Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Outcomes of Intravitreal Aflibercept 8 mg in Eyes With Neovascular Age-Related Macular Degeneration Previously Treated With Faricimab.","authors":"Bita Momenaei, Yoshihiro Yonekawa, Paige Abril, Rachel McCullough, Ashkan M Abbey","doi":"10.3928/23258160-20241205-01","DOIUrl":"10.3928/23258160-20241205-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.</p><p><strong>Results: </strong>The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (<i>P</i> = 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (<i>P</i> = 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (<i>P</i> < 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (<i>P</i> = 0.029 and 0.004), respectively.</p><p><strong>Conclusions: </strong>Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:206-211.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"206-211"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quantitative Normative Database for Expanded Field Swept-source OCT Angiography in the Pediatric Population.","authors":"Sandra Hoyek, Francesco Romano, Mauricio Garcia, Ioanna Ploumi, Itika Garg, Jack Tracy, Katherine Millner Overbey, Cade Frederick Bennett, Matthew J Finn, Peyman Razavi, Isabella Victoria Manzano Stettler, Xinyi Ding, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20250108-03","DOIUrl":"10.3928/23258160-20250108-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To report quantitative vascular metrics of healthy control eyes of children, using expanded field swept-source optical coherence tomography angiography (SS-OCTA), as a baseline to compare with pathologic findings.</p><p><strong>Patients and methods: </strong>A cross-sectional observational study of healthy eyes of children (age 6 to 18) who were imaged on the PLEX Elite 9000 instrument at 100-kHz scanning rate using 3 × 3-mm, 6 × 6-mm, and 12 × 12-mm protocols centered on the fovea (2019 to 2023). Scans were uploaded to the ARI Network (Zeiss Portal v5.4) and processed with the macular density algorithm (v.0.7.3.3) to calculate vessel density (VD) and vessel skeletonized density (VSD) in the superficial capillary plexus (SCP), deep capillary plexus, and whole retina (WR) and foveal avascular zone (FAZ) metrics.</p><p><strong>Results: </strong>Forty-eight eyes of 39 children (72% male) were included. Median age was 14 years (interquartile range 10 to 16). Male sex was associated with lower VD and VSD compared to female sex (<i>P</i> < 0.05). Older age was associated with higher VD and VSD (6 × 6-mm) (<i>P</i> < 0.05) and lower FAZ circularity (<i>P</i> = 0.017). Non-Hispanic White children had a lower VD and VSD of the SCP in the inner superior ring (3 × 3-mm), a higher VD and VSD of the SCP and WR in the central ring (6 × 6-mm), and a lower FAZ area (6 × 6-mm) (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This study presents a database for expanded field vascular metrics in pediatric subjects across various angiogram sizes. The VD increases throughout childhood and the FAZ circularity diminishes. Future studies using SS-OCTA will need to account for influencing factors such as sex, age, race, and ethnicity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:212-218.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"212-218"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Integrity\" Assessment Following Rhegmatogenous Retinal Detachment Repair.","authors":"Andrew Mihalache, Michael Balas, Marko M Popovic, Aditya Bansal, Koby Brosh, Rajeev H Muni","doi":"10.3928/23258160-20240906-02","DOIUrl":"10.3928/23258160-20240906-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"250-251"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials.","authors":"Kensington A Hatcher, Birva K Shah, Song Yu, Caroline R Baumal, Srinivas Sadda","doi":"10.3928/23258160-20250108-02","DOIUrl":"10.3928/23258160-20250108-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Outer retinal tubulation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, including geographic atrophy (GA). The objective of this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT at baseline.</p><p><strong>Patients and methods: </strong>This post hoc longitudinal analysis assessed 300 eyes randomized to sham treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus those without ORT at baseline.</p><p><strong>Results: </strong>Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes with ORT at baseline lost on average 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than eyes without ORT.</p><p><strong>Conclusion: </strong>Sham-treated eyes with ORT at baseline had less loss of BCVA over 24 months than eyes without ORT. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:228-230.