Sandra Hoyek, Francesco Romano, Mauricio Garcia, Ioanna Ploumi, Itika Garg, Jack Tracy, Katherine Millner Overbey, Cade Frederick Bennett, Matthew J Finn, Peyman Razavi, Isabella Victoria Manzano Stettler, Xinyi Ding, John B Miller, Nimesh A Patel
{"title":"A Quantitative Normative Database for Expanded Field Swept-source OCT Angiography in the Pediatric Population.","authors":"Sandra Hoyek, Francesco Romano, Mauricio Garcia, Ioanna Ploumi, Itika Garg, Jack Tracy, Katherine Millner Overbey, Cade Frederick Bennett, Matthew J Finn, Peyman Razavi, Isabella Victoria Manzano Stettler, Xinyi Ding, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20250108-03","DOIUrl":"10.3928/23258160-20250108-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To report quantitative vascular metrics of healthy control eyes of children, using expanded field swept-source optical coherence tomography angiography (SS-OCTA), as a baseline to compare with pathologic findings.</p><p><strong>Patients and methods: </strong>A cross-sectional observational study of healthy eyes of children (age 6 to 18) who were imaged on the PLEX Elite 9000 instrument at 100-kHz scanning rate using 3 × 3-mm, 6 × 6-mm, and 12 × 12-mm protocols centered on the fovea (2019 to 2023). Scans were uploaded to the ARI Network (Zeiss Portal v5.4) and processed with the macular density algorithm (v.0.7.3.3) to calculate vessel density (VD) and vessel skeletonized density (VSD) in the superficial capillary plexus (SCP), deep capillary plexus, and whole retina (WR) and foveal avascular zone (FAZ) metrics.</p><p><strong>Results: </strong>Forty-eight eyes of 39 children (72% male) were included. Median age was 14 years (interquartile range 10 to 16). Male sex was associated with lower VD and VSD compared to female sex (<i>P</i> < 0.05). Older age was associated with higher VD and VSD (6 × 6-mm) (<i>P</i> < 0.05) and lower FAZ circularity (<i>P</i> = 0.017). Non-Hispanic White children had a lower VD and VSD of the SCP in the inner superior ring (3 × 3-mm), a higher VD and VSD of the SCP and WR in the central ring (6 × 6-mm), and a lower FAZ area (6 × 6-mm) (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This study presents a database for expanded field vascular metrics in pediatric subjects across various angiogram sizes. The VD increases throughout childhood and the FAZ circularity diminishes. Future studies using SS-OCTA will need to account for influencing factors such as sex, age, race, and ethnicity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:212-218.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"212-218"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda
{"title":"Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials.","authors":"Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda","doi":"10.3928/23258160-20250108-02","DOIUrl":"10.3928/23258160-20250108-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.</p><p><strong>Patients and methods: </strong>This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.</p><p><strong>Results: </strong>Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.</p><p><strong>Conclusion: </strong>Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:228-230.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"228-230"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Landon J Rohowetz, Prashanth G Iyer, Noy Ashkenazy, Kenneth C Fan, Rita Laiginhas, Yingying Shi, Jeremy Liu, Philip Rosenfeld, Harry W Flynn
{"title":"Tractional Retinoschisis in Proliferative Diabetic Retinopathy Imaged With Swept-Source Optical Coherence Tomography Angiography.","authors":"Landon J Rohowetz, Prashanth G Iyer, Noy Ashkenazy, Kenneth C Fan, Rita Laiginhas, Yingying Shi, Jeremy Liu, Philip Rosenfeld, Harry W Flynn","doi":"10.3928/23258160-20241101-04","DOIUrl":"10.3928/23258160-20241101-04","url":null,"abstract":"<p><p>Tractional retinoschisis (TRS) secondary to proliferative diabetic retinopathy (PDR) may be differentiated from tractional retinal detachment (TRD) by its characteristically nonprogressive course. The purpose of the current study was to describe the use of swept-source optical coherence tomography angiography (SS-OCTA) in the diagnosis and monitoring of TRS secondary to PDR. Retrospective, consecutive case series of patients with TRS secondary to PDR are featured. Clinical notes, fundus photography, and SS-OCTA images are reviewed. The study comprised three eyes of three patients with PDR and TRS. Visual acuity and anatomic features on SS-OCTA were stable in all patients at one year or more of follow-up. Tractional retinoschisis secondary to PDR is typically nonprogressive and may be observed without surgery. SS-OCTA serves as a noninvasive and effective imaging tool to distinguish TRS from TRD and to demonstrate anatomic stability over time. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:244-248.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"244-248"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindsey A Chew, Nikhil V Gadiraju, Anjali M Saini, S Tammy Hsu, Vahid Ownagh, Lejla Vajzovic
