Ophthalmic surgery, lasers & imaging retina最新文献

Early Outcomes After Initiation of Faricimab for Neovascular Age-Related Macular Degeneration. 法利西单抗治疗新生血管性年龄相关性黄斑变性的早期结果。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250304-02

Ferhina S Ali, David C Tabano, Durga S Borkar, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh

{"title":"Early Outcomes After Initiation of Faricimab for Neovascular Age-Related Macular Degeneration.","authors":"Ferhina S Ali, David C Tabano, Durga S Borkar, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh","doi":"10.3928/23258160-20250304-02","DOIUrl":"https://doi.org/10.3928/23258160-20250304-02","url":null,"abstract":"Background and objective: This study assessed treatment patterns and early outcomes among patients with neovascular age-related macular degeneration (nAMD) initiating faricimab in routine clinical practice in the United States.Patients and methods: FARETINA-AMD is a retrospective study among patients with nAMD initiating faricimab from February 2022 to June 2023 identified from the US IRIS® Registry.Results: Included were 21,508 patients previously treated with anti-vascular endothelial growth factor (anti-VEGF) (25,784 eyes) and 1,836 treatment-naïve patients (1,982 eyes) with nAMD. Among previously treated eyes, visual acuity remained stable with faricimab. In treatment-naïve eyes, mean ± SD visual acuity improved from 56.7 ± 24.1 letters at index to 61.4 ± 22.3 after faricimab injection 4 (P < 0.01). Mean ± SD central subfield thickness improved from 315.2 ± 80.0 (index) to 264.9 ± 60.1 μm (injection 4) in treatment-naïve eyes and 296.2 ± 95.5 to 273.0 ± 81.4 μm in previously treated eyes (both P < 0.01).Conclusions: Among patients with nAMD receiving faricimab, visual acuity improved in treatment-naïve eyes, and both previously treated and treatment-naïve eyes experienced anatomical improvement. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Outcomes After Initiation of Faricimab in Patients With Diabetic Macular Edema. 法利昔单抗治疗糖尿病性黄斑水肿的早期疗效。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250304-01

Durga S Borkar, David C Tabano, Ferhina S Ali, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh

{"title":"Early Outcomes After Initiation of Faricimab in Patients With Diabetic Macular Edema.","authors":"Durga S Borkar, David C Tabano, Ferhina S Ali, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh","doi":"10.3928/23258160-20250304-01","DOIUrl":"https://doi.org/10.3928/23258160-20250304-01","url":null,"abstract":"Background and objective: This study evaluated treatment patterns and outcomes among patients with diabetic macular edema (DME) treated with the bispecific antibody faricimab in routine clinical practice in the United States.Patients and methods: FARETINA-DME was a retrospective study among patients with DME initiating faricimab from February 2022 to June 2023 identified from the United States IRIS® Registry.Results: Four thousand five hundred fourteen (4,514) patients (6,204 eyes) previously treated with anti-vascular endothelial growth factor (anti-VEGF) therapy and 691 treatment-naïve patients (851 eyes) were included. In previously treated eyes, mean ± SD visual acuity was 64.0 ± 18.3 letters at index and 65.3 ± 19.0 at faricimab injection 4. In treatment-naïve eyes, visual acuity improved from 60.3 ± 19.8 to 63.9 ± 18.5 letters (P < 0.01). Mean ± SD central subfield thickness improved from 364.3 ± 132.2 to 330.1 ± 121.2 μm in previously treated eyes and 359.6 ± 115.0 to 307.4 ± 114.6 μm in treatment-naïve eyes (both P < 0.01).Conclusions: In patients with DME receiving faricimab, visual acuity was maintained in previously treated and improved in treatment-naïve eyes. Both groups had anatomical improvement. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pegcetacoplan for Geographic Atrophy Over 30 Months: Data From OAKS, DERBY, and the GALE Long-Term Extension Study. 30个月以上地理萎缩的Pegcetacoplan：来自OAKS， DERBY和GALE长期扩展研究的数据。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250217-01

Roger A Goldberg, David S Boyer, Frank G Holz, Mathew W MacCumber, Sunir J Garg, David M Brown, Eleonora M Lad, Nathan Steinle, Rishi P Singh, Ian Pearce, Thomas Ach, Ramiro Ribeiro, Chao Li, Daniel Jones, Min Tsuboi, Philip J Ferrone, Caroline R Baumal, Charles C Wykoff

