Ophthalmic Research最新文献

{"title":"Accuracy of intraocular lens power calculation in microspherophakia patients: comparison of 7 formulas.","authors":"Yang Sun, Tianhui Chen, Zexu Chen, Wannan Jia, Zhennan Zhao, Yongxiang Jiang","doi":"10.1159/000545050","DOIUrl":"https://doi.org/10.1159/000545050","url":null,"abstract":"<p><strong>Introduction: </strong>To compare the accuracy of seven formulas for intraocular lens (IOL) power calculation in patients with microspherophakia (MSP).</p><p><strong>Methods: </strong>A retrospective case series included 44 eyes from 28 patients with MSP. The mean prediction error (PE) was calculated and the accuracy was determined by formula performance index (FPI), median absolute error (MedAE), and percentage of eyes with a prediction error within ± 0.25 diopters (D), ± 0.50 D, ± 0.75 D and ± 1.00 D. Depending on whether the patients had Marfan syndrome (MFS), MSP patients 36 were sub-divided into MFS and Non-MFS group.</p><p><strong>Results: </strong>In the non-MFS subgroup, the performance of formulas ranked by FPI from highest to lowest was BUII, EVO, Kane, Haigis, SRK/T, Holladay 1 and Hoffer Q. In the MFS subgroup, Kane achieved the best accuracy regarding the lowest MedAE and the largest percentage of PE in the range of ± 0.50 D. Similar results were obtained in eyes with shallow ACD. In the regular ACD subgroup, the EVO provided the highest prediction accuracy and SRK/T took the second place. In the deep ACD subgroup, Holladay 1 performed superiorly presenting the lowest SD values, MAE and MedAE.</p><p><strong>Conclusions: </strong>Overall, new generation formulas showed a better trend of refractive outcomes in MSP patients. The Holladay 1 formula was suggested for eyes with deep ACD, while Haigis was not recommended.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-27"},"PeriodicalIF":2.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Outcomes and Prognostic Factors of High Myopia Epiretinal Membrane Associated with Retinoschisis After Vitrectomy.","authors":"Xiao Feng, Xiaohan Yang, Biying Qi, Xinbo Wang, Xijin Wu, Qinlang Jia, Wu Liu","doi":"10.1159/000544928","DOIUrl":"https://doi.org/10.1159/000544928","url":null,"abstract":"<p><strong>Introduction: </strong>The outcomes and prognosis of pars plana vitrectomy (PPV) for high myopia epiretinal membranes (HM-ERM) patients with retinoschisis remains unclear. To analyze the impact of retinoschisis on the recovery of macular configuration and visual acuity following ERM removal in eyes with HM and to explore the prognostic factors.</p><p><strong>Methods: </strong>A retrospective study of 73 consecutive patients with HM-ERM who underwent PPV with ERM peeling. According to the optical coherence tomography images, eyes were classified into 4 groups: group A without retinoschisis, group B with outer retinoschisis, group C with inner retinoschisis, group D with both inner and outer retinoschisis.</p><p><strong>Results: </strong>In Groups A, B, C, and D, there were 17, 21, 22, and 16 eyes, respectively. Retinoschisis of 44 eyes (74.6%) disappeared postoperatively, including 13 eyes in group B, 20 in group C, and 9 in group D. A significant difference in the resolution of retinoschisis was observed between Groups C and D (P=0.036). No correlation was found between retinoschisis resolution and baseline factors. The mean best-corrected visual acuity (BCVA) significantly improved at the final follow-up (P＜0.001). The final BCVA was associated with baseline BCVA (P=0.007), the presence of epiretinal proliferation preoperatively (P=0.008) , and ithe postoperative integrity of the ellipsoid zone (EZ) (P<0.001) and interdigitation zone (IZ) (P=0.001).</p><p><strong>Conclusions: </strong>After surgery, the inner retinoschisis usually resolved completely. Retinoschisis was not the main factor influencing final BCVA. Preoperative BCVA and disruption of EZ and IZ were associated with good visual recovery in long-term follow-up.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-month silicone oil tamponade can decrease intraocular complications via reducing the recruitment and activation of leukocytes in Patients with Rhegmatogenous Retinal Detachment.","authors":"Lan Jiang, Yuqing Wu, Baoyi Liu, Kunbei Lai, Yuan Ma, Ziye Chen, Zijian Qin, Zhuojun Xu, Zhuangling Lin, Zitong Chen, Chin-Ling Tsai, Tao Li","doi":"10.1159/000545211","DOIUrl":"https://doi.org/10.1159/000545211","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of one-month versus routine-duration silicone oil (SO) tamponade on intraocular inflammatory cytokine levels and clinical outcomes in patients undergoing vitrectomy for rhegmatogenous retinal detachment.