Michael Y Zhao, Lauren C Kiryakoza, Landon J Rohowetz, Harry W Flynn
{"title":"Optic Pit Maculopathy Managed With Observation: Serial Optical Coherence Tomography Imaging of Fluctuating Macular Fluid.","authors":"Michael Y Zhao, Lauren C Kiryakoza, Landon J Rohowetz, Harry W Flynn","doi":"10.3928/23258160-20250326-01","DOIUrl":"10.3928/23258160-20250326-01","url":null,"abstract":"<p><p>Observation with optical coherence tomography (OCT) is a reasonable management approach for optic pit maculopathy presenting with macular fluid. We describe two patients with optic pit maculopathy who exhibited preserved vision and fluctuating macular fluid managed with serial OCTs. A 49-year-old woman presented with blurred vision in the left eye. Best-corrected visual acuity (BCVA) was 20/40 in the left eye. Examination revealed an inferotemporal gray depression in the optic disc; OCT demonstrated submacular fluid. Serial OCTs over 19 years showed fluctuating fluid with stable vision. BCVA was 20/30 at last follow-up. A 62-year-old man presented with a central scotoma in the left eye. BCVA was 20/40 in the left eye. Examination showed an inferotemporal gray-white depression in the optic disc, and OCT revealed submacular fluid. Serial OCTs over 6 years demonstrated fluctuating fluid with preserved vision. BCVA was 20/50 at last follow-up. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;55:374-377.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"374-377"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tiago N O Rassi, William W Binotti, Eduardo Mund Carreirao Danielli, Sacha Pereira Fernandes, Daniela Cristina Schroff Machado, Dillan Cunha Amaral, Eduardo A Novais, Ricardo Noguera Louzada, Fernando Marcondes Penha, Mauricio Maia, Jay S Duker
{"title":"Comparison of Multiple Techniques for Measuring Geographic Atrophy: A Systematic Review and Network Meta-Analysis.","authors":"Tiago N O Rassi, William W Binotti, Eduardo Mund Carreirao Danielli, Sacha Pereira Fernandes, Daniela Cristina Schroff Machado, Dillan Cunha Amaral, Eduardo A Novais, Ricardo Noguera Louzada, Fernando Marcondes Penha, Mauricio Maia, Jay S Duker","doi":"10.3928/23258160-20250214-03","DOIUrl":"10.3928/23258160-20250214-03","url":null,"abstract":"<p><p>This study compared techniques for measuring geographic atrophy (GA) against the standard autofluorescence blue (AF-Blue). The design was a Bayesian network meta-analysis. PubMed, Scopus, and Cochrane were searched for studies comparing GA imaging techniques. AF-Blue, autofluorescence green (AF-Green), autofluorescence infrared (AF-IR), near-infrared reflectance (NIR), multicolor autofluorescence AF (MC-AF), optical coherence tomography fundus image (OFI), en face sub-retinal pigment epithelium (SubRPE) slab, OCT angiography (OCTA), color fundus photography (CFP), and fluorescein angiography (FA) were included. A ratio of means (ROM) meta-analysis using a threshold based on an established minimally important difference was performed. (Pros-pero ID: CRD42023476459.) Included were 2,001 eyes from 18 studies and no significant differences among measurement techniques was found. The ROM showed that CFP, OCTA, SubRPE slab, OFI, and IR reflectance agreed well with AF-Blue. However, AF-Green, FA, and MC underestimated GA, and AF-IR overestimated it. It appears that there is a fair agreement between AF-Blue and current techniques for measuring GA. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:364-370.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"361-367"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth C Fan, Calvin W Wong, Braden A Nichols, Roa Sadat, Patrick C Staropoli, Troy C Becker, William A Pearce, Effie Z Rahman, Robert I Blem, David M Brown, Charles C Wykoff, Hasenin Al-Khersan
