Luiz Roisman, João Gabriel Alexander, Pedro Leite C Franco, Lisangela N Morimoto, Maurício Maia
{"title":"A Bullous Variant of Central Serous Chorioretinopathy Treated With Sclerotomy.","authors":"Luiz Roisman, João Gabriel Alexander, Pedro Leite C Franco, Lisangela N Morimoto, Maurício Maia","doi":"10.3928/23258160-20241101-01","DOIUrl":"10.3928/23258160-20241101-01","url":null,"abstract":"<p><p>Bullous serous central chorioretinopathy (bCSCR) is an atypical form of CSCR characterized by large serous detachment. This variant presents significant diagnostic challenges, and optimal treatment strategies are not well defined. This report presents a case of a 31-year-old man with bCSRC treated with scleral thinning surgery in four quadrants with scleral windows created in the two inferior quadrants. The etiology, pathogenesis, and optimal treatment of bCSCR are not fully understood. Various therapeutic options, including photocoagulation and photodynamic therapy, have been employed with varying degrees of success. We describe a case of scleral thinning (sclerectomy) with two inferior sclerotomies without subretinal drainage, which resulted in a positive outcome. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:116-119.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"116-119"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Feldman, Jesse Basra, Anjola Lawani, Yunyi Ren, Machelle Wilson, Ala Moshiri, Susanna S Park, Glenn Yiu
{"title":"Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial.","authors":"Samuel Feldman, Jesse Basra, Anjola Lawani, Yunyi Ren, Machelle Wilson, Ala Moshiri, Susanna S Park, Glenn Yiu","doi":"10.3928/23258160-20240924-03","DOIUrl":"10.3928/23258160-20240924-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA).</p><p><strong>Patients and methods: </strong>Prospective, single-masked, sham-controlled trial in 27 eyes of 19 adult patients with treatment-naïve, center-involved DME, and VA of 20/25 or better. Measures included best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), contrast sensitivity (CS), average threshold on microperimetry, and central subfield thickness (CST). The primary outcome measure was median time to vision loss of 10 letters at any visit or 5 to 9 letters at two consecutive visits ≤ 28 days apart.</p><p><strong>Results: </strong>Eight eyes met vision loss criteria during the 2-year study, with similar proportions for SML (<i>n</i> = 5) and sham (<i>n</i> = 3). Median time to vision loss was 5 months for both groups. At 6 months, there were no statistical differences in BCVA, LLVA, CS, microperimetry threshold, and CST between SML and sham arms (<i>P</i> > 0.05 in all measures).</p><p><strong>Conclusion: </strong>In eyes with center-involved DME and good VA, SML did not prevent or delay the vision loss threshold for initiating anti-VEGF therapy. However, these results may be affected by a high rate of early participant dropout from the study. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:86-93.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"86-93"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"American Football-associated Whiplash Maculopathy Presenting With Bilateral Bacillary Detachments: Case Report and Review of Literature.","authors":"Adrienne Delaney, Rachel A Downes, Danny A Mammo","doi":"10.3928/23258160-20240927-01","DOIUrl":"10.3928/23258160-20240927-01","url":null,"abstract":"<p><p>Ocular trauma is a rare cause of bacillary layer detachments (BALAD). A case report was evaluated and a literature review was performed. A 15-year-old boy presented with bilateral scotomas after a routine American football tackle and was found to have bilateral BALADs. Inflammatory and infectious causes of BALAD were excluded, and he was diagnosed with whiplash maculopathy. Without intervention, the patient's visual acuity and macular anatomy rapidly improved. Novel indocyanine green angiography findings of this condition are reported. Bacillary detachments resulting from whiplash injuries generally resolve spontaneously with good visual outcomes. Even when other sequelae of trauma are not obvious, the presence of BALAD should prompt a targeted history around recent trauma including sports-associated whiplash injuries. Patients with thicker choroids may be at increased risk of posterior segment sequalae from whiplash injury and choroidal status should be commented on in future reports. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:113-115.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"113-115"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety Profile and Practical Applications of the C3 and C5 Complement Inhibitors for Management of Geographic Atrophy.","authors":"Eric Lai, Seenu M Hariprasad, Sidney Schechet","doi":"10.3928/23258160-20241114-02","DOIUrl":"https://doi.org/10.3928/23258160-20241114-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"55 12","pages":"694-696"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
João Pedro Romero Braga, Murilo Wendeborn Rodrigues, Victor C F Bellanda, Moises Moura de Lucena, Rodrigo Jorge, Eduardo Cunha de Souza
{"title":"Abnormal Unilateral Dilated Perifoveal Venule Found During Observation of a Transient Vitreomacular Traction.","authors":"João Pedro Romero Braga, Murilo Wendeborn Rodrigues, Victor C F Bellanda, Moises Moura de Lucena, Rodrigo Jorge, Eduardo Cunha de Souza","doi":"10.3928/23258160-20240718-01","DOIUrl":"10.3928/23258160-20240718-01","url":null,"abstract":"<p><p>This case report describes a new type of perifoveal retinal vascular abnormality (RVA) incidentally discovered during a posterior vitreous detachment (PVD) investigation. A 65-year-old woman with sudden central visual loss displayed a uni-lateral focal telangiectatic venule in the perifoveal area. Multimodal imaging documented the vascular abnormality and associated retinal changes. Despite symptom resolution, the RVA persisted. This case represents a unique presentation of perifoveal RVA, likely an atypical form of macular telangiectasia. The sequential imaging documentation during a process of PVD with central bouquet traction provides insights into the underlying mechanisms in addition to diagnosing and monitoring perifoveal RVAs. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:737-741.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"737-741"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarunas P Daugirdas, Christopher M Maatouk, Hongxin J Lai, Miller J Ogidigben, Rishi P Singh