</p><p><strong>Methods: </strong>A prospective study from May 2019 to March 2022 divided patients undergoing vitrectomy into Routine and Early groups. Aqueous humor was sampled before SO removal to measure cytokine levels, including granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon(IFN)-γ, interleukin (IL)-4, IL-8, IL-10, IL-13, IL-17, macrophage inflammatory protein (MIP)-1α, tumor necrosis factor (TNF)-α and IL-1α. Clinical outcomes such as SO emulsification, cataract formation, recurrent retinal detachment, corneal endothelial cell (CEC) density, and intraocular pressure were assessed. Statistical analyses were performed to evaluate differences and correlations between cytokine levels and clinical characteristics.</p><p><strong>Results: </strong>The study analyzed 48 eyes, with 28 in the Routine group and 20 in the Early group. The Early group had significantly lower IL-8 and TNF-α levels (p=0.006 and p=0.013) and reduced SO emulsification (p=0.01). A significant trend towards fewer cataract cases and higher CEC density was observed in the Early group (p=0.019 and p=0.015). IL-8 and TNF-α levels showed positive correlations with IL-10, MIP-1α.</p><p><strong>Conclusions: </strong>One-month SO tamponade significantly reduces intraocular inflammatory cytokine levels and associated complications by decreasing the recruitment and activation of leukocytes. These findings suggest that shorter SO placement durations can effectively minimize inflammation-related complications while maintaining therapeutic efficacy. Future research should focus on optimizing SO tamponade protocols and exploring the underlying mechanisms of inflammation and emulsification to enhance the safety and efficacy of vitreoretinal surgeries.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous versus interrupted sutures for closure of scleral pocket and conjunctiva after evisceration and placement of acrylic ocular implant.","authors":"Ahmed Ali Amer, Hasan Naveed, Ibrahim Amer, Hamdy Osman Abdelrahman Osman, Mostafa Abdelrahman Ahmed Mohamed, Ashraf Mohammed GadElkareem, Ahmed Abdallah Elbarawy, Zisis Gatzioufas, Mohamed Elalfy, Mohamed A ElShafie","doi":"10.1159/000545331","DOIUrl":"https://doi.org/10.1159/000545331","url":null,"abstract":"<p><strong>Introduction: </strong>Various methods of conjunctival closure have been described, with no consensus of preference. We designed this study to compare continuous versus interrupted sutures for closure of scleral pocket and conjunctiva after evisceration and acrylic ocular implant installation.</p><p><strong>Methods: </strong>This study was a retrospective comparative observational study conducted at South Valley University Hospital on all ocular evisceration cases with acrylic implants from 1 March 2019 to 31 March 2024. For each patient, clinical data were perused including demographics, indications, clinical history, operative details, and postoperative follow-up data.</p><p><strong>Results: </strong>Forty-seven patients were included in this study. Twenty-seven were allocated to group A (continuous sutures) and 20 patients to group B (interrupted sutures). The mean age of patients was 38.52 ± 12.8 and 39.35 ± 14.5 in groups A and B respectively (P value = 0.839). Males represented 51.9% (1427) and 50% (1020) of groups A and B respectively (P value = 0.901). Absolute glaucoma was the indication in 5 (18.5%) and 3 (15%) patients in groups A and B respectively, anterior staphyloma was the indication in 7 (25.9%) and 5 (25%) patients respectively, Atrophia/Phthisis was the indication in 6 (22.2%) and 5 (25%) patients respectively, while Old Trauma was the indication in 9 (33.3%) and 7 (35%) patients respectively with P value = 0.769. The median size of the acrylic implant used was 20mm in both groups. Patients were followed up on average in group A for 20.19 ± 3.2 months, in group B for 19.95 ± 3.4 months (P value= 0.812). No cases of infection or implant extrusion were observed in both groups. But in group B, there were 3 cases (15%) of wound dehiscence and implant exposure while no reported cases in group A (0%) with clinically significant P value (0.029).</p><p><strong>Conclusion: </strong>Continuous suturing for closure, as opposed to interrupted sutures, produces better wound outcomes when closing the scleral pocket and conjunctiva post evisceration and acrylic ocular implant installation.