利用自适应光学技术研究糖尿病视网膜病变中感光器和血管参数之间的相关性。

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-11-01 DOI:10.3928/23258160-20241015-03

Michael Balas, Mariam Issa, Marko M Popovic, Chris Zajner, Lana Moayad, Paola Oquendo Aponte, Hesham Hamli, Peng Yan, Tom Wright, Isabela M Melo, Rajeev H Muni

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引用次数: 0

摘要

背景和目的：本研究旨在利用自适应光学（AO）成像技术研究不同阶段糖尿病视网膜病变（DR）中感光细胞和血管参数之间的相关性：在这项单中心前瞻性队列研究中，29 名参与者（46 只眼）被分为对照组/轻度非增殖性糖尿病视网膜病变（NPDR）、中度/重度 NPDR 和增殖性糖尿病视网膜病变。对感光细胞和视网膜血管的 AO 图像进行了分析，并使用斯皮尔曼相关性（ρ）来评估感光细胞密度和血管参数之间的关系：较高的视锥密度与总血管（ρ = 0.22，P = 0.03）和管腔直径（ρ = -0.24，P = 0.01）成反比，而较高的分散度与总血管（ρ = 0.19，P = 0.06）和管腔直径（ρ = 0.21，P = 0.04）成正比。这些相关性主要在轻度 NPDR 中显著。结论：这项研究强调了早期 DR 中错综复杂的神经血管相关性，表明这些参数可能有助于早期疾病的检测。要了解晚期 DR 是否也存在类似的相关性，还需要进一步的研究。[眼科手术激光成像视网膜2024;55:XX-XX]。

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Correlation Between Photoreceptor and Vascular Parameters in Diabetic Retinopathy Using Adaptive Optics.

Background and objective: This study aimed to investigate correlations between photoreceptor and vascular parameters in varying stages of diabetic retinopathy (DR) using adaptive optics (AO) imaging.

Patients and methods: In this single-center, prospective cohort study, 29 participants (46 eyes) were classified into control/mild non-proliferative DR (NPDR), moderate/severe NPDR, and proliferative DR. AO images of photoreceptors and retinal vasculature were analyzed, and Spearman's correlation (ρ) was used to assess relationships between photoreceptor density and vascular parameters.

Results: Higher cone density was inversely associated with total vessel (ρ = 0.22, P = 0.03) and lumen diameters (ρ = -0.24, P = 0.01), while higher dispersion was associated with total vessel (ρ = 0.19, P = 0.06) and lumen diameters (ρ = 0.21, P = 0.04). These associations were primarily significant in mild NPDR. No significant correlations were found in advanced DR stages.

Conclusion: This study underscores intricate neurovascular correlations in early-stage DR, suggesting these parameters may aid in early disease detection. Further research is needed to understand whether similar correlations exist in advanced DR. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.