use and the incidence of proliferative vitreoretinopathy (PVR) following retinal detachment (RD) repair.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted using the TriNetX Health Research Network. Patients undergoing RD repair were identified by CPT codes and stratified into MTX users (systemic exposure within one year prior to or on the day of RD repair) versus nonusers. Cases of proliferative diabetic retinopathy were excluded. The primary endpoint was development of PVR-related complications within 3, 6, and 12 months postoperatively. Propensity score matching (PSM) was performed to balance baseline demographics and clinical covariates.</p><p><strong>Results: </strong>After 1:1 PSM, 496 patients were identified in both cohorts (mean age: 56.5 (19.0) years). MTX use was associated with significantly higher odds of tractional RD at 3 months (22.38% vs 8.06%; odds ratio [OR] 3.28, 95% CI: 2.23-4.83, <i>P</i> < .0001), 6 months (24.95% vs 8.11%; OR 3.76, 95% CI: 2.57-5.52, <i>P</i> < .0001), and 12 months (20.29% vs 10.63%; OR 2.14, 95% CI: 1.44-3.17, <i>P</i> < .0001). Postoperative ERM development was more frequent in MTX cohort at 3 months (11.49% vs 6.65%, OR 1.82, 95% CI: 1.16-2.85, <i>P</i> = .0080). No significant differences were observed in complex RD repair, repeat PPV, and PPV with ERM removal.</p><p><strong>Conclusion: </strong>Systemic MTX use within one year of RD repair was not associated with a reduced risk of PVR. MTX exposure correlated with increased odds of tractional RD and higher rates of ERM development rate. These findings suggest systemic MTX may not offer protective benefit against PVR.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 5","pages":"320-326"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial Fluid-Air Exchange Enhances Submacular Injection of Retinal Sheets. 部分液气交换增强黄斑下视网膜片注射。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 Epub Date: 2026-04-21 DOI: 10.3928/23258160-20260310-04
Grace Baldwin, Yukari Akita, Koichiro Manabe, Tatsuya Kamei, Atsushi Kuwahara, Isaac Bleicher, Demetrios G Vavvas, John B Miller
{"title":"Partial Fluid-Air Exchange Enhances Submacular Injection of Retinal Sheets.","authors":"Grace Baldwin, Yukari Akita, Koichiro Manabe, Tatsuya Kamei, Atsushi Kuwahara, Isaac Bleicher, Demetrios G Vavvas, John B Miller","doi":"10.3928/23258160-20260310-04","DOIUrl":"10.3928/23258160-20260310-04","url":null,"abstract":"<p><strong>Background and objective: </strong>Subretinal therapeutics represent a growing area of research with diverse clinical applications. Inadvertent reflux of therapeutic into the vitreous after delivery represents a surgical challenge that leads to therapeutic loss. This study sought to evaluate a modified technique utilizing partial fluid-air exchange (pFAX) to reduce reflux.</p><p><strong>Materials and methods: </strong>This single-center study included 18 eyes of nine live pigs. Human iPSC-derived retinal sheets (Sumitomo Pharma) were injected into the subretinal space utilizing pFAX.</p><p><strong>Results: </strong>Retinal sheets were successfully delivered in all eyes. Incorporating pFAX reduced intraocular turbulence and reflux by maintaining (1) stable intraocular pressure, (2) self-sealing wound closure, and (3) subretinal bleb stability. When improper delivery or reflux of sheets did occur, reaspiration and reinjection was much easier with pFAX than with a fluid-filled eye.</p><p><strong>Conclusion: </strong>Incorporating pFAX reduced reflux during subretinal injection of retinal sheets. This technique may enhance current and future applications of subretinal surgery.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 5","pages":"328-333"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes and Complications of Secondary Intraocular Lens Implantation: Insights From a Vitreoretinal Surgery Cohort. 继发性人工晶状体植入术的结果和并发症:来自玻璃体视网膜手术队列的见解。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 Epub Date: 2026-04-21 DOI: 10.3928/23258160-20260320-01