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Systemic Inflammation and Morphological Changes of Retinal Neurovascular Unit in Patients with Early Signs of Diabetic Retinopathy: An OCT and OCT-Angiography Study.","authors":"Hanli Guo, Wenjie Wu, Yue Huang, Yulong Huang, Ningxuan Jin, Huazhi Ma, Qiong Li","doi":"10.1159/000545097","DOIUrl":"10.1159/000545097","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate the correlation between systemic inflammation biomarkers and morphological changes of retinal neurovascular unit (RNVU) under optical coherence tomography (OCT) and OCT-angiography (OCTA) in type 2 diabetic patients with early signs of diabetic retinopathy (DR).</p><p><strong>Methods: </strong>This cross-sectional study was carried out among 93 type 2 diabetic patients with early signs of DR (170 eyes), ranging from level 10 to level 35 based on ETDRS DR severity scale score. Age-, sex-, and axial length-matched normal subjects were enrolled as controls. Systemic inflammation biomarkers including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammatory index (SII), were calculated based on peripheral blood results. Retinal neuronal changes of RNVU were identified by accessing the thickness of macular retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) using OCT. Retinal microvascular alterations of RNVU were evaluated by measuring macular vessel density (VD) and size of foveal avascular zone (FAZ) using OCTA.</p><p><strong>Results: </strong>GCL thickness was significantly correlated with NLR (r = -0.183, p = 0.017) and MLR (r = -0.235, p = 0.002), RNFL thickness was significantly associated with MLR (r = -0.210, p = 0.008), FAZp was positively correlated with NLR (r = 0.153, p = 0.046) and MLR (r = 0.187, p = 0.014), FAZa was positively correlated with MLR (r = 0.189, p = 0.014), and VD was significantly correlated with NLR (r = -0.188, p = 0.014) on spearman correlation analysis. Additionally, VD was independently associated with SII in both univariable and multivariable GLM analysis (p＜0.05). This difference still remained statistically significant during subgroup analysis after controlling DM duration.</p><p><strong>Conclusion: </strong>Systemic inflammation biomarkers including NLR, MLR, and SII are significantly associated with not only retinal microvascular alterations but also retinal neuronal changes, providing evidence that systemic inflammation may play a crucial role on the early morphological changes of RNVU and early DR pathogenesis. SII is independently associated with VD, which supports SII may serve as a potential biomarker for monitoring early microvascular changes of DR.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-21"},"PeriodicalIF":2.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combined Index of Steady-state Pattern Electroretinogram and Optical Coherence Tomography improved the Detection of Early Glaucoma.","authors":"Hwayeong Kim, Sangwoo Moon, EunAh Kim, Jinmi Kim, Jiwoong Lee","doi":"10.1159/000545094","DOIUrl":"https://doi.org/10.1159/000545094","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the structure-function relationship between steady-state pattern electroretinogram (ssPERG), optical coherence tomography (OCT), and visual field (VF) tests, and to investigate indicators that enhance the detection of preperimetric and early-stage primary open angle glaucoma (POAG).</p><p><strong>Methods: </strong>In this retrospective cohort study, patients with POAG and normal subjects who underwent ssPERG, OCT, and VF tests were included. We defined the ratio of the amplitudes from 0.8° checks to 16° checks as the pattern electroretinogram ratio (PERGratio). The thickness of the macular ganglion cell inner plexiform layer and the peripapillary retinal nerve fiber layer (cpRNFL) were measured using spectral-domain OCT. We compared the areas under the receiver operating characteristic curves (AUCs) for ssPERG, OCT, and VF test parameters. A combined index using structural and functional measures was generated using logistic regression models to improve diagnostic accuracy.</p><p><strong>Results: </strong>Four parameters had AUCs higher than 0.8; PERGratio (AUC = 0.890), average cpRNFL thickness (AUC = 0.827), 7 o'clock cpRNFL thickness (AUC = 0.844), and inferior quadrant cpRNFL thickness (AUC = 0.830). The new index, which combines the PERGratio and 7 o'clock cpRNFL thickness, significantly improved diagnostic accuracy (AUC = 0.951), outperforming the best four parameters (all P ≤ 0.004). Furthermore, the combined index of PERGratio and 7 o'clock cpRNFL thickness showed significantly higher diagnostic accuracy compared to those combining the 7 o'clock cpRNFL thickness with visual field mean deviation, pattern standard deviation, and visual field index.