Ophthalmic Research最新文献

{"title":"Changes in Beta Parapapillary Atrophy in Primary Angle-Closure Suspect: A 5-Year Follow-Up Study.","authors":"Fei Xiang, Ye Zhang, Qing Zhang, Mengyang Li, Xiaohua Pan, Hui Feng, Caixia Li, Meijuan Zhang, Liqin Song, Yi Wang, Junying Ren, Shuning Li","doi":"10.1159/ore/aedag004","DOIUrl":"https://doi.org/10.1159/ore/aedag004","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the changes in beta parapapillary atrophy (β-PPA) in eyes with primary angle-closure suspect (PACS) after 5 years.</p><p><strong>Methods: </strong>This longitudinal cohort study included participants aged ≥50 years with PACS at baseline, who participated in the 5-year follow-up examinations. β-PPA was characterized using stereoscopic fundus and optical coherence tomography. Logistic and linear regression analyses were performed to identify factors correlating with the presence of β-PPA enlargement and with the enlargement of β-PPA parameters, respectively.</p><p><strong>Results: </strong>A total of 83 participants with PACS (83 eyes) were included. The enlargement of β-PPA was found in 26.51% of PACS eyes during the 5-year follow-up period. The parameters of area, angular extent, and maximum radial length of β-PPA were significantly enlarged at the 5-year follow-up compared with those at baseline (P < 0.001, 0.027, and < 0.001, respectively). The presence of β-PPA enlargement was associated with a larger axial length (AL; odds ratio [OR] = 2.473, 95% confidence interval [CI]: 1.119-5.446, P = 0.025) and larger vertical cup-to-disc ratio (VCDR; OR = 1.066, 95% CI: 1.001-1.135, P = 0.048). The factor associated with the enlargement of area, angular extent, and maximum radial length of β-PPA was a longer AL (P = 0.016, 0.023, and 0.018, respectively).</p><p><strong>Conclusions: </strong>The morphology parameters of β-PPA were enlarged in eyes with PACS during the 5-year follow-up period. The presence of β-PPA enlargement was associated with a longer AL and larger VCDR at baseline.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Deep Learning Using Retinal Images for Detection of Chronic Kidney Disease: A Systematic Review and Meta-analysis.","authors":"Mehrdad Farrokhi, Behnam Hoorshad, Reza Fahimi, Atousa Moghadam Fard, Behnaz Dalvandi, Reza Dalvandi, Mahshid Esmaielzade Rostami, Reza Judi Chelan, Oveis Ahmadzadeh, Sareh Salarinejad, Ramtin Shemshadigolafzani, Morteza Alipour, Parham Rahmani, Marjan Lashgari, Mahya Asadalizadeh","doi":"10.1159/ore/aedag003","DOIUrl":"https://doi.org/10.1159/ore/aedag003","url":null,"abstract":"<p><strong>Background: </strong>Multiple investigations have been conducted to diagnose chronic kidney disease (CKD) from photographs of retina using deep learning models, with a wide range of diagnostic performance, which necessitates the importance of a comprehensive review. Therefore, in this meta-analysis, we estimated the detection performance of deep learning models for the diagnosis of CKD using retinal photographs.</p><p><strong>Methods: </strong>MEDLINE, Scopus, and Web of Science were searched until 25 December 2025. Pooled estimation of heterogeneity, diagnostic parameters, and meta-regressions were performed using MetaDisc and STATA Softwares.</p><p><strong>Results: </strong>The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were 0.81 (95% CI, 0.80-0.82), 0.64 (95% CI, 0.64-0.65), and 9.15 (95% CI, 5.72-14.62), respectively. The pooled estimates of the positive and negative likelihood ratios were 2.18 (95% CI, 1.66-2.87) and 0.28 (95% CI, 0.20-0.39), respectively. The area under the summary receiver operating characteristic (SROC) curve showed a discriminative performance of 0.77.</p><p><strong>Conclusion: </strong>Deep learning based on retinal images had moderate diagnostic performance for detection of CKD. Relatively high sensitivity and modest specificity suggesting that deep learning is more effective for ruling out CKD than for confirming the diagnosis that deep learning is more effective for ruling out CKD than for confirming the diagnosis. Deep learning-based retinal analysis may therefore serve as a supportive, noninvasive screening or triage tool but should not replace established diagnostic methods for CKD.