Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Severe Macular Atrophy in an Infant With Neuromuscular Oculoauditory Syndrome.","authors":"Justin S Yun, Marcus H Yamamoto, Alejandro I Marin, Carla Sargiotto, Daniela N Schweitzer, Irena Tsui","doi":"10.3928/23258160-20250815-03","DOIUrl":"https://doi.org/10.3928/23258160-20250815-03","url":null,"abstract":"<p><p>Pathogenic variants in DEAH-box helicase 16 (DHX16) that are critical regulators of mRNA metabolism have been linked to neuromuscular oculoauditory syndrome (NMOAS), a rare disorder characterized by sensorineural hearing loss, neuromuscular deficits, and retinal abnormalities. This report covers a rare case of a 6-month-old girl with congenital SNHL, global hypotonia, and distinctive bilateral retinal dystrophy. Eye exam revealed severe macular atrophy with peripheral pigmentary changes. Spectral-domain optical coherence tomography confirmed outer retinal thinning and disruption of the photoreceptor integrity. Whole trio genome sequencing identified a <i>de novo</i> heterozygous variant in DHX16, c.1360C>T (p.Arg454Trp), previously described in only one patient, and classified as likely pathogenic. This case expands the understanding of DHX16-associated NMOAS and the importance of comprehensive ophthalmological assessment and genetic analysis in infants with multisystem involvement.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis Caused by Enterococcus Gallinarum Following Intravitreal Bevacizumab for Diabetic Macular Edema.","authors":"Michael Y Zhao, Lauren C Kiryakoza, Landon J Rohowetz, Thomas A Albini, Nicolas A Yannuzzi, Darlene Miller, Harry W Flynn","doi":"10.3928/23258160-20250815-01","DOIUrl":"https://doi.org/10.3928/23258160-20250815-01","url":null,"abstract":"<p><p>Endophthalmitis caused by <i>Enterococcus gallinarum</i> is rare. This organism is often resistant to vancomycin, but sensitive to beta-lactams. Visual outcomes for endophthalmitis caused by <i>enterococci</i> are typically poor. This report describes the first documented case of acute-onset exogenous endophthalmitis due to <i>E. gallinarum</i> following intravitreal injection. A 46-year-old man presented with acute-onset exogenous endophthalmitis after intravitreal injection with bevacizumab in the right eye. Vitreous aspiration and culture identified <i>E. gallinarum</i>. Initial treatment was intravitreal ceftazidime 2.25 mg, vancomycin 1.00 mg, and dexamethasone 0.4 mg. The patient underwent pars plana vitrectomy with anterior chamber washout and intravitreal ceftazidime 2.25 mg and amikacin 0.4 mg. This isolate was susceptible to amikacin, but resistance to aminoglycosides has been reported. Although this isolate was sensitive to the administered antibiotics, the visual outcome was poor. Presenting vision was hand motion, and best-corrected visual acuity was light perception at postoperative 6-month follow-up. Beta-lactams (eg, ceftazidime) provide consistent coverage against <i>E. gallinarum</i>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Siegrist Streaks in a Case of Biopsy-negative Giant Cell Arteritis: A Case Report.","authors":"Thomas W Cameron, Talhah Zubair, Siya Huo","doi":"10.3928/23258160-20250815-02","DOIUrl":"https://doi.org/10.3928/23258160-20250815-02","url":null,"abstract":"<p><p>This report features a case of bilateral vision loss due to initially biopsy-negative giant cell arteritis (GCA). A 78-year-old man with polymyalgia rheumatica presented with biopsy-negative GCA and a 2 to 4 week history of profoundly decreased vision bilaterally. Fundus examination of the right eye revealed Siegrist streaks and Amalric triangle sign (ATS), and optical coherence tomography (OCT) demonstrated paracentral acute middle maculopathy (PAMM) in the left eye. As a result, the patient was admitted for intravenous methylprednisolone for presumed GCA, resulting in visual improvement. However, temporal artery biopsy (TAB) returned negative for arteritis. Due to high clinical suspicion, re-evaluation of biopsy specimens was requested and subsequently confirmed the diagnosis of GCA. This case exemplifies the importance of relying on ocular diagnostics while re-examining confirmatory testing when GCA is strongly suspected. Prompt steroid treatment is essential to prevent permanent visual and systemic sequelae, especially given an initially biopsy-negative TAB.