Ophthalmic surgery, lasers & imaging retina最新文献_第2页

Bilateral Iris and Chorioretinal Colobomas in a Child With Suspected Lamb-Shaffer Syndrome. 疑为Lamb-Shaffer综合征的儿童双侧虹膜和视网膜结肠瘤1例。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.3928/23258160-20250228-02

Lauren N Hucko, Natasha F S da Cruz, Pavlina S Kemp, Carlos E Mendoza-Santiesteban, Audina M Berrocal

{"title":"Bilateral Iris and Chorioretinal Colobomas in a Child With Suspected Lamb-Shaffer Syndrome.","authors":"Lauren N Hucko, Natasha F S da Cruz, Pavlina S Kemp, Carlos E Mendoza-Santiesteban, Audina M Berrocal","doi":"10.3928/23258160-20250228-02","DOIUrl":"10.3928/23258160-20250228-02","url":null,"abstract":"Lamb-Shaffer syndrome (LSS) is a rare neurodevelopmental disorder caused by haploin-sufficiency of the SRY-related HMB box (SOX5) gene. Most cases result from de novo variants; however, some cases follow autosomal dominant inheritance patterns. Classic features of LSS include global developmental delay, dysmorphic facial features, musculoskeletal abnormalities, and cardiac and genitourinary defects. Ophthalmic manifestations of LSS such as strabismus and optic nerve abnormalities have been described in approximately 55% of patients with LSS. We report a case of a 22-month-old boy with a history of bilateral iris and chorioretinal colobomas, bilateral lens subluxation, and strabismus and a past medical history of developmental delay, syndactyly, and hearing loss. Genetic testing identified a missense variant of uncertain significance in exon 14 of the SOX5 gene, which is linked to LSS. An inherited retinal disorders panel revealed the patient was a carrier of a pathogenic variant of the PHYH gene and a variant of uncertain significance of the COL9A2 gene. Results of the inherited retinal disorders panel did not identify variants implicated with iris and chorio-retinal colobomas; therefore, we postulate colobomas as an additional ophthalmic manifestation of LSS. This case serves to broaden characterization of the LSS phenotype, while presenting an additional variant potentially associated with LSS. There is currently no treatment for LSS; however, robust understanding of LSS's heterogenous phenotypic and genetic profile will lead to improved knowledge of the syndrome and diagnostic aptitude. [Ophthalmic Surg Lasers Imaging Retina 2025;56:368-372].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"368-372"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Multiple Techniques for Measuring Geographic Atrophy: A Systematic Review and Network Meta-Analysis. 测量地理萎缩的多种技术之比较：系统回顾与网络元分析。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.3928/23258160-20250214-03

Tiago N O Rassi, William W Binotti, Eduardo Mund Carreirao Danielli, Sacha Pereira Fernandes, Daniela Cristina Schroff Machado, Dillan Cunha Amaral, Eduardo A Novais, Ricardo Noguera Louzada, Fernando Marcondes Penha, Mauricio Maia, Jay S Duker

{"title":"Comparison of Multiple Techniques for Measuring Geographic Atrophy: A Systematic Review and Network Meta-Analysis.","authors":"Tiago N O Rassi, William W Binotti, Eduardo Mund Carreirao Danielli, Sacha Pereira Fernandes, Daniela Cristina Schroff Machado, Dillan Cunha Amaral, Eduardo A Novais, Ricardo Noguera Louzada, Fernando Marcondes Penha, Mauricio Maia, Jay S Duker","doi":"10.3928/23258160-20250214-03","DOIUrl":"10.3928/23258160-20250214-03","url":null,"abstract":"This study compared techniques for measuring geographic atrophy (GA) against the standard autofluorescence blue (AF-Blue). The design was a Bayesian network meta-analysis. PubMed, Scopus, and Cochrane were searched for studies comparing GA imaging techniques. AF-Blue, autofluorescence green (AF-Green), autofluorescence infrared (AF-IR), near-infrared reflectance (NIR), multicolor autofluorescence AF (MC-AF), optical coherence tomography fundus image (OFI), en face sub-retinal pigment epithelium (SubRPE) slab, OCT angiography (OCTA), color fundus photography (CFP), and fluorescein angiography (FA) were included. A ratio of means (ROM) meta-analysis using a threshold based on an established minimally important difference was performed. (Pros-pero ID: CRD42023476459.) Included were 2,001 eyes from 18 studies and no significant differences among measurement techniques was found. The ROM showed that CFP, OCTA, SubRPE slab, OFI, and IR reflectance agreed well with AF-Blue. However, AF-Green, FA, and MC underestimated GA, and AF-IR overestimated it. It appears that there is a fair agreement between AF-Blue and current techniques for measuring GA. [Ophthalmic Surg Lasers Imaging Retina 2025;56:364-370.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"361-367"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotypic and Phenotypic Characterization of Hexokinase 1 p.Glu847Lys Variant Causing Autosomal Dominant Pericentral Retinitis Pigmentosa. 常染色体显性遗传性视网膜色素变性己糖激酶1 p.g u847lys变异的基因型和表型特征

