Ophthalmic surgery, lasers & imaging retina最新文献_第2页

Surgical Implantation of Revakinagene Taroretcellwey for the Treatment of Macular Telangiectasia Type 2: Technique and Surgical Pearls. Revakinagene taroret细胞植入术治疗黄斑毛细血管扩张ⅱ型：技术与手术珍珠。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-10-01 Epub Date: 2026-09-23 DOI: 10.3928/23258160-20260911-01

Roger A Goldberg, Charles C Wykoff, Liliya Sutherland

{"title":"Surgical Implantation of Revakinagene Taroretcellwey for the Treatment of Macular Telangiectasia Type 2: Technique and Surgical Pearls.","authors":"Roger A Goldberg, Charles C Wykoff, Liliya Sutherland","doi":"10.3928/23258160-20260911-01","DOIUrl":"10.3928/23258160-20260911-01","url":null,"abstract":"Macular telangiectasia type 2 (MacTel), a bilateral, neurodegenerative disease associated with photoreceptor loss, often leads to progressive scotomas, metamorphopsia, and impaired reading function. Revakinagene taroretcel-lwey, a Food and Drug Administration (FDA)-approved encapsulated cell-based therapy for adults with MacTel, is surgically inserted into the vitreous cavity and provides sustained intraocular delivery of recombinant human ciliary neurotrophic factor (CNTF). Results from two phase 3 randomized clinical trials support the efficacy and safety of revakinagene taroretcel-lwey; explant analyses have demonstrated bioactive CNTF release up to 14.5 years. This report summarizes the surgical procedure and techniques for revakinagene taroretcel-lwey implantation, including implant preparation, insertion, wound closure, and postoperative procedures, and highlights scenarios where expert guidance may help to prevent intraoperative errors and minimize the potential for postsurgical adverse events. Standardizing surgical steps and incorporating expert guidance into surgical technique may reduce adverse events, including migration and extrusion, wound leaks, and infections, supporting safe long-term CNTF delivery for treatment of MacTel.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"672-678"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Posterior Segment Syndrome Following Dropless Cataract Surgery With Compounded Triamcinolone-Moxifloxacin. 复方曲安奈德-莫西沙星白内障手术后毒性后段综合征。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-10-01 Epub Date: 2026-09-22 DOI: 10.3928/23258160-20260819-01

Michael Yu, Kishan G Patel, Nikhil K Bommakanti, Rajiv Anand, Deborah Y Chong, Lori E Coors, Gary E Fish, Timothy S Fuller, Robert C Wang, Yoshihiro Yonekawa, Ashkan M Abbey

{"title":"Toxic Posterior Segment Syndrome Following Dropless Cataract Surgery With Compounded Triamcinolone-Moxifloxacin.","authors":"Michael Yu, Kishan G Patel, Nikhil K Bommakanti, Rajiv Anand, Deborah Y Chong, Lori E Coors, Gary E Fish, Timothy S Fuller, Robert C Wang, Yoshihiro Yonekawa, Ashkan M Abbey","doi":"10.3928/23258160-20260819-01","DOIUrl":"10.3928/23258160-20260819-01","url":null,"abstract":"Background and objective: This report aims to describe the clinical presentation, outcomes, and prognostic risk factors of toxic posterior segment syndrome (TPSS) associated with a compounded triamcinolone-moxifloxacin formulation administered during dropless cataract surgery (DLCS).Patients and methods: This was a retrospective multicenter case series of 50 eyes with TPSS after DLCS. Data collected included clinical and multi-modal imaging features. Multivariate and ordinal logistic regression models were used to identify factors associated with disease severity.Results: TPSS severity was categorized as mild (n = 14), moderate (n = 14), or severe (n = 22) based on final best-corrected visual acuity (BCVA). Severe cases demonstrated outer retinal thinning with ellipsoid zone (EZ) and external limiting membrane (ELM) loss, disc leakage, and enlarged foveal avascular zone. Ordinal logistic regression showed worse presenting visual acuity (< 20/150; OR 7.00, P < .001) and male sex predicted severe disease (OR 3.22, P < .001), while a normal fluorescein angiography (FA) appearance was protective (coefficient -8.395, P = .001).Conclusion: This large case series describes TPSS prognostic risk factors and underscores the urgent need for standardized Food and Drug Administration (FDA)-approved intraocular formulations.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"625-632"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abiotrophia defectiva Endophthalmitis Associated With Exposed XEN Gel Stent. 无营养缺损性眼内炎与外露的XEN凝胶支架相关。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-10-01 Epub Date: 2026-09-24 DOI: 10.3928/23258160-20260818-02

