Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Dopaminergic Therapies May Decrease Risk of Early and Intermediate Non-exudative Age-related Macular Degeneration Progression.","authors":"Richard A Morgan, Peter J Weng, Sandra S Stinnett, Dilraj S Grewal, Sharon Fekrat","doi":"10.3928/23258160-20250326-02","DOIUrl":"https://doi.org/10.3928/23258160-20250326-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Age-related macular degeneration (AMD) is a leading cause of vision loss, with progression to geographic atrophy (GA) posing a significant challenge. This study aimed to assess whether dopaminergic therapies (DMTs) reduce risk of AMD progressing to GA.</p><p><strong>Patients and methods: </strong>A retrospective cohort study analyzed electronic health records of 320 patients (449 eyes) with early or intermediate nonexudative AMD at Duke Eye Center from 2014 to 2024. Of these, 80 patients (110 eyes) were on DMTs, and 240 (339 eyes) served as controls. GA progression was evaluated annually over 5 years.</p><p><strong>Results: </strong>GA progression was lower in the DMT group across all intervals, with lifetime rates of 9.4% in the non-DMT group versus 2.7% in the DMT group (<i>P</i> < 0.05). Multivariate analysis showed a significant protective effect (odds ratio 0.08, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>DMTs may significantly reduce risk of AMD progressing to GA, warranting further research. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo Iris Transillumination Defect.","authors":"Sarthak V Shah, Arthur Brant, Darius M Moshfeghi","doi":"10.3928/23258160-20250324-01","DOIUrl":"https://doi.org/10.3928/23258160-20250324-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Pit Maculopathy Managed With Observation: Serial Optical Coherence Tomography Imaging of Fluctuating Macular Fluid.","authors":"Michael Y Zhao, Lauren C Kiryakoza, Landon J Rohowetz, Harry W Flynn","doi":"10.3928/23258160-20250326-01","DOIUrl":"https://doi.org/10.3928/23258160-20250326-01","url":null,"abstract":"<p><p>Observation with optical coherence tomography (OCT) is a reasonable management approach for optic pit maculopathy presenting with macular fluid. We describe two patients with optic pit maculopathy who exhibited preserved vision and fluctuating macular fluid managed with serial OCTs. A 49-year-old woman presented with blurred vision in the left eye. Best-corrected visual acuity (BCVA) was 20/40 in the left eye. Examination revealed an inferotemporal gray depression in the optic disc; OCT demonstrated submacular fluid. Serial OCTs over 19 years showed fluctuating fluid with stable vision. BCVA was 20/30 at last follow-up. A 62-year-old man presented with a central scotoma in the left eye. BCVA was 20/40 in the left eye. Examination showed an inferotemporal gray-white depression in the optic disc, and OCT revealed submacular fluid. Serial OCTs over 6 years demonstrated fluctuating fluid with preserved vision. BCVA was 20/50 at last follow-up. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Outcomes of Faricimab Treatment for Diabetic Macular Edema in Patients Previously Treated With Anti-VEGF Therapy.","authors":"Nitesh Mohan, Andrei Szigiato, Katherine E Talcott, Danny A Mammo, Amy S Babiuch, Peter K Kaiser, Justis P Ehlers, Aleksandra Rachitskaya, Alex Yuan, Sunil K Srivastava, Sumit Sharma","doi":"10.3928/23258160-20250228-01","DOIUrl":"https://doi.org/10.3928/23258160-20250228-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to evaluate the short-term outcomes of switching to intravitreal faricimab injections (IFIs) from prior anti-vascular endothelial growth factor (anti-VEGF) therapy for the treatment of diabetic macular edema (DME).</p><p><strong>Patients and methods: </strong>A retrospective review was done of patients with DME previously treated with anti-VEGF and subsequently switched to IFIs. Optical coherence tomography scans were assessed qualitatively and quantitatively to evaluate intraretinal fluid changes and central subfield thickness (CST).</p><p><strong>Results: </strong>A total of 62 eyes from 41 patients were analyzed with a mean follow-up time of 36.4 ± 14.4 weeks. After receiving three IFIs, treatment interval increased significantly by 3.2 weeks (<i>P</i> < 0.001), CST decreased significantly by 43.8 µm (<i>P</i> = 0.014), and visual acuity remained stable (63.2 vs 64.4 approximate ETDRS letters, <i>P</i> = 0.720). Seventeen eyes (27.4%) were switched back to their prior anti-VEGF agent, with one case of suspected IFI-related uveitis.</p><p><strong>Conclusion: </strong>Faricimab appears to be a viable option for some DME patients who require a change in anti-VEGF therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Giant Choroidal Cavern in a Case of Rod-Cone Dystrophy: A Rare Presentation.","authors":"Rajul Shah, Udit Ajmani, Sameera Nayak, Niroj Kumar Sahoo, P Srinivas Rao, Brijesh Takkar","doi":"10.3928/23258160-20241216-02","DOIUrl":"10.3928/23258160-20241216-02","url":null,"abstract":"<p><p>This report presents a case of a 22-year-old woman with bilateral giant choroidal caverns (CCs) in rod-cone dystrophy. Her best-corrected visual acuity was 20/80 in the right eye and 20/50 in the left eye. Fundus examination showed optic nerve pallor, narrowed blood vessels, and diffuse pigmentary changes. Fundus autofluorescence showed a central area of reduced autofluorescence surrounded by stippled autofluorescence. An electroretinogram showed decreased amplitude of both scotopic and photopic waves, consistent with a diagnosis of rod-cone dystrophy (retinitis pigmentosa). Optical coherence tomography revealed large CC and foveal atrophy in each eye. A giant CC alongside rod-cone dystrophy is a distinctive feature. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:241-243.