Effie Z Rahman, Matthew Ellis, Timothy Pardee, Rajiv Shah
{"title":"Non-Blast Phase Chronic Myelogenous Leukemia Presenting as Bilateral Infiltration of the Optic Nerve.","authors":"Effie Z Rahman, Matthew Ellis, Timothy Pardee, Rajiv Shah","doi":"10.3928/23258160-20240923-02","DOIUrl":"10.3928/23258160-20240923-02","url":null,"abstract":"<p><p>A 27-year-old woman presented with bilateral blurry vision for 2 weeks. She had a presumed diagnosis of idiopathic intracranial hypertension given her bilateral disc edema; however, bilateral disc and retinal infiltration was noted on ophthalmoscopy. This report presents a rare case of chronic myelogenous leukemia (CML) in the non-blast phase presenting as bilateral optic disc infiltration, indicating central nervous system involvement at the time of diagnosis. The patient had no other clinical symptoms at the time of diagnosis and was promptly treated with orbital radiation and a tyrosine kinase inhibitor, resulting in 20/20 vision in both eyes. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:102-107.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"102-107"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaylie Chen, Stephanie B Engelhard, Sarah H Van Tassel, Kyle D Kovacs
{"title":"Adverse Events Associated With Yamane Scleral Fixation of Intraocular Lens as Reported to the FDA MAUDE Database.","authors":"Kaylie Chen, Stephanie B Engelhard, Sarah H Van Tassel, Kyle D Kovacs","doi":"10.3928/23258160-20241101-03","DOIUrl":"10.3928/23258160-20241101-03","url":null,"abstract":"<p><p>To identify real-world complications involving flanged scleral tunnel fixation of Zeiss CT Lucia 602 intraocular lenses, the Food and Drug Administration Manufacturer and User Facility Device Experience (FDA MAUDE) was searched by Manufacturer field for Zeiss with the terms \"Yamane\" and \"scleral fixated\". Reports containing these terms were reviewed to confirm technique and categorize adverse events. The search yielded 178 confirmed reports of lens malfunctions for CT Lucia 602 between 2013 to 2024, with 95% of reports in the last 3 years. The most common complication was lens tilt (94 reports), followed by breakage (53) comprised of haptic-optic disinsertion (31) and haptic breakage (22). Intraoperatively, 118 (66.3%) complications occurred, and 60 (33.7%) occurred postoperatively. Temporal analysis revealed that the number of reports to MAUDE has shown a ten-fold annual increase since 2020. Reports suggest haptic breakage is a noteworthy malfunction for CT Lucia 602 lenses. The occurrence of intraoperative breakage and lens tilt may be higher than previously expected in real-world settings. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:123-125.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"123-125"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda
{"title":"Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials.","authors":"Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda","doi":"10.3928/23258160-20250108-02","DOIUrl":"10.3928/23258160-20250108-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.</p><p><strong>Patients and methods: </strong>This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.</p><p><strong>Results: </strong>Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.</p><p><strong>Conclusion: </strong>Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-3"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Marcelo Zas, Se Joon Woo, Clara Vazquez-Alfageme, Sharat Hegde, Kourous A Rezaei
{"title":"RWC Update: Optic Pit Maculopathy and Lyophilized Amniotic Membrane; How Do You Choose One Biosimilar Over the Others?; Diffuse Unilateral Subacute Neuroretinitis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Marcelo Zas, Se Joon Woo, Clara Vazquez-Alfageme, Sharat Hegde, Kourous A Rezaei","doi":"10.3928/23258160-20250122-01","DOIUrl":"https://doi.org/10.3928/23258160-20250122-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 2","pages":"68-71"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard N Sather, Jade Y Moon, Francesco Romano, Kate Overbey, Hanna Choi, Inês M D C Laíns, Deeba Husain, Nimesh A Patel, John B Miller
{"title":"The Ergonomic Evaluation of Attendings and Trainees Across the Vitreoretinal Service as Measured by a Wearable Device.","authors":"Richard N Sather, Jade Y Moon, Francesco Romano, Kate Overbey, Hanna Choi, Inês M D C Laíns, Deeba Husain, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240906-01","DOIUrl":"10.3928/23258160-20240906-01","url":null,"abstract":"<p><strong>Background and objective: </strong>A cross-sectional prospective study to examine ergonomic differences in vitreoretinal settings: surgery, clinic, and dedicated procedure clinic.</p><p><strong>Patients and methods: </strong>Three vitreoretinal surgeons, three fellows, and one resident at a tertiary eye care facility. Participants wore an Upright Go 2 posture device and posture was recorded in each setting between July 1 to August 31, 2023.