Sonya Besagar, Shravika Chennupati, Xiangyu Ji, Qingxia Chen, Akshay S Thomas, Avni P Finn
{"title":"Optical Coherence Tomography Biomarkers in Epiretinal Membrane.","authors":"Sonya Besagar, Shravika Chennupati, Xiangyu Ji, Qingxia Chen, Akshay S Thomas, Avni P Finn","doi":"10.3928/23258160-20250416-01","DOIUrl":"https://doi.org/10.3928/23258160-20250416-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This retrospective, multicenter imaging analysis aims to identify pre-operative optical coherence tomography (OCT) bio-markers of idiopathic epiretinal membrane (ERM) that predict improved postoperative best-corrected visual acuity (BCVA).</p><p><strong>Patients and methods: </strong>Included were 80 eyes of 77 patients who underwent pars plana vitrectomy, membrane peel, and internal limiting membrane peel (PPV/MP/ILMP) for idiopathic ERM. Various preoperative, demographic, and surgical factors were studied, along with multiple preoperative OCT biomarkers.</p><p><strong>Results: </strong>Ellipsoid zone (EZ) disruption and focal retinal nerve fiber layer (RNFL) schisis present on preoperative OCT were associated with an increased likelihood of 2-line visual acuity improvement, independent of preoperative vision, while ERM stage, ectopic inner foveal layers, foveal herniation, central subfield thickness, cystic changes, lamellar hole, and the gap between the ERM and the retinal surface (SUKIMA) were not.</p><p><strong>Conclusion: </strong>Preoperative EZ disruption and RNFL schisis on OCT may identify patients who are more likely to have a meaningful improvement in postoperative visual outcomes for idiopathic ERM. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment.","authors":"Abdallah Safwat, Mohamed Abdullah, Ahmed Shawkat Abdelhalim, Rabei Hassanien, Khaled Mourad, Mohamed Tarek Moustafa","doi":"10.3928/23258160-20250127-03","DOIUrl":"10.3928/23258160-20250127-03","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated the use of a dual-delivery methotrexate (MTX) strategy for diabetic tractional retinal detachment (TRD). Diabetic retinopathy (DR) is a leading cause of blindness. Inflammation plays a key role in TRD, and MTX has anti-inflammatory properties.</p><p><strong>Patients and methods: </strong>This is a pilot study that included 60 patients with TRD. They were block randomized to either MTX with pars plana vitrectomy (PPV) (<i>n</i> = 30) or PPV alone (control, <i>n</i> = 30). MTX was added to the irrigation fluid during surgery and an intra-silicone injection at the end. One month after silicone oil removal, visual acuity (VA), multifocal electroretinography (mfERG), and spectral-domain optical coherence tomography (SD-OCT) were assessed.</p><p><strong>Results: </strong>One month after silicone oil removal, VA and mfERG were significantly better with a lower prevalence of epiretinal membranes, disorganization of retinal inner layers, and cystic macular changes by SD-OCT in the MTX group.</p><p><strong>Conclusion: </strong>This study found that dual-delivery MTX during PPV is a promising strategy to improve functional and anatomical results in diabetic TRD. <b><i>[Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:298-305.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"298-305"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Free and Mobile Primary Cyst of the Iris Pigment Epithelium.","authors":"Eleonora Beatriz Lavaque","doi":"10.3928/23258160-20250109-01","DOIUrl":"10.3928/23258160-20250109-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"318"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott
{"title":"Legislative Changes on Opioid Prescriptions for Ocular Procedures in a United States Cohort.","authors":"Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20250127-04","DOIUrl":"10.3928/23258160-20250127-04","url":null,"abstract":"<p><p>This ecological study examines the prevalence of postoperative opioid prescriptions among ophthalmic surgical patients during the implementation of four opioid policy interventions in Ohio. Changes in ophthalmic prescribing among 53 health care systems throughout the United States are compared to a population from the MetroHealth System in Cuyahoga County, Ohio. Opioid prescription prevalence spiked among all populations amid Ohio's \"pill mill\" and mandatory registration policies and then consistently decreased during the state's mandatory reporting and number-of-day restrictions. Black, Hispanic, and male subgroups across the country were more likely to receive opioids relative to other subgroups during most policy periods, but their rates were likely driven by trauma-related procedures. Prescribing fluctuations among ophthalmologists in the MetroHealth System generally matched national trends and did not correlate with prescribing trends among other specialties in Ohio. Consistent with previous research, opioid prescribing in ophthalmology remains low compared to other specialties throughout the country. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:312-315.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 5","pages":"312-315"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of Neovascularization Arising From an Arteriovenous Shunt in Proliferative Diabetic Retinopathy Using Ultra-Widefield Swept-Source OCT-A.","authors":"Selin Gumustop, Xinyi Ding, John B Miller","doi":"10.3928/23258160-20241201-01","DOIUrl":"10.3928/23258160-20241201-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"316-317"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raed Alnutaifi, Waleed W Khayyat, Faisal S AlQahtani
