Catherine S Yao, Victoria Lue, Sandra S Stinnett, Ulrich F O Luhmann, Eleonora M Lad
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引用次数: 0
摘要
背景和目的：本研究的目的是确定美国国家眼科研究所视力功能问卷39 （NEI-VFQ39）评分与早期（eAMD）和中期（iAMD）年龄相关性黄斑变性视力功能（VF）测试的相关性。患者和方法：33名eAMD， 47名iAMD， 21名对照组在基线时完成NEIVFQ39； 22名eAMD， 31名iAMD， 17名对照组在24个月时完成NEIVFQ39。在两次就诊期间均进行最佳矫正视力（BCVA）、低亮度视力（LLVA）、视锥对比测试（CCT）、眼球追踪显微视力（MP）和黑暗适应（DA）测试。结果：在基线和24个月时，iAMD患者的NEI-VFQ39综合评分低于eAMD参与者和对照组（P < 0.05）；纵向变化在组间无差异。基线综合评分与MP的LLVA （Spearman-r = 0.33, P < 0.001）、百分比降低阈值（PRT） （r = -0.33, P = 0.001）和绝对阈值（AT） （r = 0.31, P = 0.003）相关。结论：虽然NEI-VFQ39在24个月内没有检测到变化，但这些结果支持将NEI-VFQ39作为iAMD的横截面工具。
Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months.
Background and objective: The aim of this study was to determine the National Eye Institute Visual Function Questionnaire 39 (NEI-VFQ39) score association with visual function (VF) tests in early (eAMD) and intermediate (iAMD) age-related macular degeneration.
Patients and methods: Thirty-three eAMD, 47 iAMD, 21 control subjects completed the NEIVFQ39 at baseline and 22 eAMD, 31 iAMD, 17 control subjects at 24 months. Best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), cone contrast test (CCT), microperimetry (MP) with eye-tracking (MAIA), and dark adaptation (DA) testing were administered during both visits.
Results: At baseline and 24 months, iAMD patients scored lower NEI-VFQ39 composite scores than eAMD participants and controls (P < 0.05); longitudinal changes showed no differences between groups. Baseline composite scores were associated with LLVA (Spearman-r = 0.33, P < 0.001), percent-reduced threshold (PRT) (r = -0.33, P = 0.001), and absolute threshold (AT) (r = 0.31, P = 0.003) on MP.
Conclusion: Although the NEI-VFQ39 did not detect change over 24 months, these results support the use of NEI-VFQ39 as a cross-sectional tool in iAMD.
期刊介绍：
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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