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Citrobacter koseri</i> Endophthalmitis Following Intravitreal Fluocinolone Acetonide Implant Injection.","authors":"Kent W Small, Jessica Avetisjan, Amber M Diaz, Joanna Im, Zahur-Saleh Subedar","doi":"10.3928/23258160-20250818-02","DOIUrl":"https://doi.org/10.3928/23258160-20250818-02","url":null,"abstract":"<p><p><i>Citrobacter koseri</i> is a gram-negative bacillus primarily found in the gut. Exogenous endophthalmitis caused by <i>C. koseri</i> is exceedingly rare, with most reported cases occurring secondary to ocular trauma and resulting in poor visual outcomes. This report presents a case of a 76-year-old patient who developed endophthalmitis following a fluocinolone acetonide intravitreal injection administered for diabetic macular edema. A vitreous biopsy and intravitreal injection of vancomycin and ceftazidime were performed upon presentation. The vitreous sample culture was positive for <i>C. koseri</i>. The patient responded well with ultimate resolution of the infection and return of pre-infection visual acuity without a vitrectomy.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of Retinal, Choroidal, Scleral and Optic Disc Parameters in Acromegaly.","authors":"Onur Furundaoturan, Cumali Degirmenci, Özer Sakin, Ilgin Yildirim Simsir, Gokcen Unal Kocabas, Filiz Afrashi, Melis Palamar","doi":"10.3928/23258160-20250812-01","DOIUrl":"https://doi.org/10.3928/23258160-20250812-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to assess the impact of acromegaly and excessive growth hormone on ocular tissues using swept-source optical coherence tomography (SS-OCT).</p><p><strong>Patients and methods: </strong>Subfoveal retinal thickness (SRT), subfoveal choroidal thicknesses (SCT), peripapillary retina nerve fiber layer (pRNFL), macular ganglion cell-inner plexiform complex (GCIPL), and scleral thickness were evaluated in this prospective study. Scleral thickness was evaluated in four quadrants at 2, 4, and 6 mm posterior to the scleral spur.</p><p><strong>Results: </strong>Right eyes of 50 acromegaly (Group 1) and 50 healthy individuals (Group 2) were enrolled. SRT was significantly higher in Group 1 (<i>P</i> = 0.036). SCT measurements showed no difference (<i>P</i> = 0.31). There was no difference between the groups in terms of pRNFL and GCIPL measurements (<i>P</i> = 0.30, <i>P</i> = 0.26). Thickness measurements from all scleral quadrants and all distances were significantly thicker in Group 1 than in Group 2 (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The study suggests the sclera may be a target tissue in acromegaly, with increased scleral thickness. No differences were found in choroidal, optic disc, or GCIPL parameters compared to controls.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Intravitreal Steroid and Anti-VEGF Therapy for Double-Monotherapy-Resistant Chronic Diabetic Macular Edema.","authors":"Anna Heinke, Alexandra Warter, Melina Cavichini, Carlo Miguel B Galang, Fritz Gerald P Kalaw, Dirk-Uwe Bartsch, Lingyun Cheng, William R Freeman","doi":"10.3928/23258160-20250813-03","DOIUrl":"https://doi.org/10.3928/23258160-20250813-03","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this retrospective chart review was to evaluate the efficacy and safety of combined intravitreal long-acting corticosteroids and anti-vascular endothelial growth factor (anti-VEGF) therapeutic agents for resistant cystoid macular edema associated with diabetic retinopathy, or diabetic macular edema (DME).</p><p><strong>Patients and methods: </strong>This study included 16 eyes of 15 patients. Patients with unresponsive DME, despite aggressive monthly monotherapy with steroid or anti-VEGF (decanted triamcinolone or 4 mg aflibercept) were included. Treatment consisted of simultaneous administration of anti-VEGF and decanted triamcinolone. Optical coherence tomography (OCT) and comprehensive ophthalmic exams were performed prior to treatment, as well as every 4 weeks (for 4 months), post-treatment. Main outcome measures were central retinal thickness (CRT) measured by OCT in microns and best-corrected visual acuity (BCVA).</p><p><strong>Results: </strong>The mean treated disease duration (months) was 38.93 ± SD 8.73 [16-108]. There was a CRT reduction at post-combination 1 month (159.18 μm, <i>P</i> = 0.0003), 2 month (169.58 μm, <i>P</i> = 0.0038), 3 month visit (167.88 μm, <i>P</i> = 00.0200), and 4 month (212.88 μm, <i>P</i> = 0.0276). BCVA improved by 8.5 letters (<i>P</i> = 0.0216) at month 1. Improvement persisted with a mean of nine letters (<i>P</i> = 0.039) at month 2, 10 letters (<i>P</i> = 0.035) at month 3, and three letters (<i>P</i> = 0.638) at month 4. No ocular or systemic safety issues were noted after the combination therapy.</p><p><strong>Conclusion: </strong>Combination therapy of steroid and anti-VEGF results in clear anatomic and function improvement in eyes with DME that were resistant to monotherapy with anti-VEGF or monotherapy with steroids. The use of this combination has shown a therapeutic effect in treatment-resistant DME.