Ophthalmic Research最新文献_第8页

Analysis of the Effect of Superselective Ophthalmic Artery Thrombolysis for Central Retinal Artery Occlusion. 超选择性眼动脉溶栓治疗视网膜中央动脉闭塞的效果分析。

IF 2 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-06-19 DOI: 10.1159/000539362

Ningyu Kang, Yan Xue, Fei Wang, Qingliang Guan, Min Li

{"title":"Analysis of the Effect of Superselective Ophthalmic Artery Thrombolysis for Central Retinal Artery Occlusion.","authors":"Ningyu Kang, Yan Xue, Fei Wang, Qingliang Guan, Min Li","doi":"10.1159/000539362","DOIUrl":"10.1159/000539362","url":null,"abstract":"Introduction: The aim of the study was to investigate the clinical efficacy of superselective ophthalmic artery thrombolysis for central retinal artery occlusion (CRAO).Methods: Retrospective study of CRAO patients who attended the Department of Ophthalmology of Affiliated Hospital of Weifang Medical University from January 2022 to July 2023, 138 CRAO patients with onset time of 1-3 days were selected for the study. Among them, 86 patients refused thrombolytic treatment and chose to adopt traditional treatment, which was categorized as the control group; 52 patients adopted superselective ophthalmic artery thrombolytic treatment, which was categorized as the observation group. The visual acuity of the patients treated with traditional modality on the 4th day after the onset of the disease and the visual acuity of the patients treated with superselective ophthalmic artery thrombolysis on the 1st postoperative day were recorded, and the visual acuity improvement after different modalities of treatment was compared between the two groups.Results: In the control group, 77 (89.5%) of the treated patients had no improvement in visual acuity, 9 (10.5%) had improvement, 0 (0.0%) had significant improvement, and the total improvement was 9 (10.5%); in the observation group, 18 (34.6%) of the treated patients had no improvement in visual acuity, 21 (40.4%) had improvement, 13 (25.0%) had significant improvement, and the total improvement was 34 (65.4%). The total improvement rate of treatment in the observation group was 65.4%, which was significantly higher than the 10.5% in the control group, and the difference was statistically significant (p < 0.05).Conclusion: Superselective ophthalmic artery thrombolysis for patients with CRAO is clinically effective, promotes improvement in patient vision, and has a high safety profile.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"387-392"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Heat Shock Protein 90 Lowered Intraocular Pressure without Affecting the Production of Aqueous Humor in Rabbits. 抑制热休克蛋白 90 可降低兔子的眼压，但不会影响房水的分泌。

IF 2.1 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2023-12-10 DOI: 10.1159/000535374

Yuji Takahashi, Tomohiro Otsuka, Reijiro Arakawa, Akira Naito

{"title":"Inhibition of Heat Shock Protein 90 Lowered Intraocular Pressure without Affecting the Production of Aqueous Humor in Rabbits.","authors":"Yuji Takahashi, Tomohiro Otsuka, Reijiro Arakawa, Akira Naito","doi":"10.1159/000535374","DOIUrl":"10.1159/000535374","url":null,"abstract":"Introduction: Heat shock protein (Hsp) 90 is one of the most abundant proteins in unstressed cells and regulates stability and functional maintenance of client proteins. In ocular tissue, Hsp90 is widely expressed in the cornea and retina and has multiple roles in these tissues. The expression of HSPs was induced in the retinas of glaucomatous patients and laser-induced glaucoma in monkey while their mechanisms remain to be elucidated. For this reason, we tried to elucidate the role of Hsp90 in intraocular pressure (IOP) regulation in rabbits.Methods: IOP was measured by a pneumatonometer before and after intracameral injection of Hsp90 inhibitors. The aqueous flow rate was measured by fluorophotometry. Trans-epithelial electrical resistance was measured in primary human trabecular meshwork cells.Results: 17-AAG, a specific Hsp90 inhibitor, significantly lowered IOP at concentrations of more than 30 μ<sc>m</sc> in normotensive rabbits. Other Hsp90 inhibitors also significantly lowered IOP in normotensive rabbits at a dose of 100 μ<sc>m</sc>. No reduction of aqueous humor production was observed by injection of 17-AAG in rabbits. Topical administration of pilocarpine tended to attenuate the IOP-lowering effects induced by the Hsp90 inhibitor. No reduction of trans-epithelial electrical resistance was observed by inhibition of Hsp90 in culture cells.Conclusions: These results indicated that intraocular Hsp90 regulates IOP, and the inhibition of Hsp90 by Hsp90 inhibitor decreases IOP without affecting aqueous humor production in rabbits. Further research in elucidating the mechanism of Hsp90 inhibitors will result in a better understanding of the role of Hsp90 in the regulation of IOP.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"23-28"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Progression of Primary Open-Angle Glaucoma with Lower Normal Intraocular Pressure. 眼压正常值较低的原发性开角型青光眼病情恶化的风险因素。

