Optical Coherence Tomography Biomarkers in Epiretinal Membrane.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2025-05-12 DOI:10.3928/23258160-20250416-01

Sonya Besagar, Shravika Chennupati, Xiangyu Ji, Qingxia Chen, Akshay S Thomas, Avni P Finn

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引用次数: 0

Abstract

Background and objective: This retrospective, multicenter imaging analysis aims to identify pre-operative optical coherence tomography (OCT) bio-markers of idiopathic epiretinal membrane (ERM) that predict improved postoperative best-corrected visual acuity (BCVA).

Patients and methods: Included were 80 eyes of 77 patients who underwent pars plana vitrectomy, membrane peel, and internal limiting membrane peel (PPV/MP/ILMP) for idiopathic ERM. Various preoperative, demographic, and surgical factors were studied, along with multiple preoperative OCT biomarkers.

Results: Ellipsoid zone (EZ) disruption and focal retinal nerve fiber layer (RNFL) schisis present on preoperative OCT were associated with an increased likelihood of 2-line visual acuity improvement, independent of preoperative vision, while ERM stage, ectopic inner foveal layers, foveal herniation, central subfield thickness, cystic changes, lamellar hole, and the gap between the ERM and the retinal surface (SUKIMA) were not.

Conclusion: Preoperative EZ disruption and RNFL schisis on OCT may identify patients who are more likely to have a meaningful improvement in postoperative visual outcomes for idiopathic ERM. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

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视网膜前膜的光学相干断层扫描生物标志物。

背景和目的：这项回顾性的多中心成像分析旨在确定特发性视网膜前膜（ERM）的术前光学相干断层扫描（OCT）生物标志物，以预测术后最佳矫正视力（BCVA）的改善。患者和方法：包括77例80眼的特发性ERM患者，他们接受了睫状体部玻璃体切除术、膜剥离和内限制性膜剥离（PPV/MP/ILMP）。研究了各种术前、人口统计学和手术因素，以及多种术前OCT生物标志物。结果：术前OCT显示的椭球区（EZ）破坏和局灶性视网膜神经纤维层（RNFL）分裂与2线视力改善的可能性增加有关，与术前视力无关，而ERM阶段、内中央凹层异位、中央凹疝、中央亚野厚度、囊性改变、板层孔和ERM与视网膜表面之间的间隙（SUKIMA）则无关。结论：对于特发性ERM，术前OCT上的EZ破坏和RNFL分裂可以识别出更有可能在术后视力结果上有显著改善的患者。[眼科外科激光成像视网膜2025；56:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.