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"241-243"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Retinal Blood Flow Parameters in Sickle Cell Disease at Steady State and Healthy Subjects Using Doppler Optical Coherence Tomography.","authors":"Hernan A Rios, Sofia Ahsanuddin, Oscar Otero-Marquez, Luis Duran Muncharaz, Kana Minamide, Jordan Bellis, Elizabeth Stidham, Toco Y P Chui, Masahiro Akiba, Jeffrey A Glassberg, Richard B Rosen","doi":"10.3928/23258160-20241114-03","DOIUrl":"10.3928/23258160-20241114-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Sickle cell disease (SCD) is a vascular disease that may affect the retina. This study aimed to evaluate differences in average velocity (AV, mm/s), blood flow (BF, μL/min) and vessel diameter (VD, μm) from the temporal retinal arcades in SCD compared to healthy eyes using Doppler optical coherence tomography (DOCT).</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted between 2021 and 2023. The DOCT scan was located at the superior and inferior temporal vessel arcades of all subjects. Differences between the two groups were assessed.</p><p><strong>Results: </strong>Thirty-nine healthy eyes and 36 SCD eyes were imaged. The median of AV, BF, and VD were 1.4, 2.5, and 1.3 times higher in SCD eyes compared to healthy eyes in the superotemporal arteries (<i>P</i> = 0.002, <i>P</i> = 5.0 × 10^-3, <i>P</i> = 4.0 × 10^-6, respectively). Similar findings were observed for superotemporal veins and inferotemporal veins.</p><p><strong>Conclusion: </strong>Eyes with SCD eyes exhibited significantly elevated retinal vascular flow parameters compared to healthy eyes. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:220-227.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"220-227"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy for Subretinal Fluid Associated With Choroidal Nevus.","authors":"Jose Pena, Hidayet Sener, Carol L Shields","doi":"10.3928/23258160-20241216-04","DOIUrl":"10.3928/23258160-20241216-04","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"254-255"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Intravitreal Aflibercept 8 mg in Eyes With Neovascular Age-Related Macular Degeneration Previously Treated With Faricimab.","authors":"Bita Momenaei, Yoshihiro Yonekawa, Paige Abril, Rachel McCullough, Ashkan M Abbey","doi":"10.3928/23258160-20241205-01","DOIUrl":"10.3928/23258160-20241205-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.</p><p><strong>Results: </strong>The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (<i>P</i> = 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (<i>P</i> = 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (<i>P</i> < 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (<i>P</i> = 0.029 and 0.004), respectively.</p><p><strong>Conclusions: </strong>Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:206-211.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"206-211"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quantitative Normative Database for Expanded Field Swept-source OCT Angiography in the Pediatric Population.","authors":"Sandra Hoyek, Francesco Romano, Mauricio Garcia, Ioanna Ploumi, Itika Garg, Jack Tracy, Katherine Millner Overbey, Cade Frederick Bennett, Matthew J Finn, Peyman Razavi, Isabella Victoria Manzano Stettler, Xinyi Ding, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20250108-03","DOIUrl":"10.3928/23258160-20250108-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To report quantitative vascular metrics of healthy control eyes of children, using expanded field swept-source optical coherence tomography angiography (SS-OCTA), as a baseline to compare with pathologic findings.</p><p><strong>Patients and methods: </strong>A cross-sectional observational study of healthy eyes of children (age 6 to 18) who were imaged on the PLEX Elite 9000 instrument at 100-kHz scanning rate using 3 × 3-mm, 6 × 6-mm, and 12 × 12-mm protocols centered on the fovea (2019 to 2023). Scans were uploaded to the ARI Network (Zeiss Portal v5.4) and processed with the macular density algorithm (v.0.7.3.3) to calculate vessel density (VD) and vessel skeletonized density (VSD) in the superficial capillary plexus (SCP), deep capillary plexus, and whole retina (WR) and foveal avascular zone (FAZ) metrics.</p><p><strong>Results: </strong>Forty-eight eyes of 39 children (72% male) were included. Median age was 14 years (interquartile range 10 to 16). Male sex was associated with lower VD and VSD compared to female sex (<i>P</i> < 0.05). Older age was associated with higher VD and VSD (6 × 6-mm) (<i>P</i> < 0.05) and lower FAZ circularity (<i>P</i> = 0.017). Non-Hispanic White children had a lower VD and VSD of the SCP in the inner superior ring (3 × 3-mm), a higher VD and VSD of the SCP and WR in the central ring (6 × 6-mm), and a lower FAZ area (6 × 6-mm) (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This study presents a database for expanded field vascular metrics in pediatric subjects across various angiogram sizes. The VD increases throughout childhood and the FAZ circularity diminishes. Future studies using SS-OCTA will need to account for influencing factors such as sex, age, race, and ethnicity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:212-218.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"212-218"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Integrity\" Assessment Following Rhegmatogenous Retinal Detachment Repair.","authors":"Andrew Mihalache, Michael Balas, Marko M Popovic, Aditya Bansal, Koby Brosh, Rajeev H Muni","doi":"10.3928/23258160-20240906-02","DOIUrl":"10.3928/23258160-20240906-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"250-251"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}