Kaersti L Rickels, Marco Ji, Ahmed Shakarchi, Michalis Georgiou, Sami H Uwaydat, Ahmed B Sallam
{"title":"Fractal Changes of the Retinal Microvasculature in Birdshot Chorioretinopathy.","authors":"Kaersti L Rickels, Marco Ji, Ahmed Shakarchi, Michalis Georgiou, Sami H Uwaydat, Ahmed B Sallam","doi":"10.3928/23258160-20240528-02","DOIUrl":"10.3928/23258160-20240528-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal vascular disorders are associated with lower fractal dimension (FD). We analyzed FD in birdshot chorioretinopathy (BSCR).</p><p><strong>Patients and methods: </strong>This was a retrospective cohort study. We performed optical coherence tomography angiography (OCTA) and analyzed FD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using ImageJ. For each vascular layer, we analyzed the presence of BSCR, subjects' age, sex, and presence of diabetes mellitus to determine which may predict lower FD.</p><p><strong>Results: </strong>We compared 28 eyes (14 patients) with BSCR to 34 control eyes (17 patients). Mean FD of BSCR was lower in SCP (1.584 [± 0.126] vs 1.706 [± 0.118], <i>P</i> < 0.001), DCP (1.637 [± 0.134] vs 1.780 [± 0.096], <i>P</i> < 0.001), and CC (1.884 [± 0.063] vs 1.917 [± 0.047], <i>P</i> = 0.036). FD of SCP was lower per increasing year (0.005 [<i>P</i> = 0.014]). Male patients had lower FD-DCP (0.101 [<i>P</i> = 0.043]).</p><p><strong>Conclusion: </strong>In BSCR, fractal analysis showed significant involvement of the SCP, DCP, and to a lesser extent the CC. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:646-651.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"646-651"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thrombotic Microangiopathy Following Hematopoietic Stem Cell Transplantation: A Case of Purtscher-like Retinopathy.","authors":"Okyanus Bulut, Gulcihan Ozek, Filiz Afrashi, Cumali Degirmenci","doi":"10.3928/23258160-20240528-05","DOIUrl":"10.3928/23258160-20240528-05","url":null,"abstract":"<p><p>Purtscher-like retinopathy (PLR) is a rare entity related with retinal ischemia due to endothelial dysfunction and embolization. We present a case of a 17-year-old patient who presented with PLR associated with transplant-associated thrombotic microangiopathy. Visual acuity was finger counting at 1 meter in both eyes. Fundoscopy demonstrated peripapillary cotton-wool spots and hypopigmentation in the middle peripheral retina. Both eyes showed signs of macular edema with intraretinal hemorrhages. Optical coherence tomography and fundus fluorescence angiography was performed to support the diagnosis. After systemic treatments and panretinal photocoagulation, the patient's vision improved and the macular edema resolved. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:603-606.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"603-606"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michelle Gantois, Camila V Ventura, Ricardo Miguel Japiassú, Letícia Guerra Barretto Conrado, Renata Pontes Duarte, Lyvia Madeira De Barros Nunes
{"title":"Strawberry Retina: Hyperreflective Tomographic Findings Identified on the Interface of the Retina and 5700-Centistoke Silicone Oil.","authors":"Michelle Gantois, Camila V Ventura, Ricardo Miguel Japiassú, Letícia Guerra Barretto Conrado, Renata Pontes Duarte, Lyvia Madeira De Barros Nunes","doi":"10.3928/23258160-20240524-02","DOIUrl":"10.3928/23258160-20240524-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"617-619"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Casey Zhang, Elias Kahan, Tedi Begaj, Scott M Friedman, Avnish Deobhakta, Michael Heyang, Liangbo Linus Shen, Darius Moshfeghi, Karen Wai, Ravi Parikh
{"title":"Geographic Atrophy Natural History Versus Treatment: Time to Fovea.","authors":"Casey Zhang, Elias Kahan, Tedi Begaj, Scott M Friedman, Avnish Deobhakta, Michael Heyang, Liangbo Linus Shen, Darius Moshfeghi, Karen Wai, Ravi Parikh","doi":"10.3928/23258160-20240418-01","DOIUrl":"10.3928/23258160-20240418-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The Food and Drug Administration recently approved treatments of geographic atrophy (GA). Our study aims to quantify the time for a lesion to reach the central fovea based on reduction of GA growth rates from therapeutics compared to the natural history.</p><p><strong>Patients and methods: </strong>A previously published study calculates local border expansion rate of GA lesions at varying retinal eccentricities. In this study, we use these rates to model GA expansion toward the fovea and the effects of treatments that reduce growth in GA area by 15% to 45% on lesions of varying sizes with posterior margin 250, 500, 750, 1000, 1250, 1500, and 3000 µm from the fovea.</p><p><strong>Results: </strong>Lesions with an area 8 mm<sup>2</sup> and posterior edge 500 µm from the fovea will reach the fovea in 5.08 years with no treatment, but the same lesions will reach the fovea in 5.85, 6.52, 7.36, and 8.46 years with a treatment that reduces growth in GA area by 15%, 25%, 35%, and 45%, respectively.