Ophthalmic Research最新文献

{"title":"Bruch's membrane opening (BMO) based peripapillary OCT-A analysis.","authors":"Sebastian Fassihi Dehkordi, Julia Schottenhamml, Meike Müller, Sami Hosari, Robert Lämmer, Andreas Maier, Bettina Hohberger, Christian Mardin","doi":"10.1159/000545878","DOIUrl":"https://doi.org/10.1159/000545878","url":null,"abstract":"<p><strong>Purpose: </strong>Peripapillary OCT-A scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of BMO-based peripapillary OCT-A analysis with and without the implementation of the Anatomical Positioning System (APS) compared to manual analysis.</p><p><strong>Methods: </strong>Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analysed by the Erlangen Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (Fovea-to-Bruch's Membrane Opening-Center). Peripapillary OCT-A scans were analysed: (I) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (II) BMO-based, and (III) BMO-based with APS information. Coefficients of variation (CV) were calculated.</p><p><strong>Results: </strong>Peripapillary mean VD was 42.52±4 and 41.69±4 (manually), 50.29±4 and 48.8±4 (BMO-based), and 44.73±3 and 44.39±4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p=0.04), but not for BMO-based (p>0.05) and BMO-based and APSified analysis (p>0.05). CV were 10.0 (manually), 8.0 (BMO-based), and 8.0 (BMO-based and APSified).</p><p><strong>Conclusion: </strong>The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative outcomes of one-month silicone oil tamponade in rhegmatogenous retinal detachment: a multicenter study.","authors":"Jingyi Li, Wei Wu, Chunling Huang, Yulin Ma, Pengtao Gu, Qiuxia Lin, Jiaqi Liu, Porpor Kea, Yonggang Yuan, Ling Lin, Peiyang Shen, Jiali Li, Songfu Feng","doi":"10.1159/000546255","DOIUrl":"https://doi.org/10.1159/000546255","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate postoperative outcomes in patients who underwent rhegmatogenous retinal detachment (RRD) surgery.</p><p><strong>Methods: </strong>This was a multicenter retrospective study involving 263 patients who underwent silicone oil (SiO) tamponade for RRD. Patients were divided into three groups based on the SiO tamponade: one month (Group 1, n=55), three months (Group 2, n=176), and six months (Group 3, n=32). The main outcomes were best corrected visual acuity (BCVA), intraocular pressure ( IOP), and retinal structure one month after silicone oil removal (SOR).</p><p><strong>Results: </strong>In the analysis of retinal structure in post-SOR, The median central macular thickness (CMT) in Group 1, 2 and 3 were 182.5 μm (IQR: 156.0-214.0), 170.0 μm (IQR: 140.3-211.5), 152.0 μm (IQR: 92.3-195.3), and the median ganglion cell layer-Inner plexiform layer (GCL-IPL) in Group 1, 2 and 3 were 80.5 μm (IQR: 70.0-92.3), 73.0 μm (IQR: 65.0-81.3), 65.0 μm (IQR: 56.3-79.0), respectively. Both CMT and GCL-IPL differ significantly with the Group 1 exhibiting the thickest retinal structure (P = 0.03 and P=0.006). IOP differ significantly across groups, with Group 3 showing the highest IOP in post-SOR (P = 0.015). However, there were no significant differences in BCVA, inner retinal layer thickness (IRLT), outer retinal layer thickness (ORLT), or submacular fluid (SMF) among the groups.</p><p><strong>Conclusions: </strong>Prolonged SiO tamponade is correlated with increased IOP and the thinning of the CMT and GCL-IPL over time, with favorable postoperative outcomes for one-month silicone oil tamponade. Given the potential risks of extended tamponade, it is advisable to remove silicone oil as soon as anatomically feasible.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Changes in Macular Vessel Density in High Myopia on Optical Coherence Tomography Angiography.","authors":"Yi Wu, Yingyi Shan, Jian Bu, Ziying Li, Mingguang He, Wenyong Huang, Wei Wang","doi":"10.1159/000543975","DOIUrl":"https://doi.org/10.1159/000543975","url":null,"abstract":"<p><strong>Purpose: </strong>To quantitatively characterize the longitudinal changes in macular vessel density (VD) in eyes with high myopia using swept source-optical coherence tomography angiography (SS-OCTA).</p><p><strong>Methods: </strong>108 high myopic subjects (axial length ≥ 26.0 mm) and 180 age-matched normal subjects were recruited and followed up for at least 1 year. 6 × 6 mm SS-OCTA scans centered at the fovea were used to obtain measurements of macular vessel density (VD) in both the superficial (SCP) and deep capillary plexus (DCP). Linear regression analyses were performed to determine the independent factors associated with the change rates of parafoveal VD over time.</p><p><strong>Results: </strong>High myopia group presented a great loss of VD in both SCP and DCP, whereas control group only showed a significant reduction of VD in the SCP (all P < 0.05). The decrease of VD in the parafoveal region of high myopia group were faster than that of control group (SCP, -2.81%/year vs. -1.05%/year, P = 0.002; DCP, -1.06%/year vs. -0.01%/year, P = 0.004), as well as in the inner and outer ring (all P < 0.05). Longer baseline axial length (AL) was demonstrated to be significantly associated with faster reduction of parafoveal VD in both SCP (Estimate, -0.49; 95% CI, -0.79 to -0.18; P = 0.002) and DCP (Estimate, -0.22; 95% CI, -0.42 to -0.03; P = 0.025) in high myopia group.