Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Bilateral Pigmentary Retinopathy in a Pseudophakic Patient With Chronic Pigment Dispersion Syndrome Following Pars Plana Vitrectomy for Vitreous Opacities.","authors":"Fae B Kayarian, Steven M Cohen","doi":"10.3928/23258160-20250630-01","DOIUrl":"10.3928/23258160-20250630-01","url":null,"abstract":"<p><p>This report presents a case of bilateral pigmentary retinopathy associated with pigment dispersion syndrome in a pseudophakic patient following pars plana vitrectomy. An 81-year-old man with a history of previous uncomplicated cataract surgery 30 years ago developed progressive loss of visual function from vitreous opacities. He also complained of difficulty with driving and using a computer. The patient had uncorrected vision of 20/25 right eye and 20/20 left eye. There was mild anterior pigment dispersion syndrome. Pre-vitrectomy fundus autofluorescence did not show significant pre-retinal pigment deposition. Multimodal images obtained one year following vitrectomy revealed extensive bilateral diffuse pigmentary retinopathy with pigment deposits confined to the inner retinal surface which favored the retinal arterioles. Bilateral pigmentary retinopathy in this pseudophakic patient with pigment dispersion syndrome developed following pars plana vitrectomy. Pigment dispersion syndrome is typically associated with iris pigment deposition primarily affecting the anterior segment. We present a pseudophakic patient who developed bilateral diffuse pigmentary retinopathy from chronic pigment dispersion syndrome following pars plana vitrectomy for vitreous opacities.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"557-560"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmic Artery Occlusion as a Novel Ophthalmic Manifestation of ACTA2- Related Vascular Smooth Muscle Disorder.","authors":"Srujay Pandiri, Celine Chaaya, Ryan S Meshkin, Sandra Hoyek, Joseph F Rizzo, Diana Tambala, Emily Da Cruz, Anna Lynch, Ryan Gise, Patricia L Musolino, Nimesh A Patel","doi":"10.3928/23258160-20250627-01","DOIUrl":"10.3928/23258160-20250627-01","url":null,"abstract":"<p><p>This case describes a 12-year-old patient with a known history of an actin-alpha 2 (ACTA2) gene mutation who presented with an ophthalmic artery occlusion (OAO). The patient's medical history was significant for multiple strokes and a left homonymous hemianopia. She presented to the emergency department with acute visual loss in the right eye and hypertension and was diagnosed with an OAO affecting the right eye. The aim of this report is to highlight a unique ophthalmic complication associated with ACTA2 mutations not previously documented in the literature.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"562-565"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Method to Facilitate Tomographic Macular Neovascularization Classification in Age-related Macular Degeneration.","authors":"Santiago Montolío-Marzo, Roberto Gallego Pinazo, Elena Palacios-Pozo, Rosa Dolz-Marco","doi":"10.3928/23258160-20250717-02","DOIUrl":"10.3928/23258160-20250717-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Evaluation of contrast-modified optical coherence tomography (OCT) images as a tool for better macular neovascularization (MNV) classification in age-related macular degeneration (AMD) cases.</p><p><strong>Patients and methods: </strong>Twenty-five OCT images obtained with SPECTRALIS (Heidelberg Engineering GmbH) from patients showing MNV (10 type 1, 10 type 2, and 5 type 3) were selected. Two retina specialists (RDM and RGP) classified the MNV lesions and then the same cases were classified by 37 ophthalmologists with different degree of training. A grading tool was designed to classify these cases using standard OCT images (contrast value: 12) followed by reassessment with contrast-modified OCT images (contrast value: 1).</p><p><strong>Results: </strong>Thirty-seven ophthalmologists were involved: four 1st-year trainees, four 2nd-year trainees, four 3rd-year trainees, 12 4th-year trainees, and 13 consultants from different subspecialties. Average result for correct classification was 13.16 using standard images alone and 14.22 using contrast-modified images showing a significant improvement (<i>P</i> = 0.01). The accuracy was greater for type 1 lesions when using contrast-modified images, whereas there was no improvement with type 2 and 3 lesions (<i>P</i> = 0.039, <i>P</i> = 0.835, <i>P</i> = 0.193). The average correct answers was greater for type 2 (<i>µ</i> = 5.08) than type 1 (<i>µ</i> = 5.08) and type 3 (<i>µ</i> = 2) (<i>P</i> = 0.046). The graders (<i>n</i>; %) classified the utility of contrast-modified images as essential (1; 2,7%), very useful (29; 78.4%), indifferent (5; 13.5%), not very useful (1; 2.7%) and useless (1; 2.7%).