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.3928/23258160-20250214-02

Kenneth C Fan, Calvin W Wong, Braden A Nichols, Roa Sadat, Patrick C Staropoli, Troy C Becker, William A Pearce, Effie Z Rahman, Robert I Blem, David M Brown, Charles C Wykoff, Hasenin Al-Khersan

{"title":"Genotypic and Phenotypic Characterization of Hexokinase 1 p.Glu847Lys Variant Causing Autosomal Dominant Pericentral Retinitis Pigmentosa.","authors":"Kenneth C Fan, Calvin W Wong, Braden A Nichols, Roa Sadat, Patrick C Staropoli, Troy C Becker, William A Pearce, Effie Z Rahman, Robert I Blem, David M Brown, Charles C Wykoff, Hasenin Al-Khersan","doi":"10.3928/23258160-20250214-02","DOIUrl":"10.3928/23258160-20250214-02","url":null,"abstract":"Background and objective: The aim of this study was to clinically and molecularly characterize the largest cohort of patients with HK1 associated retinal disease. Hexokinase 1 (HK1) variants have been reported to cause retinitis pigmentosa (RP), but a clearly defined genotype-phenotype correlation has not been well established.Patients and methods: A retrospective, consecutive, single-center case series was performed on patients with molecularly confirmed HK1-associated disease. Patients between 2016 and 2024 were included.Results: Sixty eyes from 30 patients were assessed. Thirty patients of 22 unrelated families were included. The median age at presentation was 53.5 years old, and the median age of disease symptom onset was 36 years old. The p.Glu847Lys variant was exhibited by 97% of the patients. Median best-recorded visual acuity was 20/28. Pericentral RP was the predominant phenotype (90% of patients).Conclusion: HK1 p.Glu847Lys variant was found to be associated with a less severe phenotype of autosomal dominant retinitis pigmentosa (adRP) as compared to other forms of adRP based on clinical presentation and electrophysiology. Future studies are necessary to better understand the genotypephenotype relationship and explore therapeutic options. [Ophthalmic Surg Lasers Imaging Retina 2025;56:328-334.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"328-334"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Postoperative Macular Hole Status by Automated Preoperative Retinal OCT Analysis: A Narrative Review. 自动术前视网膜OCT分析预测术后黄斑孔状态的综述。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.3928/23258160-20250217-03

Lin Ni, Carolina Carvalho Soares Valentim, Priya Shukla, Rishi P Singh, Katherine E Talcott

