Changes and Influencing Factors of Corneal Endothelial Cells and Central Corneal Thickness after Pediatric Cataract Surgery.

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Jingyi Shi, Dandan Wang, Yang Xie, Ziyi Lu, Ruiwen Zhang, Renhui Dou, Mengjuan Xie, Ruru Chen, Yun-E Zhao
{"title":"Changes and Influencing Factors of Corneal Endothelial Cells and Central Corneal Thickness after Pediatric Cataract Surgery.","authors":"Jingyi Shi, Dandan Wang, Yang Xie, Ziyi Lu, Ruiwen Zhang, Renhui Dou, Mengjuan Xie, Ruru Chen, Yun-E Zhao","doi":"10.1159/000541947","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to examine the impact of cataract surgery on the corneal endothelium and central corneal thickness (CCT) in pediatric patients, and to identify the factors associated with corneal alterations.</p><p><strong>Methods: </strong>This retrospective study included consecutive children undergoing bilateral or unilateral cataract surgery and intraocular lens (IOL) implantation at the Eye Hospital of Wenzhou Medical University, with or without posterior capsulorhexis and anterior vitrectomy, and an age-matched normal control group. This study aimed to assess whether changes in corneal parameters, including CCT, corneal endothelial cell density (CD), average cell area (AVE), standard deviation of size (SD), coefficient of variation (CV), percentage of hexagonal cells (6A) before and after surgery, and endothelial cell loss (ECL) differed among the bilateral cataract, unilateral cataract, and control groups. Furthermore, the potential effects of anterior vitrectomy, axial length (AL), preoperative anterior chamber depth (ACD), surgical duration, horizontal corneal diameter (HCD), intraoperative pupil diameter (PD), and the number of corneal sutures on corneal endothelial parameters and CCT were investigated.</p><p><strong>Results: </strong>A total of 107 eyes from 107 children were included in the study. In the bilateral cataract group, CD significantly decreased, AVE and CCT significantly increased, and ECL was significantly higher than in the control group. The unilateral cataract group also exhibited a significant increase in CCT. Additionally, the number of corneal sutures was negatively correlated with CD, and PD was negatively correlated with CV in the unilateral cataract group.</p><p><strong>Conclusion: </strong>Cataract surgery in pediatric patients results in increased CCT, reduced CD, and morphological changes in corneal cells. A greater number of corneal sutures and a smaller PD increased the risk of CD reduction and elevated CV in the unilateral cataract group, underscoring the need for ophthalmologists to minimize corneal damage in these children.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000541947","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: This study aimed to examine the impact of cataract surgery on the corneal endothelium and central corneal thickness (CCT) in pediatric patients, and to identify the factors associated with corneal alterations.

Methods: This retrospective study included consecutive children undergoing bilateral or unilateral cataract surgery and intraocular lens (IOL) implantation at the Eye Hospital of Wenzhou Medical University, with or without posterior capsulorhexis and anterior vitrectomy, and an age-matched normal control group. This study aimed to assess whether changes in corneal parameters, including CCT, corneal endothelial cell density (CD), average cell area (AVE), standard deviation of size (SD), coefficient of variation (CV), percentage of hexagonal cells (6A) before and after surgery, and endothelial cell loss (ECL) differed among the bilateral cataract, unilateral cataract, and control groups. Furthermore, the potential effects of anterior vitrectomy, axial length (AL), preoperative anterior chamber depth (ACD), surgical duration, horizontal corneal diameter (HCD), intraoperative pupil diameter (PD), and the number of corneal sutures on corneal endothelial parameters and CCT were investigated.

Results: A total of 107 eyes from 107 children were included in the study. In the bilateral cataract group, CD significantly decreased, AVE and CCT significantly increased, and ECL was significantly higher than in the control group. The unilateral cataract group also exhibited a significant increase in CCT. Additionally, the number of corneal sutures was negatively correlated with CD, and PD was negatively correlated with CV in the unilateral cataract group.

Conclusion: Cataract surgery in pediatric patients results in increased CCT, reduced CD, and morphological changes in corneal cells. A greater number of corneal sutures and a smaller PD increased the risk of CD reduction and elevated CV in the unilateral cataract group, underscoring the need for ophthalmologists to minimize corneal damage in these children.

小儿白内障手术后角膜内皮细胞和角膜中央厚度的变化及影响因素
简介:本研究旨在探讨白内障手术对儿童患者角膜内皮和角膜中央厚度(CCT)的影响,并确定与角膜改变相关的因素:这项回顾性研究纳入了在温州医科大学附属眼视光医院接受双侧或单侧白内障手术并植入人工晶体(IOL)的连续患儿,以及年龄匹配的正常对照组。本研究旨在评估双侧白内障组、单侧白内障组和对照组的角膜参数,包括CCT、角膜内皮细胞密度(CD)、平均细胞面积(AVE)、大小标准差(SD)、变异系数(CV)、六角形细胞百分比(6A)以及内皮细胞丢失(ECL)在手术前后的变化是否存在差异。此外,还研究了玻璃体前部切除术、轴向长度(AL)、术前前房深度(ACD)、手术持续时间、角膜水平直径(HCD)、术中瞳孔直径(PD)和角膜缝合数量对角膜内皮参数和 CCT 的潜在影响:研究共纳入了 107 名儿童的 107 只眼睛。与对照组相比,双侧白内障组的 CD 明显降低,AVE 和 CCT 明显升高,ECL 明显升高。单侧白内障组的 CCT 也明显增加。此外,单侧白内障组的角膜缝合数量与 CD 呈负相关,PD 与 CV 呈负相关:结论:儿童白内障手术会导致 CCT 增高、CD 降低和角膜细胞形态变化。在单侧白内障组中,角膜缝合数量越多、PD越小,CD减少和CV升高的风险就越大,这说明眼科医生需要尽量减少对这些儿童角膜的损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信