Meghana Chalasani, Jonathan C Markle, Priya Shukla, Rula A Hajj-Ali, Katherine E Talcott, Rishi P Singh
{"title":"Relationship Between Janus Kinase Inhibitor Use and Development of Retinal Vein Occlusion.","authors":"Meghana Chalasani, Jonathan C Markle, Priya Shukla, Rula A Hajj-Ali, Katherine E Talcott, Rishi P Singh","doi":"10.3928/23258160-20240908-01","DOIUrl":"10.3928/23258160-20240908-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Janus kinase (Jak) inhibitors may have increased risk of thromboembolism compared to tumor necrosis factor (TNF) inhibitors. This study investigates the association between Jak inhibitor use and retinal vein occlusion.</p><p><strong>Patients and methods: </strong>This retrospective, non-randomized cohort study used a federated health research network. Propensity-score matched risk ratios with 95% CI were calculated for central and branch retinal vein occlusion (CRVO, BRVO) in patients with immune-mediated inflammatory diseases (IMIDs) treated with Jak inhibitors versus TNF inhibitors.</p><p><strong>Results: </strong>Jak and TNF inhibitor cohorts each had 5,249 patients. Risk ratio for CRVO with Jak inhibitors (<i>n</i> = 11) versus TNF inhibitors (<i>n</i> = 18) was 0.61 [CI (0.29,1.29)]. Risk ratio for BRVO with Jak inhibitors (<i>n</i> = 17) compared to TNF inhibitors (<i>n</i> = 19) was 0.89 [CI (0.47,1.72)].</p><p><strong>Conclusion: </strong>This study did not find evidence of increased risk of RVO with the use of Jak inhibitors compared to TNF inhibitors among patients with IMIDs, contributing to literature on Jak inhibitor safety. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:72-78.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"72-78"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaylie Chen, Stephanie B Engelhard, Sarah H Van Tassel, Kyle D Kovacs
{"title":"Adverse Events Associated With Yamane Scleral Fixation of Intraocular Lens as Reported to the FDA MAUDE Database.","authors":"Kaylie Chen, Stephanie B Engelhard, Sarah H Van Tassel, Kyle D Kovacs","doi":"10.3928/23258160-20241101-03","DOIUrl":"10.3928/23258160-20241101-03","url":null,"abstract":"<p><p>To identify real-world complications involving flanged scleral tunnel fixation of Zeiss CT Lucia 602 intraocular lenses, the Food and Drug Administration Manufacturer and User Facility Device Experience (FDA MAUDE) was searched by Manufacturer field for Zeiss with the terms \"Yamane\" and \"scleral fixated\". Reports containing these terms were reviewed to confirm technique and categorize adverse events. The search yielded 178 confirmed reports of lens malfunctions for CT Lucia 602 between 2013 to 2024, with 95% of reports in the last 3 years. The most common complication was lens tilt (94 reports), followed by breakage (53) comprised of haptic-optic disinsertion (31) and haptic breakage (22). Intraoperatively, 118 (66.3%) complications occurred, and 60 (33.7%) occurred postoperatively. Temporal analysis revealed that the number of reports to MAUDE has shown a ten-fold annual increase since 2020. Reports suggest haptic breakage is a noteworthy malfunction for CT Lucia 602 lenses. The occurrence of intraoperative breakage and lens tilt may be higher than previously expected in real-world settings. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:123-125.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"123-125"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Marcelo Zas, Se Joon Woo, Clara Vazquez-Alfageme, Sharat Hegde, Kourous A Rezaei
{"title":"RWC Update: Optic Pit Maculopathy and Lyophilized Amniotic Membrane; How Do You Choose One Biosimilar Over the Others?; Diffuse Unilateral Subacute Neuroretinitis.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Marcelo Zas, Se Joon Woo, Clara Vazquez-Alfageme, Sharat Hegde, Kourous A Rezaei","doi":"10.3928/23258160-20250122-01","DOIUrl":"https://doi.org/10.3928/23258160-20250122-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"56 2","pages":"68-71"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard N Sather, Jade Y Moon, Francesco Romano, Kate Overbey, Hanna Choi, Inês M D C Laíns, Deeba Husain, Nimesh A Patel, John B Miller
{"title":"The Ergonomic Evaluation of Attendings and Trainees Across the Vitreoretinal Service as Measured by a Wearable Device.","authors":"Richard N Sather, Jade Y Moon, Francesco Romano, Kate Overbey, Hanna Choi, Inês M D C Laíns, Deeba Husain, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240906-01","DOIUrl":"10.3928/23258160-20240906-01","url":null,"abstract":"<p><strong>Background and objective: </strong>A cross-sectional prospective study to examine ergonomic differences in vitreoretinal settings: surgery, clinic, and dedicated procedure clinic.</p><p><strong>Patients and methods: </strong>Three vitreoretinal surgeons, three fellows, and one resident at a tertiary eye care facility. Participants wore an Upright Go 2 posture device and posture was recorded in each setting between July 1 to August 31, 2023.</p><p><strong>Results: </strong>Time in upright and poor postures was tracked. Significant differences were found in postural score for attendings between work settings (<i>P</i> < 0.01). Trainees showed no significant difference between settings. Poor posture in surgery was linked to microscope use and scleral buckle placement; in the clinic, it was associated with pan-retinal photocoagulation and injection minutes; in procedure clinic, it was ophthalmologist-dependent and those performing injections.</p><p><strong>Conclusions: </strong>Ergonomic considerations are crucial in vitreoretinal practice. Attendings and trainees should focus on posture in surgery and clinic settings to enhance career longevity. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:80-85.