IF 2.1 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-01-16 DOI: 10.1159/000536314

Yuta Ueda, Kenji Suda, Takanori Kameda, Hanako Ohashi Ikeda, Masahiro Miyake, Tomoko Hasegawa, Shogo Numa, Akitaka Tsujikawa

{"title":"Risk Factors for Progression of Primary Open-Angle Glaucoma with Lower Normal Intraocular Pressure.","authors":"Yuta Ueda, Kenji Suda, Takanori Kameda, Hanako Ohashi Ikeda, Masahiro Miyake, Tomoko Hasegawa, Shogo Numa, Akitaka Tsujikawa","doi":"10.1159/000536314","DOIUrl":"10.1159/000536314","url":null,"abstract":"Introduction: This study aimed to investigate intraocular pressure (IOP)-independent factors associated with the progression of primary open-angle glaucoma (POAG) with IOP ≤15 mm Hg.Methods: POAG patients with maximum IOP ≤15 mm Hg at the Kyoto University Hospital between January 2011 and August 2021 were retrospectively enrolled. We evaluated effects of various factors on the rate of mean deviation (MD) changes in the visual field (VF) examinations using a linear mixed model. These factors included hypertension, diabetes mellitus (DM), hyperlipidemia (HL), cardiovascular disease, arrhythmia, disc hemorrhage, sleep apnea syndrome, orthopedic diseases, and malignant tumors.Results: In total, 98 eyes from 68 patients were included. The baseline MD was -9.74 ± 7.85 dB. The mean rate of MD change and IOP during the observation period were -0.28 ± 0.04 dB/year and 11.8 ± 1.0 mm Hg, respectively. Comorbidity of DM or HL showed a significant positive association with the rate of MD change (β = 0.35, p = 0.0006 and β = 0.18, p = 0.036, respectively) in the model adjusted for age, sex, axial length, mean IOP, and standard deviation of IOP during the observation period. However, no significant association of DM or HL was found after adjusting for central corneal thickness.Conclusion: This study suggests that DM or HL is associated with VF deterioration in glaucoma with lower IOP, but the association may be due to differences in IOP characteristics.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"184-191"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients. 慢性原发性闭角型青光眼和原发性开角型青光眼患者微囊性黄斑水肿的临床特征。

IF 2.1 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI: 10.1159/000535900

Hui Xiao, Yuan Liu, Ni Guo, Ling Jin, Zhenyu Wang, Shufen Lin, Yixiu Lin, Shaoyang Zheng, Yuheng Tan, Nachuan Luo, Xing Liu, Chengguo Zuo