</p><p><strong>Conclusions: </strong>High myopes exhibited a faster reduction of VD in parafoveal region and in the inner and outer ring in comparison to healthy controls. Longer baseline axial length was associated with greater loss of parafoveal VD in patients with high myopia.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-18"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Iris Vessel Density for Primary Glaucoma Diagnosis using Anterior Segment Optical Coherence Tomography.","authors":"Qiang Li, Wenjuan Wu, Xiaofei Man, Cuixia Dai","doi":"10.1159/000545948","DOIUrl":"https://doi.org/10.1159/000545948","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to evaluate the iris vessel density within a 15 mm × 12 mm area in primary glaucoma using anterior segment optical coherence tomography (AS-OCT) and anterior segment optical coherence tomography angiography (AS-OCTA).</p><p><strong>Methods: </strong>The study involved 30 normal eyes and 31 eyes with primary glaucoma, comprising 15 with primary open-angle glaucoma (POAG) and 16 with primary angle-closure glaucoma (PACG). OCT/OCTA images of the iris obtained were evaluated and a univariate logistic regression model was used to assess the correlation between the iris vessel density and primary glaucoma, area under the receiver operating characteristic (AUROC) and clinically relevant performance metrics of different regions (superior, inferior, temporal, and nasal regions) were compared. Additionally, the trabecular iris angle (TIA) in both the nasal and temporal regions to elaborate the mechanism of using iris vessel density for primary glaucoma detection.</p><p><strong>Results: </strong>Across all regions, the vessel density in the glaucoma group was significantly lower than in the normal eyes. The nasal 6-12 mm annular region of the iris demonstrated the highest diagnostic ability (AUROC = 0.870, P < 0.001), followed by the temporal 3-6 mm annular region (AUROC = 0.837, P < 0.001). All AUROC exceeded 0.8, with P-values below 0.01, indicating strong diagnostic accuracy. Furthermore, TIA in primary glaucoma was smaller than normal individuals. Compared with the nasal region, the temporal region exhibited higher correlation with TIA, where TIA500 demonstrated the largest diagnostic value in the temporal region (AUROC = 0.995, P < 0.001). Moreover, a strong correlation was observed between iris vessel density and TIA in the 6-12 mm region. Based on the clinical parameter metrics, the detection ability of iris vessel density in the nasal region and TIA in the temporal region are more significant.</p><p><strong>Conclusion: </strong>Iris vessel density is significantly reduced in primary glaucoma. The wide-field AS-OCTA of iris provides a comprehensive perspective of microvascular structures, facilitating precise comparison and evaluation of vessel changes in different regions associated with glaucoma. Specifically, the vessel density in the larger annular region on the nasal region have significant diagnostic value, enhancing understanding of disease mechanisms and progression.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-26"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of penetrating canaloplasty versus trabeculectomy in patients with bilateral primary glaucoma: a self-control study.","authors":"Wenqing Ye, Xiaowei Xu, Haishuang Lin, Jinxin Li, Shuqing Zhu, Yanqian Xie, Shaodan Zhang, Yuanbo Liang","doi":"10.1159/000546133","DOIUrl":"https://doi.org/10.1159/000546133","url":null,"abstract":"<p><strong>Introduction: </strong>Schlemm's canal-based minimally invasive glaucoma surgeries (MIGSs) are gaining increasing recognition and acceptance, but majority of these MIGSs are recommended in eyes with open angle. Bleb-independent penetrating canaloplasty (PCP) restores physiological aqueous outflow in eyes with both open and closed angles. We aimed to compare the efficacy, safety, and postoperative management of penetrating canaloplasty versus trabeculectomy in patients with bilateral primary glaucoma.</p><p><strong>Methods: </strong>This study is prospective self-control case series in a tertiary hospital in China. A total of 54 eyes from 27 patients with bilateral primary open angle glaucoma (n=18) or primary angle-closure glaucoma (n=9) were included. Trabeculectomy with mitomycin C (TRAB) was performed in one eye, while PCP was performed in the contralateral fellow eye. Intraocular pressure (IOP), number of glaucoma medications, surgery-related complications and postoperative interventions were compared between groups. Complete (without medication) and qualified success (with/without medication) were defined as IOP ≤21 mmHg and ≥20% IOP reduction.