Ophthalmic surgery, lasers & imaging retina最新文献

{"title":"Evaluation of Long-term Posterior Segment Parameters in Children Who Had Recovered From Multisystem Inflammatory Syndrome.","authors":"Ulviye Kıvrak, Mehmet Tolga Köle, Güzide Akçay, Ufuk Yükselmiş, Fatih Alparslan Genç, Ayşe Karaaslan, Ceren Çetin, Aysu Karatay Arsan, Yasemin Akın, Şaban Şimşek","doi":"10.3928/23258160-20240415-01","DOIUrl":"10.3928/23258160-20240415-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To evaluate long-term posterior segment findings in children recovering from multisystemic inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.</p><p><strong>Patients and methods: </strong>Our study included 22 patients who were admitted to an intensive care unit with a diagnosis of MIS-C between November 2021 and March 2022, and 25 healthy controls. The study included pediatric patients who had an eye examination an average of 12.35 ± 2.18 months after recovery from MIS-C. Detailed eye examinations and measurements of all participants were obtained retrospectively from patient files. Posterior segment parameters were measured using swept-source optical coherence tomography (OCT) and OCT-angiography (OCT-A); these parameters included peripapillary retinal nerve fiber layer (pRNFL) thickness, central macular thickness (CMT), subfoveal choroidal thickness (SCT), macular vascular densities (VD), and foveal avascular zone (FAZ) area.</p><p><strong>Results: </strong>Mean age was 9.7 ± 3.6 years in the MIS-C group and 10.6 ± 2.8 years in the healthy control group (<i>P</i> = 0.316). There were no statistically significant differences between the MIS-C group and the healthy control group in terms of pRNFL thickness, CMT, and SCT. However, in the MIS-C group, the macular superficial vascular plexus and deep vascular plexus showed significantly lower VD in the superior, inferior, nasal, and temporal quadrants compared to the healthy controls (<i>P</i> < 0.05 for all). A comparison of the superficial and deep FAZ area parameters of both groups showed no statistically significant difference (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>We showed that patients who had recovered from MIS-C had retinal vascular damage at the long-term follow-up. Following up with these patients after recovery with OCT and OCT-A, which are noninvasive methods commonly used in the detailed evaluation of the posterior segment of the eye, could be beneficial for understanding the long-term effects of MIS-C on retinal microvasculature. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:518-526.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"518-526"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Isolated Retinal Artery Occlusion Secondary to Giant Cell Arteritis.","authors":"Ji Yun Han, Julia S Gillette, Ingrid U Scott, Paul B Greenberg","doi":"10.3928/23258160-20240508-01","DOIUrl":"10.3928/23258160-20240508-01","url":null,"abstract":"<p><p>We systematically reviewed the literature to investigate the clinical features of isolated arteritic retinal artery occlusion (A-RAO) associated with giant cell arteritis (GCA). The four primary types of A-RAO were central retinal artery occlusion (CRAO), hemi-central retinal artery occlusion (hCRAO), branch retinal artery occlusion (BRAO), and cilioretinal artery occlusion (CLRAO). The most reported presentation was unilateral CRAO, followed by bilateral CRAO, unilateral CLRAO, and bilateral BRAO. Most RAOs were accompanied by typical GCA signs and symptoms, which can help distinguish them from non-arteritic RAOs. When reported, temporal artery biopsy confirmed GCA in most cases. Patients with GCA may present with a broad spectrum of isolated unilateral and bilateral A-RAOs. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:536-540.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"536-540"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faricimab in Previously Treated Eyes With Neovascular Age-Related Macular Degeneration: An Assessment of Durability and Treatment Outcomes.","authors":"Abdulla Shaheen, Noy Ashkenazy, Maria Magraner, Nimesh A Patel, Jorge Fortun, Philip J Rosenfeld, Stephen G Schwartz, Luis J Haddock, Sander R Dubovy, Jayanth Sridhar, Zohar Yehoshua, Jaclyn L Kovach, Justin H Townsend, William E Smiddy, Harry W Flynn, Nicolas A Yannuzzi","doi":"10.3928/23258160-20240410-04","DOIUrl":"10.3928/23258160-20240410-04","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated the efficacy and durability of faricimab in patients with neovascular age-related macular degeneration (nAMD) who were previously treated with anti-vascular endothelial growth factor (anti-VEGF) agents.</p><p><strong>Patients and methods: </strong>This retrospective case series was conducted at a single tertiary center in the United States. It focused on nAMD patients who transitioned to faricimab after initial anti-VEGF therapy, with a follow-up period of at least 9 months. \"Complete dryness\" was defined as the absence of intra- and/or subretinal fluid on optical coherence tomography. Durability was gauged by the extension of treatment intervals relative to the injection frequency of the previous agent.