Mario J Saravia, Jimena Rojas, Christan de Los Santos, Pablo Bazterrechea, Fernanda Forgues, Nicolas Monteros, Juan Manuel Cortalezzi, Ignacio Zeolite, Enrique Sgattoni, Luis Zeman, Matko Vidosevich, Guillermo Magnano, Marcelo Zas, Ezequiel Rosendi, Jeff Franco, Michael W Calhoun, Luana R Wilbur, Philip J Rosenfeld, Pedro Lylyk
{"title":"Feasibility Study of Balloon Angioplasty for the Treatment of Ophthalmic Artery Stenoses in Patients With Geographic Atrophy.","authors":"Mario J Saravia, Jimena Rojas, Christan de Los Santos, Pablo Bazterrechea, Fernanda Forgues, Nicolas Monteros, Juan Manuel Cortalezzi, Ignacio Zeolite, Enrique Sgattoni, Luis Zeman, Matko Vidosevich, Guillermo Magnano, Marcelo Zas, Ezequiel Rosendi, Jeff Franco, Michael W Calhoun, Luana R Wilbur, Philip J Rosenfeld, Pedro Lylyk","doi":"10.3928/23258160-20260527-01","DOIUrl":"10.3928/23258160-20260527-01","url":null,"abstract":"<p><strong>Background and objective: </strong>A safety and feasibility study was conducted using balloon angioplasty to treat ophthalmic artery (OA) stenoses in patients with age-related macular degeneration (AMD) with geographic atrophy (GA).</p><p><strong>Patients and methods: </strong>Patients ≥ 60 years of age received OA angioplasty using an investigational catheter system and were followed for 6 months. Changes in stenosis, best-corrected visual acuity (BCVA), MNRead acuity charts, ophthalmic imaging, and a validated questionnaire were evaluated.</p><p><strong>Results: </strong>Eleven patients were treated. All adverse events were treated as needed and resolved without sequelae. Treated patients demonstrated a mean improvement over baseline in BCVA (<i>P</i> = .01) and reading speed (<i>P</i> = .03) at study exit. Mean subfoveal choroidal thickness increased over baseline (<i>P</i> = .004) and fellow eyes (<i>P</i> = .03) through week 4, remaining above baseline at study exit. Participants reported mean improvements in both mobility and reading.</p><p><strong>Conclusion: </strong>Treating OA stenoses using angioplasty in patients with GA was safe with apparent visual function benefit.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"418-426"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine K Liu, Kathryn Achuck, Lucy V Cobbs, Bita Momenaei, Louis Z Cai, Sidra Zafar, Rebecca R Soares, Yoshihiro Yonekawa
{"title":"Geographic Access to Pediatric Retina Specialists in the United States.","authors":"Catherine K Liu, Kathryn Achuck, Lucy V Cobbs, Bita Momenaei, Louis Z Cai, Sidra Zafar, Rebecca R Soares, Yoshihiro Yonekawa","doi":"10.3928/23258160-20260513-03","DOIUrl":"10.3928/23258160-20260513-03","url":null,"abstract":"<p><strong>Background and objective: </strong>With rising incidence of pediatric retina disease, this study aimed to identify geographic and socioeconomic factors that predict residential access to pediatric retinal specialists.</p><p><strong>Patients and methods: </strong>This cross-sectional, retrospective study identified pediatric retina specialists in the United States and de-identified census tract-level data from public datasets. An origin-destination cost matrix was used to calculate travel time to the closest pediatric vitreoretinal specialist.</p><p><strong>Results: </strong>Factors associated with greater travel burden to the nearest pediatric retinal specialist included residing in census tracts that were rural (<i>P</i> < .001), in the South vs Northeast (<i>P</i> = .009), low income (<i>P</i> < .0001), and low education (associate and some college vs bachelor's degree; <i>P</i> = .003 and .015). Counties with higher proportion of very low birth weight infants had significantly less travel time (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Counties with higher incidences of very low birth weight infants experience reduced travel durations to pediatric retina specialists. However, residents in rural, low-income, low-education census tracts, particularly in Southern regions, face greater travel burdens.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"441-447"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Noemi Lois, Levent Karabas, Kevin Elwood, Ramon Lee, Ayushi Gupta, Vishal Agrawal, Kourous A Rezaei
