Ecem Üstündas Uzun, Gonul Kemikler, Carol L Shields, Orkun Gurbuz, Demet Akdeniz Odemis, Samuray Tuncer
{"title":"具有独特BAP1阳性的序贯双侧脉络膜恶性黑色素瘤用碘-125斑块放疗治疗。","authors":"Ecem Üstündas Uzun, Gonul Kemikler, Carol L Shields, Orkun Gurbuz, Demet Akdeniz Odemis, Samuray Tuncer","doi":"10.3928/23258160-20250805-01","DOIUrl":null,"url":null,"abstract":"<p><p>Uveal melanomas are almost always unilateral. Bilateral presentation is extremely rare, about 1 in 80 million/year. This report presents the case of a 40-year-old man who developed bilateral choroidal melanoma sequentially. The right eye with a <i>de novo</i> juxtapapillary choroidal melanoma was managed with 18-mm notched I125 plaque with full distribution. Eighteen months later, transformation of a choroidal nevus into a melanoma was detected in the fellow eye, and was treated with 12-mm round I125 plaque with full distribution. The patient tested positive for <i>BAP1</i> germline mutation (c.659+1G >A p.?; rs2153227622). After three years of follow-up, both tumors were regressed and the patient was receiving immunotherapy for related liver metastasis.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":1.1000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sequential Bilateral Choroidal Malignant Melanoma With Unique <i>BAP1</i> Positivity Managed With Iodine-125 Plaque Radiotherapy.\",\"authors\":\"Ecem Üstündas Uzun, Gonul Kemikler, Carol L Shields, Orkun Gurbuz, Demet Akdeniz Odemis, Samuray Tuncer\",\"doi\":\"10.3928/23258160-20250805-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Uveal melanomas are almost always unilateral. Bilateral presentation is extremely rare, about 1 in 80 million/year. This report presents the case of a 40-year-old man who developed bilateral choroidal melanoma sequentially. The right eye with a <i>de novo</i> juxtapapillary choroidal melanoma was managed with 18-mm notched I125 plaque with full distribution. Eighteen months later, transformation of a choroidal nevus into a melanoma was detected in the fellow eye, and was treated with 12-mm round I125 plaque with full distribution. The patient tested positive for <i>BAP1</i> germline mutation (c.659+1G >A p.?; rs2153227622). After three years of follow-up, both tumors were regressed and the patient was receiving immunotherapy for related liver metastasis.</p>\",\"PeriodicalId\":19679,\"journal\":{\"name\":\"Ophthalmic surgery, lasers & imaging retina\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic surgery, lasers & imaging retina\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/23258160-20250805-01\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic surgery, lasers & imaging retina","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/23258160-20250805-01","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Sequential Bilateral Choroidal Malignant Melanoma With Unique BAP1 Positivity Managed With Iodine-125 Plaque Radiotherapy.
Uveal melanomas are almost always unilateral. Bilateral presentation is extremely rare, about 1 in 80 million/year. This report presents the case of a 40-year-old man who developed bilateral choroidal melanoma sequentially. The right eye with a de novo juxtapapillary choroidal melanoma was managed with 18-mm notched I125 plaque with full distribution. Eighteen months later, transformation of a choroidal nevus into a melanoma was detected in the fellow eye, and was treated with 12-mm round I125 plaque with full distribution. The patient tested positive for BAP1 germline mutation (c.659+1G >A p.?; rs2153227622). After three years of follow-up, both tumors were regressed and the patient was receiving immunotherapy for related liver metastasis.
期刊介绍：
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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