{"title":"Macular Hole Self Closure While Awaiting Pre-operative Clearance.","authors":"Michael Javaheri, Angela J Oh, Pradeep S Prasad","doi":"10.3928/23258160-20240729-01","DOIUrl":"https://doi.org/10.3928/23258160-20240729-01","url":null,"abstract":"<p><p>A 69-year-old white woman with a history of vitreomacular traction (VMT) presented with a 2-week history of visual loss in the right eye. Visual acuity, with correction, measured 20/200 in the right eye. Examination revealed a partial posterior vitreous detachment and a stage 2 full-thickness macular hole (FTMH). Spectral-domain optical coherence tomography (SD-OCT) testing confirmed a stage 2 FTMH with VMT. Pars plana vitrectomy without internal limiting membrane peeling was planned and the patient was sent for preoperative clearance, where she was diagnosed with atrial fibrillation and wanted to delay surgery. Two months later, the patient returned for follow-up with a visual acuity of 20/80, a closed macular hole, and an incomplete posterior vitreous detachment in her right eye. Four months later, the patient exhibited a completely closed FTMH with a visual acuity of 20/30. Spontaneous resolution of FTMHs (stages 2 to 4) in the adult population is an extremely rare event, occurring in less than 4% of affected eyes. We describe a patient with a stage 2 FTMH who exhibited spontaneous resolution due to the resolution of VMT while awaiting preoperative clearance. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bita Momenaei, Taku Wakabayashi, Abtin Shahlaee, Asad F Durrani, Saagar A Pandit, Kristine Wang, Hana A Mansour, Robert M Abishek, David Xu, Jayanth Sridhar, Yoshihiro Yonekawa, Ajay E Kuriyan
{"title":"Assessing ChatGPT-3.5 Versus ChatGPT-4 Performance in Surgical Treatment of Retinal Diseases: A Comparative Study.","authors":"Bita Momenaei, Taku Wakabayashi, Abtin Shahlaee, Asad F Durrani, Saagar A Pandit, Kristine Wang, Hana A Mansour, Robert M Abishek, David Xu, Jayanth Sridhar, Yoshihiro Yonekawa, Ajay E Kuriyan","doi":"10.3928/23258160-20240227-02","DOIUrl":"10.3928/23258160-20240227-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"481-482"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco J López-Font, Serena M Shah, Benjamin R Lin, Natasha Ferreira Santos da Cruz, Jesse D Sengillo, Audina M Berrocal
{"title":"Coats-Like Presentation of Familial Exudative Vitreoretinopathy Associated With a Novel <i>LRP5</i> Variant.","authors":"Francisco J López-Font, Serena M Shah, Benjamin R Lin, Natasha Ferreira Santos da Cruz, Jesse D Sengillo, Audina M Berrocal","doi":"10.3928/23258160-20240410-02","DOIUrl":"10.3928/23258160-20240410-02","url":null,"abstract":"<p><p>This report describes a unique case of a Coats-like presentation of familial exudative vitreoretinopathy in an 11-year-old girl. The patient was originally referred for evaluation of presumed Coats disease and presented with telangiectatic vessels, perivascular exudates, diffuse peripheral exudation, and intraretinal hemorrhages. Clinical and angiographical findings were consistent with familial exudative vitreoretinopathy, while genetic testing identified variants of uncertain significance in two associated genes, <i>LRP5</i> and <i>ZNF408</i>. In silico analysis predicts the <i>LRP5</i> variant to be pathogenic. Retinal vasculopathies often have phenotypic overlap, warranting angiographic examination of both eyes and genetic testing to uncover the correct diagnosis and guide proper treatment. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:462-466.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"462-466"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hana A Mansour, David Xu, Michael N Cohen, Jordan D Deaner, Jason Hsu, Yoshihiro Yonekawa, Anton Orlin, Meera D Sivalingam, Jayanth Sridhar, Ajay E Kuriyan
{"title":"Google Search Trends to Assess Public Interest and Concern About Pegcetacoplan for the Treatment of Geographic Atrophy.","authors":"Hana A Mansour, David Xu, Michael N Cohen, Jordan D Deaner, Jason Hsu, Yoshihiro Yonekawa, Anton Orlin, Meera D Sivalingam, Jayanth Sridhar, Ajay E Kuriyan","doi":"10.3928/23258160-20240409-04","DOIUrl":"10.3928/23258160-20240409-04","url":null,"abstract":"<p><strong>Objective: </strong>To assess global trends in interest surrounding the newly Food and Drug Administration (FDA)-approved treatment for geographic atrophy, (GA), Syfovre (pegcetacoplan), and related searches.</p><p><strong>Methods: </strong>We utilized Google Trends, in order to gauge the public interest in Syfovre from October 16, 2022, to October 8, 2023.</p><p><strong>Results: </strong>Notable spikes in relative search volumes (RSV)s for \"Syfovre\" were observed in mid-to-late February 2023, and in March and April 2023, coinciding with the drug's FDA approval and introduction to the market. Of the various side effects, retinal vasculitis garnered the most significant attention, with a sharp rise in RSV in mid-July 2023. Geographic variation was evident, with the highest RSVs for \"Syfovre\" originating from users on the East Coast.</p><p><strong>Conclusion: </strong>Google Trends proves to be a useful tool for gaining insight into public interest in pegcetacoplan as a treatment for GA. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:452-460.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"452-460"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embedding the Retinal Flap in the Original Retinal Hole as a Treatment for Retinal Detachment of the Posterior Pole.","authors":"Hiroto Terasaki, Taiji Sakamoto","doi":"10.3928/23258160-20240805-04","DOIUrl":"https://doi.org/10.3928/23258160-20240805-04","url":null,"abstract":"<p><strong>Background and objective: </strong>Rhegmatogenous retinal detachment (RRD) of the posterior pole accounted for only 3.5% of all RRD cases in Japan, with most being macular hole retinal detachments, which are difficult to treat. Retinal detachment of the posterior pole not caused by a macular hole is rare. Herein, we report a case of RRD of the posterior pole that was successfully treated by embedding the original retinal flap with a bridging vessel into the retinal hole.