Michael Y Zhao, Joseph D Pecha, Landon J Rohowetz, Jin Kyun Oh, Salomon Merikansky, Darlene Miller, J Daniel Diaz, Harry W Flynn

{"title":"Abiotrophia defectiva Endophthalmitis Associated With Exposed XEN Gel Stent.","authors":"Michael Y Zhao, Joseph D Pecha, Landon J Rohowetz, Jin Kyun Oh, Salomon Merikansky, Darlene Miller, J Daniel Diaz, Harry W Flynn","doi":"10.3928/23258160-20260818-02","DOIUrl":"10.3928/23258160-20260818-02","url":null,"abstract":"An 80-year-old woman presented with a painful red eye four months after XEN gel stent implantation for primary open-angle glaucoma. Examination revealed an exposed gel stent through a conjunctival defect, corneal edema, hypopyon, and vitreous membranes, consistent with acute exogenous endophthalmitis. She underwent vitreous aspiration with intravitreal vancomycin and ceftazidime, followed by pars plana vitrectomy with stent explantation and silicone oil tamponade. Vitreous cultures grew Abiotrophia defectiva, recovered on routine media and identified to species by automated phenotypic testing within 6 hours, without molecular confirmation. Following silicone oil removal, vision returned to her baseline of 5/200, limited by prior central retinal vein occlusion. This represents the second reported case of A. defectiva endophthalmitis associated with an exposed gel stent. Contemporary automated identification may reduce diagnostic delay for this organism, though isolate-level susceptibility testing remains essential to guide targeted therapy.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"663-666"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Imaging Features of Degenerative Retinoschisis. 退行性视网膜裂的多模态影像特征。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-10-01 Epub Date: 2026-08-31 DOI: 10.3928/23258160-20260813-02

Landon J Rohowetz, Yale L Fisher, Sugi Panneerselvam, Alexander Higgins, Harry W Flynn

引用次数: 0

Late Exudative Retinal Detachment in Prior Treated Retinoblastoma. 先前治疗的视网膜母细胞瘤的晚期渗出性视网膜脱离。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-10-01 Epub Date: 2026-09-29 DOI: 10.3928/23258160-20260910-01

Celine Chaaya, Marfy Abousifein, Efren Gonzalez, Shizuo Mukai, Basil K Williams, Maura Di Nicola, Nathan Scott, Phill Ferrone, Jesse Berry, Victor M Villegas, Nimesh A Patel

引用次数: 0

Subretinal Sodium Fluorescein Injection and Three-Dimensional Pars Plana Vitrectomy for the Identification of Retinal Breaks. 视网膜下荧光素钠注射与三维玻璃体切割术鉴别视网膜破裂。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-09-29 DOI: 10.3928/23258160-20260818-03

Enrique López-Sánchez, Lidia Remolí-Sargues, Belén López-Salvador, Emma Marín-Payá, Enrique López-Francés, Ester Francés-Muñoz

{"title":"Subretinal Sodium Fluorescein Injection and Three-Dimensional Pars Plana Vitrectomy for the Identification of Retinal Breaks.","authors":"Enrique López-Sánchez, Lidia Remolí-Sargues, Belén López-Salvador, Emma Marín-Payá, Enrique López-Francés, Ester Francés-Muñoz","doi":"10.3928/23258160-20260818-03","DOIUrl":"https://doi.org/10.3928/23258160-20260818-03","url":null,"abstract":"This study was intended to describe a novel sodium fluorescein (SF) extrusion technique using an excitation optic filter integrated into a three-dimensional (3D) visualization system to identify retinal breaks during retinal detachment (RD) surgery. Digitally assisted pars plana vitrectomy was performed with the NGENUITY 3D system in two RD patients. When retinal breaks were not identified, up to 0.1 mL of SF (0.1 mg/mL) was injected into the subretinal space via transscleral or transretinal approaches. Retinal breaks were identified by visualizing dye extrusion during perfluorocarbon injection with an excitation optical filter and a specific digital color channel. The technique revealed previously unidentified retinal breaks in both cases, enabling completion of standard RD repair. At 3 months, both patients achieved retinal reattachment, with no SF-related complications. This novel technique facilitated retinal break detection; however, further studies are needed to confirm long-term safety and efficacy.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Systemic Comorbidities in Patients With Inherited Retinal Diseases. 遗传性视网膜疾病患者的系统性合并症风险

