Jila Noori, Christian Leal, Kai Ding, Vinay A Shah, Ronald M Kingsley
{"title":"Validity of Spectral-Domain Optical Coherence Tomography Angiography for Detection of Retinal Vasculitis.","authors":"Jila Noori, Christian Leal, Kai Ding, Vinay A Shah, Ronald M Kingsley","doi":"10.3928/23258160-20251125-03","DOIUrl":"10.3928/23258160-20251125-03","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to evaluate the validity and accuracy of spectral-domain optical coherence tomography angiography (SD-OCTA) in detecting small-vessel retinal vasculitis (RV) at the posterior pole.</p><p><strong>Patients and methods: </strong>In this prospective study, subjects with and without retinal vasculitis on fundus fluorescein angiography (FFA) were identified among the clinic population and imaged with 8 × 8-mm SDOCTA scans centered on the fovea. Retinal vasculitis was detected using a customized method based on increased perivascular retinal thickness on OCTA. Three reviewers evaluated the FFA and composite en-face scans on SD-OCTA. The method's accuracy was assessed by obtaining sensitivity, specificity, negative predictive value, and positive predictive values, together with 95% confidence intervals, where the gold standard was the consensus FFA result.</p><p><strong>Results: </strong>Eighteen eyes without RV and 34 eyes with RV were selected for evaluation. The consensus sensitivity and specificity were 88.2% (<i>P</i> < .0001) and 77.7% (<i>P</i> = .0184), respectively. Several distinct patterns were recognized on OCTA scans based on retina vessel staining, leakage, cystoid macular edema, and ischemia.</p><p><strong>Conclusions: </strong>SD-OCTA is a valid and accurate noninvasive imaging tool that detects small-vessel RV at the posterior pole using customized scans across a wide range of RV etiologies. Future studies combining wide-field images and en-face scans may demonstrate OCTA's usefulness in detecting and monitoring retinal vasculitis.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"160-167"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progressive Bilateral Retinal Pigment Epithelium Atrophy Associated With SBP-101 (Ivospemin) for Pancreatic Cancer: A Case Report.","authors":"Tatsiana Stalmashka, Rosa M Coco Martín","doi":"10.3928/23258160-20251201-01","DOIUrl":"10.3928/23258160-20251201-01","url":null,"abstract":"<p><p>This report presents a rare case of rapidly progressive retinal pigment epithelium (RPE) atrophy in a patient with no prior history of retinal disease, following treatment with the investigational drug SBP-101 (Ivospemin) for pancreatic adenocarcinoma. A 63-year-old male patient presented with complaints of bilateral vision loss, glare, and nyctalopia 2 months after completing a course of chemotherapy. He had been diagnosed with pancreatic adenocarcinoma with hepatic metastases and had participated in a 3-month clinical trial receiving nab-paclitaxel, gemcitabine, and SBP-101. Prior to and during the trial, the patient experienced no visual symptoms. However, at a 2-month follow-up visit, he exhibited RPE alterations, including progressive atrophy affecting the posterior pole. Ocular complications arising from the use of novel chemotherapeutic agents are often overlooked due to their relative infrequency and lack of life-threatening risk. However, careful monitoring of RPE changes in oncology patients is crucial, as the progression of such changes can be unpredictable.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"190-193"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lifu Luo, Jun Xiao, Zhongping Luo, Yanbo Liu, Cheng Wang
{"title":"Novel Management of a Vitreous Cyst Using Nd:YAG Ultra-Q Reflex Laser: A Case Report.","authors":"Lifu Luo, Jun Xiao, Zhongping Luo, Yanbo Liu, Cheng Wang","doi":"10.3928/23258160-20251015-01","DOIUrl":"10.3928/23258160-20251015-01","url":null,"abstract":"<p><p>This case report covers the novel use of an Nd:YAG Ultra-Q Reflex laser to treat a symptomatic vitreous cyst in a 47-year-old man. Following a single 0.3-mJ laser pulse applied to the cyst's superior pole, controlled fluid egress led to cyst collapse and inferior displacement without complications. The patient experienced immediate visual improvement, with the cyst remaining inactive in the inferior vitreous at 1-month follow-up and demonstrating no significant change in size when located in the anterior vitreous at 10 months. This laser cystotomy technique presents a safe, effective, and minimally invasive alternative to traditional management.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"198-200"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeynep Eylül Ercan, Bahadır Azizagaoglu, Imren Akkoyun, Gürsel Yılmaz
