David Shin, Victor Bellanda, Oluwapeyibomi I Runsewe, W H Wilson Tang, Sunil K Srivastava, Sumit Sharma
{"title":"Signal Strength Variation Explains Apparent Exercise-associated Vessel Density Change on Optical Coherence Tomography Angiography in Heart Failure.","authors":"David Shin, Victor Bellanda, Oluwapeyibomi I Runsewe, W H Wilson Tang, Sunil K Srivastava, Sumit Sharma","doi":"10.3928/23258160-20260618-02","DOIUrl":"10.3928/23258160-20260618-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal vessel density (VD) on optical coherence tomography angiography (OCTA) has been proposed as a biomarker in heart failure with preserved ejection fraction (HFpEF). This study evaluated VD change after exercise in HF-pEF, accounting for signal strength.</p><p><strong>Patients and methods: </strong>Patients with HFpEF underwent 3 × 3-mm OCTA before and after a 6-minute walk test. Change in parafoveal VD in superficial (SCP) and deep (DCP) capillary plexuses was modeled with and without adjustment for signal strength index (SSI) and between New York Heart Association (NYHA) functional classes.</p><p><strong>Results: </strong>Among 34 eyes (20 subjects), unadjusted DCP VD increased after exercise (1.27; 95% CI, 0.31 to 2.24; <i>P</i> = .010), more so in NYHA class III than I or II (difference, 2.39; 95% CI, 0.86 to 3.91; <i>P</i> = .002). SSI adjustment attenuated estimates to nonsignificance (overall, 0.48; 95% CI, -0.23 to 1.19; <i>P</i> = .19; NYHA difference, 0.75; 95% CI, -0.65 to 2.16; <i>P</i> = .29). SCP changes were nonsignificant.</p><p><strong>Conclusion: </strong>Postexercise VD changes in HFpEF were largely explainable by signal strength changes. OCTA analyses should adjust for signal strength to distinguish measurement artifact from true vascular differences.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"512-522"},"PeriodicalIF":1.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayanika Challa, Michael Massengill, Daniel Oh, Daniel W Wang, Jennifer I Lim
{"title":"Risk Factors for the Recurrence of Macular Holes After 25-Gauge Pars Plana Vitrectomy.","authors":"Nayanika Challa, Michael Massengill, Daniel Oh, Daniel W Wang, Jennifer I Lim","doi":"10.3928/23258160-20260501-01","DOIUrl":"10.3928/23258160-20260501-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to perform a comprehensive quantitative analysis of patients with macular holes undergoing pars plana vitrectomy (PPVx) to identify factors associated with macular holes and with recurrence of macular holes after initial closure.</p><p><strong>Patients and methods: </strong>This case-control study included 37 eyes which underwent 25-gauge vitrectomy without combined cataract extraction between January 2010 and January 2023 by a single surgeon (JIL). Various factors about each eye were noted across multiple visits. Linear regression and various statistical testing methods were used to analyze the data.</p><p><strong>Results: </strong>Larger hole size was associated with women, absence of a posterior vitreous detachment, and absence of cystoid macular edema. Higher likelihood of macular hole recurrence was associated with presence of an epiretinal membrane and in eyes that later underwent cataract extraction with insertion of intraocular lens (CEIOL).</p><p><strong>Conclusion: </strong>Analysis demonstrates that specific factors are associated with larger macular holes or higher rates of macular hole recurrence, which could provide predictive utility.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"487-491"},"PeriodicalIF":1.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Bouaziz, Brian P Marr, Jessica G Lee, Vincent A Deramo, Rubina Cocker, Philip J Ferrone
{"title":"Metastatic Cutaneous Amelanotic Melanoma to the Vitreous Masquerading as a Fungal Endophthalmitis.","authors":"Michael Bouaziz, Brian P Marr, Jessica G Lee, Vincent A Deramo, Rubina Cocker, Philip J Ferrone","doi":"10.3928/23258160-20260526-01","DOIUrl":"10.3928/23258160-20260526-01","url":null,"abstract":"<p><p>This report presents a case of amelanotic metastatic cutaneous melanoma to the vitreous masquerading as a fungal endophthalmitis. A 74-year-old immunocompromised man with a history of Stage 4 metastatic cutaneous melanoma presented with 1+ vitreous cell and a fluffy white peripheral infiltrate in the left eye. Following subsequent vitrectomy for a vitreous hemorrhage, this patient developed pre-retinal macular deposits that continued to increase in size while undergoing treatment for a presumed fungal endophthalmitis. The patient went on to develop a total retinal detachment with a diffuse hemorrhagic retinopathy. Cytopathologic analysis revealed necrotic melanoma cells from the preretinal surface and within the vitreous cavity. This case highlights the importance of including vitreous metastasis in the differential of vitritis in the setting of cutaneous melanoma. Optical coherence tomography can be used to monitor the progression of preretinal deposits, with an increase in size of the deposits prompting reevaluation of treatment options.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"461-464"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progressive Retinal and Cerebral Arteriovenous Malformations in Wyburn-Mason Syndrome: A 5-Year Follow-Up Case Report.","authors":"Asya Aktuglu, Rukiye Aydin Arslan","doi":"10.3928/23258160-20260513-02","DOIUrl":"10.3928/23258160-20260513-02","url":null,"abstract":"<p><p>This report presents a rare case of Wyburn-Mason syndrome (WMS) with documented progression of both retinal and cerebral arteriovenous malformations (AVMs) over 5 years, emphasizing the clinical significance of ocular changes that may be associated with cerebral involvement. A 6-year-old girl initially presented with unilateral blurred vision and was diagnosed with WMS due to a retinal AVMs in her left eye. Initial brain magnetic resonance imaging (MRI) showed no intracranial AVMs. At routine follow-up, she had developed headaches and nausea after 4 years, leading to diagnosis of a cerebral AVM, treated with Gamma Knife radiosurgery. Concurrently, fundus examination revealed progressive retinal AVM changes, accompanied by decreased best-corrected visual acuity and worsened optical coherence tomography findings. The parallel progression of retinal and cerebral AVMs highlights the dynamic nature of vascular malformations in WMS. This case underscores that vascular anomalies in WMS may evolve over time and may not remain isolated to a single organ. Progressive retinal AVM changes can signal potential cerebral involvement. Therefore, any ocular progression in WMS warrants timely neuroimaging, even if previous scans were normal. Reporting such rare cases can aid in improving early diagnosis and follow-up strategies in WMS.