Purna Nangia, Karen M Wai, Adrienne W Scott, Ehsan Rahimy, Prithvi Mruthyunjaya
{"title":"Ophthalmic Outcomes and Management of Retinopathy in Patients With Sickle Cell Disease: A Comprehensive Health Registry Study and Review of Management Strategies.","authors":"Purna Nangia, Karen M Wai, Adrienne W Scott, Ehsan Rahimy, Prithvi Mruthyunjaya","doi":"10.3928/23258160-20250425-01","DOIUrl":"10.3928/23258160-20250425-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The purpose of this study was to report the rates of ophthalmic complications and interventions in patients diagnosed with sickle cell disease (SCD) and sickle cell retinopathy (SCR), while reviewing current management strategies within the literature.</p><p><strong>Patients and methods: </strong>This retrospective cohort study included patients ≥ 18 years of age with the diagnosis of SCD and SCR. The electronic health record system TriNetX was utilized to identify patients diagnosed with SCD and SCR. The main outcome measures included rates of ophthalmic complications and interventions.</p><p><strong>Results: </strong>We identified 1,249 patients with the diagnosis of both SCD and SCR. The mean age at diagnosis of SCR was 34.9 ± 14.8 years. The most common ocular complication was vitreous hemorrhage (VH) (19.5%) followed by cataracts (17.8%), rhegmatogenous retinal detachment (12.4%), and tractional retinal detachment (4.7%). The most common ocular intervention was retinal laser photocoagulation (13.6%).</p><p><strong>Conclusions: </strong>In a large, contemporary population-based study for SCD patients with SCR, the rates of preventable visually significant complications are high. Timely screening, diagnosis, and management strategies can help prevent these complications.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"488-493"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer D Huang, Kapil Mishra, Karen Wai, Prithvi Mruthyunjaya, Ehsan Rahimy
{"title":"Morbidity and Mortality Associated With Systemic Lupus Erythematosus and Retinal Vasculitis: A Multicenter Cohort Study.","authors":"Jennifer D Huang, Kapil Mishra, Karen Wai, Prithvi Mruthyunjaya, Ehsan Rahimy","doi":"10.3928/23258160-20250417-01","DOIUrl":"10.3928/23258160-20250417-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To determine the long-term rates of death, myocardial infarction (MI), dialysis, and stroke in patients with systemic lupus erythematosus (SLE) and retinal vasculitis (RV).</p><p><strong>Patients and methods: </strong>A total of 435 patients with SLE/RV were identified using TriNetX, a federated electronic health records network from January 1, 2004 to January 1, 2024. Patients were matched for age, sex, race, and propensity score, excluding those with MI, dialysis, or cerebrovascular complication in the year prior to diagnosis.</p><p><strong>Results: </strong>The risk of death, MI, and dialysis was not statistically different between cohorts at 5 and 10 years. The risk of stroke was increased at 5 and 10 years in the SLE/RV cohort, but no statistically significant difference in risk was found at 1 year.</p><p><strong>Conclusion: </strong>Although patients with and without RV may have similar long-term rates of death, MI, and dialysis, patients with SLE/RV may have an elevated risk of stroke in the subsequent 5 and 10 years after diagnosis, highlighting the need for multidisciplinary care.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"460-466"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shivesh Shah, William Foulsham, Jia Xu, Luis Martinez-Velazquez, Jennifer Hu, Selin Gumustop, Kayla Nodecker, John B Miller
{"title":"Epiretinal Amniotic Membrane Patch as a Temporary Scaffold for Refractory Macular Hole Closure: A Case Report.","authors":"Shivesh Shah, William Foulsham, Jia Xu, Luis Martinez-Velazquez, Jennifer Hu, Selin Gumustop, Kayla Nodecker, John B Miller","doi":"10.3928/23258160-20250417-04","DOIUrl":"10.3928/23258160-20250417-04","url":null,"abstract":"<p><p>Macular holes are central retinal defects that can severely impair vision. While standard surgical management including pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling is highly effective for most macular holes, lower success rates are observed with chronic or large holes. Several advanced surgical maneuvers have recently emerged, including inverted ILM flaps, autologous retinal transplant, subretinal blebs, and subretinal amniotic membrane (AM) grafts. While subretinal AM grafts demonstrate improved closure rates, amniotic tissue can block reformation of subfoveal outer retinal structures. The use of larger AM patches (> 6 mm diameter) to facilitate hole closure through the creation of a temporary pre-retinal scaffold is a novel surgical approach for refractory macular holes. We describe a large chronic stage-4 macular hole refractory to standard treatment, successfully treated with epiretinal AM transplantation and patch removal 2 months later. We highlight the feasibility of AM removal and importance of further refining this technique. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:442-445.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"442-445"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celine Chaaya, Ioanna Ploumi, Srujay Pandiri, Xinyi Ding, Sandra Hoyek, Chong Chen, Kayla N Nodecker, Audrey Kim, Nimesh A Patel, John B Miller