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"80-85"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macular Hole Surgery Without Postoperative Head Positioning: A Technique of Viscoelastic Device Injection Covering the Temporal Internal Limiting Membrane Flap.","authors":"Oğuzhan Saygılı, Sevim Ayça Seyyar","doi":"10.3928/23258160-20241015-01","DOIUrl":"10.3928/23258160-20241015-01","url":null,"abstract":"<p><p>The purpose of this study was to describe a technique in which a dispersive viscoelastic device is injected under air onto and around the inverted temporal internal limiting membrane (ILM) flap to close the macular hole (MH) without the need for any postoperative head positioning. A temporal ILM flap was created in the patients. The created ILM flap was inverted over the MH using perfluorocarbon (PCFL) injection. Then, after a fluid-air exchange, careful PFCL-air exchange was performed. Under air, two to three disc diameters of viscoelastic device were injected over and around the inverted flap. No postoperative head position was recommended to any patient. In all 16 eyes treated with this approach, the MH was closed with a single procedure, and there were no intraoperative or postoperative complications. Injection of a viscoelastic device over the inverted ILM flap in MH surgery is an innovative approach that does not require any special postoperative head positioning. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:120-122.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"120-122"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiz Roisman, João Gabriel Alexander, Pedro Leite C Franco, Lisangela N Morimoto, Maurício Maia
{"title":"A Bullous Variant of Central Serous Chorioretinopathy Treated With Sclerotomy.","authors":"Luiz Roisman, João Gabriel Alexander, Pedro Leite C Franco, Lisangela N Morimoto, Maurício Maia","doi":"10.3928/23258160-20241101-01","DOIUrl":"10.3928/23258160-20241101-01","url":null,"abstract":"<p><p>Bullous serous central chorioretinopathy (bCSCR) is an atypical form of CSCR characterized by large serous detachment. This variant presents significant diagnostic challenges, and optimal treatment strategies are not well defined. This report presents a case of a 31-year-old man with bCSRC treated with scleral thinning surgery in four quadrants with scleral windows created in the two inferior quadrants. The etiology, pathogenesis, and optimal treatment of bCSCR are not fully understood. Various therapeutic options, including photocoagulation and photodynamic therapy, have been employed with varying degrees of success. We describe a case of scleral thinning (sclerectomy) with two inferior sclerotomies without subretinal drainage, which resulted in a positive outcome. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:116-119.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"116-119"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Feldman, Jesse Basra, Anjola Lawani, Yunyi Ren, Machelle Wilson, Ala Moshiri, Susanna S Park, Glenn Yiu
{"title":"Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial.","authors":"Samuel Feldman, Jesse Basra, Anjola Lawani, Yunyi Ren, Machelle Wilson, Ala Moshiri, Susanna S Park, Glenn Yiu","doi":"10.3928/23258160-20240924-03","DOIUrl":"10.3928/23258160-20240924-03","url":null,"abstract":"<p><strong>Background and objective: </strong>To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA).</p><p><strong>Patients and methods: </strong>Prospective, single-masked, sham-controlled trial in 27 eyes of 19 adult patients with treatment-naïve, center-involved DME, and VA of 20/25 or better. Measures included best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), contrast sensitivity (CS), average threshold on microperimetry, and central subfield thickness (CST). The primary outcome measure was median time to vision loss of 10 letters at any visit or 5 to 9 letters at two consecutive visits ≤ 28 days apart.</p><p><strong>Results: </strong>Eight eyes met vision loss criteria during the 2-year study, with similar proportions for SML (<i>n</i> = 5) and sham (<i>n</i> = 3). Median time to vision loss was 5 months for both groups. At 6 months, there were no statistical differences in BCVA, LLVA, CS, microperimetry threshold, and CST between SML and sham arms (<i>P</i> > 0.05 in all measures).</p><p><strong>Conclusion: </strong>In eyes with center-involved DME and good VA, SML did not prevent or delay the vision loss threshold for initiating anti-VEGF therapy. However, these results may be affected by a high rate of early participant dropout from the study. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:86-93.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"86-93"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"American Football-associated Whiplash Maculopathy Presenting With Bilateral Bacillary Detachments: Case Report and Review of Literature.","authors":"Adrienne Delaney, Rachel A Downes, Danny A Mammo","doi":"10.3928/23258160-20240927-01","DOIUrl":"10.3928/23258160-20240927-01","url":null,"abstract":"<p><p>Ocular trauma is a rare cause of bacillary layer detachments (BALAD). A case report was evaluated and a literature review was performed. A 15-year-old boy presented with bilateral scotomas after a routine American football tackle and was found to have bilateral BALADs. Inflammatory and infectious causes of BALAD were excluded, and he was diagnosed with whiplash maculopathy. Without intervention, the patient's visual acuity and macular anatomy rapidly improved. Novel indocyanine green angiography findings of this condition are reported. Bacillary detachments resulting from whiplash injuries generally resolve spontaneously with good visual outcomes. Even when other sequelae of trauma are not obvious, the presence of BALAD should prompt a targeted history around recent trauma including sports-associated whiplash injuries. Patients with thicker choroids may be at increased risk of posterior segment sequalae from whiplash injury and choroidal status should be commented on in future reports. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:113-115.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"113-115"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}