Henry W Zhou, Ioanna Ploumi, Kayla N Nodecker, Karim Barake, Dan Gong, Jose R Davila, Mohammad Dahrouj, Nimesh A Patel, John B Miller
{"title":"Outcomes and Complications of Secondary Intraocular Lens Implantation: Insights From a Vitreoretinal Surgery Cohort.","authors":"Henry W Zhou, Ioanna Ploumi, Kayla N Nodecker, Karim Barake, Dan Gong, Jose R Davila, Mohammad Dahrouj, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20260320-01","DOIUrl":"10.3928/23258160-20260320-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study reports outcomes of secondary intraocular lens (IOL) surgeries from a vitreoretinal service.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was performed of consecutive patients undergoing secondary IOL implantation between January 2017 and September 2024 by five vitreoretinal surgeons at a single tertiary academic center. Eyes were categorized by secondary IOL type: sulcus IOL, scleral fixated IOL (SFIOL, eg, Yamane technique), scleral sutured IOL (SSIOL, eg, Akreos lens), and anterior chamber IOL (ACIOL). Primary outcomes include intraoperatively identified retinal breaks and postoperative retinal detachments. Secondary outcomes include anesthesia type, case duration, and rates of lens repositioning or exchange due to rotation, dislocation, or other complication, endolaser for retinal tufts/tags, rescued IOL, iridotomy, combination silicone oil removal, air or gas used, and fibrin sealant use. Comparisons between categorical variables were made using the chi-square test of independence or the likelihood ratio if chi-square assumptions were not met. Comparisons between continuous variables were analyzed using Mann-Whitney U or Kruskal-Wallis ANOVA. Equal variances were not assumed. <i>P</i> values < .05 were considered statistically significant, with Bonferroni correction applied for multiple comparisons.</p><p><strong>Results: </strong>A total of 138 eyes from 136 patients were included in the study (42 ACIOL, 27 sulcus IOL, 43 SFIOL, 26 SSIOL). Retinal tears or holes were intraoperatively identified in nine (6.5%) eyes. Of those, two (1.4%) also had focal retinal detachments (RD). Retinal tags and other suspicious areas of retina were prophylactically lasered in nine (6.5%) cases, and 16 (11.6%) eyes received endolaser retinopexy. Postoperative RD occurred in three cases (2.2%). Eyes with a history of RD or PPV were associated with a lower rate of intraoperatively identified retinal breaks (<i>P</i> = .01 and 0.008, respectively). Rates of iridotomy differed significantly between IOL types (<i>P</i> < .001). ACIOLs were associated with worse vision at POM3 and higher rates of postoperative CME (<i>P</i> = .002). SSIOLs were associated with higher rates of vitreous hemorrhage (<i>P</i> < .001). Among SFIOL cases, three (7.0%) developed severe IOL rotation, and all required repeat IOL surgery.</p><p><strong>Conclusions: </strong>Secondary IOL surgery performed by vitreoretinal surgeons was associated with a lower rate of intraoperative retinal breaks and postoperative RD compared to previous reports. There was a trend towards lower rates of intraoperatively identified retinal breaks in eyes with prior RD or PPV. Some IOL types were associated with higher rates of postoperative complications such as CME and vitreous hemorrhage.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 5","pages":"310-318"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Intravitreal Viscoelastic Injection (PIVOT) for Surgical Optimization in Rhegmatogenous Retinal Detachment With Choroidal Detachment. 玻璃体内粘弹性注射(PIVOT)用于孔源性视网膜脱离伴脉络膜脱离的手术优化。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 Epub Date: 2026-04-15 DOI: 10.3928/23258160-20260310-02