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Neighborhood Factors Influencing Participation in a Personalized Glaucoma Coaching Program.","authors":"Stephanie Lee, Patrice M Hicks, Justus N Dobson, Jamie Ann Mitchell, Deborah Darnley-Fisch, Michele Heisler, Nauman R Imami, Paula Anne Newman-Casey","doi":"10.1159/ore/aedag001","DOIUrl":"https://doi.org/10.1159/ore/aedag001","url":null,"abstract":"<p><strong>Introduction: </strong>To assess barriers and facilitators to program engagement for participants in the Support, Educate, Empower (SEE) Personalized Glaucoma Coaching Pilot Program and identify differences by demographics or neighborhood area deprivation.</p><p><strong>Methods: </strong>This mixed-methods study analyzed SEE glaucoma coaching program participants. Patient characteristics included age, sex, race, and neighborhood socioeconomic status (area deprivation index [ADI]). Interview transcripts were coded using the adapted Penchansky and Thomas framework, which defines healthcare access through access dimensions: availability (supply of services), accessibility (location), accommodation (organization of services), affordability (cost), awareness (communication/information), and acceptability (attitudes and comfort), to categorize barriers and facilitators. Thematic frequencies were calculated and stratified by participant characteristics.</p><p><strong>Results: </strong>The 44 participants in the SEE pilot program were 52% ≥65 years old, 55% male, 46% White, and 34% lived in high ADI neighborhoods. Awareness (100%) and acceptability (66%) were the most cited themes. Low ADI participants experienced more acceptability (79% vs. 39% high ADI) and awareness barriers (79% vs. 43% mid ADI). Mid ADI participants had more accessibility barriers (71% vs 13% low ADI) and accommodation facilitators (43% vs 8% low ADI). High ADI participants reported more patient-level facilitators (44% vs 14% mid ADI). No differences emerged by other demographics.</p><p><strong>Conclusion: </strong>Among SEE pilot program participants, acceptability barriers and awareness facilitators were the most frequently cited. There were ADI differences for barriers and facilitators. Neighborhood factors should be considered when implementing glaucoma coaching programs, as program interaction varies by these characteristics. The SEE pilot program facilitated glaucoma medication adherence through educational resources and adherence monitoring tools.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease.","authors":"Kenneth Ka Hei Lai, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Nicole Tsz Yan Wong, Kevin Ka Fai Yuen, Carly S K Yeung, George Pak Man Cheng, Winnie Chiu Wing Chu, Wilson Wai Kuen Yip, Alvin Lerrmann Young, Hunter Kwok Lai Yuen, Alan Chun Hong Lee, Chiu Ming Ng, Clement Chee Yung Tham, Chi Pui Pang, Kelvin Kam Lung Chong","doi":"10.1159/000553278","DOIUrl":"https://doi.org/10.1159/000553278","url":null,"abstract":"<p><strong>Purpose: </strong>Clinical activity score (CAS) is widely used to assess thyroid eye disease (TED) activity, but its predictive value in East Asian patients remains unclear. This study evaluated correlation between CAS and both radiological and serological markers in treatment-naïve ethnic Han Chinese TED patients.</p><p><strong>Methods: </strong>Cross-sectional study of treatment-naïve ethnic Han Chinese TED patients managed at The Chinese University of Hong Kong between January 2014 and May 2022. STIR signal intensity was quantified using signal intensity ratio (SIR), while disease activity was assessed clinically using CAS.</p><p><strong>Results: </strong>A total of 188 patients with a mean onset age of 50±14 years who underwent baseline MRI were included. The mean presenting CAS was 1.4±1.3. A weak positive correlation was observed between CAS and the SIR of the levator palpebral superioris/superior rectus complex (r=0.196, P=0.00709). Nominal positive correlations were observed between CAS and the SIRs of the inferior rectus (r=0.185, P=0.0112), and medial rectus (r=0.167, P=0.0224). In subgroup analysis of patients presenting with CAS ≥3, nominal positive correlations were observed between CAS and the SIRs of the lateral rectus (r=0.374, P=0.0416), medial rectus (r=0.351, P=0.0487), and inferior rectus (r=0.335, P=0.0348). No correlation was identified in patient with CAS <3. No significant correlation was found between CAS and serological markers.</p><p><strong>Conclusions: </strong>The correlation between CAS and STIR signals was generally weak, and no significant correlation was identified between CAS and serological markers. These findings suggest that orbital MRI may provide complementary information beyond clinical assessment in evaluating disease activity in Ethnic Chinese TED patients.