</p><p><strong>Results: </strong>Time in upright and poor postures was tracked. Significant differences were found in postural score for attendings between work settings (<i>P</i> < 0.01). Trainees showed no significant difference between settings. Poor posture in surgery was linked to microscope use and scleral buckle placement; in the clinic, it was associated with pan-retinal photocoagulation and injection minutes; in procedure clinic, it was ophthalmologist-dependent and those performing injections.</p><p><strong>Conclusions: </strong>Ergonomic considerations are crucial in vitreoretinal practice. Attendings and trainees should focus on posture in surgery and clinic settings to enhance career longevity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:80-85.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"80-85"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindsey A Chew, Nikhil V Gadiraju, Anjali M Saini, S Tammy Hsu, Vahid Ownagh, Lejla Vajzovic
{"title":"Pediatric Eye Screening: Current Standards and Gaps in Care.","authors":"Lindsey A Chew, Nikhil V Gadiraju, Anjali M Saini, S Tammy Hsu, Vahid Ownagh, Lejla Vajzovic","doi":"10.3928/23258160-20241216-03","DOIUrl":"https://doi.org/10.3928/23258160-20241216-03","url":null,"abstract":"<p><p>The nonmydriatic, noncontact, and rapid acquisition features of ultra-widefield fundus (UWF) imaging create an invaluable tool for pediatric retinal screening in primary care. This review assesses the landscape of pediatric eye screening, identifies gaps in diagnosing a range of pediatric retinal conditions, and discusses potential uses of UWF imaging for retinal screening. The standards for pediatric eye screening in primary care include red reflex testing, direct ophthalmoscopy, external ocular exam, instrument-based screening, and visual acuity testing. These tests fail to diagnose several treatable retinal diseases. In this gap, UWF retinal imaging provides a panoramic view of the retinal landscape, allowing for a more comprehensive examination. For several pediatric retinal conditions (eg, retinal detachment, retinopathy of prematurity, Coats' disease, familial exudative vitreoretinopathy, Stargardt disease, ocular toxocariasis), UWF retinal imaging provides the high spatial resolution necessary for reliable diagnosis, expediting time to treatment while maintaining low false positive rates. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan
{"title":"Difluprednate for the Treatment of Postoperative Hypotony Following Complicated Retinal Detachment Surgery.","authors":"Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan","doi":"10.3928/23258160-20250127-01","DOIUrl":"https://doi.org/10.3928/23258160-20250127-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.</p><p><strong>Patients and methods: </strong>A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.</p><p><strong>Results: </strong>Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, <i>P</i> = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.</p><p><strong>Conclusion: </strong>Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles C Wykoff, Timothy L Jackson, Clare F Price, Megan E Baldwin, Ian M Leitch, Jason Slakter
{"title":"Sozinibercept Combination Therapy for Neovascular Age-related Macular Degeneration: Phase 2b Study Subgroup Analysis by Lesion Type.","authors":"Charles C Wykoff, Timothy L Jackson, Clare F Price, Megan E Baldwin, Ian M Leitch, Jason Slakter","doi":"10.3928/23258160-20250108-04","DOIUrl":"https://doi.org/10.3928/23258160-20250108-04","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this study was to evaluate the angiographic predictors of response to the anti-vascular endothelial growth factor-C/-D agent, sozinibercept.</p><p><strong>Patients and methods: </strong>Prespecified and post hoc subgroup analyses of a phase 2b, randomized, double-masked, sham-controlled trial of 240 participants with treatment-naïve neovascular age-related macular degeneration, comparing monthly intravitreal sozinibercept 0.5 mg or 2 mg, plus ranibizumab 0.5 mg, versus monthly ranibizumab monotherapy.</p><p><strong>Results: </strong>Visual acuity benefits at week 24 were greatest in participants with occult lesions receiving 2 mg sozinibercept combination therapy (+15.65 [<i>n</i> = 53] letters versus +9.62 [<i>n</i> = 51] with ranibizumab monotherapy; least squares mean difference +6.03; <i>P</i> = 0.0009). A composite analysis of occult and minimally classic lesions excluding retinal angiomatous proliferation (<i>n</i> = 175/240) also favored sozinibercept over control (+16.08 versus +10.34 letters; +5.74; <i>P</i> = 0.0002). Structural outcomes mirrored sozinibercept visual acuity benefits, with less leakage and smaller lesions on multimodal imaging.</p><p><strong>Conclusion: </strong>Angiographic lesion characteristics were found to predict the response to sozinibercept combination therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}