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"465-467"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Puranjay Gupta, Emily Kao, William F Chadwick, Reem Alahmadi, Michael J Heiferman
{"title":"Precision-Guided Suprachoroidal Injection Using Ultrasound Biomicroscopy and Custom-Length Microneedles.","authors":"Puranjay Gupta, Emily Kao, William F Chadwick, Reem Alahmadi, Michael J Heiferman","doi":"10.3928/23258160-20260521-01","DOIUrl":"10.3928/23258160-20260521-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Suprachoroidal (SC) injection enables targeted posterior drug delivery but relies on subjective tactile feedback to confirm depth. This can require multiple passes or cause intravitreal delivery, increasing patient discomfort and complication risk. This study evaluates whether ultrasound biomicroscopy (UBM) can guide custom needle selection based on scleral thickness to improve first-pass SC injection success.</p><p><strong>Patients and methods: </strong>Ten ex vivo porcine eyes underwent pre-injection UBM to measure scleral thickness. Custom-length needles (0.5-1.5 mm) were selected accordingly. SC injections were performed under UBM guidance, with imaging confirming entry and injectate spread.</p><p><strong>Results: </strong>UBM confirmed successful SC injection in all specimens, with hypoechoic separation between sclera and choroid. Post-injection, scleral thickness increased significantly (1.13 ± 0.13 mm to 2.28 ± 0.19 mm, <i>P</i> < .0001), validating drug delivery.</p><p><strong>Conclusion: </strong>UBM-guided needle selection enables accurate SC injection and may reduce failed attempts. This approach could enhance the efficacy of SC delivery and support broader clinical use across posterior segment diseases.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"448-454"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John T Moir, Sonia B Kim, Kevin C Allan, David C Kaelber, Rishi P Singh, Katherine E Talcott
{"title":"Demographic and Prevalence Dynamics of Macular Telangiectasia Type 2 From 2015 to 2024.","authors":"John T Moir, Sonia B Kim, Kevin C Allan, David C Kaelber, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20260513-01","DOIUrl":"10.3928/23258160-20260513-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study sought to provide a recent estimate for the prevalence of macular telangiectasia type 2 (MacTel) with respect to age, race/ethnicity, and sex.</p><p><strong>Patients and methods: </strong>A cross-sectional study from 2015 to 2024 was performed for adults in the United States aged ≥ 35 years within an electronic health record data platform. Patients with MacTel were identified as those with a corresponding International Classification of Diseases 10th revision (ICD-10) diagnosis code. The prevalence of MacTel was calculated at each year of the study period and stratification was performed by age, race, ethnicity, and sex.</p><p><strong>Results: </strong>In 2024, the prevalence of MacTel was 9.06 patients per 100,000, representing a 1.91-fold increase from 2015 (95% CI 1.79-2.03). Over that same timespan, the ratio of increase in MacTel was greater than the ratio of increase of age-related macular degeneration (AMD) (odds ratio 1.25, 95% 1.17-1.33).</p><p><strong>Conclusion: </strong>The prevalence of MacTel is lower than previously estimated but has been increasing at a striking rate from 2015 to 2024 that outpaces AMD.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"427-432"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles Zhang, Sinan Ersan, Joaquin A Sosa-Lockward, Molly P Aldred, Hong-Uyen Hua, Audina M Berrocal
{"title":"Trends in the Initial Treatment for Retinopathy of Prematurity in the United States.","authors":"Charles Zhang, Sinan Ersan, Joaquin A Sosa-Lockward, Molly P Aldred, Hong-Uyen Hua, Audina M Berrocal","doi":"10.3928/23258160-20260512-01","DOIUrl":"10.3928/23258160-20260512-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to characterize trends in choice of initial therapy for retinopathy of prematurity (ROP) in the United States.</p><p><strong>Patients and methods: </strong>This is a cross-sectional time-series analysis on infants diagnosed with ROP categorized by initial treatment modality (laser photocoagulation/cryotherapy or intravitreal injection). TriNetX was used for data collection, and Cochran-Armitage trend tests were used to evaluate changes in the proportion of treatment modalities and agent usage over time.</p><p><strong>Results: </strong>A total of 2,050 infants met inclusion criteria. The proportion of infants treated with laser/cryotherapy decreased from 100% to 62.7% (<i>P</i> < .0001). Bevacizumab decreased from 100% of all intravitreal injections to 76.7% (<i>P</i> < .0001). Aflibercept use increased from 0% to 18.8% (<i>P</i> < .0001). White infants were more likely to be treated with intravitreal anti-VEGF than Black or Hispanic infants (<i>P</i> = .0061).</p><p><strong>Conclusion: </strong>The rates of anti-VEGF for initial treatment have been rising over the years; however, laser photocoagulation remains the most common treatment for ROP in the United States.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"434-440"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}