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Keratitis in Southern Arizona.","authors":"Ahmed Abdelhady, Jonathan Han, Robert Wu, Max Coffeen, Zachary E Leibovit-Reiben, Meet Panjwani, Mingwu Wang, Ovette F Villavicencio, Xuemin Zhang, Jonathan M Holmes","doi":"10.1159/000551714","DOIUrl":"10.1159/000551714","url":null,"abstract":"<p><strong>Introduction: </strong>There is a paucity of data on microbial keratitis in the southwestern USA, specifically southern Arizona. Understanding demographic factors and causative organisms will help design future treatments and preventative measures.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on all cases (>17 years old) of microbial keratitis at Banner University Medical Center Tucson, Arizona, from September 1, 2017, to August 31, 2022. Frequencies of social, demographic, ocular factors, and isolated organisms were reported. We used Fisher's exact tests to compare findings with 2023 census data.</p><p><strong>Results: </strong>We identified 272 eyes in 268 patients. Compared with census data, demographic factors overrepresented in microbial keratitis were as follows: unemployment (50.4%) and homelessness (8.2%). Drug use was identified in 22.4% of patients. Associated factors were contact lens wear (33.1%) and preceding ocular trauma (14.7%). Among eyes associated with contact lens use, 49 (54.4%) were worn overnight. Of 203 eyes with culture results, 152 (74.9%) yielded a positive microbial culture; 96.5% were bacterial and 3.4% were fungal. Gram-positive bacteria were found in 54.7%, most commonly Staphylococcus epidermidis (16.7%). The most common gram-negative isolate was Pseudomonas aeruginosa (12.8%).</p><p><strong>Conclusion: </strong>In southern Arizona, microbial keratitis is particularly associated with drug use, unemployment, and homelessness. Contact lens use and overnight wear were common, warranting education on safe practices. Positive fungal cultures were rare. Each factor deserves consideration for societal intervention, to reduce the burden of microbial keratitis in southern Arizona, and should be evaluated as potential risk factors in other communities. Overall culture results may influence choice of initial therapy.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"120-128"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Tissue Impact on Descemet Membrane Endothelial Keratoplasty Graft Preparation and Clinical Outcome.","authors":"Silvia Schrittenlocher, Jithmi Weliwitage, Mara Serban, Aline Woitas, Mario Matthaei, Björn Bachmann, Claus Cursiefen","doi":"10.1159/000551253","DOIUrl":"10.1159/000551253","url":null,"abstract":"<p><strong>Introduction: </strong>Aims of the study were to determine which donor characteristics, like previous diseases and surgeries, influence the graft preparation difficulty of the Descemet membrane/endothelial lamella in DMEK surgery and to analyze the impact on the 1-year clinical outcome.</p><p><strong>Methods: </strong>Overall, 1,051 eyes with DMEK surgery between January, 2018, and January, 2021, performed at the University Hospital Cologne, Germany, were included in this single-center and retrospective study. Information regarding the donors' previous diseases and surgeries were provided by a large database of a cornea bank (Multi Tissue Bank Mecklenburg-Vorpommern) and merged with the Cologne DMEK database that contains information regarding preparation characteristics of the surgeon-prepared graft directly preoperatively and postoperative clinical follow-up. Three preparation groups (easy, difficult, and very difficult) were correlated to the donors' previous disease and surgeries. Also, outcome parameters, like visual acuity, endothelial cell density, and graft survival, were correlated to the graft preparation group.</p><p><strong>Results: </strong>Donor diabetes was found as significant predictor for central adhesions (p < 0.001). Diabetes patients are 2 times more likely to have central adhesions complicating preparation than non-diabetes patients (OR = 2.2). Previous cataract surgery was significantly associated with difficult stripping and preparation (p < 0.001), with an estimated 1.07-fold increase in stripping difficulty (95% CI: 0.80-1.34) and overall 1.99-fold increase in preparation difficulty (95% CI: 1.71-2.29). Chronic kidney disease (p = 0.012) and previous cataract surgery (p = 0.005) show significant associations to tissue loss. Donor diagnosis such as diabetes mellitus type 2, chronic ischemic heart disease, and respiratory insufficiency has a significant association with the preparation group (p = 0.001; p = 0.004; and p = 0.032, respectively). No interactions were found between preparation difficulties and visual acuity (p = 0.122), rebubbling rate (p = 0.780), or endothelial cell density (p = 0.886) nor graft survival (p value = 0.157) 1 year postoperatively.