Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Central Retinal Thickness Variability as a Predictive Factor for Visual Acuity After Dexamethasone Implant in Retinal Vein Occlusion.","authors":"Sarunas P Daugirdas, Christopher M Maatouk, Hongxin J Lai, Miller J Ogidigben, Rishi P Singh","doi":"10.3928/23258160-20240621-04","DOIUrl":"10.3928/23258160-20240621-04","url":null,"abstract":"<p><strong>Background and objective: </strong>Investigate central retinal thickness (CRT) variability and changes in best-corrected visual acuity (BCVA) after 12 months in patients with retinal vein occlusion (RVO) treated with dexamethasone intravitreal implants.</p><p><strong>Patients and methods: </strong>Post hoc analyses of two randomized trials in patients with macular edema associated with branch or central RVO treated with a 0.7-mg dexamethasone implant. Central retinal thickness standard deviation (CRT-SD) and central retinal thickness amplitude (CRT-A) were measures of variability. Analyses included multinomial and simple linear regression.</p><p><strong>Results: </strong>In 400 patients, CRT-SD and CRT-A were significantly associated with central RVO, second dexamethasone implant, and baseline CRT. Baseline BCVA was associated with CRT-A. CRT-SD and CRT-A were significantly correlated with a 12-month change in BCVA (effect sizes of -0.032 and -0.013 letters/µm; <i>P</i> < 0.001). Patients in the highest CRT-SD quartile gained significantly fewer letters (+1.88 letters; 95% CI: -0.46 to 4.23).</p><p><strong>Conclusion: </strong>Greater CRT variability was associated with smaller BCVA improvements in patients with RVO treated with dexamethasone implants. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:722-729.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"722-729"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitrectomy With tPA for Submacular Hemorrhage Following Domestic Abuse.","authors":"Miguel A Busquets, Fareed Rifai","doi":"10.3928/23258160-20240705-01","DOIUrl":"10.3928/23258160-20240705-01","url":null,"abstract":"<p><p>A 35-year-old woman presented with visual acuity of 20/400 due to submacular hemorrhage 24 hours after confirmed domestic abuse with blunt trauma to the head. Surgical intervention with pars plana vitrectomy, subretinal tissue plasminogen activator (tPA) injection, and fluid-air exchange yielded prompt resolution of the pathology, regaining functional vision of 20/40 and an ability to return to work within one week. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:734-736.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"734-736"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Gliovascular Proliferation Secondary to Retinoblastoma Treated With Radiotherapy.","authors":"Hannah Istre-Wilz, Jared J Ebert, James J Augsburger, Maura Di Nicola, Zelia M Correa, Basil K Williams","doi":"10.3928/23258160-20240801-01","DOIUrl":"10.3928/23258160-20240801-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal gliovascular proliferation (RGVP) is a benign lesion of the retina that can arise idiopathically or secondary to another disease entity. This study describes the clinical features, treatment, and outcomes of six patients with secondary RGVP associated with irradiated, regressed retinoblastoma, and distinguishes it from late local relapse of retinoblastoma.</p><p><strong>Patients and methods: </strong>In a retrospective review of available clinical records of 550 patients evaluated for retinoblastoma in a single ocular oncology practice between 1975 and 2022, seven eyes of six patients were identified as having secondary RGVP overlying a treated and regressed retinoblastoma. The clinical features, treatment, and outcomes are described.</p><p><strong>Results: </strong>The median age at RGVP diagnosis was 20 years. All RGVPs were associated with a completely regressed retinoblastoma and in proximity to a calcific tumor residue or chorioretinal atrophy that remained after external beam radiotherapy (six eyes) or plaque brachytherapy (one eye). Lesions were measured between 2.8 to 12 mm in largest basal diameter and 1.3 to 4.4 mm in thickness and described as globular, raised areas with focal retinal telangiectasis often associated with overlying subretinal fluid or hemorrhage. Median time between initial retinoblastoma treatment and detection of RGVP was 20 years. Treatment was decided based on evidence of lesion growth and most often consisted of laser photocoagulation and intravitreal anti-VEGF injection. Through available follow-up of the treated lesions, all exhibited at least partial regression, while two untreated lesions remained stable, reassuring us against late local relapse of retinoblastoma.</p><p><strong>Conclusions: </strong>Secondary RGVP develops occasionally in association with regressed previously irradiated retinoblastoma. This lesion must be distinguished from late local relapse of active retinoblastoma. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:714-720.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"714-720"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Central Retinal Vein Occlusion in an Older Man With Multiple Myeloma: A Case Report.","authors":"Matthew J Finn, John B Miller","doi":"10.3928/23258160-20240718-02","DOIUrl":"10.3928/23258160-20240718-02","url":null,"abstract":"<p><p>This report aims to describe the clinical presentation of a patient with an atypical central retinal vein occlusion (CRVO) in the setting of multiple myeloma. The patient was a 72-year-old man with an extensive hematologic-oncologic history and cardiovascular risk factors who presented with new-onset blurry vision and visual acuity (VA) of 20/40 in the left eye. The VA worsened to 20/60 two months after the initial presentation. By the 6-month follow-up visit, a series of three intravitreal bevacizumab injections for macular edema improved VA from 20/60 to 20/40. This case demonstrates the importance of fluorescein angiography in diagnosing a CRVO and exemplifies an atypical presentation on exam and imaging studies. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:730-733.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"730-733"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Relationship Between Lipid-Lowering Agents and the Complications of Diabetic Retinopathy.","authors":"Hejin Jeong, Jacqueline K Shaia, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20240729-03","DOIUrl":"10.3928/23258160-20240729-03","url":null,"abstract":"<p><strong>Background and objective: </strong>As the therapeutic efficacy of lipid-lowering agents (LLA) against diabetic retinopathy (DR) remains controversial, this study aimed to evaluate whether various LLA therapies are associated with a reduced risk of DR progression.</p><p><strong>Patients and methods: </strong>This retrospective study of the medical records of adults with type 2 diabetes mellitus and DR compared the risk of adverse progression of DR between patients who received statins, fibrates, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and no LLA (control).</p><p><strong>Results: </strong>Patients in the statin cohort had a reduced rate of progression to proliferative DR compared to controls (HR = 0.30, CI = 0.11 to 0.83). The PCSK9 inhibitor cohort had a reduced risk of progressing to other secondary complications of DR compared to the control (RR = 0.52, CI = 0.43 to 0.64), statin (RR = 0.69, CI = 0.61 to 0.79), and fibrate (RR = 0.67, CI = 0.59 to 0.77) cohorts.</p><p><strong>Conclusions: </strong>These findings suggest use of statins and PCSK9 inhibitors are associated with a reduced risk of adverse progression of DR. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:706-713.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"706-713"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Intravitreal Steroid and Anti-VEGF Therapy for Monotherapy-Resistant Chronic Wet Age-Related Macular Degeneration.","authors":"Alexandra Warter, Anna Heinke, Melina Cavichini, Carlo Miguel B Galang, Fritz Gerald P Kalaw, Dirk-Uwe Bartsch, Lingyun Cheng, William R Freeman","doi":"10.3928/23258160-20240705-03","DOIUrl":"10.3928/23258160-20240705-03","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this study was to analyze the safety and efficacy of combined intravitreal anti-vascular endothelial growth factor (anti-VEGF) and steroid therapeutic agents for resistant choroidal neovascularization (CNV). A retrospective observational clinical study was performed assessing anatomic and visual changes in a consecutive cohort of patients with refractory chronic wet age-related macular degeneration resistant to high-dose aflibercept therapy.</p><p><strong>Patients and methods: </strong>Twelve eyes of 12 patients with unresponsive CNV despite aggressive monthly anti-VEGF (4-mg aflibercept [mean: 43.75 ± SD23.08]) were included. Combination consisted of simultaneous administration of anti-VEGF and corticosteroids. Study measures evaluated visual acuity, central retinal thickness (CRT), and intraocular pressure.</p><p><strong>Results: </strong>Paired tests revealed significant CRT reduction from the baseline at the 1-month (388.58 ± 89.31 versus 334.00 ± 92.88, <i>P</i> = 0.0117), 2-month (388.58 ± 89.31 versus 312.08 ± 75.61, <i>P</i> = 0.0185), and 3-month (388.53 ± 89.31 versus 304.56 ± 53.28, <i>P</i> = 0.046) visit. The Kaplan-Meier curve showed a median time of remission (no retinal fluid) of 70 days (95% CI 53, 147 days).</p><p><strong>Conclusion: </strong>Combination treatment demonstrated clear anatomic improvement in eyes with anti-VEGF-resistant CNV. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:698-704.