</p><p><strong>Conclusions: </strong>In challenging cases, it might be easier to locate the retinal pigment epithelium (RPE), evaluate RPE integrity, classify MNV, and study subretinal hyperreflective material using contrast enhanced OCT images. The accuracy for MNV classification increases with contrast-modified images in type 1 MNV. It is an accessible tool that could show even better performance as the ophthalmologist gains more experience using it.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"540-544"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Incidence of Retinal Vein Occlusion Among Young Adults Following the COVID-19 Pandemic.","authors":"Shivesh H Shah, Edward S Lu, Ioanna Ploumi, Sandra Hoyek, Kayla Nodecker, Selin Gumustop, Sarah L Wagner, Xinyi Ding, Ying Zhu, Chong Chen, Leo A Kim, Demetrios G Vavvas, Joan W Miller, Deeba Husain, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20250701-01","DOIUrl":"10.3928/23258160-20250701-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal vein occlusion (RVO) incidence among adults under age 50 years before and during the coronavirus disease 2019 (COVID-19) pandemic was evaluated to clarify whether COVID-19 infection increases RVO risk.</p><p><strong>Patients and methods: </strong>This was a retrospective study of adult patients under age 50 years diagnosed with RVO between 2016 and 2023.</p><p><strong>Results: </strong>The study included 268 patients with RVO. Cases increased from 111 (41%) pre-pandemic (2016 to 2019) to 157 (59%) post-pandemic (2020 to 2023). Incidence rose from 2.7% to 4.2% of retina clinic diagnoses (<i>P</i> = 0.006). Age at diagnosis did not differ (median 40.4 vs 39.6 years, <i>P</i> > 0.05). The youngest tertile (18 to 29 years) trended towards a greater proportion of cases post-pandemic (19.6% vs 10.6%, <i>P</i> = 0.20), while the oldest tertile (39 to 49 years) trended towards a smaller proportion (48.4% vs 56.1%, <i>P</i> = 0.42).</p><p><strong>Conclusion: </strong>An increase in RVO incidence during COVID-19 was observed, with a trend towards younger age groups.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"534-538"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>COL4A1</i> Related Retinal Vascular Tortuosity.","authors":"Bhagyashree Nachiket Joshi, Gabriella De Salvo","doi":"10.3928/23258160-20250422-01","DOIUrl":"10.3928/23258160-20250422-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"575"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poretti-Boltshauser Syndrome: A Potential Pathognomonic \"Wolfjaw\" Pattern of Retinal Perfusion.","authors":"Asritha Sure, Celine Chaaya, Srujay Pandiri, Ryan S Meshkin, Francisco Altamirano, Henry W Zhou, Ayush A Parikh, Frances A High, Kalpathy S Krishnamoorthy, Efren Gonzalez, Anne Fulton, Nimesh A Patel","doi":"10.3928/23258160-20250630-02","DOIUrl":"10.3928/23258160-20250630-02","url":null,"abstract":"<p><p>This is a case of a 9-month-old boy who presented to the ophthalmology clinic with bilateral tearing, strabismus, and upward-gaze nystagmus. Physical examination revealed large-angle esotropia with cross-fixation, hypertonia, and repetitive head movements. Optical coherence tomography showed bilateral staphylomas and abnormal retinal contour. Fluorescein angiography (FA) demonstrated complete nonperfusion of the macula and temporal periphery corresponding to the ciliary nerve region, with some leakage and abnormal vessel dilation. Electroretinography exhibited significant dysfunction of rod and cone photoreceptors, with magnetic resonance imaging demonstrating cerebellar hypoplasia. The constellation of findings prompted genetic testing, which was initially negative. However, additional testing identified a variant implicated in Poretti-Boltshauser syndrome. This case highlights a characteristic \"wolfjaw\" pattern of perfusion and underscores the necessity of strong clinical suspicion, even in the face of inconclusive testing, to identify rare syndromic conditions.