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorodecalin Toxicity Following Retinal Autograft Surgery in a Case With Chronic Recurrent Large Macular Hole.","authors":"Semra Tiryaki Demir, Merve Hotoglu","doi":"10.3928/23258160-20250805-04","DOIUrl":"https://doi.org/10.3928/23258160-20250805-04","url":null,"abstract":"<p><p>In cases with chronic recurrent large macular holes (MH), retinal autograft can be used to close the MH and perfluorocarbon liquids can be left in the eye for a short time to stabilize the graft. However, there are some cases reported in the literature regarding retinal toxicity due to the use of perfluorocarbon liquids as tamponade in vitreo-retinal surgery. This case report presents a 49-year-old patient with chronic recurrent large MH despite undergoing vitrectomy and internal limiting membrane peeling surgery 8 years prior. Retinal autograft was used to close the MH and stabilization of the autograft was achieved with short-term perfluorodecalin liquid tamponade. However, after the removal of perfluorodecalin fluid, widespread retinal toxicity developed in the macula.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Torpedo Maculopathy With Outer Retinal Cavitation in a Young Adult: A Case Report and Literature Review.","authors":"Dimitrios Kalogeropoulos, Imran Akram, Nolan Remedios Cota, Ahmed Ibraheem, Nikolaos Krassas","doi":"10.3928/23258160-20250805-05","DOIUrl":"https://doi.org/10.3928/23258160-20250805-05","url":null,"abstract":"<p><p>Torpedo maculopathy (TM) is a rare, congenital chorioretinal disorder defined by a solitary, fusiform hypopigmented lesion at the temporal macula. Although most patients are typically asymptomatic, clinical variations have been described, and the possibility of progression remains a subject of interest. This report presents a case of an otherwise healthy 22-year-old man with a type 2 TM lesion, featuring outer retinal cavitation and choroidal excavation, confirmed through multi-modal imaging including widefield color photography, autofluorescence, spectral domain optical coherence tomography (SD-OCT), OCT angiography, and indocyanine green angiography. There were no signs of choroidal neovascularization or subretinal fluid, and the patient remained stable with no visual changes at his 6-month follow-up. This case adds to the growing body of evidence that Type 2 TM with cavitation is not exclusive to older patients and can be present in young adulthood, highlighting the need for long-term monitoring to understand the condition's natural history.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Polar Annular Choroidal Dystrophy With Macular Involvement.","authors":"Neha Goel, Sandepan Bandopadhyay","doi":"10.3928/23258160-20250813-01","DOIUrl":"https://doi.org/10.3928/23258160-20250813-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Outcomes of Secondary Intraocular Lens Utilization Among Vitreoretinal Surgeons Compared to Vitreoretinal and Anterior Segment Surgeons.","authors":"Maria A Bantounou, Nitika Aggarwal, Nicholas Boucher, Chakshu Sharma, Matthew R Starr","doi":"10.3928/23258160-20250725-01","DOIUrl":"https://doi.org/10.3928/23258160-20250725-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Scleral-fixated intraocular lens (SFIOL), scleral-sutured IOL (SSIOL), anterior chamber IOL (ACIOL) are used to manage aphakia or lens subluxation. This study compared trends in surgical techniques and outcomes of secondary IOL implantation based on surgeon type.</p><p><strong>Patients and methods: </strong>This retrospective study included patients from United States (US) retinal centers who underwent surgery by vitreoretinal (VR cohort) or VR and anterior segment (AS) (combined cohort) surgeons from 2015 to 2024. Complications assessed included retinal detachment, endophthalmitis, suture erosion, haptic erosion, repeat pas plana vitrectomy, and corneal edema.</p><p><strong>Results: </strong>VR surgeons performed 4,143 secondary IOL surgeries (1,977 ACIOL, 1,327 SFIOL, 839 SSIOL) while VR and AS surgeons performed 511 (342 ACIOL, 125 SFIOL, 44 SSIOL). SFIOL and SSIOL surgeries by VR surgeons increased, whereas ACIOL surgeries decreased. VR and AS surgeons maintained a steady but lower volume of SFIOL and SSIOL cases, with increasing ACIOL surgeries. Postoperative visual acuity for the VR and combination cohorts was 54.3 ± 27.8 and 51.5 ± 27.2 (≈ 20/100 Snellen) (<i>P</i> value = 0.102), respectively. Complication rates were similar between cohorts, except for postoperative retinal detachment (VR: 144, 3.5%; combined: 26, 5.1%; <i>P</i> value < 0.001).</p><p><strong>Conclusion: </strong>ACIOLs were the most commonly performed secondary IOL surgery. However, a shift toward SFIOL and SSIOL techniques among vitreo-retinal surgeons emerged. Outcomes were comparable between approaches.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}