{"title":"Central Retinal Thickness Variability as a Predictive Factor for Visual Acuity After Dexamethasone Implant in Retinal Vein Occlusion.","authors":"Sarunas P Daugirdas, Christopher M Maatouk, Hongxin J Lai, Miller J Ogidigben, Rishi P Singh","doi":"10.3928/23258160-20240621-04","DOIUrl":"10.3928/23258160-20240621-04","url":null,"abstract":"<p><strong>Background and objective: </strong>Investigate central retinal thickness (CRT) variability and changes in best-corrected visual acuity (BCVA) after 12 months in patients with retinal vein occlusion (RVO) treated with dexamethasone intravitreal implants.</p><p><strong>Patients and methods: </strong>Post hoc analyses of two randomized trials in patients with macular edema associated with branch or central RVO treated with a 0.7-mg dexamethasone implant. Central retinal thickness standard deviation (CRT-SD) and central retinal thickness amplitude (CRT-A) were measures of variability. Analyses included multinomial and simple linear regression.</p><p><strong>Results: </strong>In 400 patients, CRT-SD and CRT-A were significantly associated with central RVO, second dexamethasone implant, and baseline CRT. Baseline BCVA was associated with CRT-A. CRT-SD and CRT-A were significantly correlated with a 12-month change in BCVA (effect sizes of -0.032 and -0.013 letters/µm; <i>P</i> < 0.001). Patients in the highest CRT-SD quartile gained significantly fewer letters (+1.88 letters; 95% CI: -0.46 to 4.23).</p><p><strong>Conclusion: </strong>Greater CRT variability was associated with smaller BCVA improvements in patients with RVO treated with dexamethasone implants. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:722-729.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"722-729"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitrectomy With tPA for Submacular Hemorrhage Following Domestic Abuse.","authors":"Miguel A Busquets, Fareed Rifai","doi":"10.3928/23258160-20240705-01","DOIUrl":"10.3928/23258160-20240705-01","url":null,"abstract":"<p><p>A 35-year-old woman presented with visual acuity of 20/400 due to submacular hemorrhage 24 hours after confirmed domestic abuse with blunt trauma to the head. Surgical intervention with pars plana vitrectomy, subretinal tissue plasminogen activator (tPA) injection, and fluid-air exchange yielded prompt resolution of the pathology, regaining functional vision of 20/40 and an ability to return to work within one week. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:734-736.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"734-736"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah Istre-Wilz, Jared J Ebert, James J Augsburger, Maura Di Nicola, Zelia M Correa, Basil K Williams
{"title":"Retinal Gliovascular Proliferation Secondary to Retinoblastoma Treated With Radiotherapy.","authors":"Hannah Istre-Wilz, Jared J Ebert, James J Augsburger, Maura Di Nicola, Zelia M Correa, Basil K Williams","doi":"10.3928/23258160-20240801-01","DOIUrl":"10.3928/23258160-20240801-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal gliovascular proliferation (RGVP) is a benign lesion of the retina that can arise idiopathically or secondary to another disease entity. This study describes the clinical features, treatment, and outcomes of six patients with secondary RGVP associated with irradiated, regressed retinoblastoma, and distinguishes it from late local relapse of retinoblastoma.</p><p><strong>Patients and methods: </strong>In a retrospective review of available clinical records of 550 patients evaluated for retinoblastoma in a single ocular oncology practice between 1975 and 2022, seven eyes of six patients were identified as having secondary RGVP overlying a treated and regressed retinoblastoma. The clinical features, treatment, and outcomes are described.</p><p><strong>Results: </strong>The median age at RGVP diagnosis was 20 years. All RGVPs were associated with a completely regressed retinoblastoma and in proximity to a calcific tumor residue or chorioretinal atrophy that remained after external beam radiotherapy (six eyes) or plaque brachytherapy (one eye). Lesions were measured between 2.8 to 12 mm in largest basal diameter and 1.3 to 4.4 mm in thickness and described as globular, raised areas with focal retinal telangiectasis often associated with overlying subretinal fluid or hemorrhage. Median time between initial retinoblastoma treatment and detection of RGVP was 20 years. Treatment was decided based on evidence of lesion growth and most often consisted of laser photocoagulation and intravitreal anti-VEGF injection. Through available follow-up of the treated lesions, all exhibited at least partial regression, while two untreated lesions remained stable, reassuring us against late local relapse of retinoblastoma.</p><p><strong>Conclusions: </strong>Secondary RGVP develops occasionally in association with regressed previously irradiated retinoblastoma. This lesion must be distinguished from late local relapse of active retinoblastoma. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:714-720.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"714-720"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}