</p><p><strong>Conclusions: </strong>Donor diabetes mellitus, heart failure, hypertension, respiratory insufficiency, kidney disease, and previous cataract surgery are associated with difficult DMEK graft preparation, the latter two also with tissue loss. No impact of donor factors on clinical outcome was found.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"98-104"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AROMA Dataset for Automatic Detection of Artifact Type and Severity in Retinal Optical Coherence Tomography Angiography.","authors":"Lucas Szwarcberg, Atif Anwer, Alexandre Gozlan, Paul Drouard, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Fabrice Mériaudeau, Louis Arnould","doi":"10.1159/000551126","DOIUrl":"10.1159/000551126","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, retinal vascular imaging has attracted growing interest and is experiencing rapid technological advancements in imaging modalities such as swept-source optical coherence tomography angiography (SS OCT-A). OCT-A enables precise, noninvasive, quantitative measurements of retinal vascularization. However, it is also prone to artifacts that are challenging to detect and can significantly limit diagnostic accuracy and biomarker reliability.</p><p><strong>Methods: </strong>We present a dataset of en face retinal SS OCT-A images, labeled by artifact type and severity. Each patient's OCT-A scan consists of 14 images that are graded by multiple experts and assigned corresponding artifact labels with an overall quality grade. We also report results for two deep-learning binary classification models trained on the dataset: one based on image compression via principal component analysis (PCA) and the other using a six-channel tensor.</p><p><strong>Results: </strong>The dataset comprised 281 OCT-A scans from 115 anonymized patients. The PCA-based model achieved a precision of 87% for image quality classification, while the six-channel model achieved 97%.</p><p><strong>Conclusion: </strong>Using a curated dataset of en face SS OCT-A images with detailed artifact annotations, we trained a deep-learning model capable of high-precision image quality classification. These results demonstrate the feasibility of using task-specific artificial intelligence for quality assessment based on artifact detection in retinal imaging.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"105-119"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Intraocular Lens Power Calculation Formulas in Cataract Eyes after Vitrectomy with Silicone Oil Tamponade: A Network Meta-Analysis.","authors":"Peng Zhao, Meng Li, Zhao-Xing Guo, Zhi-Yong Tian, Jing-Shang Zhang, Ying-Yan Mao, Zheng Xin, Zhong-Yan Li, Xiu-Hua Wan","doi":"10.1159/000551331","DOIUrl":"10.1159/000551331","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to systematically compare the accuracy of artificial intelligence and traditional intraocular lens (IOL) calculation formulas in cataract eyes after vitrectomy with silicone oil tamponade.</p><p><strong>Methods: </strong>PubMed, Cochrane, Embase, and Web of Science databases were searched to select relevant studies published up to October 29, 2025. A total of 12 formulas (SRK/T, Hoffer Q, Hoffer QST, Haigis, Barrett Universal II, Holladay I, Holladay II, RBF, LSF, EVO, Kane, and Pearl-DGS) were included for final comparison. The primary outcomes were the percentage of eyes with prediction errors (PE) within ± 0.50 D and ± 1.00 D.</p><p><strong>Results: </strong>This meta-analysis included 7 studies comprising 1,060 eyes. Overall, compared to traditional formulas, newer formulas demonstrated relatively higher accuracy. The results indicated that among all the formulas being compared, the optimal formula was Kane. For the percentage of eyes with PE within ± 0.50 D, Kane had the highest precision. For the IOL power percentage within ± 1.00 D, EVO performed the best, with Kane also ranking highly. Furthermore, RBF also performed very well.</p><p><strong>Conclusion: </strong>Kane and EVO appear to be better choices for silicone oil-filled eyes after vitrectomy.