Ophthalmic Outcomes and Management of Retinopathy in Patients With Sickle Cell Disease: A Comprehensive Health Registry Study and Review of Management Strategies.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-06-18 DOI:10.3928/23258160-20250425-01

Purna Nangia, Karen M Wai, Adrienne W Scott, Ehsan Rahimy, Prithvi Mruthyunjaya

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Abstract

Background and objective: The purpose of this study was to report the rates of ophthalmic complications and interventions in patients diagnosed with sickle cell disease (SCD) and sickle cell retinopathy (SCR), while reviewing current management strategies within the literature.

Patients and methods: This retrospective cohort study included patients ≥ 18 years of age with the diagnosis of SCD and SCR. The electronic health record system TriNetX was utilized to identify patients diagnosed with SCD and SCR. The main outcome measures included rates of ophthalmic complications and interventions.

Results: We identified 1,249 patients with the diagnosis of both SCD and SCR. The mean age at diagnosis of SCR was 34.9 ± 14.8 years. The most common ocular complication was vitreous hemorrhage (VH) (19.5%) followed by cataracts (17.8%), rhegmatogenous retinal detachment (12.4%), and tractional retinal detachment (4.7%). The most common ocular intervention was retinal laser photocoagulation (13.6%).

Conclusions: In a large, contemporary population-based study for SCD patients with SCR, the rates of preventable visually significant complications are high. Timely screening, diagnosis, and management strategies can help prevent these complications. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

查看原文本刊更多论文

镰状细胞病患者视网膜病变的眼科预后和管理：一项全面的健康登记研究和管理策略综述

背景和目的：本研究的目的是报告镰状细胞病（SCD）和镰状细胞视网膜病变（SCR）患者的眼部并发症发生率和干预措施，同时回顾文献中的当前管理策略。患者和方法：本回顾性队列研究纳入年龄≥18岁且诊断为SCD和SCR的患者。利用电子健康记录系统TriNetX识别诊断为SCD和SCR的患者。主要结局指标包括眼科并发症和干预措施的发生率。结果：我们确定了1249例同时诊断为SCD和SCR的患者。SCR的平均诊断年龄为34.9±14.8岁。最常见的眼部并发症是玻璃体出血（VH）（19.5%），其次是白内障（17.8%）、孔源性视网膜脱离（12.4%）和牵引性视网膜脱离（4.7%）。最常见的眼部干预是视网膜激光光凝（13.6%）。结论：在一项针对SCD合并SCR患者的大型当代人群研究中，可预防的视觉显著并发症的发生率很高。及时的筛查、诊断和管理策略可以帮助预防这些并发症。[眼科外科激光成像视网膜2025；56:XX-XX]。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.