{"title":"Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients.","authors":"Hui Xiao, Yuan Liu, Ni Guo, Ling Jin, Zhenyu Wang, Shufen Lin, Yixiu Lin, Shaoyang Zheng, Yuheng Tan, Nachuan Luo, Xing Liu, Chengguo Zuo","doi":"10.1159/000535900","DOIUrl":"10.1159/000535900","url":null,"abstract":"Introduction: This study investigated the clinical characteristics of and risk factors for microcystic macular edema (MME) in patients with chronic primary angle-closure glaucoma (CPACG) and primary open-angle glaucoma (POAG).Methods: This retrospective observational study included 1,588 eyes from 926 glaucoma inpatients and analyzed the patients' basic demographic information, visual field parameters, macular scans, and peripapillary retinal nerve fiber layer thickness.Results: Our findings were that the incidence rate of MME was 3.97% (34/857) in CPACG and 5.88% (43/731) in POAG. MME was predominantly diagnosed at an advanced stage in CPACG (almost 100%) compared to POAG (93.02%). MME was most frequently involved in the inferior (83.12%) quadrant of the peri-macular region in both CPACG and POAG. Risk factors for MME occurrence in CPACG and POAG included lower visual field mean deviation (OR = 1.14, 95%: CI 1.05-1.24, p = 0.003; OR = 1.14, 95% CI: 1.06-1.21, p < 0.001) and younger age (OR = 0.92, 95% CI: 0.88-0.96, p < 0.001; OR = 0.96, 95% CI: 0.93-0.99, p = 0.003), while female sex (OR = 0.30, 95% CI: 0.11-0.84, p = 0.022) reduced the MME occurrence in POAG.Conclusion: MME could develop in both CPACG and POAG patients, occurring earlier in POAG. The inferior peri-macular region is commonly affected. Younger age and poorer visual field are risk factors for MME in glaucoma patients.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"145-153"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Changes in Choroidal Thickness and Choroidal Vascularity Index in Age-Related Macular Degeneration. 老年性黄斑变性患者脉络膜厚度和脉络膜血管指数的纵向变化。

IF 2 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-11-04 DOI: 10.1159/000541481

Lourdes Vidal-Oliver, Sabrina Spissinger, Elisa Herzig-de Almeida, Davide Garzone, Robert P Finger

{"title":"Longitudinal Changes in Choroidal Thickness and Choroidal Vascularity Index in Age-Related Macular Degeneration.","authors":"Lourdes Vidal-Oliver, Sabrina Spissinger, Elisa Herzig-de Almeida, Davide Garzone, Robert P Finger","doi":"10.1159/000541481","DOIUrl":"10.1159/000541481","url":null,"abstract":"Introduction: The aim of the study was to investigate the rate of choroidal thinning and Choroidal Vascularity Index (CVI) changes over time in eyes with different stages of age-related macular degeneration (AMD) and control eyes.Methods: Retrospective longitudinal study of 105 eyes with different stages of AMD: non-advanced (n = 46), exudative (n = 28), central complete retinal pigment epithelium and outer retinal atrophy (cRORA) (n = 5) and healthy eyes (n = 26). We evaluated choroidal thickness (CT) and CVI at baseline and during 2-4 years of follow-up. After adjustment for age and sex, we estimated the rate of change per year of CT and CVI in each group. We also performed logistic regression to analyze the relationship between baseline CT and CVI with AMD progression.Results: The mean age of the included patients was 77.1 years with a mean follow-up of 3.36 years. Healthy eyes had higher baseline CT and CVI values compared to eyes with AMD. Exudative AMD showed a significant annual decrease in subfoveal CT (-5.1% per year vs. -3.5% in controls) and in the temporal and nasal sectors (-5.3% and -6.3%). CVI decreased during follow-up in all study groups, most in eyes with central cRORA (-1.09% per year).Conclusion: CVI and CT values are reduced in eyes with AMD compared to healthy eyes. Eyes with exudative AMD have the highest annual rate of choroidal thinning, while CVI decreases most in eyes with central cRORA. CT and CVI may aid in a further stratification of AMD progression risk.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"654-661"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worldwide Burden of Retinoblastoma from 1990 to 2021. 1990-2021 年全球视网膜母细胞瘤发病率。

IF 2 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-11-13 DOI: 10.1159/000542193