{"title":"Pegcetacoplan for Geographic Atrophy Over 30 Months: Data From OAKS, DERBY, and the GALE Long-Term Extension Study.","authors":"Roger A Goldberg, David S Boyer, Frank G Holz, Mathew W MacCumber, Sunir J Garg, David M Brown, Eleonora M Lad, Nathan Steinle, Rishi P Singh, Ian Pearce, Thomas Ach, Ramiro Ribeiro, Chao Li, Daniel Jones, Min Tsuboi, Philip J Ferrone, Caroline R Baumal, Charles C Wykoff","doi":"10.3928/23258160-20250217-01","DOIUrl":"https://doi.org/10.3928/23258160-20250217-01","url":null,"abstract":"Background and objective: This study will report safety and efficacy of pegcetacoplan for geographic atrophy (GA) secondary to age-related macular degeneration (AMD).Patients and methods: GALE is a phase 3, open-label, multicenter, 36-month extension of the OAKS and DERBY studies. Patients who received pegcetacoplan monthly (PM) or every other month (PEOM) in OAKS or DERBY continued the same regimen in GALE (PM-PM and PEOM-PEOM); sham-observed patients initiated pegcetacoplan, maintaining the same interval.Results: In the first 6 months of GALE, 3.0% of study eyes developed exudative AMD, 1.3% intraocular inflammation, 0.1% ischemic optic neuropathy, and none endophthalmitis. Pegcetacoplan reduced GA growth rate by 39% (PM-PM) and 32% (PEOM-PEOM), with increasing efficacy over time across GA subtypes. In eyes with nonsubfoveal GA, pegcetacoplan reduced GA growth rate by 45% (PM-PM) and 33% (PEOM-PEOM).Conclusion: Pegcetacoplan reduced GA growth rate up to 45% with increasing efficacy over 30 months and demonstrated a favorable safety profile. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitreous Cavity Fibrin Reaction Following Diabetic Vitrectomy. 糖尿病玻璃体切除术后玻璃体腔纤维蛋白反应。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250508-01

Shivesh Varma, Edward Roufail

引用次数: 0

Time for "Cyanescence" to Become Cyanotic. It's ICG "Fluorescence". 是时候让“青涩”变成“青涩”了。这是ICG“荧光”。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-12 DOI: 10.3928/23258160-20250217-02

Nikhil Bommakanti, Jose S Pulido, Howard F Fine, Yoshihiro Yonekawa

引用次数: 0

Ultra Widefield Swept Source OCTA Findings in Coats Plus Syndrome. Coats Plus综合征的超广角扫描源OCTA表现。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-12 DOI: 10.3928/23258160-20250417-02

Celine Chaaya, Ioanna Ploumi, Srujay Pandiri, Xinyi Ding, Sandra Hoyek, Chong Chen, Kayla N Nodecker, Audrey Kim, Nimesh A Patel, John B Miller

{"title":"Ultra Widefield Swept Source OCTA Findings in Coats Plus Syndrome.","authors":"Celine Chaaya, Ioanna Ploumi, Srujay Pandiri, Xinyi Ding, Sandra Hoyek, Chong Chen, Kayla N Nodecker, Audrey Kim, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20250417-02","DOIUrl":"https://doi.org/10.3928/23258160-20250417-02","url":null,"abstract":"Coats plus syndrome (CPS), also referred to as cerebroretinal microangiopathy with calcifications and cysts (CMCC), is a rare autosomal recessive disease that primarily targets the microvasculature of the retina, brain, bones, and gastrointestinal system. This study reports the case of a 24-year-old female patient who was initially diagnosed with familial exudative vitreoretinopathy (FEVR) and was lost to follow-up. The patient underwent multimodal retinal imaging, including ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) (DREAM OCT, Intalight). Examination revealed areas of peripheral avascular retina with limited exudation and telangiectasis. Ultra-widefield SS-OCTA provided a detailed view of the peripheral retinal changes, including temporal retinal ischemia, vessel tortuosity, dilated intercapillary spaces, and vessel shunting. Genetic testing was positive for CTC1 mutation and the diagnosis of CPS was made. Mild phenotypes of Coats plus can mimic FEVR and there is a need to maintain a level of suspicion in patients with any systemic symptoms. Ultra-widefield OCTA can be used to assess peripheral avascularity and telangiectasias to aid in the diagnosis and management. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COL4A1 Related Retinal Vascular Tortuosity. COL4A1相关视网膜血管扭曲。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-12 DOI: 10.3928/23258160-20250422-01

Bhagyashree Nachiket Joshi, Gabriella De Salvo

引用次数: 0

Optical Coherence Tomography Biomarkers in Epiretinal Membrane. 视网膜前膜的光学相干断层扫描生物标志物。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-12 DOI: 10.3928/23258160-20250416-01

Sonya Besagar, Shravika Chennupati, Xiangyu Ji, Qingxia Chen, Akshay S Thomas, Avni P Finn