{"title":"Pediatric Eye Screening: Current Standards and Gaps in Care.","authors":"Lindsey A Chew, Nikhil V Gadiraju, Anjali M Saini, S Tammy Hsu, Vahid Ownagh, Lejla Vajzovic","doi":"10.3928/23258160-20241216-03","DOIUrl":"10.3928/23258160-20241216-03","url":null,"abstract":"<p><p>The nonmydriatic, noncontact, and rapid acquisition features of ultra-widefield fundus (UWF) imaging create an invaluable tool for pediatric retinal screening in primary care. This review assesses the landscape of pediatric eye screening, identifies gaps in diagnosing a range of pediatric retinal conditions, and discusses potential uses of UWF imaging for retinal screening. The standards for pediatric eye screening in primary care include red reflex testing, direct ophthalmoscopy, external ocular exam, instrument-based screening, and visual acuity testing. These tests fail to diagnose several treatable retinal diseases. In this gap, UWF retinal imaging provides a panoramic view of the retinal landscape, allowing for a more comprehensive examination. For several pediatric retinal conditions (eg, retinal detachment, retinopathy of prematurity, Coats' disease, familial exudative vitreoretinopathy, Stargardt disease, ocular toxocariasis), UWF retinal imaging provides the high spatial resolution necessary for reliable diagnosis, expediting time to treatment while maintaining low false positive rates. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:232-239.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"232-239"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth A Mellencamp, Dimitrios C Arhontoulis, Sydney C DiBona, David E Baxley, Nicolas A Yannuzzi, Peter H Tang
{"title":"Novel Gore-Tex Scleral Fixation Technique for Dual-Eyelet Intraocular Lenses.","authors":"Elizabeth A Mellencamp, Dimitrios C Arhontoulis, Sydney C DiBona, David E Baxley, Nicolas A Yannuzzi, Peter H Tang","doi":"10.3928/23258160-20241216-05","DOIUrl":"10.3928/23258160-20241216-05","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"202-204"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raziyeh Mahmoudzadeh, Mirataollah Salabati, Taku Wakabayashi, Dillan Patel, Sonia Mehta, Ajay E Kuriyan, M Ali Khan, Michael A Klufas, Sunir J Garg, Omesh P Gupta, Carl D Regillo, Yoshihiro Yonekawa, Michael N Cohen, Shreya Swaminathan
{"title":"Reply: \"Integrity\" Assessment Following Rhegmatogenous Retinal Detachment Repair.","authors":"Raziyeh Mahmoudzadeh, Mirataollah Salabati, Taku Wakabayashi, Dillan Patel, Sonia Mehta, Ajay E Kuriyan, M Ali Khan, Michael A Klufas, Sunir J Garg, Omesh P Gupta, Carl D Regillo, Yoshihiro Yonekawa, Michael N Cohen, Shreya Swaminathan","doi":"10.3928/23258160-20241207-01","DOIUrl":"10.3928/23258160-20241207-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"251-252"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reut Shor, Marko Popovic, Andrew Mihalache, Rajeev H Muni
{"title":"A Cross-Sectional Survey of Optometrists in Canada Regarding Referral Patterns and a Needs Assessment for an Artificial Intelligence Referral Screening Tool for Epiretinal Membrane.","authors":"Reut Shor, Marko Popovic, Andrew Mihalache, Rajeev H Muni","doi":"10.3928/23258160-20241217-01","DOIUrl":"10.3928/23258160-20241217-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated optometrists' referral patterns for epiretinal membrane (ERM) patients in Ontario, Canada, and their attitudes towards an artificial intelligence (AI) tool for improving referral accuracy. An anonymous online survey with 11 questions was conducted.</p><p><strong>Patients and methods: </strong>The survey targeted optometrists across Ontario, Canada. The survey aimed to understand optometrists' reasons for referring ERM patients to retina specialists, their expectations of the specialists' management, and their openness to using an AI tool for triage. To prevent bias, the survey described an AI tool as an online consultation feature limited to predefined questions without directly mentioning \"AI.\" The main objective was to assess if this AI tool could decrease unnecessary ERM referrals to retina specialists.</p><p><strong>Results: </strong>A total of 135 optometrists participated. They reported seeing an average of eight ERM cases monthly, referring every fourth case to a specialist. The primary referral reason (84.3%) was to evaluate for surgery. In terms of referral confidence, 34.3% felt fully confident (5/5), and 47.8% slightly less so (4/5). They anticipated that 20% of patients would have a change in management post-consultation with a specialist. When introduced to the concept of an online consultation tool for patient screening, optometrists believed it could reduce their ERM referrals by 40%.</p><p><strong>Conclusions: </strong>Optometrists often refer ERM patients to retina specialists. An AI tool for screening ERM referrals, based on presenting vision and OCT images, could significantly lower the number of unnecessary referrals, offering clinical guidance to optometrists. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:166-169.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"166-169"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}