Yaling Feng, Xiaoyi Feng, Yun Lv

{"title":"Worldwide Burden of Retinoblastoma from 1990 to 2021.","authors":"Yaling Feng, Xiaoyi Feng, Yun Lv","doi":"10.1159/000542193","DOIUrl":"10.1159/000542193","url":null,"abstract":"Introduction: The aim of the study was to report the global, regional, and national burden of retinoblastoma between 1990 and 2021, by age, sex, and sociodemographic index (SDI).Methods: We leveraged the Global Burden of Disease 2021 Study to elucidate the epidemiological landscape of retinoblastoma, encompassing prevalence, incidence, mortality, and disability-adjusted life years (DALYs) across 204 nations and territories spanning the period from 1990 to 2021. The SDI was employed to evaluate the interplay between socioeconomic development and the burden of retinoblastoma.Results: In 2021, global estimates unveiled 57,333 prevalent cases of retinoblastoma, yielding 6,274 incident cases, 2,762 deaths, and 243,204 DALYs. Globally, the age-standardized prevalence, incidence, mortality, and DALY rates for retinoblastoma in 2021 were 0.86, 0.09, 0.04, and 3.65 per 100,000 population, respectively. Tokelau, Kenya, and Portugal demonstrated the highest age-standardized prevalence and incidence rates of retinoblastoma in 2021. The global prevalence of retinoblastoma peaks among children aged 2-4 years and subsequently declines with increasing age. At the regional level, the correlation between SDI and age-standardized prevalence rates for retinoblastoma manifested a V-shaped pattern.Conclusions: This comprehensive examination of retinoblastoma epidemiological trends underscores the imperative for heightened vigilance and more efficacious therapeutic interventions, especially within resource-limited environments. The findings accentuate the need for targeted strategies to address the disparate burden of retinoblastoma across diverse socioeconomic landscapes.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"672-682"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Accuracy of In-The-Bag Intraocular Lens Power Calculation in Adult Eyes with Unilateral Subluxated Lenses by Using the Anterior Chamber Depth of the Unaffected Eye. 通过使用未受影响眼的前房深度，提高单侧晶状体下移成眼的袋内眼内透镜功率计算的准确性。

IF 2.1 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-03-25 DOI: 10.1159/000538234

Wei Lou, Ziang Chen, Yang Huang, Haiying Jin

{"title":"Improving Accuracy of In-The-Bag Intraocular Lens Power Calculation in Adult Eyes with Unilateral Subluxated Lenses by Using the Anterior Chamber Depth of the Unaffected Eye.","authors":"Wei Lou, Ziang Chen, Yang Huang, Haiying Jin","doi":"10.1159/000538234","DOIUrl":"10.1159/000538234","url":null,"abstract":"Introduction: This study aimed to determine the interchangeability of bilateral anterior chamber depth (ACD) in intraocular lens (IOL) power calculations for cataractous eyes and refractive outcomes using the unaffected fellow eye's ACD in subluxated crystalline lenses.Methods: The predicted postoperative spherical equivalent (SE) calculated using the Kane formula with and without fellow eye's ACD in 202 cataract patients was compared. Refractive outcomes of the newer formulas (the Kane, Barrett Universal II [BUII], and Pearl-DGS formulas) with affected eye's ACD and with unaffected fellow eye's ACD were compared in 33 eyes with lens subluxation (the affected eye) undergoing in-the-bag IOL implantation. The SD of the prediction error (PE) was assessed using the heteroscedastic method.Results: In 202 paired cataractous eyes, no marked ACD difference was found bilaterally; the predicted SE obtained without the fellow eye's ACD was comparable with that calculated with the fellow eye one (p = 0.90), with a mean absolute difference of 0.03 ± 0.03 D. With the affected eye AL, keratometry, and ACD, the median absolute error (MedAE) was 0.38-0.64 D, and the percentage of PE within ±0.50 D was 30.30-57.58%. The unaffected eye's ACD improved the results (MedAE, 0.35-0.49 D; the percentage of PE within ±0.50 D, 54.55-63.64%). The SDs of the BUII (0.82 D) and Pearl-DGS formulas (0.87 D) with the affected eye's ACD were significantly larger than those of the Kane and Pearl-DGS formulas (both 0.69 D) with the unaffected eye's ACD.Conclusion: Bilateral ACD was interchangeable in IOL power calculation for cataractous eyes when using the Kane formula. Unaffected eye's ACD in lieu of affected eye's ACD can enhance the accuracy of newer formulas in patients with unilateral subluxated lenses undergoing in-the-bag IOL implantation.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"248-256"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics-Based Safety Evaluation in Half-Dose Verteporfin Photodynamic Therapy. 基于药代动力学的半剂量维替泊芬光动力疗法安全性评估