</p><p><strong>Conclusion: </strong>Combined index of ssPERG, indicative of RGC dysfunction, and the OCT test, indicative of focal structural damage, improved the detection of patients with POAG in its early stage.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-18"},"PeriodicalIF":2.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior segment anatomic parameters based on the scleral spur and cornea for risk profiling of primary angle-closure glaucoma.","authors":"Yue Fu, Bin Jiang, Yang Liu, Lufan Li, Yuting Li, Zhaohui Chang, Wen Zeng, Min Ke","doi":"10.1159/000543866","DOIUrl":"https://doi.org/10.1159/000543866","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG).</p><p><strong>Methods: </strong>A retrospective study was conducted, collecting parametric measurements obtained using CASIA 2 and IOLMaster 700. Univariate and multivariate logistic regression models were utilized to compare ocular parameters between the narrow angle (NA) group and PACG group, as well as identify risk factors for PACG. The predictive performance of each parameter was evaluated using the area under the receiver operating characteristic curve (AUROC).</p><p><strong>Results: </strong>A total of 84 patients with PACG (48 with PACG and 36 with chronic PACG) and 84 patients with NA were included in this study. In the multivariable model, it was demonstrated that individuals with a smaller trabecular scleral-spur angle (TSA; OR = 0.810, per 1 degree increase, p < 0.001, AUROC =0.738) and larger relative lens vault (rLV: OR = 1.112, per 1 percent increase, p < 0.001, AUROC =0.720) had an increased risk of developing PACG. Furthermore, combining TSA with rLV yielded an improved AUROC value of 0.807 (p<0.001).</p><p><strong>Conclusion: </strong>AS-OCT is a valuable tool for early assessment of progression risk in NA patients at risk for developing PACG. Our findings suggest that both TSA and rLV are significant risk factors for PACG. Moreover, the novel parameter TSA demonstrates promising potential as a predictive tool for early PACG screening.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-20"},"PeriodicalIF":2.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biometric Factors Associated with Prediction Errors Related to Lens Position in Vitrectomized Patients.","authors":"Eloi Debourdeau, Pierre Pineau, Chloe Chamard, Julien Plat, Didier Hoa, Frederico Manna, Sandrine Akouete, Thibault Mura, Max Villain, Nicolas Molinari, Vincent Daien","doi":"10.1159/000542358","DOIUrl":"10.1159/000542358","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate clinical and biometric factors leading to a prediction error related to lens position in pars plana vitrectomy.</p><p><strong>Methods: </strong>This study was conducted as a consecutive retrospective case series at the Department of Ophthalmology, Montpellier University Hospital. All medical files and PCI biometrical reports from a single surgeon were reviewed from 2017 to 2019. Patients who had phacoemulsification with the ASPHINA 509 MP® intraocular lens were selected and stratified into 3 groups: phacoemulsification alone (group 1), phacoemulsification and vitrectomy with gas tamponade (group 2), and phacoemulsification and vitrectomy without tamponade (group 3). Clinical factors and biometry factors from initial and final biometry were collected. Refractive error, actual lens position, C constant, axial length delta, and pre-operative and post-operative anterior and posterior segment variation parameters were calculated.</p><p><strong>Results: </strong>A total of 140 eyes were analyzed, 90 in group 1, and 25 in group 2 and 3. The mean prediction error was 0.10 ± 0.55 D (group 1); -0.36 ± 0.74 D (group 2); and -0.12 ± 0.54 D (group 3) with p < 0.05 for group 1 vs. group 2. The mean actual lens position was 5.25 ± 0.29 mm; 5.66 ± 0.60 mm; and 5.50 ± 0.43 mm for the 3 groups, respectively (p < 0.001). Axial length delta was -0.10 ± 0.13 mm in group 1, -0.062 ± 0.20 mm in group 2, and -0.022 ± 0.17 mm in group 3 (p = 0.015). Multilinear regression analysis found a significant and independent influence of vitrectomy and gas tamponade on prediction error.</p><p><strong>Conclusion: </strong>Myopic shift in the case of vitrectomy is multifactorial, effective lens position is modified by vitrectomy and vitreous refractive index is changing. The integration of these data in formulas may improve refractive outcome after cataract and vitrectomy surgery.