Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Favorable Outcome After Pegcetacoplan (Syfovre)-Associated Occlusive Retinal Vasculitis.","authors":"Ella H Leung, Steven Yeh, Scott Lampert","doi":"10.3928/23258160-20241216-01","DOIUrl":"https://doi.org/10.3928/23258160-20241216-01","url":null,"abstract":"<p><p>An 86-year-old woman with advanced dry age-related macular degeneration developed occlusive retinal vasculitis 11 days after her first pegcetacoplan injection. Vision decreased from 20/30 to counting fingers. Vision improved to 20/200 with periocular and systemic steroids. Two different sets of culture plates and gram stains were all negative, but one thioglycolate broth had a light growth of <i>Staphylococcus epidermidis</i> and repeat vitreous culture broth grew a different organism (<i>Staphylococcus capitis</i>). After intravitreal steroids and ceftazidime, the vision ultimately improved to 20/20. Periocular and systemic steroids and antibiotics were associated with a favorable visual outcome in this patient. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Reviewers.","authors":"","doi":"10.3928/23258160-20250106-01","DOIUrl":"https://doi.org/10.3928/23258160-20250106-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 2","pages":"67"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incomplete RPE and Outer Retinal Atrophy (iRORA) Development in Eyes With Fellow-eye Neovascular Age-related Macular Degeneration.","authors":"Hanna Choi, Giulia Corradetti, Sophiana Lindenberg, Ayesha N Karamat, Deniz Oncel, Henry Liu, Ramya Gnanaraj, Sohaib Fasih-Ahmad, Kenneth M Marion, Kirstie L Baker, Shilpa Gulati, Bradley Foster, Andrew Lam, SriniVas R Sadda, David R Lally","doi":"10.3928/23258160-20250108-01","DOIUrl":"https://doi.org/10.3928/23258160-20250108-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The utility of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) in intermediate age-related macular degeneration (iAMD) as a clinical endpoint is not yet elucidated. We aim to understand the time to iRORA development in iAMD.</p><p><strong>Patients and methods: </strong>Eyes with iAMD without iRORA of subjects with fellow-eye neovascular AMD (nAMD) were identified from visits between 2010 and 2019 at a tertiary clinic. Spectral Domain Optical Coherence Tomography 512 × 128mm macular cubes (Cirrus HD-OCT, Zeiss) were assessed for time to first detection of iRORA and complete RPE and Outer retinal atrophy (cRORA) at 24 months. Up to three iRORA lesions were followed. Univariable Cox regressions evaluated baseline OCT characteristics, age, and gender as predictors for iRORA or cRORA development. Baseline OCT characteristics included intraretinal hyperreflective foci (IHRF), subretinal drusenoid deposits (SDD), hyporeflective drusen cores (hDC), and drusen volume measured with semi-automatic segmentation of Bruch's membrane to RPE.</p><p><strong>Results: </strong>In 101 eyes of 101 subjects (64% female; median 81 years old), 28.70% (<i>n</i> = 30) developed iRORA whereas 2.97% (<i>n</i> = 3) developed cRORA without iRORA at 24 months. Median (range) time to first iRORA or cRORA was 20 (12 to 24) months. The presence of baseline IHRF was associated with increased risk of iRORA development at month 24 (HR = 2.28, 95% CI: 1.14 to 4.56; <i>P</i> value = 0.019).</p><p><strong>Conclusion: </strong>In subjects with fellow-eye nAMD, approximately one third of iAMD eyes developed iRORA at 24 months. Intraretinal hyperreflective foci was associated with a two-fold increased risk in iRORA development. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bullous Variant of Central Serous Chorioretinopathy Treated With Sclerotomy.","authors":"Luiz Roisman, João Gabriel Alexander, Pedro Leite C Franco, Lisangela N Morimoto, Maurício Maia","doi":"10.3928/23258160-20241101-01","DOIUrl":"10.3928/23258160-20241101-01","url":null,"abstract":"<p><p>Bullous serous central chorioretinopathy (bCSCR) is an atypical form of CSCR characterized by large serous detachment. This variant presents significant diagnostic challenges, and optimal treatment strategies are not well defined. This report presents a case of a 31-year-old man with bCSRC treated with scleral thinning surgery in four quadrants with scleral windows created in the two inferior quadrants. The etiology, pathogenesis, and optimal treatment of bCSCR are not fully understood. Various therapeutic options, including photocoagulation and photodynamic therapy, have been employed with varying degrees of success. We describe a case of scleral thinning (sclerectomy) with two inferior sclerotomies without subretinal drainage, which resulted in a positive outcome. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:116-119.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"116-119"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial.","authors":"Samuel Feldman, Jesse Basra, Anjola Lawani, Yunyi Ren, Machelle Wilson, Ala Moshiri, Susanna S Park, Glenn Yiu","doi":"10.3928/23258160-20240924-03","DOIUrl":"10.3928/23258160-20240924-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA).</p><p><strong>Patients and methods: </strong>Prospective, single-masked, sham-controlled trial in 27 eyes of 19 adult patients with treatment-naïve, center-involved DME, and VA of 20/25 or better. Measures included best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), contrast sensitivity (CS), average threshold on microperimetry, and central subfield thickness (CST). The primary outcome measure was median time to vision loss of 10 letters at any visit or 5 to 9 letters at two consecutive visits ≤ 28 days apart.</p><p><strong>Results: </strong>Eight eyes met vision loss criteria during the 2-year study, with similar proportions for SML (<i>n</i> = 5) and sham (<i>n</i> = 3). Median time to vision loss was 5 months for both groups. At 6 months, there were no statistical differences in BCVA, LLVA, CS, microperimetry threshold, and CST between SML and sham arms (<i>P</i> > 0.05 in all measures).