{"title":"Genotypic and Phenotypic Characterization of <i>Hexokinase 1</i> p.Glu847Lys Variant Causing Autosomal Dominant Pericentral Retinitis Pigmentosa.","authors":"Kenneth C Fan, Calvin W Wong, Braden A Nichols, Roa Sadat, Patrick C Staropoli, Troy C Becker, William A Pearce, Effie Z Rahman, Robert I Blem, David M Brown, Charles C Wykoff, Hasenin Al-Khersan","doi":"10.3928/23258160-20250214-02","DOIUrl":"10.3928/23258160-20250214-02","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to clinically and molecularly characterize the largest cohort of patients with HK1 associated retinal disease. <i>Hexokinase 1</i> (HK1) variants have been reported to cause retinitis pigmentosa (RP), but a clearly defined genotype-phenotype correlation has not been well established.</p><p><strong>Patients and methods: </strong>A retrospective, consecutive, single-center case series was performed on patients with molecularly confirmed HK1-associated disease. Patients between 2016 and 2024 were included.</p><p><strong>Results: </strong>Sixty eyes from 30 patients were assessed. Thirty patients of 22 unrelated families were included. The median age at presentation was 53.5 years old, and the median age of disease symptom onset was 36 years old. The p.Glu847Lys variant was exhibited by 97% of the patients. Median best-recorded visual acuity was 20/28. Pericentral RP was the predominant phenotype (90% of patients).</p><p><strong>Conclusion: </strong>HK1 p.Glu847Lys variant was found to be associated with a less severe phenotype of autosomal dominant retinitis pigmentosa (adRP) as compared to other forms of adRP based on clinical presentation and electrophysiology. Future studies are necessary to better understand the genotypephenotype relationship and explore therapeutic options. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:328-334.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"328-334"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lin Ni, Carolina Carvalho Soares Valentim, Priya Shukla, Rishi P Singh, Katherine E Talcott
{"title":"Prediction of Postoperative Macular Hole Status by Automated Preoperative Retinal OCT Analysis: A Narrative Review.","authors":"Lin Ni, Carolina Carvalho Soares Valentim, Priya Shukla, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20250217-03","DOIUrl":"10.3928/23258160-20250217-03","url":null,"abstract":"<p><p>Optical coherence tomography (OCT) is a non-invasive imaging modality essential for macular hole (MH) management. Artificial intelligence (AI) algorithms could be applied to OCT to garner insights for MH prognosis and outcomes. The objective was to review literature assessing automated image analysis algorithms in predicting postoperative outcomes for MH patients based on OCT images. A narrative search of all available published studies in peer-reviewed journals was conducted up to June 2023 following PRISMA guidelines. Three hundred sixty-eight publications underwent screening, with 14 selected for full-text review and seven determined as relevant. In MH status prediction, AI models achieved an area under the curve (AUC) of 83.6% to 98.4%. For postoperative visual acuity prediction, algorithm performance ranged from AUCs of 57% to 85%. In conclusion, novel AI algorithms were found to be predictive for postoperative MH status and postoperative visual acuity. More research in larger populations should be conducted to gauge the value of these novel algorithms in a real-world setting. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:372-377.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"355-360"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment.","authors":"Abdallah Safwat, Mohamed Abdullah, Ahmed Shawkat Abdelhalim, Rabei Hassanien, Khaled Mourad, Mohamed Tarek Moustafa","doi":"10.3928/23258160-20250127-03","DOIUrl":"10.3928/23258160-20250127-03","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated the use of a dual-delivery methotrexate (MTX) strategy for diabetic tractional retinal detachment (TRD). Diabetic retinopathy (DR) is a leading cause of blindness. Inflammation plays a key role in TRD, and MTX has anti-inflammatory properties.</p><p><strong>Patients and methods: </strong>This is a pilot study that included 60 patients with TRD. They were block randomized to either MTX with pars plana vitrectomy (PPV) (<i>n</i> = 30) or PPV alone (control, <i>n</i> = 30). MTX was added to the irrigation fluid during surgery and an intra-silicone injection at the end. One month after silicone oil removal, visual acuity (VA), multifocal electroretinography (mfERG), and spectral-domain optical coherence tomography (SD-OCT) were assessed.</p><p><strong>Results: </strong>One month after silicone oil removal, VA and mfERG were significantly better with a lower prevalence of epiretinal membranes, disorganization of retinal inner layers, and cystic macular changes by SD-OCT in the MTX group.