</p><p><strong>Results: </strong>Sixty-two eyes from 62 patients were included. Treatment interval ranged from 5 to 10 weeks; 10 (16%) patients were able to be extended by 2 or more weeks compared to their previous regimen. Median (interquartile range [IQR]) central field thickness was 310 μm (254, 376) on initiating faricimab and declined by the ninth month (<i>P</i> values at 3, 6, and 9 months were 0.01, 0.02, and 0.07, respectively). Median (IQR) visual acuity at initiation of faricimab was 0.4 (0.20, 0.50) and did not change by the ninth month. Complete anatomical dryness was present in 10 (16%) eyes before switching; 90% remained dry at 9 months. Of 52 (84%) incompletely dry eyes before switching, 15% achieved complete dryness by 9 months on faricimab.</p><p><strong>Conclusions: </strong>Faricimab modestly improved the treatment intervals for a small proportion of previously treated patients on anti-VEGF therapy. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:504-509.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"504-509"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on Expanded Field Imaging Findings in Proliferative Sickle Cell Retinopathy.","authors":"Francesco Romano, Xinyi Ding, John B Miller","doi":"10.3928/23258160-20240906-03","DOIUrl":"https://doi.org/10.3928/23258160-20240906-03","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast Sensitivity Better Reflects Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity.","authors":"Grace Baldwin, Jack Tracy, Filippos Vingopoulos, Mary Munsell, Cade Bennett, Jocelyn Marie Rodriguez, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew J Finn, Peyman Razavi, Augustine Bannerman, Rebecca Zeng, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240411-01","DOIUrl":"10.3928/23258160-20240411-01","url":null,"abstract":"<p><strong>Background and objective: </strong>To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.</p><p><strong>Patients and methods: </strong>Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.</p><p><strong>Results: </strong>Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41, <i>P</i> = 0.007) and VSD (β = 0.42, <i>P</i> = 0.006) on 12 × 12 mm images.</p><p><strong>Conclusions: </strong>Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:494-502.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"494-502"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Segment Manifestations of Syphilis and Correlation With Serologic Markers of Infection.","authors":"Kaersti L Rickels, Sayena Jabbehdari, Vignesh J Krishnan, Muhammad Z Chauhan, Marco H Ji, Pedro S Tetelbom, Ahmed B Sallam, Joseph G Chacko, Ahmad M Mansour, Sami H Uwaydat","doi":"10.3928/23258160-20240411-03","DOIUrl":"10.3928/23258160-20240411-03","url":null,"abstract":"<p><strong>Background and objective: </strong>Retrospective analysis correlating serologic titers of ocular syphilis with posterior segment manifestations.</p><p><strong>Patients and methods: </strong>This study consisted of 40 patients (80 eyes imaged, 68 affected) with positive rapid plasma reagin (RPR) and <i>Treponema Pallidum</i> immunoglobulin G. We collected demographic and presentation data including HIV status, absolute CD4 count, RPR, cerebrospinal fluid-venereal disease research laboratory (CSF-VDRL) test, and retinal zone. We categorized imaging into syphilitic outer retinopathy (SOR), acute syphilitic posterior placoid chorioretinopathy, retinitis/chorioretinitis (RC), and papillitis. Multivariate analysis correlated HIV status, RPR, and VDRL titers with posterior segment findings and zone.</p><p><strong>Results: </strong>Mean age of 42.8 ± 10.7 years, with 70% male patients. Presenting visual acuity (logMAR) 0.66 ± 0.74 did not correlate with RPR, nor was it associated with papillitis, RC, or acute syphilitic posterior placoid chorioretinopathy. Higher RPR (≥ 1:128) positively associated with SOR (<i>P</i> = 0.031) and zone 1 (odds ratio [OR], 1.62; <i>P</i> = 0.02), but negatively associated with zone 2 (OR 0.35; <i>P</i> = 0.005). HIV positivity increased RC odds (OR, 4.45; <i>P</i> = 0.047).</p><p><strong>Conclusion: </strong>Higher RPR correlated with SOR and zone 1, whereas HIV positivity correlated with RC. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:511-516.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"511-516"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Oral Pharmaceuticals for Dry Age-Related Macular Degeneration: Mechanism of Action, Current Clinical Status, and Future Directions.","authors":"Charles M T DeBoer, Ditte K Rasmussen, Joel A Franco, Vinit B Mahajan","doi":"10.3928/23258160-20240430-02","DOIUrl":"10.3928/23258160-20240430-02","url":null,"abstract":"<p><p>Dry age-related macular degeneration (AMD) has been historically managed with lifestyle modifications, monitoring for conversion to wet AMD, and vitamins. Recently there has been a flurry of research focused on discovering new targets to prevent worsening of dry AMD. In 2023, the US Food and Drug Administration approved the first two intravitreal complement inhibitors to slow the rate of geographic atrophy progression. However, serial intravitreal injections for a chronic progressive disease are burdensome for patients and have procedural risks. Therefore, there is significant research to discover novel oral medications to manage dry AMD. Several oral medications are currently in phase 2 and 3 clinical trials for dry AMD, whereas others have had recent readouts on their clinical trials and efficacy. The purpose of this review is to describe the therapeutic pathways currently being investigated and to provide an update on the clinical status of novel oral medications for the management of dry AMD. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:528-534.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"528-534"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigated Focal Laser of Macular Telangiectasia Type I (Adult-Onset Coats' Disease).","authors":"Francesca Amoroso, Alexandra Miere, Donato Colantuono, Alexandre Pedinielli, Salomon Yves Cohen, Eric Souied","doi":"10.3928/23258160-20240412-02","DOIUrl":"10.3928/23258160-20240412-02","url":null,"abstract":"<p><p>We aimed to evaluate the anatomical and functional outcome of selective photocoagulation of idiopathic macular telangiectasia type 1 by navigated focal laser (Navilas, OD-OS GmBH). Consecutive patients with idiopathic macular telangiectasia type 1 were included in the analysis. All patients were treated with navigated focal laser, planned on multimodal imaging. Seven eyes of seven patients were retrospectively analyzed. Navigated laser photocoagulation of idiopathic macular telangiectasia type 1 successfully occluded the microaneurysms, inducing regression of macular edema and exudation, significative improvement in best-corrected visual acuity at 3 (<i>P</i> = 0.035) and 6 months (<i>P</i> = 0.034) and a decrease in central macular thickness at 3 (<i>P</i> = 0.01) and 6 months (<i>P</i> = 0.01). Patients with idiopathic macular telangiectasia type 1 are ideal candidates for navigated laser treatment. Navigated focal treatment has been shown to be effective and safe in occluding aneurysmal dilations without any side effects. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:545-551.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"545-551"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and Clinical Outcomes of Eyes With Posterior Segment Intraocular Foreign Bodies Seen at a Tertiary Referral Center.","authors":"Puren Isik, Selcuk Sizmaz, Ebru Esen, Mustafa Aksoy, Burcu Cam, Nihal Demircan, Ferenc Kuhn, Hulya Binokay","doi":"10.3928/23258160-20240402-01","DOIUrl":"10.3928/23258160-20240402-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to identify the prognostic factors regarding the visual and anatomic outcomes of eyes with posterior segment intraocular foreign body (PS-IOFB).</p><p><strong>Patients and methods: </strong>The medical records of 95 patients who underwent pars plana vitrectomy and PS-IOFB removal between 2004 and 2021 were retrospectively reviewed. Data on anatomical and visual outcomes, as well as preoperative, intraoperative, and postoperative variables were statistically analyzed.</p><p><strong>Results: </strong>The mean age of the patients was 31.9 ± 12.3 years. The mean follow-up time was 21.9 ± 28.3 months. The median time interval from trauma to IOFB removal was 9 days. In univariate analysis, there was a positive correlation between initial visual acuity (VA) and final VA (<i>P</i> < 0.001). A higher ocular trauma score (OTS) was significantly associated with both anatomical and functional success (<i>P</i> < 0.001). Linear regression analysis showed that OTS was not superior to initial VA in predicting final VA (<i>r</i> = 0.625 vs <i>r</i> = -0.601). Anatomic and functional outcomes were not affected by the injury site, nature of PS-IOFB, or timing of PS-IOFB removal (<i>P</i> > 0.05 for all). Subretinal IOFB location, the need for silicone oil tamponade, and endophthalmitis (<i>P</i> = 0.005, <i>P</i> < 0.001, <i>P</i> = 0.044, respectively) were risk factors for poor visual outcome.</p><p><strong>Conclusions: </strong>The initial VA, the extent of the initial ocular damage, and the presence of endophthalmitis are important prognostic factors for functional success. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:434-442.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"434-442"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pars Plana Vitrectomy With and Without Supplemental Scleral Buckle for the Repair of Rhegmatogenous Detachment Due to Inferior Retinal Breaks: A Systematic Review.","authors":"Eleanor R Lena, Nikhil S Patil, Marko M Popovic, Arshia Eshtiaghi, Arjan S Dhoot, Rajeev H Muni, Peter J Kertes","doi":"10.3928/23258160-20240801-02","DOIUrl":"https://doi.org/10.3928/23258160-20240801-02","url":null,"abstract":"<p><p>In this systematic review, the efficacy of scleral buckle (SB) with pars plana vitrectomy (PPV) was compared to PPV alone in eyes with rhegmatogenous retinal detachment (RRD) due to inferior retinal breaks (IRB). Measured outcomes included final best-corrected visual acuity (BCVA), anatomic success, and complication rates in randomized controlled trials and observational studies from 2000 to 2022. Among four studies (696 eyes), three studies demonstrated no significant difference between PPV and PPV/SB for final BCVA, whereas one study reported better BCVA with added SB. PPV/SB yielded comparable single-surgery anatomical success (SSAS) and final anatomical success (FAS) in three studies relative to PPV alone (<i>P</i> < 0.05); however, one study reported better SSAS with added SB. Stratifying by lens status revealed a SSAS benefit with PPV/SB in phakic eyes (<i>P</i> = 0.046). No significant difference was seen in complication rates. In conclusion, PPV and PPV/SB were associated with similar functional outcomes and risk profile, whereas SSAS may be improved with PPV/SB in phakic eyes with RRD due to IRB. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}