Ritweez Sahu, Devesh Kumawat, Ananya Kaginalkar, Saurabh Verma, Shorya Vardhan Azad, Pradeep Venkatesh
{"title":"Preoperative Intravitreal Viscoelastic Injection (PIVOT) for Surgical Optimization in Rhegmatogenous Retinal Detachment With Choroidal Detachment.","authors":"Ritweez Sahu, Devesh Kumawat, Ananya Kaginalkar, Saurabh Verma, Shorya Vardhan Azad, Pradeep Venkatesh","doi":"10.3928/23258160-20260310-02","DOIUrl":"10.3928/23258160-20260310-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Rhegmatogenous retinal detachment with choroidal detachment (RRDCD) is a challenging situation. This study evaluates the safety and efficacy of preoperative intravitreal viscoelastic injection (PIVOT) in facilitating vitrectomy in RRD-CD.</p><p><strong>Patients and methods: </strong>This consecutive series included eight eyes of eight patients with RRD-CD (CD reaching to equator), managed between December 2024 and April 2025. Healon™ PRO (1% sodium hyaluronate) was injected intravitreally, typically one day prior to vitrectomy, along with topical difluprednate, cycloplegics, and oral corticosteroids. Outcome measures were intraocular pressure (IOP), cumulative CD height (by ultrasonography), injection-related adverse events, and intraoperative complications.</p><p><strong>Results: </strong>Mean IOP increased from 4.75 ± 2.05 mmHg at baseline to 10.0 ± 3.34 mmHg on day of surgery (<i>P</i> = .001). Cumulative CD reduced from 15.82 ± 4.88 mm to 5.49 ± 6.01 mm (<i>P</i> = .003). No adverse events were noted. Vitrectomy was safely completed, ensuring adequate silicone oil fill in all eyes.</p><p><strong>Conclusion: </strong>PIVOT combined with anti-inflammatory treatment appears safe and effective in optimizing surgical conditions for RRD-CD.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"287-292"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RWC Update: Modern One Health Approaches to Novel Challenges in Infectious Uveitis-Parasitic, Fungal and Mycobacterial Uveitis (Part 2); Management of 180° Iridodialysis With Aphakia and Total Hyphema; Retinal Astrocytic Hamartoma. RWC更新:传染性葡萄膜炎新挑战的现代统一健康方法-寄生虫,真菌和分枝杆菌葡萄膜炎(第二部分);180°环烯透析合并无泪和全房积血的处理视网膜星形细胞错构瘤。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-05-01 DOI: 10.3928/23258160-20260413-03
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Ashish Sharma, Jessica Carag, Sarah Zohdy, Reem AlAhmadi, Ann-Marie Lobo-Chan, Camila Ventura, Francisco J Rodriguez, Raul Velez-Montoya, Dilraj Grewal, Stacy Andrew, Jonel Steffen, Debbie Espe, Nam Nguyen, Parisa Emami-Naeini, Audina Berrocal, Thomas Albini, Steven Yeh, Baruch D Kuppermann, Jorge Rocha, Kourous Rezaei, Rohit Agrawal, Dhaivat Shah, Nida Khan, Kourous A Rezaei
{"title":"RWC Update: Modern One Health Approaches to Novel Challenges in Infectious Uveitis-Parasitic, Fungal and Mycobacterial Uveitis (Part 2); Management of 180° Iridodialysis With Aphakia and Total Hyphema; Retinal Astrocytic Hamartoma.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Ashish Sharma, Jessica Carag, Sarah Zohdy, Reem AlAhmadi, Ann-Marie Lobo-Chan, Camila Ventura, Francisco J Rodriguez, Raul Velez-Montoya, Dilraj Grewal, Stacy Andrew, Jonel Steffen, Debbie Espe, Nam Nguyen, Parisa Emami-Naeini, Audina Berrocal, Thomas Albini, Steven Yeh, Baruch D Kuppermann, Jorge Rocha, Kourous Rezaei, Rohit Agrawal, Dhaivat Shah, Nida Khan, Kourous A Rezaei","doi":"10.3928/23258160-20260413-03","DOIUrl":"https://doi.org/10.3928/23258160-20260413-03","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 5","pages":"277-280"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RWC Update: Modern One Health Approaches to Novel Challenges in Infectious Uveitis-Emerging Viral Diseases (Part 1); Repair of Closed Funnel Retinal Detachment Through Boston KPro; Choroidal Rupture. RWC更新:传染性葡萄膜炎新挑战的现代统一健康方法-新出现的病毒性疾病(第一部分);Boston KPro修复闭合性漏斗型视网膜脱离脉络膜的破裂。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-04-01 DOI: 10.3928/23258160-20260316-01