{"title":"RWC Update: Are We Operating Too Late on Diabetic Tractional Retinal Detachment?; Trocar-Assisted Yamane Secondary Intraocular Lens; Hemorrhagic Occlusive Retinal Vasculitis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Noemi Lois, Levent Karabas, Kevin Elwood, Ramon Lee, Ayushi Gupta, Vishal Agrawal, Kourous A Rezaei","doi":"10.3928/23258160-20260622-01","DOIUrl":"https://doi.org/10.3928/23258160-20260622-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 7","pages":"413-416"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alport Syndrome With Wheel-like Bilateral Macular Holes: A Case Report and Literature Review.","authors":"MengYao Han, YaQin Wang, YiQiao Xing","doi":"10.3928/23258160-20260601-01","DOIUrl":"10.3928/23258160-20260601-01","url":null,"abstract":"<p><p>Macular hole, a rare but vision-threatening complication in Alport syndrome, presents unique therapeutic challenges. Although the ocular manifestations of Alport syndrome, such as anterior lenticonus and retinal flecks, have been well documented for decades, the progressive nature of the associated vitreoretinopathy has historically limited the ability of clinicians to prevent irreversible visual deterioration. A 39-year-old woman with genetically confirmed Alport syndrome presented with a 2-month history of progressive bilateral blurred vision. Multimodal ophthalmic imaging revealed wheel-like retinal changes accompanied by full-thickness foveal defects in both eyes. Pars plana vitrectomy combined with amniotic membrane transplantation was performed on the left eye. At 5-month follow-up, the visual acuity of the left eye remained 6/20, consistent with the preoperative best-corrected visual acuity of the same eye. Optical coherence tomography confirmed complete closure of the left macular hole. Pars plana vitrectomy combined with human amniotic membrane transplantation represents a promising therapeutic strategy for the management of macular holes in patients with Alport syndrome.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"468-471"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akshi Sharma, Landon J Rohowetz, Harry W Flynn, Thomas A Albini, Rudvij Pandya, Anup Kelgaonkar, Avinash Pathengay, Anamika Patel
{"title":"Bilateral Combined Retinal Vasculitis With Multiple Cotton Wool Spot-Like Lesions.","authors":"Akshi Sharma, Landon J Rohowetz, Harry W Flynn, Thomas A Albini, Rudvij Pandya, Anup Kelgaonkar, Avinash Pathengay, Anamika Patel","doi":"10.3928/23258160-20260527-02","DOIUrl":"10.3928/23258160-20260527-02","url":null,"abstract":"<p><p>This retrospective chart review presents a case of bilateral noninfectious retinitis exhibiting cotton wool spot-like lesions, associated with combined retinal vasculitis. A 26-year-old woman with no known systemic illness presented with bilateral combined retinal vasculitis, associated with multiple cotton wool-like lesions along the vessels. Swept-source optical coherence tomography (SS-OCT) revealed a prominent middle limiting membrane (MLM) sign with cystoid macular edema. Fundus fluorescein angiography (FFA) showed blocked hypofluorescence and optic disc leakage, but notably, no vascular leakage. Serological investigations and neuroimaging were unremarkable, except for a positive antinuclear antibody (ANA). Following initiation of oral corticosteroids, the cotton wool spot-like lesions began to resolve within 2 days, accompanied by an increase in hemorrhagic components, which subsequently resolved over 3 weeks. After complete resolution, optic disc pallor and retinal thinning were observed. This rare case of bilateral combined retinal vasculitis with distinctive cotton wool spot-like lesions along the vascular arcades showed a rapid response to corticosteroid therapy and remained clinically quiescent over long-term follow-up.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 7","pages":"456-460"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sam Karimaghaei, Frances B Lancaster, J Anthony Chacko, Ahmed F Shakarchi, Sami Uwaydat