{"title":"Long-term Anatomical and Visual Success of Pneumatic Retinopexy in Sequential Bilateral Giant Retinal Tears: A 20-Year Follow-up Case Report.","authors":"Zeynep Eylül Ercan, Bahadır Azizagaoglu, Imren Akkoyun, Gürsel Yılmaz","doi":"10.3928/23258160-20260123-01","DOIUrl":"10.3928/23258160-20260123-01","url":null,"abstract":"<p><p>This case report presents a rare case of sequential bilateral giant retinal tears (GRTs) successfully managed with pneumatic retinopexy, highlighting the long-term anatomical and visual outcomes. A 43-year-old woman with a history of mild myopia and bilateral pseudophakia developed a superior temporal GRT in the left eye in 2005 and a similar tear in the right eye in 2010. Both eyes were treated with pneumatic retinopexy using intravitreal sulfur hexafluoride gas injection, followed by laser photocoagulation. The patient was monitored regularly for 20 years. Complete retinal reattachment was achieved in both eyes without the need for pars plana vitrectomy. Best-corrected visual acuity remained 20/20 bilaterally throughout the follow-up period. No recurrence or secondary complications were observed. Although pars plana vitrectomy is typically the preferred treatment for GRTs, this case demonstrates that, in carefully selected patients, pneumatic retinopexy can be a viable and durable alternative even in the context of bilateral GRTs. The 20-year follow-up underscores the long-term effectiveness and safety of this less invasive approach.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"194-197"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Callet, Raphael Lejoyeux, Margherita Barzilai, Kevin Varanda-Ramos, Catherine Vignal Clermont, Olivier Galatoire, Aurore Couturier
{"title":"Turning the Angle: Vertical Scans Improve Chorioretinal Fold Detection-Comparative Evaluation of B-scan Directions for Chorioretinal Folds in SD-OCT.","authors":"Marie Callet, Raphael Lejoyeux, Margherita Barzilai, Kevin Varanda-Ramos, Catherine Vignal Clermont, Olivier Galatoire, Aurore Couturier","doi":"10.3928/23258160-20251113-01","DOIUrl":"10.3928/23258160-20251113-01","url":null,"abstract":"<p><strong>Background and objective: </strong>This study investigated the impact of scan orientation on the detection of chorioretinal folds using spectral-domain optical coherence tomography (SD-OCT).</p><p><strong>Patients and methods: </strong>A total of 64 eyes with chorioretinal folds were included. The ability to identify folds was compared between horizontal and vertical B-scan acquisitions. Two independent observers evaluated the SD-OCT scans to determine the visibility of folds.</p><p><strong>Results: </strong>Vertical scan orientation revealed folds in 63 of 64 cases (98.4%), whereas horizontal scans identified folds in only 26 cases (40.6%).</p><p><strong>Conclusion: </strong>Our findings show that chorioretinal folds were more consistently and clearly identified in vertically oriented scans than in horizontal scans, suggesting that scan direction significantly influences the detection and evaluation of these lesions.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"174-177"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dmitrii S Maltsev, Alexei N Kulikov, Yana A Kalinicheva
{"title":"Possible Association Between Retinal Arterial Occlusions and Subretinal Drusenoid Deposits: A Missing Link.","authors":"Dmitrii S Maltsev, Alexei N Kulikov, Yana A Kalinicheva","doi":"10.3928/23258160-20251202-01","DOIUrl":"10.3928/23258160-20251202-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The aim of this study was to investigate the association between retinal artery occlusion (RAO), subretinal drusenoid deposits (SDD), and choroidal circulation.</p><p><strong>Patients and methods: </strong>Patients with RAO and healthy age-matched volunteers were included in this study. The presence of SDD, choriocapillaris perfusion area, and subfoveal choroidal thickness were analyzed using optical coherence tomography (OCT) and OCT angiography.