Param Bhatter, Katherine E Talcott, Alex Yuan, Danny A Mammo
{"title":"Development and Resolution of Subfoveal Lucency and Hyperreflective Deposits Following Silicone Oil Insertion and Removal.","authors":"Param Bhatter, Katherine E Talcott, Alex Yuan, Danny A Mammo","doi":"10.3928/23258160-20240624-03","DOIUrl":"10.3928/23258160-20240624-03","url":null,"abstract":"<p><p>Silicone oil (SO) is commonly used as a retinal tamponade during pars plana vitrectomy for complicated retinal detachments. Although fairly inert, complications such as cataract formation, intraocular pressure elevation, corneal changes, inner retinal thinning, and optic neuropathy have been noted. We report two cases of postoperative subfoveal outer retinal lucency and hyperreflective deposits following SO insertion and resolution following removal. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:675-678.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"675-678"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Saeed Mohammadi, Jared T Sokol, Darius M Moshfeghi
{"title":"Significant Improvement in Retinal Capillary Hemangioblastoma With Belzutifan.","authors":"S Saeed Mohammadi, Jared T Sokol, Darius M Moshfeghi","doi":"10.3928/23258160-20240607-01","DOIUrl":"10.3928/23258160-20240607-01","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"682-683"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Strand, Ryan S Meshkin, Sandra Hoyek, John B Miller, Nimesh A Patel
{"title":"Nondiabetic Vitreous Hemorrhage: A Review of Management Strategy and Outcomes.","authors":"Eric Strand, Ryan S Meshkin, Sandra Hoyek, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20240620-01","DOIUrl":"10.3928/23258160-20240620-01","url":null,"abstract":"<p><p>Vitreous hemorrhage involves blood leakage into or around the vitreous cavity, which presents complex management decisions. Treatment options for nondiabetic vitreous hemorrhage (NDVH) traditionally include observation or early vitrectomy. Traditional guidelines have long emphasized an initial period of cautious observation. This systematic review shows that a significant portion (∼62% to 75%) of NDVH patients present a retinal tear and/or detachment upon initial presentation. B-scan ultrasonography, the primary diagnostic tool, exhibits variable sensitivities and may miss approximately half (46.4%) of underlying tears or detachments. Only 25% of observed NDVH cases clear spontaneously, while the remaining will ultimately require vitrectomy due to nonclearance (45%) or sight-threatening complications (30%). Patients under observation experience visual deficits as hemorrhage clears slowly, challenging the efficacy of traditional guidelines favoring observation. While there is no clear guideline concerning the management of NDVH, our findings suggest that early vitrectomy for severe NDVH may be the safest and most appropriate approach, provided the patient accepts procedural risks like cataract development. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:660-667.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"660-667"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaersti L Rickels, Marco Ji, Ahmed Shakarchi, Michalis Georgiou, Sami H Uwaydat, Ahmed B Sallam
{"title":"Fractal Changes of the Retinal Microvasculature in Birdshot Chorioretinopathy.","authors":"Kaersti L Rickels, Marco Ji, Ahmed Shakarchi, Michalis Georgiou, Sami H Uwaydat, Ahmed B Sallam","doi":"10.3928/23258160-20240528-02","DOIUrl":"10.3928/23258160-20240528-02","url":null,"abstract":"<p><strong>Background and objective: </strong>Retinal vascular disorders are associated with lower fractal dimension (FD). We analyzed FD in birdshot chorioretinopathy (BSCR).</p><p><strong>Patients and methods: </strong>This was a retrospective cohort study. We performed optical coherence tomography angiography (OCTA) and analyzed FD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using ImageJ. For each vascular layer, we analyzed the presence of BSCR, subjects' age, sex, and presence of diabetes mellitus to determine which may predict lower FD.</p><p><strong>Results: </strong>We compared 28 eyes (14 patients) with BSCR to 34 control eyes (17 patients). Mean FD of BSCR was lower in SCP (1.584 [± 0.126] vs 1.706 [± 0.118], <i>P</i> < 0.001), DCP (1.637 [± 0.134] vs 1.780 [± 0.096], <i>P</i> < 0.001), and CC (1.884 [± 0.063] vs 1.917 [± 0.047], <i>P</i> = 0.036). FD of SCP was lower per increasing year (0.005 [<i>P</i> = 0.014]). Male patients had lower FD-DCP (0.101 [<i>P</i> = 0.043]).