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"85-97"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Change in Corneal Curvature and Fourier Indices after Corneal Suture Removal in Corneal Lacerations.","authors":"Xiaolin Chen, Xixuan Ke, Huiyu Liang, Meiqing Yang, Xiaoting Mai, Vishal Jhanji, Haoyu Chen","doi":"10.1159/000552364","DOIUrl":"10.1159/000552364","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to investigate the longitudinal changes in corneal curvature and refractive components after suture removal in full-thickness corneal laceration using swept-source anterior segment optical coherence tomography (SS AS-OCT).</p><p><strong>Methods: </strong>Thirty patients were included in this study. The patients were divided into three groups according to the location of the wound on the cornea: central, paracentral, and peripheral. SS AS-OCT was performed before corneal suture removal, 1 h, 1 week, and 2 weeks after corneal suture removal. The corneal curvature parameters and Fourier indices were compared longitudinally in each group.</p><p><strong>Results: </strong>After removing the corneal suture, the changes in average keratometry and spherical component were mostly in the first week and less than 0.25D in the second week except the spherical component in the central group. The cylinder, regular astigmatism, asymmetry, and higher order irregularity decreased after suture removal. The patterns of change in the refractive components differ a little with different locations of the wound. The best-corrected visual acuity improved after suture removal in all groups.</p><p><strong>Conclusion: </strong>The current study demonstrates the changes in corneal curvature and refractive components after corneal suture removal in various locations of corneal laceration. This information provides a reference for deciding the time and strategy of subsequent procedures for visual rehabilitation.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"198-212"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between Spectral Domain Optical Coherence Tomography Measurements and Visual Acuity in Patients with Retinitis Pigmentosa at Baseline and One-Year Follow-Up.","authors":"Emma Carpenter, Khushi Saigal, Elizabeth Slaney, Jessica Yang Walia, Kyle Fallgatter, Jinghua Chen","doi":"10.1159/000550474","DOIUrl":"10.1159/000550474","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between spectral domain optical coherence tomography (SD-OCT) structural findings and visual acuity in patients with retinitis pigmentosa (RP), with and without cystoid macular edema (CME), at baseline and 1-year follow-up.</p><p><strong>Methods: </strong>This retrospective chart review included 30 patients with RP treated at the University of Florida Health Eye Center from 2014 to 2020. Patient records were analyzed for SD-OCT structural features and visual acuity outcomes. Statistical analyses included descriptive statistics, χ2 tests, independent t tests, and Pearson's correlation tests. Main outcome measures were best corrected visual acuity (BCVA), presence of the ellipsoid zone (EZ) in the fovea and macula, central retinal thickness (CRT), total macular volume (TMV), and presence of an epiretinal membrane (ERM).</p><p><strong>Results: </strong>The study included 30 patients (21 female, 9 male) with an average age of 46.83 ± 18.86 years (range, 10-80 years). The average follow-up period between visits was 11.9 ± 1.6 months (range, 9-15 months). Among the 60 eyes analyzed, 50% had CME. Eyes with CME had a greater CRT at the follow-up visit (p = 0.029). No significant differences were found in BCVA or TMV between RP patients with and without CME. Correlation analyses revealed a significant relationship between CRT and BCVA at both visits (p = 0.001, p = 0.004) in RP patients without CME, but not in RP patients with CME. EZ foveal sparing consistently predicted BCVA outcomes (p < 0.001) and CRT (p ≤ 0.001) at both visits in RP patients with and without CME. Greater TMV at both visits (p = 0.009, p = 0.012) and the presence of an ERM at the follow-up visit (p = 0.046) were significantly associated with a decline in BCVA between visits in RP patients without CME.</p><p><strong>Conclusions: </strong>EZ foveal sparing is a significant predictor of visual acuity in RP patients regardless of the presence of CME. While CRT correlates with visual acuity in patients without CME, it does not predict outcomes in those with CME. TMV may serve as a marker for preclinical CME, and both increased TMV and ERM presence may predict visual decline in RP patients with undetectable CME on SD-OCT.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"64-73"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}