Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Trends in Research Payments for Age-Related Macular Degeneration From 2015 to 2021.","authors":"April M Lee, Timothy T Xu, Matthew R Starr","doi":"10.3928/23258160-20240903-01","DOIUrl":"https://doi.org/10.3928/23258160-20240903-01","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate characteristics of industry and public research payments for age-related macular degeneration studies.</p><p><strong>Materials and methods: </strong>Studies involving \"age-related macular degeneration\" or \"AMD\" from 2015 to 2021 were extracted from the Open Payments Database and the National Eye Institute RePORTER tool and compared to each other.</p><p><strong>Results: </strong>From 2015 to 2021, 620 ophthalmologists received $178,394,734.09 in industry research payments with a 76.9% increase from 2015 to 2020 and a subsequent 40.7% decrease in 2021. There were 84 female industry funding recipients (13.7%) compared to 528 (86.3%) male recipients (<i>P</i> < 0.001). For public funding, 119 ophthalmologists received $157,319,575.00 with a 31.0% increase from 2015 to 2021. Among 119 principal investigators, 37 (31.1%) were women and 82 (68.9%) were men (<i>P</i> = 0.05).</p><p><strong>Conclusion: </strong>Industry-funded and publicly funded age-related macular degeneration-related research payments overall increased from 2015 to 2021. Funding distribution by sex trended towards male recipients. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:xx-xx.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serous-Exudative Detachment and Progressive Macular Degeneration in a Patient With Kabuki and Marfan Syndrome.","authors":"Michael Bouaziz, Philip J Ferrone","doi":"10.3928/23258160-20240624-01","DOIUrl":"10.3928/23258160-20240624-01","url":null,"abstract":"<p><p>To our knowledge, this is the first report of a patient with both genetically confirmed Kabuki and Marfan syndrome demonstrating a perifoveal macular degeneration in one eye. Progressive loss of the outer retinal layers was captured and demonstrated with spectral-domain optical coherence tomography imaging. Fundus autofluorescence imaging revealed perifoveal hypoautofluorescence. The patient had initially presented with a spontaneously resolved serous-exudative retinal detachment associated with tortuous retinal vasculature and preretinal proliferative vitreoretinopathy in the other eye. Prior to presentation, the patient had an ocular history of bilateral ectopia lentis treated with crystalline lens removal and placement of iris-claw intraocular lenses. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:541-544.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Visual Outcomes With Dedicated Retina Call Block Time in Primary Retinal Detachment Repair.","authors":"Matthew J Finn, Luis Martinez-Velazque, Rebecca Zeng, Yilin Feng, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240813-01","DOIUrl":"https://doi.org/10.3928/23258160-20240813-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To investigate visual outcomes for macula-off rhegmatogenous retinal detachments (RRD) compared to macula-on RRDs based on duration from diagnosis to surgical repair performed by a single surgeon with access to a retina call block system.</p><p><strong>Patients and methods: </strong>A case-control study reviewing the visual acuity (VA) after surgical repair in consecutive macula-off (<i>n</i> = 127) and maculaon (<i>n</i> = 63) RRD comparison eyes that underwent primary RRD repair performed by a single surgeon with dedicated retina call block time.</p><p><strong>Results: </strong>Our results revealed significantly improved VA in macula-off RRD eyes repaired within 3 days of diagnosis at 3, 6, and 12 months/last follow-up, and that duration from diagnosis to surgery is a predictor of VA at 3- and 12-month/last follow-up postoperative visits.</p><p><strong>Conclusion: </strong>Our findings support the use of mechanisms that improve access to operating room time, such as a retina call block system, to expedite surgical repair access. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Long-term Posterior Segment Parameters in Children Who Had Recovered From Multisystem Inflammatory Syndrome.","authors":"Ulviye Kıvrak, Mehmet Tolga Köle, Güzide Akçay, Ufuk Yükselmiş, Fatih Alparslan Genç, Ayşe Karaaslan, Ceren Çetin, Aysu Karatay Arsan, Yasemin Akın, Şaban Şimşek","doi":"10.3928/23258160-20240415-01","DOIUrl":"10.3928/23258160-20240415-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To evaluate long-term posterior segment findings in children recovering from multisystemic inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.</p><p><strong>Patients and methods: </strong>Our study included 22 patients who were admitted to an intensive care unit with a diagnosis of MIS-C between November 2021 and March 2022, and 25 healthy controls. The study included pediatric patients who had an eye examination an average of 12.35 ± 2.18 months after recovery from MIS-C. Detailed eye examinations and measurements of all participants were obtained retrospectively from patient files. Posterior segment parameters were measured using swept-source optical coherence tomography (OCT) and OCT-angiography (OCT-A); these parameters included peripapillary retinal nerve fiber layer (pRNFL) thickness, central macular thickness (CMT), subfoveal choroidal thickness (SCT), macular vascular densities (VD), and foveal avascular zone (FAZ) area.