{"title":"Ultra-Widefield Swept-Source OCTA Findings in Coats Plus Syndrome.","authors":"Celine Chaaya, Ioanna Ploumi, Srujay Pandiri, Xinyi Ding, Sandra Hoyek, Chong Chen, Kayla N Nodecker, Audrey Kim, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20250417-02","DOIUrl":"10.3928/23258160-20250417-02","url":null,"abstract":"<p><p>Coats plus syndrome (CPS), also referred to as cerebroretinal microangiopathy with calcifications and cysts (CMCC), is a rare autosomal recessive disease that primarily targets the microvasculature of the retina, brain, bones, and gastrointestinal system. This study reports the case of a 24-year-old female patient who was initially diagnosed with familial exudative vitreoretinopathy (FEVR) and was lost to follow-up. The patient underwent multimodal retinal imaging, including ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA) (DREAM OCT, Intalight). Examination revealed areas of peripheral avascular retina with limited exudation and telangiectasis. Ultra-widefield SS-OCTA provided a detailed view of the peripheral retinal changes, including temporal retinal ischemia, vessel tortuosity, dilated intercapillary spaces, and vessel shunting. Genetic testing was positive for CTC1 mutation and the diagnosis of CPS was made. Mild phenotypes of Coats plus can mimic FEVR and there is a need to maintain a level of suspicion in patients with any systemic symptoms. Ultra-wide-field OCTA can be used to assess peripheral avascularity and telangiectasias to aid in the diagnosis and management. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:437-441.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"437-441"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikhil Bommakanti, Jose S Pulido, Howard F Fine, Yoshihiro Yonekawa
{"title":"Time for \"Cyanescence\" to Become Cyanotic. It's ICG \"Fluorescence\".","authors":"Nikhil Bommakanti, Jose S Pulido, Howard F Fine, Yoshihiro Yonekawa","doi":"10.3928/23258160-20250217-02","DOIUrl":"10.3928/23258160-20250217-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"394-396"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Şengül Özdek, Dilraj S Grewal, Ahmed F Shakarchi, Ahmed B Sallam, Joaquin Romano, Ayushi Gupta, Vishal Agrawal, Kourous A Rezaei
{"title":"RWC Update: Surgical Intervention in Pediatric Uveitis; L-Shape Technique: Engineering for Intraocular Foreign Bodies; Post-Viral Frosted Branch Angiitis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Şengül Özdek, Dilraj S Grewal, Ahmed F Shakarchi, Ahmed B Sallam, Joaquin Romano, Ayushi Gupta, Vishal Agrawal, Kourous A Rezaei","doi":"10.3928/23258160-20250619-01","DOIUrl":"https://doi.org/10.3928/23258160-20250619-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 7","pages":"389-392"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pseudo Iris Transillumination Defect.","authors":"Sarthak V Shah, Arthur Brant, Darius M Moshfeghi","doi":"10.3928/23258160-20250324-01","DOIUrl":"10.3928/23258160-20250324-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"446-447"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard A Morgan, Peter J Weng, Sandra S Stinnett, Dilraj S Grewal, Sharon Fekrat
{"title":"Dopaminergic Therapies May Decrease Risk of Early and Intermediate Non-exudative Age-related Macular Degeneration Progression.","authors":"Richard A Morgan, Peter J Weng, Sandra S Stinnett, Dilraj S Grewal, Sharon Fekrat","doi":"10.3928/23258160-20250326-02","DOIUrl":"10.3928/23258160-20250326-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Age-related macular degeneration (AMD) is a leading cause of vision loss, with progression to geographic atrophy (GA) posing a significant challenge. This study aimed to assess whether dopaminergic therapies (DMTs) reduce risk of AMD progressing to GA.</p><p><strong>Patients and methods: </strong>A retrospective cohort study analyzed electronic health records of 320 patients (449 eyes) with early or intermediate nonexudative AMD at Duke Eye Center from 2014 to 2024. Of these, 80 patients (110 eyes) were on DMTs, and 240 (339 eyes) served as controls. GA progression was evaluated annually over 5 years.</p><p><strong>Results: </strong>GA progression was lower in the DMT group across all intervals, with lifetime rates of 9.4% in the non-DMT group versus 2.7% in the DMT group (<i>P</i> < 0.05). Multivariate analysis showed a significant protective effect (odds ratio 0.08, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>DMTs may significantly reduce risk of AMD progressing to GA, warranting further research. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:416-421.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"416-421"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}