Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Incomplete RPE and Outer Retinal Atrophy (iRORA) Development in Eyes With Fellow-eye Neovascular Age-related Macular Degeneration.","authors":"Hanna Choi, Giulia Corradetti, Sophiana Lindenberg, Ayesha N Karamat, Deniz Oncel, Henry Liu, Ramya Gnanaraj, Sohaib Fasih-Ahmad, Kenneth M Marion, Kirstie L Baker, Shilpa Gulati, Bradley Foster, Andrew Lam, SriniVas R Sadda, David R Lally","doi":"10.3928/23258160-20250108-01","DOIUrl":"10.3928/23258160-20250108-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The utility of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) in intermediate age-related macular degeneration (iAMD) as a clinical endpoint is not yet elucidated. We aim to understand the time to iRORA development in iAMD.</p><p><strong>Patients and methods: </strong>Eyes with iAMD without iRORA of subjects with fellow-eye neovascular AMD (nAMD) were identified from visits between 2010 and 2019 at a tertiary clinic. Spectral Domain Optical Coherence Tomography 512 × 128mm macular cubes (Cirrus HD-OCT, Zeiss) were assessed for time to first detection of iRORA and complete RPE and Outer retinal atrophy (cRORA) at 24 months. Up to three iRORA lesions were followed. Univariable Cox regressions evaluated baseline OCT characteristics, age, and gender as predictors for iRORA or cRORA development. Baseline OCT characteristics included intraretinal hyperreflective foci (IHRF), subretinal drusenoid deposits (SDD), hyporeflective drusen cores (hDC), and drusen volume measured with semi-automatic segmentation of Bruch's membrane to RPE.</p><p><strong>Results: </strong>In 101 eyes of 101 subjects (64% female; median 81 years old), 28.70% (<i>n</i> = 30) developed iRORA whereas 2.97% (<i>n</i> = 3) developed cRORA without iRORA at 24 months. Median (range) time to first iRORA or cRORA was 20 (12 to 24) months. The presence of baseline IHRF was associated with increased risk of iRORA development at month 24 (HR = 2.28, 95% CI: 1.14 to 4.56; <i>P</i> value = 0.019).</p><p><strong>Conclusion: </strong>In subjects with fellow-eye nAMD, approximately one third of iAMD eyes developed iRORA at 24 months. Intraretinal hyperreflective foci was associated with a two-fold increased risk in iRORA development. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:274-279.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"274-279"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Visual Response After Lapse in Treatment Among Patients With Neovascular Age-related Macular Degeneration.","authors":"Jovana Hanna, Jonathan Markle, Christopher Maatouk, Nikhil Das, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20250128-01","DOIUrl":"10.3928/23258160-20250128-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to analyze baseline predictors of visual response in patients with neovascular age-related macular degeneration (nAMD) who have undergone lapses in treatment with anti-VEGF therapy. The mainstay treatment option for nAMD is intravitreal vascular endothelial growth factor inhibitor (anti-VEGF) therapy. Given the chronic nature of nAMD, patients who undergo lapses in treatment with these agents can have progression of their disease.</p><p><strong>Patients and methods: </strong>This retrospective, comprehensive chart review included 261 adults aged 18 years or older who were diagnosed with nAMD between January 2012 and June 2020 and had undergone at least one anti-VEGF injection prior to an unintended lapse in follow-up of 3 months or greater. Following exclusion criteria, in which individuals were not administered an anti-VEGF injection at the pre-lapse visit, a total of 163 patients were analyzed. Patients were separated into \"vision loss\" and \"stable vision\" categories and classified based on degree of vision loss. A stepwise backward logistic regression was used to analyze baseline medical and ophthalmic factors between each group to determine which factors were more likely to be associated with more significant vision loss.</p><p><strong>Results: </strong>Out of 261 nAMD patients reviewed, 163 patients were investigated in the main analysis. Higher cube volume (1.24 ± 0.24, <i>P</i> = 0.22), and lapse length (2.89 ± 0.056, <i>P</i> = 0.004) increased the likelihood of vision loss, while lack of smoking history (-2.07 ± 0.46, <i>P</i> = 0.038) decreased the likelihood. The two groups were significantly different in post-lapse ophthalmologic continuous variables, including cube volume (9.69 ± 0.98 and 10.2 ± 1.39 in the stable vision and unstable vision groups, respectively, <i>P</i> = 0.01) and cube average thickness (269 ± 27.3 and 282 ± 38.4 in the stable vision and unstable vision groups, respectively, <i>P</i> = 0.02). The main model had an area under the curve (AUC) of 58% and predictive accuracy of 78.1%.