</p><p><strong>Results: </strong>Mean age was 9.7 ± 3.6 years in the MIS-C group and 10.6 ± 2.8 years in the healthy control group (<i>P</i> = 0.316). There were no statistically significant differences between the MIS-C group and the healthy control group in terms of pRNFL thickness, CMT, and SCT. However, in the MIS-C group, the macular superficial vascular plexus and deep vascular plexus showed significantly lower VD in the superior, inferior, nasal, and temporal quadrants compared to the healthy controls (<i>P</i> < 0.05 for all). A comparison of the superficial and deep FAZ area parameters of both groups showed no statistically significant difference (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>We showed that patients who had recovered from MIS-C had retinal vascular damage at the long-term follow-up. Following up with these patients after recovery with OCT and OCT-A, which are noninvasive methods commonly used in the detailed evaluation of the posterior segment of the eye, could be beneficial for understanding the long-term effects of MIS-C on retinal microvasculature. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:518-526.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Janus Kinase Inhibitor Use and Development of Retinal Vein Occlusion.","authors":"Meghana Chalasani, Jonathan C Markle, Priya Shukla, Rula A Hajj-Ali, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20240908-01","DOIUrl":"https://doi.org/10.3928/23258160-20240908-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Janus kinase (Jak) inhibitors may have increased risk of thromboembolism compared to tumor necrosis factor (TNF) inhibitors. This study investigates the association between Jak inhibitor use and retinal vein occlusion.</p><p><strong>Patients and methods: </strong>This retrospective, non-randomized cohort study used a federated health research network. Propensity-score matched risk ratios with 95% CI were calculated for central and branch retinal vein occlusion (CRVO, BRVO) in patients with immune-mediated inflammatory diseases (IMIDs) treated with Jak inhibitors versus TNF inhibitors.</p><p><strong>Results: </strong>Jak and TNF inhibitor cohorts each had 5,249 patients. Risk ratio for CRVO with Jak inhibitors (<i>n</i> = 11) versus TNF inhibitors (<i>n</i> = 18) was 0.61 [CI (0.29,1.29)]. Risk ratio for BRVO with Jak inhibitors (<i>n</i> = 17) compared to TNF inhibitors (<i>n</i> = 19) was 0.89 [CI (0.47,1.72)].</p><p><strong>Conclusion: </strong>This study did not find evidence of increased risk of RVO with the use of Jak inhibitors compared to TNF inhibitors among patients with IMIDs, contributing to literature on Jak inhibitor safety. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:xx-xx.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Electromyogram Analysis of Postural Musculature With Three-dimensional Screen Display Versus Operating Microscope in Ophthalmic Surgery: A Clinical Methods Study.","authors":"Arjan S Hura, Moshe A Mizrahi, Charu D Eluvathingal, John G Quinlan, Robert W Neel, Christopher D Riemann","doi":"10.3928/23258160-20240624-02","DOIUrl":"https://doi.org/10.3928/23258160-20240624-02","url":null,"abstract":"<p><strong>Background and objective: </strong>To objectively analyze the effect of three-dimensional screen-based surgery (3D SBS) versus traditional operating microscope (TOM) on operating surgeon posterior chain postural musculature during ophthalmic surgery. We hypothesized an increase in median amplitude of electromyography (EMG) signals when using a TOM compared to 3D SBS. The goal was to assess surgical ergonomics that may contribute to cervical and lumbar spine pathology. EMG analysis was conducted at the University of Cincinnati Medical Center Epilepsy Monitoring Unit. Data were collected in the private practice setting at Cincinnati Eye Institute.</p><p><strong>Materials and methods: </strong>This was an institutional review board exempt, nonrandomized, prospective, single center, <i>n</i> = 1 clinical methods study. EMG surface electrodes were affixed to the bilateral splenius capitis, sternocleidomastoid, upper trapezius, anterior deltoid, and quadratus lumborum musculature. EMG data were collected across four sessions consisting of one day each using 3D SBS or a TOM, and two cross-over days. A survey regarding surgeon comfort was administered before, during, and after each surgery, and at the end of each day.</p><p><strong>Results: </strong>EMG cross-over data demonstrated an increase in muscle activation in all measured muscles except the anterior deltoids and right quadratus lumborum with use of a TOM. Survey data showed increased fatigue when using a TOM relative to 3D SBS.</p><p><strong>Conclusion: </strong>EMG demonstrated increased postural muscle activation when utilizing TOM relative to 3D SBS. Similar to previous studies, our survey data suggest inferior ergonomics of TOM relative to 3D SBS. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Isolated Retinal Artery Occlusion Secondary to Giant Cell Arteritis.","authors":"Ji Yun Han, Julia S Gillette, Ingrid U Scott, Paul B Greenberg","doi":"10.3928/23258160-20240508-01","DOIUrl":"10.3928/23258160-20240508-01","url":null,"abstract":"<p><p>We systematically reviewed the literature to investigate the clinical features of isolated arteritic retinal artery occlusion (A-RAO) associated with giant cell arteritis (GCA). The four primary types of A-RAO were central retinal artery occlusion (CRAO), hemi-central retinal artery occlusion (hCRAO), branch retinal artery occlusion (BRAO), and cilioretinal artery occlusion (CLRAO). The most reported presentation was unilateral CRAO, followed by bilateral CRAO, unilateral CLRAO, and bilateral BRAO. Most RAOs were accompanied by typical GCA signs and symptoms, which can help distinguish them from non-arteritic RAOs. When reported, temporal artery biopsy confirmed GCA in most cases. Patients with GCA may present with a broad spectrum of isolated unilateral and bilateral A-RAOs. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:536-540.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ergonomic Evaluation of Attendings and Trainees Across the Vitreoretinal Service as Measured by a Wearable Device.","authors":"Richard N Sather, Jade Y Moon, Francesco Romano, Kate Overbey, Hanna Choi, Inês M D C Laíns, Deeba Husain, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240906-01","DOIUrl":"https://doi.org/10.3928/23258160-20240906-01","url":null,"abstract":"<p><strong>Background and objective: </strong>A cross-sectional prospective study to examine ergonomic differences in vitreoretinal settings: surgery, clinic, and dedicated procedure clinic.</p><p><strong>Patients and methods: </strong>Three vitreoretinal surgeons, three fellows, and one resident at a tertiary eye care facility. Participants wore an Upright Go 2 posture device and posture was recorded in each setting between July 1 to August 31, 2023.</p><p><strong>Results: </strong>Time in upright and poor postures was tracked. Significant differences were found in postural score for attendings between work settings (<i>P</i> < 0.01). Trainees showed no significant difference between settings. Poor posture in surgery was linked to microscope use and scleral buckle placement; in the clinic, it was associated with pan-retinal photocoagulation and injection minutes; in procedure clinic, it was ophthalmologist-dependent and those performing injections.</p><p><strong>Conclusions: </strong>Ergonomic considerations are crucial in vitreoretinal practice. Attendings and trainees should focus on posture in surgery and clinic settings to enhance career longevity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faricimab in Previously Treated Eyes With Neovascular Age-Related Macular Degeneration: An Assessment of Durability and Treatment Outcomes.","authors":"Abdulla Shaheen, Noy Ashkenazy, Maria Magraner, Nimesh A Patel, Jorge Fortun, Philip J Rosenfeld, Stephen G Schwartz, Luis J Haddock, Sander R Dubovy, Jayanth Sridhar, Zohar Yehoshua, Jaclyn L Kovach, Justin H Townsend, William E Smiddy, Harry W Flynn, Nicolas A Yannuzzi","doi":"10.3928/23258160-20240410-04","DOIUrl":"10.3928/23258160-20240410-04","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated the efficacy and durability of faricimab in patients with neovascular age-related macular degeneration (nAMD) who were previously treated with anti-vascular endothelial growth factor (anti-VEGF) agents.</p><p><strong>Patients and methods: </strong>This retrospective case series was conducted at a single tertiary center in the United States. It focused on nAMD patients who transitioned to faricimab after initial anti-VEGF therapy, with a follow-up period of at least 9 months. \"Complete dryness\" was defined as the absence of intra- and/or subretinal fluid on optical coherence tomography. Durability was gauged by the extension of treatment intervals relative to the injection frequency of the previous agent.</p><p><strong>Results: </strong>Sixty-two eyes from 62 patients were included. Treatment interval ranged from 5 to 10 weeks; 10 (16%) patients were able to be extended by 2 or more weeks compared to their previous regimen. Median (interquartile range [IQR]) central field thickness was 310 μm (254, 376) on initiating faricimab and declined by the ninth month (<i>P</i> values at 3, 6, and 9 months were 0.01, 0.02, and 0.07, respectively). Median (IQR) visual acuity at initiation of faricimab was 0.4 (0.20, 0.50) and did not change by the ninth month. Complete anatomical dryness was present in 10 (16%) eyes before switching; 90% remained dry at 9 months. Of 52 (84%) incompletely dry eyes before switching, 15% achieved complete dryness by 9 months on faricimab.</p><p><strong>Conclusions: </strong>Faricimab modestly improved the treatment intervals for a small proportion of previously treated patients on anti-VEGF therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:504-509.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on Expanded Field Imaging Findings in Proliferative Sickle Cell Retinopathy.","authors":"Francesco Romano, Xinyi Ding, John B Miller","doi":"10.3928/23258160-20240906-03","DOIUrl":"https://doi.org/10.3928/23258160-20240906-03","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}