{"title":"Prediction of Postoperative Macular Hole Status by Automated Preoperative Retinal OCT Analysis: A Narrative Review.","authors":"Lin Ni, Carolina Carvalho Soares Valentim, Priya Shukla, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20250217-03","DOIUrl":"10.3928/23258160-20250217-03","url":null,"abstract":"Optical coherence tomography (OCT) is a non-invasive imaging modality essential for macular hole (MH) management. Artificial intelligence (AI) algorithms could be applied to OCT to garner insights for MH prognosis and outcomes. The objective was to review literature assessing automated image analysis algorithms in predicting postoperative outcomes for MH patients based on OCT images. A narrative search of all available published studies in peer-reviewed journals was conducted up to June 2023 following PRISMA guidelines. Three hundred sixty-eight publications underwent screening, with 14 selected for full-text review and seven determined as relevant. In MH status prediction, AI models achieved an area under the curve (AUC) of 83.6% to 98.4%. For postoperative visual acuity prediction, algorithm performance ranged from AUCs of 57% to 85%. In conclusion, novel AI algorithms were found to be predictive for postoperative MH status and postoperative visual acuity. More research in larger populations should be conducted to gauge the value of these novel algorithms in a real-world setting. [Ophthalmic Surg Lasers Imaging Retina 2025;56:372-377.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"355-360"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonsyndromic Retinitis Pigmentosa With Pathogenic CEP290 Mutations. 非综合征性视网膜色素变性伴致病性CEP290突变。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-23 DOI: 10.3928/23258160-20250513-01

Bijal A Kikani, Jordan A Ueberroth, Cory A Christensen, Mark P Breazzano

{"title":"Nonsyndromic Retinitis Pigmentosa With Pathogenic CEP290 Mutations.","authors":"Bijal A Kikani, Jordan A Ueberroth, Cory A Christensen, Mark P Breazzano","doi":"10.3928/23258160-20250513-01","DOIUrl":"https://doi.org/10.3928/23258160-20250513-01","url":null,"abstract":"CEP290 variants, commonly associated with Leber congenital amaurosis, cause severe visual impairment within the first year of life. Herein, we report a unique case of nonsyndromic retinitis pigmentosa with foveal sparing and preserved central vision in a patient harboring two pathogenic CEP290 variants. A 28-year-old woman presented with long-standing poor peripheral vision and nyctalopia since childhood, but with visual acuity of 20/25 bilaterally. Examination showed retinal arteriolar attenuation, diffuse foveal-sparing retinal atrophy, and peripheral bone spicule pigmentation. Genetic testing identified two pathogenic nonsense mutations in CEP290 (c.1666del and c.4057G>T) and heterozygous missense mutations in BBS5 (c.715A>G), PDE6A (c.367G>T), and RPGR (c.2594_2596del), which were variants of unknown significance. Although nonsense mutations in CEP290 are associated with severe and early-onset vision loss, our patient demonstrated a mild retinitis pigmentosa phenotype with stable disease over 6 months. This case expands the phenotypic spectrum of CEP290-associated diseases and suggests a potential role for genetic modifiers in disease severity. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epiretinal Amniotic Membrane Patch as a Temporary Scaffold for Refractory Macular Hole Closure: A Case Report. 视网膜上羊膜贴片作为难治性黄斑孔闭合的临时支架：1例报告。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-23 DOI: 10.3928/23258160-20250417-04

Shivesh Shah, William Foulsham, Jia Xu, Luis Martinez-Velazquez, Jennifer Hu, Selin Gumustop, Kayla Nodecker, John B Miller

{"title":"Epiretinal Amniotic Membrane Patch as a Temporary Scaffold for Refractory Macular Hole Closure: A Case Report.","authors":"Shivesh Shah, William Foulsham, Jia Xu, Luis Martinez-Velazquez, Jennifer Hu, Selin Gumustop, Kayla Nodecker, John B Miller","doi":"10.3928/23258160-20250417-04","DOIUrl":"https://doi.org/10.3928/23258160-20250417-04","url":null,"abstract":"Macular holes are central retinal defects that can severely impair vision. While standard surgical management including pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling is highly effective for most macular holes, lower success rates are observed with chronic or large holes. Several advanced surgical maneuvers have recently emerged, including inverted ILM flaps, autologous retinal transplant, subretinal blebs, and subretinal amniotic membrane (AM) grafts. While subretinal AM grafts demonstrate improved closure rates, amniotic tissue can block reformation of subfoveal outer retinal structures. The use of larger AM patches (> 6 mm diameter) to facilitate hole closure through the creation of a temporary pre-retinal scaffold is a novel surgical approach for refractory macular holes. We describe a large chronic stage-4 macular hole refractory to standard treatment, successfully treated with epiretinal AM transplantation and patch removal 2 months later. We highlight the feasibility of AM removal and importance of further refining this technique. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morbidity and Mortality Associated With Systemic Lupus Erythematosus and Retinal Vasculitis: A Multicenter Cohort Study. 系统性红斑狼疮和视网膜血管炎相关的发病率和死亡率：一项多中心队列研究。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-23 DOI: 10.3928/23258160-20250417-01