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Ashish Sharma, Jessica Carag, Sarah Zohdy, Reem AlAhmadi, Ann-Marie Lobo-Chan, Camila Ventura, Francisco J Rodriguez, Raul Velez-Montoya, Dilraj Grewal, Stacy Andrew, Jonel Steffen, Debbie Espe, Nam Nguyen, Parisa Emami-Naeini, Audina Berrocal, Thomas Albini, Steven Yeh, Baruch D Kuppermann, Jorge Rocha, Kourous Rezaei, Alan J Franklin, Malvika Singh, Manish Nagpal, Kourous A Rezaei
{"title":"RWC Update: Modern One Health Approaches to Novel Challenges in Infectious Uveitis-Emerging Viral Diseases (Part 1); Repair of Closed Funnel Retinal Detachment Through Boston KPro; Choroidal Rupture.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Ashish Sharma, Jessica Carag, Sarah Zohdy, Reem AlAhmadi, Ann-Marie Lobo-Chan, Camila Ventura, Francisco J Rodriguez, Raul Velez-Montoya, Dilraj Grewal, Stacy Andrew, Jonel Steffen, Debbie Espe, Nam Nguyen, Parisa Emami-Naeini, Audina Berrocal, Thomas Albini, Steven Yeh, Baruch D Kuppermann, Jorge Rocha, Kourous Rezaei, Alan J Franklin, Malvika Singh, Manish Nagpal, Kourous A Rezaei","doi":"10.3928/23258160-20260316-01","DOIUrl":"https://doi.org/10.3928/23258160-20260316-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 4","pages":"207-210"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posttraumatic Stress Disorder and Macular, Choroidal, and Peripapillary Perfusion Using Optical Coherence Tomography and Angiography. 创伤后应激障碍与黄斑、脉络膜和乳头周围灌注的光学相干断层扫描和血管造影。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-04-01 Epub Date: 2026-03-16 DOI: 10.3928/23258160-20260127-01
Grant A Justin, Cason B Robbins, Anita Kundu, Lauren Winslow, Praruj Pant, S Tammy Hsu, Sheriel Choo, Richard Blanch, Sandra S Stinnett, Rupesh Agrawal, Dilraj S Grewal, Sharon Fekrat
{"title":"Posttraumatic Stress Disorder and Macular, Choroidal, and Peripapillary Perfusion Using Optical Coherence Tomography and Angiography.","authors":"Grant A Justin, Cason B Robbins, Anita Kundu, Lauren Winslow, Praruj Pant, S Tammy Hsu, Sheriel Choo, Richard Blanch, Sandra S Stinnett, Rupesh Agrawal, Dilraj S Grewal, Sharon Fekrat","doi":"10.3928/23258160-20260127-01","DOIUrl":"10.3928/23258160-20260127-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Posttraumatic stress disorder (PTSD) is a chronic psychiatric condition associated with long-term neurobiological and neurovascular changes. In this study, optical coherence tomography (OCT) and OCT angiography (OCTA) were used to assess macular, choroidal, and peripapillary architecture and microvasculature in patients with PTSD.</p><p><strong>Patients and methods: </strong>Patients with a documented history of PTSD and age- and sex-matched controls were recruited. OCT and OCTA parameters were measured using the Zeiss Cirrus HD-5000 Spectral-Domain OCT with AngioPlex. Primary outcome measure was the associations between differences in OCT and OCTA parameters and PTSD. Secondary outcome measures were the association of OCT and OCTA parameters and other mental illnesses including depression, anxiety, and bipolar disorder, and history of migraine or traumatic brain injury (TBI).