{"title":"Rare Case of Disseminated Histoplasmosis Presenting as Endogenous <i>Histoplasma Capsulatum</i> Endophthalmitis in an Immunocompetent Patient.","authors":"Sam Karimaghaei, Frances B Lancaster, J Anthony Chacko, Ahmed F Shakarchi, Sami Uwaydat","doi":"10.3928/23258160-20260512-02","DOIUrl":"10.3928/23258160-20260512-02","url":null,"abstract":"<p><p>This report presents a case of a 75-year-old man living in Arkansas, United States, who presented with subacute eye pain and severe vision loss in the left eye for 5 to 6 weeks and a history of 40-lb unintentional weight loss over the previous year. Exam revealed panuveitis initially suspicious for endogenous bacterial versus fungal endophthalmitis in the context of recent intravenous (IV) vitamin infusions. However, a systemic work-up revealed a positive serum and urine <i>Histoplasma</i> antigen, diagnostic for disseminated histoplasmosis. Vitreous cultures were negative, but pan-fungal polymerase chain reaction (PCR) testing returned positive for <i>Histoplasma capsulatum</i>, confirming a diagnosis of endogenous <i>Histoplasma capsulatum</i> endophthalmitis in the setting of disseminated histoplasmosis. Inflammation resolved after intravitreal injections of voriconazole and dexamethasone and initiation of systemic antifungal therapy, which included IV liposomal amphotericin B for 14 days and oral voriconazole planned for 1 year duration. <i>Histoplasma capsulatum</i> is a rare cause of endogenous fungal endophthalmitis and should be considered in cases of panuveitis, especially in the context of characteristic systemic symptoms of disseminated histoplasmosis and travel or residence in an endemic region.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 6","pages":"401-404"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia J Abbass, Matthew Regueiro, David C Kaelber, Elias I Traboulsi, Rishi P Singh, Katherine E Talcott
{"title":"Risk of Ocular Comorbidities in Patients With Inherited Retinal Diseases.","authors":"Nadia J Abbass, Matthew Regueiro, David C Kaelber, Elias I Traboulsi, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20260323-02","DOIUrl":"10.3928/23258160-20260323-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Given limited inherited retinal disease (IRD) treatment options, identifying and treating co-occurring ocular conditions is essential for optimizing outcomes. This study aimed to evaluate the prevalence and types of ophthalmic conditions occurring more frequently in patients with IRDs compared to individuals in the general population, in order to guide screening and management strategies.</p><p><strong>Patients and methods: </strong>Retrospective cohort study utilizing a large International Classification of Diseases, Tenth Revision (ICD-10) coded platform. Patients with ≥ 2 IRD ICD-10 codes were compared to controls with a documented eye exam (1:1) propensity matched on demographics and systemic conditions.</p><p><strong>Results: </strong>At 3 years, IRD patients demonstrated higher risk of several anterior segment abnormalities including cataracts (risk ratio [RR] 1.31, 95% CI 1.27-1.34) and lens dislocation (RR 2.61, 1.73-3.95), and posterior segment conditions including retinal detachment (RR 2.59, 2.31-2.90), retinoschisis (RR 6.85, 4.78-9.82), and cystoid macular edema (RR 6.51, 5.56-7.62). Nystagmus (RR 9.22, 7.38-11.53), color blindness (RR 13.29, 7.72-22.86), and legal blindness (RR 52.15, 35.40-76.85) were also elevated. Five- and seven-year analyses confirmed similar trends.</p><p><strong>Conclusion: </strong>IRD patients have a higher risk of several ocular comorbidities, underscoring the need for close monitoring and periodic examinations.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"355-360"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Michael Singer, Daniel Kermany, Sobha Sivaprasad, Anjana Mirajkar, Manish Nagpal, Akansha Sharma, Kourous A Rezaei