</p><p><strong>Results: </strong>In total, 25 patients with RAO (14 women and 11 men, 71.5 ± 8.9 years) and 19 healthy individuals (10 women and 9 men, 69.0 ± 5.2 years) were included. SDD were found in seven RAO patients (28.0%), among whom four (18.2%) had no age-related macular degeneration. Patients with RAO had a statistically significantly lower choriocapillaris perfusion area and subfoveal choroidal thickness than healthy controls (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>RAO may have an association with the presence of SDD that agrees with common systemic risk factors and changes of posterior eye segment microcirculation for both conditions.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"168-173"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Arshad M Khanani, Mark Gillies, Fulya Yaylacıoğlu Tuncay, Daniela Rueda-Latorre, Gökçen Deniz, Şengül Özdek, Kourous A Rezaei
{"title":"RWC Update: Gene Therapy in Common Retinal Disorders: Hope, Hype, or Near-term Reality?; 1.4-mm Trophy; Persistent Fetal Vasculature with Tractional Retinal Detachment.","authors":"Ashish Sharma, Lihteh Wu, Steven Bloom, Paulo Stanga, Arshad M Khanani, Mark Gillies, Fulya Yaylacıoğlu Tuncay, Daniela Rueda-Latorre, Gökçen Deniz, Şengül Özdek, Kourous A Rezaei","doi":"10.3928/23258160-20260223-01","DOIUrl":"https://doi.org/10.3928/23258160-20260223-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"141-144"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akın Çakır, Emine B Akbaş Özyürek, Tahsin Uzundede
{"title":"Inner Collagenous Layer Detachment: A Novel Optical Coherence Tomography Sign in Avascular Serous Pigment Epithelial Detachment Secondary to Central Serous Chorioretinopathy.","authors":"Akın Çakır, Emine B Akbaş Özyürek, Tahsin Uzundede","doi":"10.3928/23258160-20260126-02","DOIUrl":"10.3928/23258160-20260126-02","url":null,"abstract":"<p><p>This case series describes a novel optical coherence tomography (OCT) finding in avascular serous pigment epithelial detachment (PED) secondary to central serous chorioretinopathy (CSC), and evaluates its multimodal imaging features and clinical relevance. Two patients with CSC demonstrated a well-demarcated, hyperreflective band extending between the retinal pigment epithelium and Bruch's membrane within the serous PED on macular OCT. Multimodal imaging, encompassing fluorescein angiography and OCT angiography, was employed to ascertain the absence of neovascularization, thereby substantiating the avascular nature of the lesion. The structure exhibited dynamic behavior, characterized by a regression with PED resolution and subsequent reappearance with recurrence. This OCT finding, termed inner collagenous layer detachment (ICLD), is indicative of a localized separation within Bruch's membrane. ICLD may serve as a novel imaging biomarker of PED activity in CSC, thereby offering insights into its underlying pathophysiology. Further studies are needed to determine its prevalence, specificity, and potential role in clinical management.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"186-189"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Patient Experience: 5% Povidone-Iodine vs 0.05% Aqueous Chlorhexidine.","authors":"Brandon Bates, Edward Wood, Philip Storey","doi":"10.3928/23258160-20260123-02","DOIUrl":"10.3928/23258160-20260123-02","url":null,"abstract":"<p><p>Aqueous chlorhexidine (aqCHX) is emerging as a safe and potentially gentler alternative to povidone-iodine (PI) for intravitreal injection anti-sepsis. In a single-center patient survey, we compared experiences with PI (141 patients) and aqCHX (92 patients). Patients receiving aqCHX reported less ocular pain or eye irritation than those receiving PI one hour (2.35 vs 1.45, <i>P</i> = .005) and one day (0.79 vs 0.34, <i>P</i> = .027) after their injection. They also described greater satisfaction with the IVI process (9.70 vs. 9.29, <i>P</i> = .014). A lower frequency of participants experienced worsened vision with use of aqCHX (19.6%) vs PI (33.6%, <i>P</i> = .02). This may suggest improved tolerability and patient experience with aqCHX over PI.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"201-203"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photobiomodulation for Dry Age-related Macular Degeneration.","authors":"Sofia Prenner, Howard F Fine, Diana V Do","doi":"10.3928/23258160-20251125-02","DOIUrl":"https://doi.org/10.3928/23258160-20251125-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":"57 3","pages":"146-148"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}