Jennifer D Huang, Kapil Mishra, Karen Wai, Prithvi Mruthyunjaya, Ehsan Rahimy

{"title":"Morbidity and Mortality Associated With Systemic Lupus Erythematosus and Retinal Vasculitis: A Multicenter Cohort Study.","authors":"Jennifer D Huang, Kapil Mishra, Karen Wai, Prithvi Mruthyunjaya, Ehsan Rahimy","doi":"10.3928/23258160-20250417-01","DOIUrl":"https://doi.org/10.3928/23258160-20250417-01","url":null,"abstract":"Background and objective: To determine the long-term rates of death, myocardial infarction (MI), dialysis, and stroke in patients with systemic lupus erythematosus (SLE) and retinal vasculitis (RV).Patients and methods: A total of 435 patients with SLE/RV were identified using TriNetX, a federated electronic health records network from January 1, 2004 to January 1, 2024. Patients were matched for age, sex, race, and propensity score, excluding those with MI, dialysis, or cerebrovascular complication in the year prior to diagnosis.Results: The risk of death, MI, and dialysis was not statistically different between cohorts at 5 and 10 years. The risk of stroke was increased at 5 and 10 years in the SLE/RV cohort, but no statistically significant difference in risk was found at 1 year.Conclusion: Although patients with and without RV may have similar long-term rates of death, MI, and dialysis, patients with SLE/RV may have an elevated risk of stroke in the subsequent 5 and 10 years after diagnosis, highlighting the need for multidisciplinary care. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Outcomes After Initiation of Faricimab for Neovascular Age-Related Macular Degeneration. 法利西单抗治疗新生血管性年龄相关性黄斑变性的早期结果。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250304-02

Ferhina S Ali, David C Tabano, Durga S Borkar, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh

{"title":"Early Outcomes After Initiation of Faricimab for Neovascular Age-Related Macular Degeneration.","authors":"Ferhina S Ali, David C Tabano, Durga S Borkar, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh","doi":"10.3928/23258160-20250304-02","DOIUrl":"https://doi.org/10.3928/23258160-20250304-02","url":null,"abstract":"Background and objective: This study assessed treatment patterns and early outcomes among patients with neovascular age-related macular degeneration (nAMD) initiating faricimab in routine clinical practice in the United States.Patients and methods: FARETINA-AMD is a retrospective study among patients with nAMD initiating faricimab from February 2022 to June 2023 identified from the US IRIS® Registry.Results: Included were 21,508 patients previously treated with anti-vascular endothelial growth factor (anti-VEGF) (25,784 eyes) and 1,836 treatment-naïve patients (1,982 eyes) with nAMD. Among previously treated eyes, visual acuity remained stable with faricimab. In treatment-naïve eyes, mean ± SD visual acuity improved from 56.7 ± 24.1 letters at index to 61.4 ± 22.3 after faricimab injection 4 (P < 0.01). Mean ± SD central subfield thickness improved from 315.2 ± 80.0 (index) to 264.9 ± 60.1 μm (injection 4) in treatment-naïve eyes and 296.2 ± 95.5 to 273.0 ± 81.4 μm in previously treated eyes (both P < 0.01).Conclusions: Among patients with nAMD receiving faricimab, visual acuity improved in treatment-naïve eyes, and both previously treated and treatment-naïve eyes experienced anatomical improvement. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Outcomes After Initiation of Faricimab in Patients With Diabetic Macular Edema. 法利昔单抗治疗糖尿病性黄斑水肿的早期疗效。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250304-01

Durga S Borkar, David C Tabano, Ferhina S Ali, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh

{"title":"Early Outcomes After Initiation of Faricimab in Patients With Diabetic Macular Edema.","authors":"Durga S Borkar, David C Tabano, Ferhina S Ali, Theodore Leng, Vincent Garmo, Ayesha Ahmed, Rachel Myers, Jacqueline K Shaia, Giulio Barteselli, Rishi P Singh","doi":"10.3928/23258160-20250304-01","DOIUrl":"https://doi.org/10.3928/23258160-20250304-01","url":null,"abstract":"Background and objective: This study evaluated treatment patterns and outcomes among patients with diabetic macular edema (DME) treated with the bispecific antibody faricimab in routine clinical practice in the United States.Patients and methods: FARETINA-DME was a retrospective study among patients with DME initiating faricimab from February 2022 to June 2023 identified from the United States IRIS® Registry.Results: Four thousand five hundred fourteen (4,514) patients (6,204 eyes) previously treated with anti-vascular endothelial growth factor (anti-VEGF) therapy and 691 treatment-naïve patients (851 eyes) were included. In previously treated eyes, mean ± SD visual acuity was 64.0 ± 18.3 letters at index and 65.3 ± 19.0 at faricimab injection 4. In treatment-naïve eyes, visual acuity improved from 60.3 ± 19.8 to 63.9 ± 18.5 letters (P < 0.01). Mean ± SD central subfield thickness improved from 364.3 ± 132.2 to 330.1 ± 121.2 μm in previously treated eyes and 359.6 ± 115.0 to 307.4 ± 114.6 μm in treatment-naïve eyes (both P < 0.01).Conclusions: In patients with DME receiving faricimab, visual acuity was maintained in previously treated and improved in treatment-naïve eyes. Both groups had anatomical improvement. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pegcetacoplan for Geographic Atrophy Over 30 Months: Data From OAKS, DERBY, and the GALE Long-Term Extension Study. 30个月以上地理萎缩的Pegcetacoplan：来自OAKS， DERBY和GALE长期扩展研究的数据。

IF 0.9 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-15 DOI: 10.3928/23258160-20250217-01

Roger A Goldberg, David S Boyer, Frank G Holz, Mathew W MacCumber, Sunir J Garg, David M Brown, Eleonora M Lad, Nathan Steinle, Rishi P Singh, Ian Pearce, Thomas Ach, Ramiro Ribeiro, Chao Li, Daniel Jones, Min Tsuboi, Philip J Ferrone, Caroline R Baumal, Charles C Wykoff

{"title":"Pegcetacoplan for Geographic Atrophy Over 30 Months: Data From OAKS, DERBY, and the GALE Long-Term Extension Study.","authors":"Roger A Goldberg, David S Boyer, Frank G Holz, Mathew W MacCumber, Sunir J Garg, David M Brown, Eleonora M Lad, Nathan Steinle, Rishi P Singh, Ian Pearce, Thomas Ach, Ramiro Ribeiro, Chao Li, Daniel Jones, Min Tsuboi, Philip J Ferrone, Caroline R Baumal, Charles C Wykoff","doi":"10.3928/23258160-20250217-01","DOIUrl":"https://doi.org/10.3928/23258160-20250217-01","url":null,"abstract":"Background and objective: This study will report safety and efficacy of pegcetacoplan for geographic atrophy (GA) secondary to age-related macular degeneration (AMD).Patients and methods: GALE is a phase 3, open-label, multicenter, 36-month extension of the OAKS and DERBY studies. Patients who received pegcetacoplan monthly (PM) or every other month (PEOM) in OAKS or DERBY continued the same regimen in GALE (PM-PM and PEOM-PEOM); sham-observed patients initiated pegcetacoplan, maintaining the same interval.Results: In the first 6 months of GALE, 3.0% of study eyes developed exudative AMD, 1.3% intraocular inflammation, 0.1% ischemic optic neuropathy, and none endophthalmitis. Pegcetacoplan reduced GA growth rate by 39% (PM-PM) and 32% (PEOM-PEOM), with increasing efficacy over time across GA subtypes. In eyes with nonsubfoveal GA, pegcetacoplan reduced GA growth rate by 45% (PM-PM) and 33% (PEOM-PEOM).Conclusion: Pegcetacoplan reduced GA growth rate up to 45% with increasing efficacy over 30 months and demonstrated a favorable safety profile. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0