IF 2 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1159/000541619

Hyeong Min Kim, Hyuncheol Kim, Jae Yong Chung, Se Joon Woo

{"title":"Pharmacokinetics-Based Safety Evaluation in Half-Dose Verteporfin Photodynamic Therapy.","authors":"Hyeong Min Kim, Hyuncheol Kim, Jae Yong Chung, Se Joon Woo","doi":"10.1159/000541619","DOIUrl":"10.1159/000541619","url":null,"abstract":"Introduction: This study was conducted to assess the systemic pharmacokinetic profiles of half-dose verteporfin photodynamic therapy (PDT) using concentration data from a previous clinical trial and to subsequently suggest safety precaution guidelines.Methods: Coefficients for the bi-exponential model were obtained from published data on post-infusion plasma verteporfin concentrations within a period of 0.17-4 h. Using the extrapolative forecasting method, we plotted the 48-h post-verteporfin plasma concentration model. The time required to achieve a comparable level of verteporfin 48 h after a conventional dose (6 mg/m2 body surface area, BSA) infusion was calculated for a half-dose infusion (3 mg/m2 BSA).Results: At 24 and 48 h post-verteporfin infusion, the plasma concentration following the conventional dose was 1.28 × 10-4 µg/mL and 5.06 × 10-8 µg/mL, compared to 3.57 × 10-5 µg/mL and 7.54 × 10-9 µg/mL for the half-dose PDT, representing concentrations that were 3.6 times and 6.7 times higher, respectively. The estimated time required to attain the same level of verteporfin 48 h after a conventional dose was calculated as 42-h post-half-dose PDT.Conclusions: The results of this study indicate that precautionary measures should be taken to avoid sunlight following both half and conventional doses of PDT during the similar post-treatment periods of two days. Nevertheless, given the substantially higher plasma concentration levels associated with conventional-dose PDT compared with the half-dose, systemic safety should be carefully considered when administering conventional-dose PDT.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"594-599"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Sensitivity in Macular Subfields and Their Association with Contrast Sensitivity in Early and Intermediate Age-Related Macular Degeneration. 早期和中期老年性黄斑变性的黄斑亚区视网膜敏感度及其与对比敏感度的关系。

IF 2 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.1159/000540312

Eric J Chan, Philipp Anders, Simona A Garobbio, Ursula Hall, Chrysoula Gabrani, Kristina Pfau, Hanna Camenzind Zuche, Stefan Futterknecht, Maximilian Pfau, Michael Herzog, Ghislaine L Traber, Hendrik P N Scholl