</p><p><strong>Conclusions: </strong>Distance of the posterior edge of the lesion was the primary factor in GA growth toward the fovea, and lesion size only minimally affects growth rates of GA. Based on the efficacy of current and future therapeutics and distance of GA to the fovea, our study provides the marginal time benefit of treatment to guide patients and clinicians, placing both the natural history of GA and the effects of current and future treatments into clinical context. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:576-585.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"576-585"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperreflective Ganglion Cell Layer Band in Gyrate Atrophy.","authors":"Ahana Sen, Janhavi Desai, Survee Sharma, Sanatombi Thounaojam, Urvashi Kala, Bristi Majumdar, Amrita Pradhan, Ruchira Chowdhury, Surabhi Chattree, Kumar Saurabh, Rupak Roy","doi":"10.3928/23258160-20240528-04","DOIUrl":"10.3928/23258160-20240528-04","url":null,"abstract":"<p><p>We have described the hyperreflective ganglion cell layer band (HGCB) in a series of cases of gyrate atrophy. Clinical fundus examination and multimodal imaging which included optical coherence tomography (OCT) was done in all cases. Four patients (one male, three female) were studied. In all four cases, a hyperreflective band was noted in the ganglion cell layer. In three patients, the band was continuous, and in one patient, the band was patchy. To conclude, HGCB is a novel OCT sign in gyrate atrophy and can be valuable in prognostication of disease. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:598-602.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"598-602"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rasadokht Forati, Sandra Hoyek, Francesco Romano, John B Miller, Nimesh A Patel
{"title":"Full-Thickness Macular Hole in a Pediatric Patient With Normal Vision.","authors":"Rasadokht Forati, Sandra Hoyek, Francesco Romano, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20240621-02","DOIUrl":"10.3928/23258160-20240621-02","url":null,"abstract":"<p><p>A 17-year-old boy presented with a full-thickness macular hole, with 20/20 vision with eccentric fixation in the left eye. Examination of the left eye showed a large macular hole with a base diameter measuring 1,680 μm and temporal macular and mid-peripheral retinal atrophy on ultra-high-definition optical coherence tomography (OCT) scans. Microperimetry showed eccentric fixation with good nasal sensitivity. A 12 x 12-mm extended-field swept-source OCT angiogram showed flow loss in the temporal macula, with slight reduction noted in the choriocapillaris. Given excellent visual acuity, good tolerance by the patient, and large atrophic hole, the decision was made for observation rather than surgery. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:607-612.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"607-612"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew M O'Riordan, Claire Behan, Fionn O'Leary, Natalie Hudson, Colin P Doherty, Mark T Cahill, Matthew Campbell
{"title":"Multimodal Analysis of the Retinal Manifestations of Tuberous Sclerosis Complex: A Case Series.","authors":"Matthew M O'Riordan, Claire Behan, Fionn O'Leary, Natalie Hudson, Colin P Doherty, Mark T Cahill, Matthew Campbell","doi":"10.3928/23258160-20240523-03","DOIUrl":"10.3928/23258160-20240523-03","url":null,"abstract":"<p><strong>Background and objective: </strong>We used a multi-modal imaging approach including fundus fluorescein angiography (FFA) to assess the retinal lesions in tuberous sclerosis complex (TSC) and evaluate their correlation with intracranial tuber burden on magnetic resonance imaging (MRI).</p><p><strong>Patients and methods: </strong>Participants with TSC underwent bilateral fundus photography, optical coherence tomography (OCT), infrared (IR) imaging, and FFA. Participants' most recent MRI brain scans were analyzed to determine intracranial tuber load.</p><p><strong>Results: </strong>Nine participants were included. OCT identified all retinal astrocytic hamartoma (RAH) lesions, IR identified 75%, fundus photography identified 63%, and FFA detected just 57%. On FFA, 20% of flat-type hamartomas and all multi-nodular and transitional types were hyperfluorescent. There were significant positive correlations between the quantities of intracranial tubers and all TSC-retinal lesions (<i>r</i> = 0.8, <i>P</i> < 0.01) and all RAH lesions (<i>r</i> = 0.8, <i>P</i> = 0.01).</p><p><strong>Conclusions: </strong>A multimodal imaging-based approach with fundal photography, IR imaging, and OCT should be used to assess the retina in TSC as it may indicate the intracranial tuber burden. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:568-574.