</p><p><strong>Patients and methods: </strong>A 56-year-old woman with a preoperative visual acuity of 20/100 was diagnosed with RRD of the posterior pole. We sealed the original retinal tear by embedding the retinal flap within the tear.</p><p><strong>Results: </strong>One year after surgery, blood flow was maintained in the bridging vessels and peripheral retina.</p><p><strong>Conclusion: </strong>This technique may be useful for treating retinal detachment caused by retinal tears of the posterior pole. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kensington A Hatcher, Birva K Shah, Mark Burch, Srinivas Sai A Kondapalli, Caroline R Baumal
{"title":"Outer Retinal Tubulation in Geographic Atrophy.","authors":"Kensington A Hatcher, Birva K Shah, Mark Burch, Srinivas Sai A Kondapalli, Caroline R Baumal","doi":"10.3928/23258160-20240411-02","DOIUrl":"10.3928/23258160-20240411-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is observed on optical coherence tomography images from patients with geographic atrophy (GA), but its clinical implications are unclear. The objective of this study was to investigate the prevalence of ORT and its association with GA lesion growth rates.</p><p><strong>Materials and methods: </strong>This post hoc longitudinal analysis assessed 62 eyes randomized to sham treatment in the phase 2 FILLY trial. ORT prevalence was estimated at baseline, month 12, and month 18 and change in GA lesion growth from baseline to month 18 was calculated.</p><p><strong>Results: </strong>ORT prevalence rates were 24%, 43%, and 43% at baseline, month 12, and month 18, respectively. Slower mean GA lesion growth was observed in eyes with ORT present at baseline in the overall population as well as the subfoveal and nonsubfoveal GA subgroups.</p><p><strong>Conclusion: </strong>ORT presence may indicate a slower-growing GA lesion phenotype, independent of foveal involvement. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:448-451.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"448-451"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marissa Firlie, Shannon Scarboro, C Armitage Harper
{"title":"Spontaneous Resolution of a Combined Hamartoma in a One-Year-Old Child.","authors":"Marissa Firlie, Shannon Scarboro, C Armitage Harper","doi":"10.3928/23258160-20240412-01","DOIUrl":"10.3928/23258160-20240412-01","url":null,"abstract":"<p><p>The combined hamartoma of the retina and the retinal pigment epithelium (CHR-RPE) is a rare but histologically benign tumor of which no clear consensus exists regarding its appropriate management. Most commonly CHR-RPE presents unilaterally in children as an elevated, pigmented lesion associated with vascular tortuosity and an epiretinal membrane (ERM). Patients may have decreased visual acuity (VA) in the affected eye, notably if the overlying ERM extends into the macula. For this reason, surgical intervention in the form of ERM removal has been pursued with notable success. Still, those who pursue observation cite the interwoven nature of the overlying glial membrane within the dysplastic retina, complicating surgery and accounting for variability in post-operative VA success. Given the rarity of the tumor coupled with the scarcity of data on its natural evolution, clinicians who pursue observation cannot know for sure whether withholding surgical management is predisposing their patients to worse visual outcomes as compared to those patients who undergo ERM peel as first-line therapy. This case report will discuss an infant with clinically diagnosed CHR-RPE whose lesion showed significant regression after 6 months of observation. This success story should cause ophthalmologists to reconsider the management options at their disposal when faced with a case of CHR-RPE, and to call for further research to better define the risks of observation over surgical intervention. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:471-473.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"471-473"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Birkaran Sadhar, Amanda G Yarkoni, Kush K Patel, Dimosthenis Mantopoulos, Tatyana Milman, Carol L Shields, Howard F Fine
{"title":"Vitreoretinal Lymphoma Masquerading as Central Serous Chorioretinopathy.","authors":"Birkaran Sadhar, Amanda G Yarkoni, Kush K Patel, Dimosthenis Mantopoulos, Tatyana Milman, Carol L Shields, Howard F Fine","doi":"10.3928/23258160-20240410-03","DOIUrl":"10.3928/23258160-20240410-03","url":null,"abstract":"<p><p>The following is a case of vitreoretinal lymphoma masquerading as central serous chorioretinopathy (CSCR). A 74-year-old man presented with blurred vision in the left eye with unilateral subretinal fluid in the setting of exogenous corticosteroid use, which was diagnosed as CSCR and resolved with corticosteroid cessation. He later experienced a similar self-limited episode in the right eye. Subsequently, he developed bilateral vitritis with yellow-white subretinal pigment epithelial infiltrates. Vitreous biopsy confirmed a diagnosis of large B-cell lymphoma. Vitreoretinal lymphoma can masquerade as a number of ocular pathologies, including CSCR. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:467-470.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"467-470"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}