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.3928/23258160-20260722-02

Matthew L Regueiro, Sindhu B Kosuru, Nadia J Abbass, David C Kaelber, Elias I Traboulsi, Katherine E Talcott, Rishi P Singh

{"title":"Risk of Systemic Comorbidities in Patients With Inherited Retinal Diseases.","authors":"Matthew L Regueiro, Sindhu B Kosuru, Nadia J Abbass, David C Kaelber, Elias I Traboulsi, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20260722-02","DOIUrl":"10.3928/23258160-20260722-02","url":null,"abstract":"Background and objective: There is limited evidence of the rates at which inherited retinal disease (IRD) patients experience systemic conditions. This study aimed to evaluate the association between IRDs and systemic comorbidities to inform appropriate screening and referral guidelines for ophthalmologists.Patients and methods: This was a retrospective cohort study utilizing a large International Classification of Diseases, Tenth Revision (ICD-10) coded platform. Patients with ≥ 2 IRD ICD-10 codes were compared to controls (1:1) propensity matched on demographics. Syndromic IRDs could not be disaggregated.Results: At 5 years, patients with IRDs (n = 13,471) demonstrated higher rates of hypertension (risk ratio [RR] 1.16, 95% CI 1.12-1.20, P < .001), peripheral vascular disease (RR 1.74, 1.48-4.05, P < .001), cerebral infarction (RR 1.31, 1.14-1.52, P < .001), chronic kidney disease (RR 1.85, 1.65-2.06, P < .001), renal failure (RR 2.37, 1.60-3.52, P < .001), hearing loss (RR 4.52, 3.92-5.22, P < .001), ataxia (RR 3.46, 2.47-4.83, P < .001), intellectual disabilities (RR 5.14, 3.61-7.30, P < .001), and diabetes (RR 1.40, 1.32-1.48, P < .001). Ten-year analysis confirmed significant increases in these comorbidities.Conclusion: IRD patients exhibit higher rates of cardiovascular, renal, and neurologic conditions, highlighting the importance of routine screening to monitor, detect, and treat these comorbidities.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"558-564"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Persistent Avascular Retina in Retinopathy of Prematurity: An International Survey. 早产儿视网膜病变持续性无血管视网膜的处理：一项国际调查。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-09-01 Epub Date: 2026-08-17 DOI: 10.3928/23258160-20260717-03

Andrea Orpia, Riva Menon, Christina Kilby, Jeong-Yoon Wu, He Eun Forbes, Jason Zhou, Kristin Williams, Moran R Levin, Sripriya Sundararajan, Sarah H Rodriguez, Janet Leath Alexander

{"title":"Management of Persistent Avascular Retina in Retinopathy of Prematurity: An International Survey.","authors":"Andrea Orpia, Riva Menon, Christina Kilby, Jeong-Yoon Wu, He Eun Forbes, Jason Zhou, Kristin Williams, Moran R Levin, Sripriya Sundararajan, Sarah H Rodriguez, Janet Leath Alexander","doi":"10.3928/23258160-20260717-03","DOIUrl":"10.3928/23258160-20260717-03","url":null,"abstract":"Background and objective: Indications for laser photocoagulation of persistent avascular retina (PAR) in retinopathy of prematurity (ROP) remain controversial. This study aimed to characterize current clinical practice patterns to inform future studies addressing these discrepancies.Patients and methods: A cross-sectional REDCap (Research Electronic Data Capture) survey was conducted, distributed primarily via email to vitreo-retinal and pediatric ophthalmology fellowship directors. Responses from 106 ROP specialists across six continents were analyzed. The primary outcome was the proportion of respondents recommending laser treatment for PAR following spontaneous ROP regression or intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy.Results: Most respondents had completed vitreo-retinal (57%) or pediatric (42%) ophthalmology fellowship training, with many (84%) based in North America. Anti-VEGF was preferred by 80% of respondents as primary ROP treatment for the majority of patients. Laser was more frequently considered for zone II (69%) than zone III (58%) PAR, particularly following anti-VEGF therapy. Following post-anti-VEGF reactivation, laser was recommended in the majority of cases (59%). In spontaneously regressed ROP, 50% of respondents did not routinely recommend laser.Conclusion: Practice patterns for PAR management vary, with greater support for laser in zone II disease and after anti-VEGF therapy.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"576-583"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Hormone Replacement Therapy on Risk of Age-related Macular Degeneration Among an Aggregate Health Record Cohort. 激素替代疗法对年龄相关性黄斑变性风险的影响