</p><p><strong>Conclusion: </strong>In BSCR, fractal analysis showed significant involvement of the SCP, DCP, and to a lesser extent the CC. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:646-651.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"646-651"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thrombotic Microangiopathy Following Hematopoietic Stem Cell Transplantation: A Case of Purtscher-like Retinopathy.","authors":"Okyanus Bulut, Gulcihan Ozek, Filiz Afrashi, Cumali Degirmenci","doi":"10.3928/23258160-20240528-05","DOIUrl":"10.3928/23258160-20240528-05","url":null,"abstract":"<p><p>Purtscher-like retinopathy (PLR) is a rare entity related with retinal ischemia due to endothelial dysfunction and embolization. We present a case of a 17-year-old patient who presented with PLR associated with transplant-associated thrombotic microangiopathy. Visual acuity was finger counting at 1 meter in both eyes. Fundoscopy demonstrated peripapillary cotton-wool spots and hypopigmentation in the middle peripheral retina. Both eyes showed signs of macular edema with intraretinal hemorrhages. Optical coherence tomography and fundus fluorescence angiography was performed to support the diagnosis. After systemic treatments and panretinal photocoagulation, the patient's vision improved and the macular edema resolved. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:603-606.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"603-606"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michelle Gantois, Camila V Ventura, Ricardo Miguel Japiassú, Letícia Guerra Barretto Conrado, Renata Pontes Duarte, Lyvia Madeira De Barros Nunes
{"title":"Strawberry Retina: Hyperreflective Tomographic Findings Identified on the Interface of the Retina and 5700-Centistoke Silicone Oil.","authors":"Michelle Gantois, Camila V Ventura, Ricardo Miguel Japiassú, Letícia Guerra Barretto Conrado, Renata Pontes Duarte, Lyvia Madeira De Barros Nunes","doi":"10.3928/23258160-20240524-02","DOIUrl":"10.3928/23258160-20240524-02","url":null,"abstract":"","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"617-619"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Casey Zhang, Elias Kahan, Tedi Begaj, Scott M Friedman, Avnish Deobhakta, Michael Heyang, Liangbo Linus Shen, Darius Moshfeghi, Karen Wai, Ravi Parikh
{"title":"Geographic Atrophy Natural History Versus Treatment: Time to Fovea.","authors":"Casey Zhang, Elias Kahan, Tedi Begaj, Scott M Friedman, Avnish Deobhakta, Michael Heyang, Liangbo Linus Shen, Darius Moshfeghi, Karen Wai, Ravi Parikh","doi":"10.3928/23258160-20240418-01","DOIUrl":"10.3928/23258160-20240418-01","url":null,"abstract":"<p><strong>Background and objective: </strong>The Food and Drug Administration recently approved treatments of geographic atrophy (GA). Our study aims to quantify the time for a lesion to reach the central fovea based on reduction of GA growth rates from therapeutics compared to the natural history.</p><p><strong>Patients and methods: </strong>A previously published study calculates local border expansion rate of GA lesions at varying retinal eccentricities. In this study, we use these rates to model GA expansion toward the fovea and the effects of treatments that reduce growth in GA area by 15% to 45% on lesions of varying sizes with posterior margin 250, 500, 750, 1000, 1250, 1500, and 3000 µm from the fovea.</p><p><strong>Results: </strong>Lesions with an area 8 mm<sup>2</sup> and posterior edge 500 µm from the fovea will reach the fovea in 5.08 years with no treatment, but the same lesions will reach the fovea in 5.85, 6.52, 7.36, and 8.46 years with a treatment that reduces growth in GA area by 15%, 25%, 35%, and 45%, respectively.</p><p><strong>Conclusions: </strong>Distance of the posterior edge of the lesion was the primary factor in GA growth toward the fovea, and lesion size only minimally affects growth rates of GA. Based on the efficacy of current and future therapeutics and distance of GA to the fovea, our study provides the marginal time benefit of treatment to guide patients and clinicians, placing both the natural history of GA and the effects of current and future treatments into clinical context. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:576-585.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"576-585"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperreflective Ganglion Cell Layer Band in Gyrate Atrophy.","authors":"Ahana Sen, Janhavi Desai, Survee Sharma, Sanatombi Thounaojam, Urvashi Kala, Bristi Majumdar, Amrita Pradhan, Ruchira Chowdhury, Surabhi Chattree, Kumar Saurabh, Rupak Roy","doi":"10.3928/23258160-20240528-04","DOIUrl":"10.3928/23258160-20240528-04","url":null,"abstract":"<p><p>We have described the hyperreflective ganglion cell layer band (HGCB) in a series of cases of gyrate atrophy. Clinical fundus examination and multimodal imaging which included optical coherence tomography (OCT) was done in all cases. Four patients (one male, three female) were studied. In all four cases, a hyperreflective band was noted in the ganglion cell layer. In three patients, the band was continuous, and in one patient, the band was patchy. To conclude, HGCB is a novel OCT sign in gyrate atrophy and can be valuable in prognostication of disease. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:598-602.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"598-602"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rasadokht Forati, Sandra Hoyek, Francesco Romano, John B Miller, Nimesh A Patel
{"title":"Full-Thickness Macular Hole in a Pediatric Patient With Normal Vision.","authors":"Rasadokht Forati, Sandra Hoyek, Francesco Romano, John B Miller, Nimesh A Patel","doi":"10.3928/23258160-20240621-02","DOIUrl":"10.3928/23258160-20240621-02","url":null,"abstract":"<p><p>A 17-year-old boy presented with a full-thickness macular hole, with 20/20 vision with eccentric fixation in the left eye. Examination of the left eye showed a large macular hole with a base diameter measuring 1,680 μm and temporal macular and mid-peripheral retinal atrophy on ultra-high-definition optical coherence tomography (OCT) scans. Microperimetry showed eccentric fixation with good nasal sensitivity. A 12 x 12-mm extended-field swept-source OCT angiogram showed flow loss in the temporal macula, with slight reduction noted in the choriocapillaris. Given excellent visual acuity, good tolerance by the patient, and large atrophic hole, the decision was made for observation rather than surgery. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:607-612.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"607-612"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew M O'Riordan, Claire Behan, Fionn O'Leary, Natalie Hudson, Colin P Doherty, Mark T Cahill, Matthew Campbell
{"title":"Multimodal Analysis of the Retinal Manifestations of Tuberous Sclerosis Complex: A Case Series.","authors":"Matthew M O'Riordan, Claire Behan, Fionn O'Leary, Natalie Hudson, Colin P Doherty, Mark T Cahill, Matthew Campbell","doi":"10.3928/23258160-20240523-03","DOIUrl":"10.3928/23258160-20240523-03","url":null,"abstract":"<p><strong>Background and objective: </strong>We used a multi-modal imaging approach including fundus fluorescein angiography (FFA) to assess the retinal lesions in tuberous sclerosis complex (TSC) and evaluate their correlation with intracranial tuber burden on magnetic resonance imaging (MRI).</p><p><strong>Patients and methods: </strong>Participants with TSC underwent bilateral fundus photography, optical coherence tomography (OCT), infrared (IR) imaging, and FFA. Participants' most recent MRI brain scans were analyzed to determine intracranial tuber load.</p><p><strong>Results: </strong>Nine participants were included. OCT identified all retinal astrocytic hamartoma (RAH) lesions, IR identified 75%, fundus photography identified 63%, and FFA detected just 57%. On FFA, 20% of flat-type hamartomas and all multi-nodular and transitional types were hyperfluorescent. There were significant positive correlations between the quantities of intracranial tubers and all TSC-retinal lesions (<i>r</i> = 0.8, <i>P</i> < 0.01) and all RAH lesions (<i>r</i> = 0.8, <i>P</i> = 0.01).</p><p><strong>Conclusions: </strong>A multimodal imaging-based approach with fundal photography, IR imaging, and OCT should be used to assess the retina in TSC as it may indicate the intracranial tuber burden. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:568-574.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"568-574"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}