{"title":"Retinal Sensitivity in Macular Subfields and Their Association with Contrast Sensitivity in Early and Intermediate Age-Related Macular Degeneration.","authors":"Eric J Chan, Philipp Anders, Simona A Garobbio, Ursula Hall, Chrysoula Gabrani, Kristina Pfau, Hanna Camenzind Zuche, Stefan Futterknecht, Maximilian Pfau, Michael Herzog, Ghislaine L Traber, Hendrik P N Scholl","doi":"10.1159/000540312","DOIUrl":"10.1159/000540312","url":null,"abstract":"Introduction: The objective of this study was to evaluate retinal sensitivity in subfields and its association with the novel quantitative contrast sensitivity function (qCSF) in patients with early age-related macular degeneration (eAMD), in patients with intermediate AMD (iAMD), and in healthy controls.Methods: In this prospective longitudinal study, retinal sensitivity of a customized 24-point grid was assessed by microperimetry Macular Integrity Assessment (MAIA, CenterVue, Padova, Italy) and divided into different subfields. The Multiple Contrast Vision Meter (Adaptive Sensory Technology, San Diego, CA, USA) was used for qCSF testing. Linear models were used to test the association of functional metrics with variables of interest.Results: 92 study eyes from 92 participants were analyzed (13 eAMD, 31 iAMD, and 48 controls). Microperimetry subfield comparison showed significant differences (p < 0.0001) in the control group between superior and inferior hemifield as well as between central and peripheral subfields. For eAMD, significant differences were found between central and peripheral subfields (p < 0.001) and specific subfields (p < 0.05) and finally for iAMD between specific quadrants (p < 0.05) and specific squares (p < 0.05). Significant associations of retinal sensitivity with qCSF metrics were found for the area underneath the logarithmic contrast sensitivity function, contrast acuity and for the contrast sensitivity at specific spatial frequencies.Conclusions: This study showed significant differences in the evaluated retinal sensitivity subfields, providing localized natural history data for retinal sensitivity in healthy controls and patients with eAMD and iAMD.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"458-469"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Changes in Retinal Vascular Parameters and Density in Patients with Moyamoya Disease: A Retrospective Study. 莫亚莫亚病患者视网膜血管参数和密度变化的比较：回顾性研究

IF 2.1 4区医学

Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-03-14 DOI: 10.1159/000538296

Xijuan Wang, Ying Meng, Dan Song, Cunxin Tan, Guanzheng Wang, Bin Lv, Yuan Ni, Guotong Xie, Ting Cui, Yan Zhang, Yaqian Niu, Chengxia Zhang, Guangfeng Liu

{"title":"Comparison of Changes in Retinal Vascular Parameters and Density in Patients with Moyamoya Disease: A Retrospective Study.","authors":"Xijuan Wang, Ying Meng, Dan Song, Cunxin Tan, Guanzheng Wang, Bin Lv, Yuan Ni, Guotong Xie, Ting Cui, Yan Zhang, Yaqian Niu, Chengxia Zhang, Guangfeng Liu","doi":"10.1159/000538296","DOIUrl":"10.1159/000538296","url":null,"abstract":"Introduction: This study aimed to compare retinal vascular parameters and density in patients with moyamoya disease using the optical coherence tomography angiography.Methods: This clinical trial totally enrolls 78 eyes from 39 participants, and all these patients with moyamoya disease (N = 13) are set as experimental group and participants with health who matched with age and gender are considered as the control group (N = 26). Then all these participants receive optical coherence tomography angiography detection. Participants' general data are collected and analyzed. Skeleton density (SD) value, vessel density (VD) value, fractal dimension (FD) value, vessel diameter index (VDI) value, foveal avascular zone (FAZ) value are analyzed.Results: A total of 39 participants are included in this study. The SD value in the experimental group was significantly lower than that in control group (0.175 [0.166, 0.181] vs. 0.184 [0.175, 0.188], p = 0.017). Similarly, the VD value in the experimental group was significantly lower than that in the control group (0.333 [0.320, 0.350] vs. 0.354 [0.337, 0.364], p = 0.024). Additionally, the FD value in the experimental group was significantly lower than that in the control group (2.088 [2.083, 2.094] vs. 2.096 [2.090, 2.101], p = 0.022). As for the VDI and FAZ, VDI and FAZ values in the experimental group were lower than those in the control group, there was no significant difference in VDI and FAZ values between the two groups.Conclusions: Our study, using non-invasive and rapid OCTA imaging, confirmed decreased retinal vascular parameters and density in patients with moyamoya disease.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"211-220"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0