Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda
{"title":"视网膜外管和视觉在地理萎缩：从3期OAKS和DERBY试验的自然历史分析。","authors":"Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda","doi":"10.3928/23258160-20250108-02","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.</p><p><strong>Patients and methods: </strong>This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.</p><p><strong>Results: </strong>Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.</p><p><strong>Conclusion: </strong>Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:228-230.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"228-230"},"PeriodicalIF":0.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials.\",\"authors\":\"Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda\",\"doi\":\"10.3928/23258160-20250108-02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.</p><p><strong>Patients and methods: </strong>This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.</p><p><strong>Results: </strong>Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.</p><p><strong>Conclusion: </strong>Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:228-230.]</b>.</p>\",\"PeriodicalId\":19679,\"journal\":{\"name\":\"Ophthalmic surgery, lasers & imaging retina\",\"volume\":\" \",\"pages\":\"228-230\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic surgery, lasers & imaging retina\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/23258160-20250108-02\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic surgery, lasers & imaging retina","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/23258160-20250108-02","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials.
Background and objective: Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.
Patients and methods: This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.
Results: Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.
Conclusion: Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. [Ophthalmic Surg Lasers Imaging Retina 2025;56:228-230.].
期刊介绍：
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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