Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"RWC Update: Intraocular Inflammation and Retinal Pharmacotherapy; Giant Retinal Tear; ILM Peeling in Myopic Macular Schisis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, David A Eichenbaum, Arshad M Khanani, Lorenzo Iuliano, Daniele Veritti, Valentina Sarao, Paolo Lanzetta, Anjana Mirajkar, Manish Nagpal, Kevin F Elwood, Mathew W MacCumber, Kourous A Rezaei","doi":"10.3928/23258160-20250220-01","DOIUrl":"https://doi.org/10.3928/23258160-20250220-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 3","pages":"133-135"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Photoreceptor and Vascular Parameters in Diabetic Retinopathy Using Adaptive Optics.","authors":"Michael Balas, Mariam Issa, Marko M Popovic, Chris Zajner, Lana Moayad, Paola Oquendo Aponte, Hesham Hamli, Peng Yan, Tom Wright, Isabela M Melo, Rajeev H Muni","doi":"10.3928/23258160-20241015-03","DOIUrl":"10.3928/23258160-20241015-03","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to investigate correlations between photoreceptor and vascular parameters in varying stages of diabetic retinopathy (DR) using adaptive optics (AO) imaging.</p><p><strong>Patients and methods: </strong>In this single-center, prospective cohort study, 29 participants (46 eyes) were classified into control/mild non-proliferative DR (NPDR), moderate/severe NPDR, and proliferative DR. AO images of photoreceptors and retinal vasculature were analyzed, and Spearman's correlation (ρ) was used to assess relationships between photoreceptor density and vascular parameters.</p><p><strong>Results: </strong>Higher cone density was inversely associated with total vessel (ρ = 0.22, <i>P</i> = 0.03) and lumen diameters (ρ = -0.24, <i>P</i> = 0.01), while higher dispersion was associated with total vessel (ρ = 0.19, <i>P</i> = 0.06) and lumen diameters (ρ = 0.21, <i>P</i> = 0.04). These associations were primarily significant in mild NPDR. No significant correlations were found in advanced DR stages.</p><p><strong>Conclusion: </strong>This study underscores intricate neurovascular correlations in early-stage DR, suggesting these parameters may aid in early disease detection. Further research is needed to understand whether similar correlations exist in advanced DR. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:150-158.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"150-158"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Survey of Optometrists in Canada Regarding Referral Patterns and a Needs Assessment for an Artificial Intelligence Referral Screening Tool for Epiretinal Membrane.","authors":"Reut Shor, Marko Popovic, Andrew Mihalache, Rajeev H Muni","doi":"10.3928/23258160-20241217-01","DOIUrl":"10.3928/23258160-20241217-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated optometrists' referral patterns for epiretinal membrane (ERM) patients in Ontario, Canada, and their attitudes towards an artificial intelligence (AI) tool for improving referral accuracy. An anonymous online survey with 11 questions was conducted.</p><p><strong>Patients and methods: </strong>The survey targeted optometrists across Ontario, Canada. The survey aimed to understand optometrists' reasons for referring ERM patients to retina specialists, their expectations of the specialists' management, and their openness to using an AI tool for triage. To prevent bias, the survey described an AI tool as an online consultation feature limited to predefined questions without directly mentioning \"AI.\" The main objective was to assess if this AI tool could decrease unnecessary ERM referrals to retina specialists.</p><p><strong>Results: </strong>A total of 135 optometrists participated. They reported seeing an average of eight ERM cases monthly, referring every fourth case to a specialist. The primary referral reason (84.3%) was to evaluate for surgery. In terms of referral confidence, 34.3% felt fully confident (5/5), and 47.8% slightly less so (4/5). They anticipated that 20% of patients would have a change in management post-consultation with a specialist. When introduced to the concept of an online consultation tool for patient screening, optometrists believed it could reduce their ERM referrals by 40%.</p><p><strong>Conclusions: </strong>Optometrists often refer ERM patients to retina specialists. An AI tool for screening ERM referrals, based on presenting vision and OCT images, could significantly lower the number of unnecessary referrals, offering clinical guidance to optometrists. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:166-169.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"166-169"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Vascular Changes in a Case of Straatsma Syndrome.","authors":"Efe Koser, Rukiye Aydin Arslan, Merve Ozbek","doi":"10.3928/23258160-20241101-02","DOIUrl":"10.3928/23258160-20241101-02","url":null,"abstract":"<p><p>A 34-year-old asymptomatic woman with a history of amblyopia in her right eye presented for a routine examination. Fundus examination revealed broad myelinated nerve fibers along with telangiectatic vessels. Wide-field fluorescein angiography revealed no evidence of ischemia or active retinal neovascularization. However, myelinated nerve fibers can infrequently exhibit cooccurring retinal vascular anomalies, harboring the potential for sight-threatening complications. Patients should be carefully monitored for the development of neovascularization and secondary complications. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:174-176.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"174-176"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Experience on Visual Search Patterns in Retinal Imaging Analysis.","authors":"Puranjay Gupta, Neil Sheth, Reem AlAhmadi, Xincheng Yao, Michael J Heiferman","doi":"10.3928/23258160-20250228-03","DOIUrl":"https://doi.org/10.3928/23258160-20250228-03","url":null,"abstract":"<p><strong>Background and objective: </strong>The increasing use of retinal diagnostic imaging necessitates a standardized viewing technique. This study investigates visual search patterns among ophthalmologists at various experience levels using eye-tracking technology.</p><p><strong>Patients and methods: </strong>Participants included postgraduate year 2, 3, and 4 residents, retina fellows, and attending ophthalmologists, who analyzed fundus images while their eye movements were tracked.</p><p><strong>Results: </strong>Results indicated that attendings had shorter fixation durations (0.15 ± 0.04 seconds) and saccade lengths (0.06° ± 0.01°), indicating faster image information processing than novice physicians. Experts also analyzed a higher proportion of the image area (49.43% ± 7.34%) and possessed a global-focal search pattern, suggesting increased thoroughness.</p><p><strong>Conclusion: </strong>Experts in ophthalmology demonstrate gaze characteristics that reflect faster image processing and a more thorough analysis of diagnostic imaging. We recommend that residents be taught a standardized method for image interpretation that emulates expert analysis through a disc-macula-vessel-periphery sequence with radial sweeps. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features Associated With Return to Pre-endophthalmitis Visual Acuity Following Presumed Infectious Endophthalmitis.","authors":"Richmond Woodward, Todd L Fleming, Cason B Robbins, Delaram Mirzania, Henry L Feng, Sharon Fekrat","doi":"10.3928/23258160-20241015-02","DOIUrl":"10.3928/23258160-20241015-02","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to investigate clinical characteristics associated with return to pre-endophthalmitis visual acuity (VA) following treatment for presumed infectious endophthalmitis.</p><p><strong>Patients and methods: </strong>This was a retrospective study of 74 eyes with endophthalmitis and VA recorded ≤ 12 weeks before presentation and 6 months after presentation between 2009 and 2018.</p><p><strong>Results: </strong>Thirty-six of 74 eyes (49%) returned to preendophthalmitis VA. Eyes with a positive intraocular fluid culture had 71.5% lower odds of returning to pre-endophthalmitis VA. Nine of 10 eyes (90%) treated with initial pars plana vitrectomy failed to return to pre-endophthalmitis VA. Endophthalmitis following cataract surgery was a characteristic of eyes that returned to pre-endophthalmitis VA. Symptom duration, time to presentation, and treatment with systemic corticosteroids were not significant predictors of visual recovery.</p><p><strong>Conclusion: </strong>Just under 50% of eyes with presumed infectious endophthalmitis returned to preendophthalmitis VA. A positive intraocular culture is associated with failure to return to pre-endophthalmitis VA. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:145-149.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"145-149"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral Fixation of an Intraocular Lens With Gore-Tex^® Suture From a Temporal Approach.","authors":"Yaqoob Qaseem, J Ben Margines, Weilin Song, Adrian Au, Omesh P Gupta, Jayanth Sridhar","doi":"10.3928/23258160-20241204-01","DOIUrl":"10.3928/23258160-20241204-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"136-138"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gore-Tex Suture-Associated Endophthalmitis in a Young Patient.","authors":"Raed Alnutaifi, Waleed W Khayyat, Faisal S AlQahtani","doi":"10.3928/23258160-20250124-02","DOIUrl":"https://doi.org/10.3928/23258160-20250124-02","url":null,"abstract":"<p><p>Gore-Tex sutures are commonly used for scleral-fixated intraocular lenses (SFIOL) due to their high tensile strength and lower risk of breakage. However, complications such as suture erosion and infection remain a concern. This report presents a case of Gore-Tex suture-associated endophthalmitis in a young patient. A 21-year-old man with a history of penetrating eye injury and subsequent aphakia in the left eye underwent SFIOL surgery using Gore-Tex sutures, with a resultant best-corrected visual acuity (BCVA) of 20/30. Eighteen months later, he presented with sudden pain and an exposed suture. He was initially managed with topical antibiotics under observation. However, as signs of endophthalmitis developed, he was managed with an intravitreal antibiotic injection followed by pars plana vitrectomy with intraocular lens explantation. Culture of the vitreous sample identified <i>Haemophilus influenzae</i>. The patient gradually recovered, achieving a final BCVA of 20/125. This case underscores the importance of vigilant postoperative monitoring and timely intervention in managing suture-related complications. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ONS-5010 (bevacizumab-vikg) Safety and Efficacy in Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration.","authors":"Firas M Rahhal, Allen Hu, Mark Humayun, Meena S George, Cameron Javid, Jeremiah Brown, John D Pitcher, Terry Dagnon, Jennifer Kissner","doi":"10.3928/23258160-20240924-01","DOIUrl":"10.3928/23258160-20240924-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This was a prospective multicenter, randomized, double-masked, active-controlled study, the aim of which was to demonstrate the efficacy and safety of intravitreal ONS-5010 (bevacizumab-vikg) in eyes with neovascular age-related macular degeneration (nAMD). This was a phase III trial on ONS-5010 (NORSE TWO).</p><p><strong>Materials and methods: </strong>Treatment-naïve nAMD patients aged 50 years and older with a best-corrected distance visual acuity (BCVA) of 25 to 67 Early Treatment Diabetic Retinopathy Study (ETDRS) letters and evidence of disease activity were included. Patients randomized to ONS-5010 received monthly intravitreal doses of 1.25 mg of ONS-5010, bevacizumab-vikg (Outlook Therapeutics) for 12 months. Patients randomized to ranibizumab received 0.50 mg of ranibizumab on days 0, 30, 60, 150, and 240 based on the PIER study dosing regimen.</p><p><strong>Results: </strong>The primary end point was the proportion of patients who gained ≥ 15 letters from baseline in BCVA at 11 months, and evaluating the safety and tolerability of intravitreal injections of ONS-5010 administered monthly from baseline to 12 months. One hundred thirteen participants were included in the ONS-5010 group and 115 participants were included in the ranibizumab group. Respectively, 41.7% and 23.1% of patients gained ≥ 15 letters (3 lines) of visual acuity, with a risk difference of 0.1859 [95% CI = 0.0442, 0.3086]; <i>P</i> = 0.0052. The change in BCVA from baseline to 11 months was found to be 11.2 ± 12.19 and 5.8 ± 14.80 ETDRS letters, respectively. The number of patients gaining ≥ 5 and ≥ 10 letters and patients losing < 15 letters was significantly higher in the ONS-5010 group. Similarly, patients with a Snellen visual acuity equivalent of 20/200 (35 ETDRS letters) or worse at 11 months were significantly fewer in the ONS-5010 group. Only one patient in the ONS-5010 group had a study-related serious ocular adverse event (SAE), namely, elevated intraocular pressure. The most common adverse event in the ONS-5010 group was conjunctival hemorrhage (8.8%), and reduced visual acuity in the ranibizumab group (12.2%).</p><p><strong>Conclusions: </strong>In the prescribed treatment plan, ONS-5010 exhibited strong effectiveness in improving or stabilizing visual acuity and was also well tolerated. Bevacizumab and ranibizumab displayed a comparable safety profile. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:178-189.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"178-189"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hispanic Ethnicity and OCT-based Biomarkers as Predictive Factors of DME Refractory to Bevacizumab.","authors":"Erin Jennings, Dinah Chen, Alexi Geevarghese, Alexis Kaiser, Sara Coulon, Yasha Modi","doi":"10.3928/23258160-20250127-02","DOIUrl":"https://doi.org/10.3928/23258160-20250127-02","url":null,"abstract":"<p><strong>Background and objective: </strong>While anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized treatment for diabetic macular edema, many patients still manifest refractory disease. This study evaluated rates of diabetic macular edema (DME) refractory to intravitreal bevacizumab in a diverse real-world setting, with the aim of studying demographic and optical coherence tomography (OCT)-based morphological factors associated with refractory disease.</p><p><strong>Patients and methods: </strong>This was a retrospective cohort study of patients receiving treatment. Refractory DME was defined as a gain in visual acuity of < 5 letters after three consecutive injections of bevacizumab or less than 20% reduction in central retinal thickness (CRT) after three consecutive injections of bevacizumab. OCT images from preand post-injection visits were reviewed by two independent image readers. Multivariate logistic regression analysis evaluated for statistical significance between responders and those refractory to bevacizumab, and between Hispanic and non-Hispanic groups.</p><p><strong>Results: </strong>Ninety-nine patients were included. Of the participants, 42% were Hispanic, 10% were reported as white, 11% were Asian, 11% were Black, and 26% were defined as \"not reported.\" Fifty-four (54.5%) patients were refractory to bevacizumab and 45 were responders. Between responders and refractory patients, race was statistically significant (<i>P</i> = 0.04) with more refractory subjects found to be Hispanic (28/54, 51.9%). OCT morphologic characteristics (CRT, number of hyperreflective foci, disorganization of inner retinal layers, ellipsoid zone discontinuity, and sub-retinal fluid) were not statistically significant between responders and refractory subjects. Multivariate logistic regression demonstrated an odds ratio of 5.7 for refractory disease for Hispanics (CI 1.687 to 19.445, <i>P</i> = 0.01). When comparing Hispanics to non-Hispanics, Hispanics had an average lower baseline visual acuity, lower CSTs, and higher HbA1C.</p><p><strong>Conclusions: </strong>Our study showed that Hispanics have a nearly 6 times relatively higher likelihood of refractory disease. There is a notable under-representation of these patients in completed clinical trials for diabetic retinopathy and DME. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}