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"698-704"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel CEP78 Variant Presenting as Cone Dystrophy and Hearing Loss.","authors":"Promie R Faruque, Baichun Hou, Jin Kyun Oh, Stephen H Tsang","doi":"10.3928/23258160-20240717-01","DOIUrl":"10.3928/23258160-20240717-01","url":null,"abstract":"<p><p>Mutations in CEP78 lead to abnormal production of cilia and have previously been identified to cause cone-rod dystrophy (CRD) with progressive sensorineural hearing loss. The authors describe a case of cone dystrophy (CD) with sensorineural hearing loss in a variant that had previously been reported to be of unknown significance and associated with CRD only. This report corroborates the pathogenicity of this variant and highlights that different phenotypes may be associated with one genotype. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:742-746.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"742-746"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Photoreceptor and Vascular Parameters in Diabetic Retinopathy Using Adaptive Optics.","authors":"Michael Balas, Mariam Issa, Marko M Popovic, Chris Zajner, Lana Moayad, Paola Oquendo Aponte, Hesham Hamli, Peng Yan, Tom Wright, Isabela M Melo, Rajeev H Muni","doi":"10.3928/23258160-20241015-03","DOIUrl":"https://doi.org/10.3928/23258160-20241015-03","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to investigate correlations between photoreceptor and vascular parameters in varying stages of diabetic retinopathy (DR) using adaptive optics (AO) imaging.</p><p><strong>Patients and methods: </strong>In this single-center, prospective cohort study, 29 participants (46 eyes) were classified into control/mild non-proliferative DR (NPDR), moderate/severe NPDR, and proliferative DR. AO images of photoreceptors and retinal vasculature were analyzed, and Spearman's correlation (ρ) was used to assess relationships between photoreceptor density and vascular parameters.</p><p><strong>Results: </strong>Higher cone density was inversely associated with total vessel (ρ = 0.22, <i>P</i> = 0.03) and lumen diameters (ρ = -0.24, <i>P</i> = 0.01), while higher dispersion was associated with total vessel (ρ = 0.19, <i>P</i> = 0.06) and lumen diameters (ρ = 0.21, <i>P</i> = 0.04). These associations were primarily significant in mild NPDR. No significant correlations were found in advanced DR stages.</p><p><strong>Conclusion: </strong>This study underscores intricate neurovascular correlations in early-stage DR, suggesting these parameters may aid in early disease detection. Further research is needed to understand whether similar correlations exist in advanced DR. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable Fluocinolone Implant for the Management of Cystoid Macular Edema in Coats' Disease.","authors":"Kishan G Patel, Ashkan M Abbey","doi":"10.3928/23258160-20240621-03","DOIUrl":"10.3928/23258160-20240621-03","url":null,"abstract":"<p><p>A six-year-old boy with history of Coats' disease and cystoid macular edema (CME) was treated with a combination of peripheral retinal laser, anti-vascular endothelial grown factor injections, and short-acting injectable steroids to control his disease process. Given the excellent response to shorter acting steroids and the need for general anesthesia for each procedure, the patient underwent placement of the injectable fluocinolone acetonide implant 0.18 mg (YUTIQ) with control of his CME at 30 months of follow-up. The authors conclude that a long-acting steroid implant may be beneficial in select patients with Coats' disease. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:679-681.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"679-681"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crocodile Skin Retinal Appearance: Miliary Distribution of Bilateral Idiopathic Multifocal Retinal Pigment Epithelial Detachments.","authors":"Alexandros Chatzirallis, Dimitrios Kalogeropoulos, Fatima Shawkat, Anna M Roszkowska, Rino Frisina, Gabriella De Salvo","doi":"10.3928/23258160-20240923-03","DOIUrl":"https://doi.org/10.3928/23258160-20240923-03","url":null,"abstract":"<p><p>This report presents cases of an unusual appearance of bilateral idiopathic multifocal retinal pigment epithelial detachments (PEDs) in three patients, using multimodal imaging. Three patients with multiple PEDs, initially diagnosed as drusen, were referred for evaluation. They underwent comprehensive ophthalmic examination and multimodal imaging. All patients had a best-corrected visual acuity of 6/6 in both eyes. Fundoscopy revealed multiple idiopathic PEDs in a miliary distribution, resembling crocodile skin. Systemic workup excluded associated diseases, though one patient was pregnant. The pathogenesis and progression are poorly understood, but prognosis is favorable without intervention unless complications arise. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}