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"568-574"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Surgical Approach for Managing Refractory Macular Holes Using the Human Amniotic Membrane Patch Technique.","authors":"Yen-Ting Chen, Chi-Chun Lai, Yih-Shiou Hwang, Kuan-Jen Chen, Wei-Chi Wu","doi":"10.3928/23258160-20240411-04","DOIUrl":"10.3928/23258160-20240411-04","url":null,"abstract":"<p><p>To introduce a novel surgical technique using the human amniotic membrane (hAM) patch technique to address refractory macular holes (MHs). After vitrectomy, the hAM patch was positioned on top of the MH with the chorion side facing downward. Viscoat (Alcon Laboratories) was applied on top of the hAM patch for better fixation. Fluid-air exchange was then performed and 20% SF6 or 10% C3F8 tamponade was administered after the surgery. Five patients with refractory MHs larger than 400 µm underwent the hAM patch technique. After a minimum 2-year follow-up, results showed 100% closure of MHs, 80% improvement in visual acuity, and a notable enhancement in best-corrected logMAR visual acuity from 0.98 to 0.72 (<i>P</i> = 0.039). Dislocation of hAM patch occurred among 3 out of 5 patients (60%). The hAM patch technique appears to be a promising approach for addressing refractory MHs. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:613-616.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"613-616"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blanche L Kuo, Justin C Muste, Matthew W Russell, Anna K Wu, Carolina C S Valentim, Rishi P Singh
{"title":"Evidence for the Hepato-Retinal Axis: A Systematic Review.","authors":"Blanche L Kuo, Justin C Muste, Matthew W Russell, Anna K Wu, Carolina C S Valentim, Rishi P Singh","doi":"10.3928/23258160-20240524-01","DOIUrl":"10.3928/23258160-20240524-01","url":null,"abstract":"<p><strong>Background and objective: </strong>Liver health has been reported to be associated with retinal pathology in various ways. These include deposition of retino-toxins, neovascular drive, and disruption of the blood-retina barrier. Extrahepatic synthesis of implicated molecules and hemodynamic changes in liver dysfunction are also considered. The objective was to review the current evidence for and against a hepato-retinal axis that may guide further areas of preclinical and clinical investigation.</p><p><strong>Methods: </strong>This was a systematic review. PubMed and Cochrane were queried for English language studies examining the connection between hepatic dysfunction and retinal pathology.</p><p><strong>Results: </strong>Fourteen studies were included and examined out of 604 candidate publications. The studies selected include preclinical studies as well as clinical case series and studies.</p><p><strong>Conclusions: </strong>Several liver pathologies may be linked to retinal pathology as mediated by hepatically synthesized molecules. The hepato-retinal axis may be present and further, targeted studies of the axis are warranted. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:587-596.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"587-596"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raziyeh Mahmoudzadeh, Shreya Swaminathan, Mirataollah Salabati, Taku Wakabayashi, Dillan Patel, Sonia Mehta, Ajay E Kuriyan, M Ali Khan, Michael A Klufas, Sunir J Garg, Omesh P Gupta, Carl D Regillo, Yoshihiro Yonekawa, Michael N Cohen
{"title":"Retinal Displacement Following Rhegmatogenous Retinal Detachment Repair.","authors":"Raziyeh Mahmoudzadeh, Shreya Swaminathan, Mirataollah Salabati, Taku Wakabayashi, Dillan Patel, Sonia Mehta, Ajay E Kuriyan, M Ali Khan, Michael A Klufas, Sunir J Garg, Omesh P Gupta, Carl D Regillo, Yoshihiro Yonekawa, Michael N Cohen","doi":"10.3928/23258160-20240528-01","DOIUrl":"10.3928/23258160-20240528-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aimed to report retinal displacement incidence following rhegmatogenous retinal detachment (RRD) repair with pars plana vitrectomy (PPV), scleral buckle (SB), or combined SB/PPV.</p><p><strong>Patients and methods: </strong>A single-center, case series using Optos fundus autofluorescence (FAF) images was performed after RRD repair between April 2020 and February 2022. Retinal displacement was identified by imprinted retinal vessels on FAF imaging.</p><p><strong>Results: </strong>One hundred ninety-four eyes were included. Ninety-seven (50.0%) eyes underwent PPV, 46 (23.7%) underwent SB, and 51 (26.3%) underwent SB/PPV. A total of 25/194 eyes (12.9%) had retinal vessel imprinting on FAF imaging consistent with retinal displacement. The SB/PPV group (9/51, 17.6%) and the PPV group (15/97, 15.5%) had significantly higher displacement rates when compared to the SB group (1/46, 2.2%; <i>P</i> = 0.017, <i>P</i> = 0.021, respectively).</p><p><strong>Conclusions: </strong>Retinal displacement after RRD repair is more prevalent after PPV. There was a low rate of displacement with SB. Retinal displacement was not associated with a visual acuity difference. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:560-566.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"560-566"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}