{"title":"Optical Coherence Tomography Biomarkers in Epiretinal Membrane.","authors":"Sonya Besagar, Shravika Chennupati, Xiangyu Ji, Qingxia Chen, Akshay S Thomas, Avni P Finn","doi":"10.3928/23258160-20250416-01","DOIUrl":"https://doi.org/10.3928/23258160-20250416-01","url":null,"abstract":"Background and objective: This retrospective, multicenter imaging analysis aims to identify pre-operative optical coherence tomography (OCT) bio-markers of idiopathic epiretinal membrane (ERM) that predict improved postoperative best-corrected visual acuity (BCVA).Patients and methods: Included were 80 eyes of 77 patients who underwent pars plana vitrectomy, membrane peel, and internal limiting membrane peel (PPV/MP/ILMP) for idiopathic ERM. Various preoperative, demographic, and surgical factors were studied, along with multiple preoperative OCT biomarkers.Results: Ellipsoid zone (EZ) disruption and focal retinal nerve fiber layer (RNFL) schisis present on preoperative OCT were associated with an increased likelihood of 2-line visual acuity improvement, independent of preoperative vision, while ERM stage, ectopic inner foveal layers, foveal herniation, central subfield thickness, cystic changes, lamellar hole, and the gap between the ERM and the retinal surface (SUKIMA) were not.Conclusion: Preoperative EZ disruption and RNFL schisis on OCT may identify patients who are more likely to have a meaningful improvement in postoperative visual outcomes for idiopathic ERM. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment. 双重应用甲氨蝶呤改善糖尿病牵引性视网膜脱离的功能和解剖结果。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-01 Epub Date: 2025-02-01 DOI: 10.3928/23258160-20250127-03

Abdallah Safwat, Mohamed Abdullah, Ahmed Shawkat Abdelhalim, Rabei Hassanien, Khaled Mourad, Mohamed Tarek Moustafa

{"title":"Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment.","authors":"Abdallah Safwat, Mohamed Abdullah, Ahmed Shawkat Abdelhalim, Rabei Hassanien, Khaled Mourad, Mohamed Tarek Moustafa","doi":"10.3928/23258160-20250127-03","DOIUrl":"10.3928/23258160-20250127-03","url":null,"abstract":"Background and objective: This study evaluated the use of a dual-delivery methotrexate (MTX) strategy for diabetic tractional retinal detachment (TRD). Diabetic retinopathy (DR) is a leading cause of blindness. Inflammation plays a key role in TRD, and MTX has anti-inflammatory properties.Patients and methods: This is a pilot study that included 60 patients with TRD. They were block randomized to either MTX with pars plana vitrectomy (PPV) (n = 30) or PPV alone (control, n = 30). MTX was added to the irrigation fluid during surgery and an intra-silicone injection at the end. One month after silicone oil removal, visual acuity (VA), multifocal electroretinography (mfERG), and spectral-domain optical coherence tomography (SD-OCT) were assessed.Results: One month after silicone oil removal, VA and mfERG were significantly better with a lower prevalence of epiretinal membranes, disorganization of retinal inner layers, and cystic macular changes by SD-OCT in the MTX group.Conclusion: This study found that dual-delivery MTX during PPV is a promising strategy to improve functional and anatomical results in diabetic TRD. [Ophthalmic Surg Lasers Imaging Retina 2025;56:298-305.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"298-305"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legislative Changes on Opioid Prescriptions for Ocular Procedures in a United States Cohort. 一项美国队列眼科手术阿片类药物处方的立法变化。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.3928/23258160-20250127-04

Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott

{"title":"Legislative Changes on Opioid Prescriptions for Ocular Procedures in a United States Cohort.","authors":"Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20250127-04","DOIUrl":"https://doi.org/10.3928/23258160-20250127-04","url":null,"abstract":"This ecological study examines the prevalence of postoperative opioid prescriptions among ophthalmic surgical patients during the implementation of four opioid policy interventions in Ohio. Changes in ophthalmic prescribing among 53 health care systems throughout the United States are compared to a population from the MetroHealth System in Cuyahoga County, Ohio. Opioid prescription prevalence spiked among all populations amid Ohio's \"pill mill\" and mandatory registration policies and then consistently decreased during the state's mandatory reporting and number-of-day restrictions. Black, Hispanic, and male subgroups across the country were more likely to receive opioids relative to other subgroups during most policy periods, but their rates were likely driven by trauma-related procedures. Prescribing fluctuations among ophthalmologists in the MetroHealth System generally matched national trends and did not correlate with prescribing trends among other specialties in Ohio. Consistent with previous research, opioid prescribing in ophthalmology remains low compared to other specialties throughout the country. [Ophthalmic Surg Lasers Imaging Retina 2025;56:312-315.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 5","pages":"312-315"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0