Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan
{"title":"Difluprednate for the Treatment of Postoperative Hypotony Following Complicated Retinal Detachment Surgery.","authors":"Viren Govindaraju, Amro Omari, Zara Saleem, Daeun Jeong, Konstantinos Koustas, Ryan A Shields, George A Williams, Tarek S Hassan","doi":"10.3928/23258160-20250127-01","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.</p><p><strong>Patients and methods: </strong>A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.</p><p><strong>Results: </strong>Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, <i>P</i> = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.</p><p><strong>Conclusion: </strong>Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:XX-XX.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"1-7"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic surgery, lasers & imaging retina","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/23258160-20250127-01","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objective: This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.
Patients and methods: A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.
Results: Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, P = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.
Conclusion: Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].
期刊介绍:
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.