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-09-01 Epub Date: 2026-08-31 DOI: 10.3928/23258160-20260813-03

Charles W Guo, Alison H Zhao, David Kaelber, Rishi P Singh, Katherine E Talcott

{"title":"Effect of Hormone Replacement Therapy on Risk of Age-related Macular Degeneration Among an Aggregate Health Record Cohort.","authors":"Charles W Guo, Alison H Zhao, David Kaelber, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20260813-03","DOIUrl":"10.3928/23258160-20260813-03","url":null,"abstract":"Background and objective: Estrogen in hormone replacement therapy (HRT) exerts anti-inflammatory effects believed to oppose age-related macular degeneration (AMD) pathogenesis, but whether HRT can be protective against AMD is contested. The aim of the study was to evaluate the association between HRT use and the risk of development and progression of AMD in postmenopausal women.Patients and methods: This was a retrospective cohort study utilizing International Classification of Diseases, Tenth Revision (ICD-10) codes for HRT usage and rates of AMD development and progression.Results: There was a decreased risk of developing AMD in patients more than 60 years of age at 5 years (RR 0.72, 95% CI: 0.63-0.82) and 8 years (0.68, 0.60-0.76) after HRT initiation. Patients more than 75 years of age also demonstrated a reduced risk of developing AMD after 5 years (0.70, 0.60-0.82) and 8 years (0.64, 0.56-0.74) of HRT use. Patients more than 75 years of age had a reduced risk of progression to exudative AMD at 8 years (0.66, 0.49-0.89) after HRT initiation.Conclusion: HRT may be associated with a decreased risk of developing AMD, with continued effects at more chronic timepoints after HRT initiation.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"566-574"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraocular Pressure Spikes After Ophthalmic Laser Leading to Wipe-Out in Only-Eyed Patients: A Serious Complication Not to Be Overlooked. 单眼患者在眼科激光治疗后眼压升高：一个不容忽视的严重并发症。

IF 1.1 4区医学

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.3928/23258160-20260730-01

Jacinta W Y Tse, Alexander K C Chiu, Emily W H Tang, Kenneth K W Li

{"title":"Intraocular Pressure Spikes After Ophthalmic Laser Leading to Wipe-Out in Only-Eyed Patients: A Serious Complication Not to Be Overlooked.","authors":"Jacinta W Y Tse, Alexander K C Chiu, Emily W H Tang, Kenneth K W Li","doi":"10.3928/23258160-20260730-01","DOIUrl":"10.3928/23258160-20260730-01","url":null,"abstract":"Intraocular pressure (IOP) spike following various ophthalmic laser procedures, such as laser peripheral iridotomy (LPI), Nd:YAG capsulotomy and laser trabeculoplasty, is a known risk of these procedures. Most cases are mild, amenable to medical treatment, with no impact on final vision. We present five only-eyed cases of wipe-out secondary to elevated IOP following ophthalmic laser procedures and their outcomes. Four out of five cases were associated with a poor visual outcome. Such cases should not be overlooked. In certain places like the UK, only post-LPI IOP is measured, but not other ophthalmic lasers, nor is pre- and post-procedure brimonodine or apraclonidine routinely prescribed to mitigate the IOP spike. We advocate the importance of post-procedure IOP checking, especially in advanced glaucoma patients with narrow safety margins. Precautions and assessment within the first hour post-procedure are critical for patients with very advanced or end-stage glaucoma and narrow safety margins, as urgent treatment may potentially reverse the adverse outcome for these patients.","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"604-606"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0