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"228-230"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tractional Retinoschisis in Proliferative Diabetic Retinopathy Imaged With Swept-Source Optical Coherence Tomography Angiography.","authors":"Landon J Rohowetz, Prashanth G Iyer, Noy Ashkenazy, Kenneth C Fan, Rita Laiginhas, Yingying Shi, Jeremy Liu, Philip Rosenfeld, Harry W Flynn","doi":"10.3928/23258160-20241101-04","DOIUrl":"10.3928/23258160-20241101-04","url":null,"abstract":"<p><p>Tractional retinoschisis (TRS) secondary to proliferative diabetic retinopathy (PDR) may be differentiated from tractional retinal detachment (TRD) by its characteristically nonprogressive course. The purpose of the current study was to describe the use of swept-source optical coherence tomography angiography (SS-OCTA) in the diagnosis and monitoring of TRS secondary to PDR. Retrospective, consecutive case series of patients with TRS secondary to PDR are featured. Clinical notes, fundus photography, and SS-OCTA images are reviewed. The study comprised three eyes of three patients with PDR and TRS. Visual acuity and anatomic features on SS-OCTA were stable in all patients at one year or more of follow-up. Tractional retinoschisis secondary to PDR is typically nonprogressive and may be observed without surgery. SS-OCTA serves as a noninvasive and effective imaging tool to distinguish TRS from TRD and to demonstrate anatomic stability over time. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:244-248.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"244-248"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrared Autofluorescence to Identify Activity in Punctate Inner Choroidopathy.","authors":"Vishal Sanjay Jadhav, Anup Kelgaonkar, Soumyava Basu","doi":"10.3928/23258160-20240923-01","DOIUrl":"10.3928/23258160-20240923-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"253"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Eye Screening: Current Standards and Gaps in Care.","authors":"Lindsey A Chew, Nikhil V Gadiraju, Anjali M Saini, S Tammy Hsu, Vahid Ownagh, Lejla Vajzovic","doi":"10.3928/23258160-20241216-03","DOIUrl":"10.3928/23258160-20241216-03","url":null,"abstract":"<p><p>The nonmydriatic, noncontact, and rapid acquisition features of ultra-widefield fundus (UWF) imaging create an invaluable tool for pediatric retinal screening in primary care. This review assesses the landscape of pediatric eye screening, identifies gaps in diagnosing a range of pediatric retinal conditions, and discusses potential uses of UWF imaging for retinal screening. The standards for pediatric eye screening in primary care include red reflex testing, direct ophthalmoscopy, external ocular exam, instrument-based screening, and visual acuity testing. These tests fail to diagnose several treatable retinal diseases. In this gap, UWF retinal imaging provides a panoramic view of the retinal landscape, allowing for a more comprehensive examination. For several pediatric retinal conditions (eg, retinal detachment, retinopathy of prematurity, Coats' disease, familial exudative vitreoretinopathy, Stargardt disease, ocular toxocariasis), UWF retinal imaging provides the high spatial resolution necessary for reliable diagnosis, expediting time to treatment while maintaining low false positive rates. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:232-239.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"232-239"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Gore-Tex Scleral Fixation Technique for Dual-Eyelet Intraocular Lenses.","authors":"Elizabeth A Mellencamp, Dimitrios C Arhontoulis, Sydney C DiBona, David E Baxley, Nicolas A Yannuzzi, Peter H Tang","doi":"10.3928/23258160-20241216-05","DOIUrl":"10.3928/23258160-20241216-05","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"202-204"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RWC Update: Prophylactic Treatment of Pediatric Rhegmatogenous Retinal Detachment; Degenerative Retinoschisis With Inner and Outer Layer Holes and Prior Unnecessary Thermal Laser Demarcation; Another One Bites the Dust.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Sengul Ozdek, Yoshihiro Yonekawa, Lauren Kiryakoza, Audina M Berrocal, Vaibhav Sethi, Jamil Poletti Jabbour, Kourous A Rezaei","doi":"10.3928/23258160-20250317-01","DOIUrl":"https://doi.org/10.3928/23258160-20250317-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 4","pages":"199-201"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: \"Integrity\" Assessment Following Rhegmatogenous Retinal Detachment Repair.","authors":"Raziyeh Mahmoudzadeh, Mirataollah Salabati, Taku Wakabayashi, Dillan Patel, Sonia Mehta, Ajay E Kuriyan, M Ali Khan, Michael A Klufas, Sunir J Garg, Omesh P Gupta, Carl D Regillo, Yoshihiro Yonekawa, Michael N Cohen, Shreya Swaminathan","doi":"10.3928/23258160-20241207-01","DOIUrl":"10.3928/23258160-20241207-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"251-252"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}