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"52-60"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma.","authors":"Leyi Wang, Bozhao Wang, Ying Wang, Xin Wang, Hongling Yang, Ran Wu, Yan Cui","doi":"10.1159/000544002","DOIUrl":"10.1159/000544002","url":null,"abstract":"<p><strong>Introduction: </strong>Cataract may cause severe visual impairment in eyes with microphthalmos (MO) and uveal coloboma (UC). Despite their similarities, distinguishing between these conditions is crucial for cataract surgery. We aimed to compare complications, nucleus hardness, surgical strategies, and outcomes of cataract surgery between MO and UC.</p><p><strong>Methods: </strong>This retrospective comparative study included 19 eyes with MO and 20 with UC. Preoperative, intraoperative, and postoperative data of eyes that underwent cataract surgery were analysed.</p><p><strong>Results: </strong>MO eyes had lower high-hardness nucleus rates (p = 0.002) than UC. The most common preoperative complications in the MO and UC groups were glaucoma (37.5%) and retinal detachment (15.4%), respectively. No significant differences in the phacoemulsification (p = 0.45) or intraocular lens implantation (p > 0.99) rates between the two groups. Extracapsular cataract extraction was performed in five eyes (25%), and posterior capsular rupture was the most common surgical complication (15%) in the UC group. Combined surgery was mainly used to deal with high or unstable intraocular pressure (IOP; 77%) in the MO group versus posterior pars plana vitrectomy (85.71%) in the UC group to treat vitreoretinal pathologies. Corrected distance visual acuity was significantly improved in both MO (p = 0.0005) and UC (p < 0.001) groups, while IOP was decreased (p = 0.03) in the MO group.</p><p><strong>Conclusion: </strong>Eyes with MO and UC exhibited distinct cataract grades and complications, necessitating varied surgical strategies; while cataract surgery has proven to be effective in improving the visual acuity in both groups. Our findings hold significant value for guiding clinical treatment decision-making.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"147-155"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Factors behind Patient Nonadherence to Intravitreal Anti-Vascular Endothelial Growth Factor Injections in Macular Diseases.","authors":"Efrat Naaman, Noa Yanir-Prat, Diana Shair-Nakhleh, Nitai Bar, Beata Miller, Anna Fishman, Shiri Zayit-Soudry","doi":"10.1159/000543352","DOIUrl":"10.1159/000543352","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, intravitreal injections (IVTs) of vascular endothelial growth factor (VEGF) inhibitors have become the standard of care for several macular disorders. Frequently, the therapeutic course requires numerous injections, posing a burden on patients. Nonadherence to treatment may result in reduced visual outcomes, therefore understanding and addressing the underlying causes is imperative.</p><p><strong>Methods: </strong>A cross-sectional study of patients who missed their scheduled appointment for anti-VEGF IVT as part of the routine management of their macular disease at a single tertiary center between November 2020 and February 2021. A telephone survey was conducted and patient medical charts were reviewed for ophthalmological data.</p><p><strong>Results: </strong>A total of 100/556 (18%) patients who failed to attend their scheduled anti-VEGF IVT appointments were documented. Among these subjects, the average age was 66 (SD ± 14) years with a nearly equal gender distribution of 49:51 F:M ratio. Reported no-show reasons included concurrent illness (39%), administrative issues such as missing financial coverage forms or scheduling problems (28%), and lack of motivation (11%). Additionally, 73% of patients who missed appointments expressed a need for accompaniment, and 74% resided outside the hospital city.</p><p><strong>Conclusions: </strong>Study results highlight modifiable factors contributing to no-shows to anti-VEGF IVT, such as poor transportation access, complicated administrative processes, and difficulty rescheduling missed appointments. Understanding potential obstacles to anti-VEGF IVT therapy, particularly those that are preventable, can enhance adherence and potentially improve the clinical outcome.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"221-227"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}