{"title":"RWC Update: Are We Overtreating Wet AMD in the Anti-VEGF Era?; Unveiling Sub-Internal Limiting Membrane (ILM) Hemorrhage; Tubercular Serpiginous-Like Choroiditis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Michael Singer, Daniel Kermany, Sobha Sivaprasad, Anjana Mirajkar, Manish Nagpal, Akansha Sharma, Kourous A Rezaei","doi":"10.3928/23258160-20260522-01","DOIUrl":"https://doi.org/10.3928/23258160-20260522-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 6","pages":"345-348"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Romano, Katherine Overbey, Antoine Durocher-Jean, Anthéa Rojewski, François St-Hilaire, Xinyi Ding, Filippos Vingopoulos, Isabella Stettler, Jean Daniel Arbour, Marc-André Rhéaume, Ramina Nissan, Patricia Sorya, Lara Santucci, Shannon Campbell, Claudia Chevrefils, Deeba Husain, Demetrios Vavvas, Joan W Miller, Jean-Philippe Sylvestre, John B Miller
{"title":"Assessment of Geographic Atrophy Using a Novel Hyperspectral Gradient Imaging Approach.","authors":"Francesco Romano, Katherine Overbey, Antoine Durocher-Jean, Anthéa Rojewski, François St-Hilaire, Xinyi Ding, Filippos Vingopoulos, Isabella Stettler, Jean Daniel Arbour, Marc-André Rhéaume, Ramina Nissan, Patricia Sorya, Lara Santucci, Shannon Campbell, Claudia Chevrefils, Deeba Husain, Demetrios Vavvas, Joan W Miller, Jean-Philippe Sylvestre, John B Miller","doi":"10.3928/23258160-20260323-01","DOIUrl":"10.3928/23258160-20260323-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study describes a novel hyperspectral imaging (HSI) approach for visualizing and measuring geographic atrophy (GA) lesions in age-related macular degeneration.</p><p><strong>Patients and methods: </strong>This cross-sectional subanalysis was conducted at Clinique Ophtalmologique 2121 (Montreal, Canada) between November 2022 and August 2023. Participants underwent color fundus photography (CFP), optical coherence tomography (OCT), and HSI using the Optina-4CTM camera. HSI gradient images at 560 nm were generated to visualize melanin depletion within the retinal pigment epithelium.</p><p><strong>Results: </strong>Among 152 eyes screened, eight (5.3%) showed GA. All GA lesions identified on OCT appeared as dark areas on HSI, while CFP failed to detect GA in two cases. HSI identified more GA lesions per eye than CFP (<i>P</i> = .001) and yielded larger lesion dimensions compared with OCT (<i>P</i> < .05).</p><p><strong>Conclusions: </strong>HSI at 560 nm provides complementary information for GA visualization and measurement to CFP and OCT, supporting further validation in future studies.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 6","pages":"393-399"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Tang, Ana D Collazo Martinez, Minsoo Kim, Anoush Shahidzadeh, Shu Jie Ting, Brinda Vaidya, Xuejuan Jiang, Hoan V Le, Ruikang Wang, Alexa Beiser, Lucia Sobrin, Sudha Seshadri, Amir H Kashani
{"title":"Effect of Optical Coherence Tomography Angiography Image Artifacts on Quantitation of Vessel Density and Perfusion.","authors":"Anna Tang, Ana D Collazo Martinez, Minsoo Kim, Anoush Shahidzadeh, Shu Jie Ting, Brinda Vaidya, Xuejuan Jiang, Hoan V Le, Ruikang Wang, Alexa Beiser, Lucia Sobrin, Sudha Seshadri, Amir H Kashani","doi":"10.3928/23258160-20260501-02","DOIUrl":"10.3928/23258160-20260501-02","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to quantify the effects of four common artifacts of optical coherence tomography angiography (OCTA) on metrics of perfusion.</p><p><strong>Patients and methods: </strong>Data from the Framingham Heart Study were reviewed to select consecutive OCTA scans with and without representative image artifacts. Four artifact categories were defined (decentration, motion, shadowing, defocus) and graded using a severity scale of \"Not Present,\" \"Mild,\" or \"Severe.\" Multivariate linear mixed-effects models were used to assess the impact of each artifact on vessel skeleton density (VSD), vessel area density (VAD), and flux.</p><p><strong>Results: </strong>The study included 141 OCTA scans from 20 participants. Severe shadowing or any severity of defocus significantly attenuated all OCTA parameters. Severe decentration significantly attenuated VAD and flux, but not VSD. Motion artifacts and mild decentration had no significant effects.</p><p><strong>Conclusion: </strong>Image defocus and shadowing significantly affect all OCTA measures. VSD is the most robust measure against most artifacts.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 6","pages":"383-392"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13289213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}