</p><p><strong>Conclusion: </strong>The calculated AUC was not high enough to establish reliable predictability in this study. However, additional factors may need to be considered for greater predictability. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:280-285.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"280-285"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Cenegermin-Bkbj Dramatically Resolves Neurotrophic Keratitis Associated With Pars Plana Vitrectomy.","authors":"Anny M S Cheng, Shaden H Yassin, Shailesh K Gupta, Kakarla V Chalam","doi":"10.3928/23258160-20250124-01","DOIUrl":"10.3928/23258160-20250124-01","url":null,"abstract":"<p><p>Neurotrophic keratitis (NK) may occur secondary to pars plana vitrectomy (PPV). A subset of patients with very severe NK corneal defects may require therapy escalation, and Cenegermin-Bkbj, a recombinant human nerve growth factor, represents a novel treatment option. This case report presents the successful treatment of refractory NK using Cenegermin-Bkbj in a patient after undergoing multiple PPV surgeries. A 60-year-old woman with recurrent retinal detachments in the right eye after receiving the third PPV developed persistent irritation, photophobia, and worsening visual acuity due to iatrogenic NK despite lubrication, bandage contact lens, preservative-free artificial tears, restasis, and right lower lid punctal cautery over 6 weeks. She received daily topical Cenegermin-Bkbj for 8 weeks to achieve complete corneal reepithelialization, restoration of corneal sensation, and visual acuity improvement from hand motion to 20/80. She remained symptom-free at the 8-week follow-up. This case highlights the importance of early recognition, tailored management, and the potential efficacy of Cenegermin-Bkbj in treating NK arising after retinal procedures. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:309-311.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"309-311"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopaminergic Therapies May Decrease Risk of Early and Intermediate Non-exudative Age-related Macular Degeneration Progression.","authors":"Richard A Morgan, Peter J Weng, Sandra S Stinnett, Dilraj S Grewal, Sharon Fekrat","doi":"10.3928/23258160-20250326-02","DOIUrl":"https://doi.org/10.3928/23258160-20250326-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Age-related macular degeneration (AMD) is a leading cause of vision loss, with progression to geographic atrophy (GA) posing a significant challenge. This study aimed to assess whether dopaminergic therapies (DMTs) reduce risk of AMD progressing to GA.</p><p><strong>Patients and methods: </strong>A retrospective cohort study analyzed electronic health records of 320 patients (449 eyes) with early or intermediate nonexudative AMD at Duke Eye Center from 2014 to 2024. Of these, 80 patients (110 eyes) were on DMTs, and 240 (339 eyes) served as controls. GA progression was evaluated annually over 5 years.</p><p><strong>Results: </strong>GA progression was lower in the DMT group across all intervals, with lifetime rates of 9.4% in the non-DMT group versus 2.7% in the DMT group (<i>P</i> < 0.05). Multivariate analysis showed a significant protective effect (odds ratio 0.08, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>DMTs may significantly reduce risk of AMD progressing to GA, warranting further research. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo Iris Transillumination Defect.","authors":"Sarthak V Shah, Arthur Brant, Darius M Moshfeghi","doi":"10.3928/23258160-20250324-01","DOIUrl":"https://doi.org/10.3928/23258160-20250324-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Pit Maculopathy Managed With Observation: Serial Optical Coherence Tomography Imaging of Fluctuating Macular Fluid.","authors":"Michael Y Zhao, Lauren C Kiryakoza, Landon J Rohowetz, Harry W Flynn","doi":"10.3928/23258160-20250326-01","DOIUrl":"https://doi.org/10.3928/23258160-20250326-01","url":null,"abstract":"<p><p>Observation with optical coherence tomography (OCT) is a reasonable management approach for optic pit maculopathy presenting with macular fluid. We describe two patients with optic pit maculopathy who exhibited preserved vision and fluctuating macular fluid managed with serial OCTs. A 49-year-old woman presented with blurred vision in the left eye. Best-corrected visual acuity (BCVA) was 20/40 in the left eye. Examination revealed an inferotemporal gray depression in the optic disc; OCT demonstrated submacular fluid. Serial OCTs over 19 years showed fluctuating fluid with stable vision. BCVA was 20/30 at last follow-up. A 62-year-old man presented with a central scotoma in the left eye. BCVA was 20/40 in the left eye. Examination showed an inferotemporal gray-white depression in the optic disc, and OCT revealed submacular fluid. Serial OCTs over 6 years demonstrated fluctuating fluid with preserved vision. BCVA was 20/50 at last follow-up. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Outcomes of Faricimab Treatment for Diabetic Macular Edema in Patients Previously Treated With Anti-VEGF Therapy.","authors":"Nitesh Mohan, Andrei Szigiato, Katherine E Talcott, Danny A Mammo, Amy S Babiuch, Peter K Kaiser, Justis P Ehlers, Aleksandra Rachitskaya, Alex Yuan, Sunil K Srivastava, Sumit Sharma","doi":"10.3928/23258160-20250228-01","DOIUrl":"https://doi.org/10.3928/23258160-20250228-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to evaluate the short-term outcomes of switching to intravitreal faricimab injections (IFIs) from prior anti-vascular endothelial growth factor (anti-VEGF) therapy for the treatment of diabetic macular edema (DME).</p><p><strong>Patients and methods: </strong>A retrospective review was done of patients with DME previously treated with anti-VEGF and subsequently switched to IFIs. Optical coherence tomography scans were assessed qualitatively and quantitatively to evaluate intraretinal fluid changes and central subfield thickness (CST).</p><p><strong>Results: </strong>A total of 62 eyes from 41 patients were analyzed with a mean follow-up time of 36.4 ± 14.4 weeks. After receiving three IFIs, treatment interval increased significantly by 3.2 weeks (<i>P</i> < 0.001), CST decreased significantly by 43.8 µm (<i>P</i> = 0.014), and visual acuity remained stable (63.2 vs 64.4 approximate ETDRS letters, <i>P</i> = 0.720). Seventeen eyes (27.4%) were switched back to their prior anti-VEGF agent, with one case of suspected IFI-related uveitis.</p><p><strong>Conclusion: </strong>Faricimab appears to be a viable option for some DME patients who require a change in anti-VEGF therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Giant Choroidal Cavern in a Case of Rod-Cone Dystrophy: A Rare Presentation.","authors":"Rajul Shah, Udit Ajmani, Sameera Nayak, Niroj Kumar Sahoo, P Srinivas Rao, Brijesh Takkar","doi":"10.3928/23258160-20241216-02","DOIUrl":"10.3928/23258160-20241216-02","url":null,"abstract":"<p><p>This report presents a case of a 22-year-old woman with bilateral giant choroidal caverns (CCs) in rod-cone dystrophy. Her best-corrected visual acuity was 20/80 in the right eye and 20/50 in the left eye. Fundus examination showed optic nerve pallor, narrowed blood vessels, and diffuse pigmentary changes. Fundus autofluorescence showed a central area of reduced autofluorescence surrounded by stippled autofluorescence. An electroretinogram showed decreased amplitude of both scotopic and photopic waves, consistent with a diagnosis of rod-cone dystrophy (retinitis pigmentosa). Optical coherence tomography revealed large CC and foveal atrophy in each eye. A giant CC alongside rod-cone dystrophy is a distinctive feature. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:241-243.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"241-243"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Retinal Blood Flow Parameters in Sickle Cell Disease at Steady State and Healthy Subjects Using Doppler Optical Coherence Tomography.","authors":"Hernan A Rios, Sofia Ahsanuddin, Oscar Otero-Marquez, Luis Duran Muncharaz, Kana Minamide, Jordan Bellis, Elizabeth Stidham, Toco Y P Chui, Masahiro Akiba, Jeffrey A Glassberg, Richard B Rosen","doi":"10.3928/23258160-20241114-03","DOIUrl":"10.3928/23258160-20241114-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Sickle cell disease (SCD) is a vascular disease that may affect the retina. This study aimed to evaluate differences in average velocity (AV, mm/s), blood flow (BF, μL/min) and vessel diameter (VD, μm) from the temporal retinal arcades in SCD compared to healthy eyes using Doppler optical coherence tomography (DOCT).</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted between 2021 and 2023. The DOCT scan was located at the superior and inferior temporal vessel arcades of all subjects. Differences between the two groups were assessed.</p><p><strong>Results: </strong>Thirty-nine healthy eyes and 36 SCD eyes were imaged. The median of AV, BF, and VD were 1.4, 2.5, and 1.3 times higher in SCD eyes compared to healthy eyes in the superotemporal arteries (<i>P</i> = 0.002, <i>P</i> = 5.0 × 10^-3, <i>P</i> = 4.0 × 10^-6, respectively). Similar findings were observed for superotemporal veins and inferotemporal veins.</p><p><strong>Conclusion: </strong>Eyes with SCD eyes exhibited significantly elevated retinal vascular flow parameters compared to healthy eyes. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:220-227.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"220-227"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy for Subretinal Fluid Associated With Choroidal Nevus.","authors":"Jose Pena, Hidayet Sener, Carol L Shields","doi":"10.3928/23258160-20241216-04","DOIUrl":"10.3928/23258160-20241216-04","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"254-255"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}