</p><p><strong>Results: </strong>Fifty-nine eyes of 32 PTSD patients and 64 eyes of 32 control patients were included. PTSD participants had significantly lower 3 × 3-mm macular perfusion density (PD) and vessel density (VD) (all <i>P</i> ≤ .001), and foveal avascular zone circularity (<i>P</i> < .001) compared to controls. For PTSD subjects with a history of TBI versus those without, there were no significant differences across macular, choroidal, or peripapillary perfusion measurements. However, for PTSD subjects with a history of migraine, there were significantly decreased PD and VD in the 6 × 6-mm circle and inner ring. For associated mental illnesses, there were no differences between PTSD subjects with and without depression, anxiety, or bipolar disorder.</p><p><strong>Conclusion: </strong>Decreased macular perfusion was noted in patients with PTSD. Further investigation is needed to evaluate OCT and OCTA imaging as a noninvasive modality for screening and assessing interventions in patients with PTSD.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"235-241"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Inherited Retinal Diseases in the United States: IRIS® Registry (Intelligent Research in Sight) Analysis. 美国遗传性视网膜疾病的流行病学:IRIS®注册(视觉智能研究)分析。
IF 1.1 4区 医学
Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-04-01 Epub Date: 2026-03-27 DOI: 10.3928/23258160-20260310-03
Ahmad Al-Moujahed, Md Enamul Haque, Vinit B Mahajan, Rachel Huckfeldt, Suzann Pershing
{"title":"Epidemiology of Inherited Retinal Diseases in the United States: IRIS<sup>®</sup> Registry (Intelligent Research in Sight) Analysis.","authors":"Ahmad Al-Moujahed, Md Enamul Haque, Vinit B Mahajan, Rachel Huckfeldt, Suzann Pershing","doi":"10.3928/23258160-20260310-03","DOIUrl":"10.3928/23258160-20260310-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Evaluate disease characteristics and secondary comorbidities following retinitis pigmentosa (RP), choroideremia (CHM), and achromatopsia (ACHM) diagnosis in the United States.</p><p><strong>Patients and methods: </strong>A retrospective cohort study of patients with new RP, CHM, or ACHM diagnoses between January 1, 2013, and December 31, 2019, in the IRIS<sup>®</sup> Registry. Main outcome measures were frequency of new RP, CHM, and ACHM, and frequency and hazard ratios for subsequent comorbidities.</p><p><strong>Results: </strong>Overall, 40,302 IRIS Registry patients (58% female) received a new diagnosis of RP, CHM, or ACHM. RP was most common (95%, <i>n</i> = 38,179), followed by ACHM (4%, <i>n</i> = 1583), and CHM (1%, <i>n</i> = 540). RP and CHM presented in younger patients (plurality 45 to 64 years old) compared to ACHM (plurality 75 to 84 years old). In multivariable regression, patients with ACHM were significantly less likely to receive a cataract diagnosis (hazard ratio [HR] = 0.43, 95% CI = 0.39 to 0.47), cataract surgery (HR = 0.64, 95% CI = 0.56 to 0.74), or CME diagnosis (HR = 0.28, 95% CI = 0.23 to 0.33) compared to patients with RP. There was no significant difference between CHM and RP. Rhegmatogenous retinal detachment (RRD) diagnosis and repair were most likely among patients with CHM, compared to patients with RP, and patients with ACHM were less likely to receive an RRD diagnosis but more likely to undergo surgical repair compared to patients with RP (HR = 0.62, 95% CI = 0.49 to 0.79, and HR = 2.57, 95% CI = 1.59 to 4.14, respectively).</p><p><strong>Conclusion: </strong>Patients with inherited retinal diseases can develop treatable ocular conditions that may affect their vision. Cataract and cystoid macular edema (CME) appear to be most associated with RP. Although RRD is rare, it may be disproportionately diagnosed in RP relative to repair rates and was most likely among CHM patients, perhaps reflecting coding practices and/or misdiagnosis.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"257-262"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147531624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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