Clinical Outcomes of Pars Plana Vitrectomy for Persistent Vitreous Opacities in Infectious and Noninfectious Uveitis.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-08-11 DOI:10.3928/23258160-20250718-01

Ludovico Alisi, Marta Armentano, Giacomo Visioli, Massimo Accorinti, Elvia Mastrogiuseppe, Mattia D'Andrea, Giulia Firmani, Maria Pia Pirraglia, Magda Gharbiya, Ludovico Iannetti

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Abstract

Background and objective: This study evaluated functional and inflammatory outcomes after pars plana vitrectomy (PPV) in patients with persistent vitreous opacities due to infectious and noninfectious uveitis unresponsive to medical therapy.

Patients and methods: Twenty-three eyes with noninfectious uveitis and 16 eyes with infectious uveitis were enrolled. Functional and inflammatory parameters were assessed, focusing on best-corrected visual acuity (BCVA), vitreous haze, and inflammation.

Results: At 6 months, both vitreous haze and anterior chamber inflammation decreased from severe to minimal levels. BCVA improved in 28 eyes (71.8%), remained stable in five eyes (12.8%), and worsened in six eyes (15.4%). Linear regression analysis showed that preoperative BCVA significantly predicted visual improvement (coefficient = 0.60, 95% confidence interval [CI]: 0.22-0.98, P = 0.003), while etiology (P = 0.217) and lens status (P = 0.201) were not significant factors (R² = 0.34). Elevated intraocular pressure occurred in five patients, with two requiring trabeculectomy after 3 months. In two cases, epiretinal membrane formation progressed to tractional retinal detachment within 6 months.

Conclusion: PPV is an effective treatment for persistent vitreous opacities, resulting in visual improvement and stabilization of inflammation. Postoperative follow-up is necessary due to potential complications and recurrence.

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感染性和非感染性葡萄膜炎持续性玻璃体混浊的玻璃体切除术的临床效果。

背景和目的：本研究评估了感染性和非感染性葡萄膜炎对药物治疗无反应的持续性玻璃体混浊患者行玻璃体切除术（PPV）后的功能和炎症结果。患者与方法：非感染性葡萄膜炎患者23只眼，感染性葡萄膜炎患者16只眼。评估功能和炎症参数，重点是最佳矫正视力（BCVA）、玻璃体浑浊和炎症。结果：6个月时，玻璃体浑浊和前房炎症均由严重减轻到轻微。BCVA改善28眼（71.8%），稳定5眼（12.8%），恶化6眼（15.4%）。线性回归分析显示术前BCVA可显著预测视力改善（系数= 0.60,95%可信区间[CI]: 0.22-0.98, P = 0.003），而病因（P = 0.217）和晶状体状态（P = 0.201）不是显著因素（R2 = 0.34）。5例患者出现眼压升高，其中2例在3个月后需要小梁切除术。2例视网膜前膜形成在6个月内发展为牵引性视网膜脱离。结论：PPV是治疗持续性玻璃体混浊的有效方法，可改善视力，稳定炎症。由于可能出现并发症和复发，术后随访是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.