</p><p><strong>Conclusion: </strong>This study found that dual-delivery MTX during PPV is a promising strategy to improve functional and anatomical results in diabetic TRD. <b><i>[Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:298-305.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"298-305"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Free and Mobile Primary Cyst of the Iris Pigment Epithelium.","authors":"Eleonora Beatriz Lavaque","doi":"10.3928/23258160-20250109-01","DOIUrl":"10.3928/23258160-20250109-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"318"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott
{"title":"Legislative Changes on Opioid Prescriptions for Ocular Procedures in a United States Cohort.","authors":"Paul T Singh, Jacqueline K Shaia, Jacob James Rich, David Zhang, Rishi P Singh, Katherine E Talcott","doi":"10.3928/23258160-20250127-04","DOIUrl":"10.3928/23258160-20250127-04","url":null,"abstract":"<p><p>This ecological study examines the prevalence of postoperative opioid prescriptions among ophthalmic surgical patients during the implementation of four opioid policy interventions in Ohio. Changes in ophthalmic prescribing among 53 health care systems throughout the United States are compared to a population from the MetroHealth System in Cuyahoga County, Ohio. Opioid prescription prevalence spiked among all populations amid Ohio's \"pill mill\" and mandatory registration policies and then consistently decreased during the state's mandatory reporting and number-of-day restrictions. Black, Hispanic, and male subgroups across the country were more likely to receive opioids relative to other subgroups during most policy periods, but their rates were likely driven by trauma-related procedures. Prescribing fluctuations among ophthalmologists in the MetroHealth System generally matched national trends and did not correlate with prescribing trends among other specialties in Ohio. Consistent with previous research, opioid prescribing in ophthalmology remains low compared to other specialties throughout the country. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:312-315.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 5","pages":"312-315"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of Neovascularization Arising From an Arteriovenous Shunt in Proliferative Diabetic Retinopathy Using Ultra-Widefield Swept-Source OCT-A.","authors":"Selin Gumustop, Xinyi Ding, John B Miller","doi":"10.3928/23258160-20241201-01","DOIUrl":"10.3928/23258160-20241201-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"316-317"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raed Alnutaifi, Waleed W Khayyat, Faisal S AlQahtani
{"title":"Gore-Tex Suture-Associated Endophthalmitis in a Young Patient.","authors":"Raed Alnutaifi, Waleed W Khayyat, Faisal S AlQahtani","doi":"10.3928/23258160-20250124-02","DOIUrl":"10.3928/23258160-20250124-02","url":null,"abstract":"<p><p>Gore-Tex sutures are commonly used for scleral-fixated intraocular lenses (SFIOL) due to their high tensile strength and lower risk of breakage. However, complications such as suture erosion and infection remain a concern. This report presents a case of Gore-Tex suture-associated endophthalmitis in a young patient. A 21-year-old man with a history of penetrating eye injury and subsequent aphakia in the left eye underwent SFIOL surgery using Gore-Tex sutures, with a resultant best-corrected visual acuity (BCVA) of 20/30. Eighteen months later, he presented with sudden pain and an exposed suture. He was initially managed with topical antibiotics under observation. However, as signs of endophthalmitis developed, he was managed with an intravitreal antibiotic injection followed by pars plana vitrectomy with intraocular lens explantation. Culture of the vitreous sample identified <i>Haemophilus influenzae</i>. The patient gradually recovered, achieving a final BCVA of 20/125. This case underscores the importance of vigilant postoperative monitoring and timely intervention in managing suture-related complications. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:306-308.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"306-308"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}