</p><p><strong>Conclusion: </strong>In eyes with center-involved DME and good VA, SML did not prevent or delay the vision loss threshold for initiating anti-VEGF therapy. However, these results may be affected by a high rate of early participant dropout from the study. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:86-93.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"86-93"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular Hole Surgery Without Postoperative Head Positioning: A Technique of Viscoelastic Device Injection Covering the Temporal Internal Limiting Membrane Flap.","authors":"Oğuzhan Saygılı, Sevim Ayça Seyyar","doi":"10.3928/23258160-20241015-01","DOIUrl":"10.3928/23258160-20241015-01","url":null,"abstract":"<p><p>The purpose of this study was to describe a technique in which a dispersive viscoelastic device is injected under air onto and around the inverted temporal internal limiting membrane (ILM) flap to close the macular hole (MH) without the need for any postoperative head positioning. A temporal ILM flap was created in the patients. The created ILM flap was inverted over the MH using perfluorocarbon (PCFL) injection. Then, after a fluid-air exchange, careful PFCL-air exchange was performed. Under air, two to three disc diameters of viscoelastic device were injected over and around the inverted flap. No postoperative head position was recommended to any patient. In all 16 eyes treated with this approach, the MH was closed with a single procedure, and there were no intraoperative or postoperative complications. Injection of a viscoelastic device over the inverted ILM flap in MH surgery is an innovative approach that does not require any special postoperative head positioning. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:120-122.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"120-122"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Football-associated Whiplash Maculopathy Presenting With Bilateral Bacillary Detachments: Case Report and Review of Literature.","authors":"Adrienne Delaney, Rachel A Downes, Danny A Mammo","doi":"10.3928/23258160-20240927-01","DOIUrl":"10.3928/23258160-20240927-01","url":null,"abstract":"<p><p>Ocular trauma is a rare cause of bacillary layer detachments (BALAD). A case report was evaluated and a literature review was performed. A 15-year-old boy presented with bilateral scotomas after a routine American football tackle and was found to have bilateral BALADs. Inflammatory and infectious causes of BALAD were excluded, and he was diagnosed with whiplash maculopathy. Without intervention, the patient's visual acuity and macular anatomy rapidly improved. Novel indocyanine green angiography findings of this condition are reported. Bacillary detachments resulting from whiplash injuries generally resolve spontaneously with good visual outcomes. Even when other sequelae of trauma are not obvious, the presence of BALAD should prompt a targeted history around recent trauma including sports-associated whiplash injuries. Patients with thicker choroids may be at increased risk of posterior segment sequalae from whiplash injury and choroidal status should be commented on in future reports. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:113-115.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"113-115"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Retinal Blood Flow Parameters in Sickle Cell Disease at Steady State and Healthy Subjects Using Doppler Optical Coherence Tomography.","authors":"Hernan A Rios, Sofia Ahsanuddin, Oscar Otero-Marquez, Luis Duran Muncharaz, Kana Minamide, Jordan Bellis, Elizabeth Stidham, Toco Y P Chui, Masahiro Akiba, Jeffrey A Glassberg, Richard B Rosen","doi":"10.3928/23258160-20241114-03","DOIUrl":"https://doi.org/10.3928/23258160-20241114-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Sickle cell disease (SCD) is a vascular disease that may affect the retina. This study aimed to evaluate differences in average velocity (AV, mm/s), blood flow (BF, μL/min) and vessel diameter (VD, μm) from the temporal retinal arcades in SCD compared to healthy eyes using Doppler optical coherence tomography (DOCT).</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted between 2021 and 2023. The DOCT scan was located at the superior and inferior temporal vessel arcades of all subjects. Differences between the two groups were assessed.</p><p><strong>Results: </strong>Thirty-nine healthy eyes and 36 SCD eyes were imaged. The median of AV, BF, and VD were 1.4, 2.5, and 1.3 times higher in SCD eyes compared to healthy eyes in the superotemporal arteries (<i>P</i> = 0.002, <i>P</i> = 5.0 × 10-3, <i>P</i> = 4.0 × 10-6, respectively). Similar findings were observed for superotemporal veins and inferotemporal veins.</p><p><strong>Conclusion: </strong>Eyes with SCD eyes exhibited significantly elevated retinal vascular flow parameters compared to healthy eyes. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Retinal Displacement Following Rhegmatogenous Retinal Detachment Repair.","authors":"Andrew Mihalache, Michael Balas, Marko M Popovic, Aditya Bansal, Koby Brosh, Rajeev H Muni","doi":"10.3928/23258160-20240906-02","DOIUrl":"https://doi.org/10.3928/23258160-20240906-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Intravitreal Aflibercept 8 mg in Eyes With Neovascular Age-Related Macular Degeneration Previously Treated With Faricimab.","authors":"Bita Momenaei, Yoshihiro Yonekawa, Paige Abril, Rachel McCullough, Ashkan M Abbey","doi":"10.3928/23258160-20241205-01","DOIUrl":"https://doi.org/10.3928/23258160-20241205-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.</p><p><strong>Results: </strong>The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (<i>P</i> = 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (<i>P</i> = 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (<i>P</i> < 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (<i>P</i> = 0.029 and 0.004), respectively.</p><p><strong>Conclusions: </strong>Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:xx-xx.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}