{"title":"Gore-Tex Suture-Associated Endophthalmitis in a Young Patient.","authors":"Raed Alnutaifi, Waleed W Khayyat, Faisal S AlQahtani","doi":"10.3928/23258160-20250124-02","DOIUrl":"10.3928/23258160-20250124-02","url":null,"abstract":"<p><p>Gore-Tex sutures are commonly used for scleral-fixated intraocular lenses (SFIOL) due to their high tensile strength and lower risk of breakage. However, complications such as suture erosion and infection remain a concern. This report presents a case of Gore-Tex suture-associated endophthalmitis in a young patient. A 21-year-old man with a history of penetrating eye injury and subsequent aphakia in the left eye underwent SFIOL surgery using Gore-Tex sutures, with a resultant best-corrected visual acuity (BCVA) of 20/30. Eighteen months later, he presented with sudden pain and an exposed suture. He was initially managed with topical antibiotics under observation. However, as signs of endophthalmitis developed, he was managed with an intravitreal antibiotic injection followed by pars plana vitrectomy with intraocular lens explantation. Culture of the vitreous sample identified <i>Haemophilus influenzae</i>. The patient gradually recovered, achieving a final BCVA of 20/125. This case underscores the importance of vigilant postoperative monitoring and timely intervention in managing suture-related complications. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:306-308.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"306-308"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Use of 18-Gauge Angiocatheter to Remove Perfluorocarbon-Silicone Oil Admixture Through Internal Choroidotomy.","authors":"Sohani Amarasekera, Ajay E Kuriyan, Jay Chhablani","doi":"10.3928/23258160-20250217-05","DOIUrl":"10.3928/23258160-20250217-05","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"262-264"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan
{"title":"Difluprednate for the Treatment of Postoperative Hypotony Following Complicated Retinal Detachment Surgery.","authors":"Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan","doi":"10.3928/23258160-20250127-01","DOIUrl":"10.3928/23258160-20250127-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.</p><p><strong>Patients and methods: </strong>A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.</p><p><strong>Results: </strong>Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, <i>P</i> = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.</p><p><strong>Conclusion: </strong>Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:266-272.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"266-272"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles C Wykoff, Timothy L Jackson, Clare F Price, Megan E Baldwin, Ian M Leitch, Jason Slakter
{"title":"Sozinibercept Combination Therapy for Neovascular Age-related Macular Degeneration: Phase 2b Study Subgroup Analysis by Lesion Type.","authors":"Charles C Wykoff, Timothy L Jackson, Clare F Price, Megan E Baldwin, Ian M Leitch, Jason Slakter","doi":"10.3928/23258160-20250108-04","DOIUrl":"10.3928/23258160-20250108-04","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this study was to evaluate the angiographic predictors of response to the anti-vascular endothelial growth factor-C/-D agent, sozinibercept.</p><p><strong>Patients and methods: </strong>Prespecified and post hoc subgroup analyses of a phase 2b, randomized, double-masked, sham-controlled trial of 240 participants with treatment-naïve neovascular age-related macular degeneration, comparing monthly intravitreal sozinibercept 0.5 mg or 2 mg, plus ranibizumab 0.5 mg, versus monthly ranibizumab monotherapy.</p><p><strong>Results: </strong>Visual acuity benefits at week 24 were greatest in participants with occult lesions receiving 2 mg sozinibercept combination therapy (+15.65 [<i>n</i> = 53] letters versus +9.62 [<i>n</i> = 51] with ranibizumab monotherapy; least squares mean difference +6.03; <i>P</i> = 0.0009). A composite analysis of occult and minimally classic lesions excluding retinal angiomatous proliferation (<i>n</i> = 175/240) also favored sozinibercept over control (+16.08 versus +10.34 letters; +5.74; <i>P</i> = 0.0002). Structural outcomes mirrored sozinibercept visual acuity benefits, with less leakage and smaller lesions on multimodal imaging.</p><p><strong>Conclusion: </strong>Angiographic lesion characteristics were found to predict the response to sozinibercept combination therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:287-296.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"287-296"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}