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"570-574"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Bilateral Choroidal Malignant Melanoma With Unique <i>BAP1</i> Positivity Managed With Iodine-125 Plaque Radiotherapy.","authors":"Ecem Üstündas Uzun, Gonul Kemikler, Carol L Shields, Orkun Gurbuz, Demet Akdeniz Odemis, Samuray Tuncer","doi":"10.3928/23258160-20250805-01","DOIUrl":"https://doi.org/10.3928/23258160-20250805-01","url":null,"abstract":"<p><p>Uveal melanomas are almost always unilateral. Bilateral presentation is extremely rare, about 1 in 80 million/year. This report presents the case of a 40-year-old man who developed bilateral choroidal melanoma sequentially. The right eye with a <i>de novo</i> juxtapapillary choroidal melanoma was managed with 18-mm notched I125 plaque with full distribution. Eighteen months later, transformation of a choroidal nevus into a melanoma was detected in the fellow eye, and was treated with 12-mm round I125 plaque with full distribution. The patient tested positive for <i>BAP1</i> germline mutation (c.659+1G >A p.?; rs2153227622). After three years of follow-up, both tumors were regressed and the patient was receiving immunotherapy for related liver metastasis.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperreflective Foci in Blowout Pigmented Epithelium Detachment Secondary to Pachychoroid Mimicking Type 3 Macular Neovascularization.","authors":"Federico Beretta, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques","doi":"10.3928/23258160-20250723-02","DOIUrl":"https://doi.org/10.3928/23258160-20250723-02","url":null,"abstract":"<p><p>Pigmented epithelial detachment (PED) blowout in central serous chorioretinopathy (CSC) can present with intraretinal and subretinal fluid and hyperreflective foci, mimicking Type 3 macular neovascularization (MNV). Differentiating between pachychoroid neovasculopathy (PNV) and PED blowout is crucial for appropriate treatment. This report highlights the case of a 47-year-old male patient with chronic CSC and suspected PNV, experiencing persistent blurred vision despite nine intravitreal aflibercept 2 mg injections. Multimodal imaging revealed serous PED, dilated choroidal vessels, intraretinal fluid and subretinal fluid, but optical coherence tomography (OCT) angiography ruled out MNV. Despite similarities to Type 3 MNV on structural OCT, the absence of neovascularization suggested PED blowout instead. Treatment with photodynamic therapy led to anatomical improvement. Unlike Type 3 MNV, fluid accumulation was likely due to retinal pigment epithelial dysfunction rather than neovascularization. The term \"pseudo-type 3\" is proposed for such cases, emphasizing the role of multimodal imaging in distinguishing pachychoroid-driven pathology from MNV to guide optimal management.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle Albumin Bound-paclitaxel Combined With Pegylated Liposomal Doxorubicin for the Treatment of Breast Cancer-induced Cystoid Macular Edema: A Case Report.","authors":"Yuxiao Chen, Bing Bin, Shengyu Lu, Xiaoyong Cai, Guohong Lin","doi":"10.3928/23258160-20250813-02","DOIUrl":"https://doi.org/10.3928/23258160-20250813-02","url":null,"abstract":"<p><p>Cystoid macular edema (CME) is a rare condition that can develop as a complication of chemotherapy. The nanoparticle albumin-bound paclitaxel (nab-PTX) is an innovative paclitaxel formulation that has shown significant effectiveness against various drug-resistant cancers. Nab-PTX can cause rare ocular adverse events including CME. Although nab-PTX has been associated with CME, there have been no documented cases of CME resulting from PEGylated liposomal doxorubicin (PLD). This report presents the case of a 55-year-old woman who experienced CME one week after starting combination chemotherapy with nab-PTX and PLD. This occurred much earlier than previously reported cases of CME induced by nab-PTX. Despite discontinuing PLD treatment for 2 months, her symptoms did not improve. It is possible that interactions between multiple chemotherapeutic drugs contribute to this adverse reaction. Although nab-PTX and PLD are known to have improved efficacy and safety profiles, their combined use can result in CME. Clinicians should be vigilant about this rare but serious complication when administering combination chemotherapy with multiple agents, to ensure early recognition and timely referral for ophthalmological care.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular Telangiectasia With Bilateral Obliterated Capillaries in CREST Syndrome.","authors":"Kemal Tekin, Cemile Ucgul Atilgan","doi":"10.3928/23258160-20250805-06","DOIUrl":"https://doi.org/10.3928/23258160-20250805-06","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1"},"PeriodicalIF":1.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}