</p><p><strong>Results: </strong>Mean IOP decreased from 32.5±8.87mmHg on 2.3±1.43 medications at baseline to 14.6±4.41mmHg on 0.20±0.58 medications at 12 months in TRAB group (both p<0.0001) and from 30.0±9.61mmHg on 2.7±1.10 medications to 14.8±4.63mmHg on 0.12±0.44 medications in PCP group (both p<0.0001). Equal complete success (84.0%, P＞0.999) was achieved at 12 months in two groups. Although not statistically significant, higher qualified success was observed in TRAB (96.0%) than in PCP group (88.0%, p=0.609) at 12 month. However, 63.0% eyes (n=17) in TRAB group needed bleb managements to maintain a lower IOP. Transient IOP spike (>25mmHg, 22.2%) and microhyphaema (22.2%) were the most common complications for PCP, while hypotony (14.8%) and wound leakage (11.1%) were frequently seen after TRAB.</p><p><strong>Conclusion: </strong>Penetrating canaloplasty demonstrates comparable IOP-lowering effect with trabeculectomy in eyes with primary glaucoma, but with less post-operative complications and interventions.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma.","authors":"Leyi Wang, Bozhao Wang, Ying Wang, Xin Wang, Hongling Yang, Ran Wu, Yan Cui","doi":"10.1159/000544002","DOIUrl":"10.1159/000544002","url":null,"abstract":"<p><strong>Introduction: </strong>Cataract may cause severe visual impairment in eyes with microphthalmos (MO) and uveal coloboma (UC). Despite their similarities, distinguishing between these conditions is crucial for cataract surgery. We aimed to compare complications, nucleus hardness, surgical strategies, and outcomes of cataract surgery between MO and UC.</p><p><strong>Methods: </strong>This retrospective comparative study included 19 eyes with MO and 20 with UC. Preoperative, intraoperative, and postoperative data of eyes that underwent cataract surgery were analysed.</p><p><strong>Results: </strong>MO eyes had lower high-hardness nucleus rates (p = 0.002) than UC. The most common preoperative complications in the MO and UC groups were glaucoma (37.5%) and retinal detachment (15.4%), respectively. No significant differences in the phacoemulsification (p = 0.45) or intraocular lens implantation (p > 0.99) rates between the two groups. Extracapsular cataract extraction was performed in five eyes (25%), and posterior capsular rupture was the most common surgical complication (15%) in the UC group. Combined surgery was mainly used to deal with high or unstable intraocular pressure (IOP; 77%) in the MO group versus posterior pars plana vitrectomy (85.71%) in the UC group to treat vitreoretinal pathologies. Corrected distance visual acuity was significantly improved in both MO (p = 0.0005) and UC (p < 0.001) groups, while IOP was decreased (p = 0.03) in the MO group.</p><p><strong>Conclusion: </strong>Eyes with MO and UC exhibited distinct cataract grades and complications, necessitating varied surgical strategies; while cataract surgery has proven to be effective in improving the visual acuity in both groups. Our findings hold significant value for guiding clinical treatment decision-making.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"147-155"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biometric Factors Associated with Prediction Errors Related to Lens Position in Vitrectomized Patients.","authors":"Eloi Debourdeau, Pierre Pineau, Chloe Chamard, Julien Plat, Didier Hoa, Frederico Manna, Sandrine Akouete, Thibault Mura, Max Villain, Nicolas Molinari, Vincent Daien","doi":"10.1159/000542358","DOIUrl":"10.1159/000542358","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate clinical and biometric factors leading to a prediction error related to lens position in pars plana vitrectomy.</p><p><strong>Methods: </strong>This study was conducted as a consecutive retrospective case series at the Department of Ophthalmology, Montpellier University Hospital. All medical files and PCI biometrical reports from a single surgeon were reviewed from 2017 to 2019. Patients who had phacoemulsification with the ASPHINA 509 MP® intraocular lens were selected and stratified into 3 groups: phacoemulsification alone (group 1), phacoemulsification and vitrectomy with gas tamponade (group 2), and phacoemulsification and vitrectomy without tamponade (group 3). Clinical factors and biometry factors from initial and final biometry were collected. Refractive error, actual lens position, C constant, axial length delta, and pre-operative and post-operative anterior and posterior segment variation parameters were calculated.</p><p><strong>Results: </strong>A total of 140 eyes were analyzed, 90 in group 1, and 25 in group 2 and 3. The mean prediction error was 0.10 ± 0.55 D (group 1); -0.36 ± 0.74 D (group 2); and -0.12 ± 0.54 D (group 3) with p < 0.05 for group 1 vs. group 2. The mean actual lens position was 5.25 ± 0.29 mm; 5.66 ± 0.60 mm; and 5.50 ± 0.43 mm for the 3 groups, respectively (p < 0.001). Axial length delta was -0.10 ± 0.13 mm in group 1, -0.062 ± 0.20 mm in group 2, and -0.022 ± 0.17 mm in group 3 (p = 0.015). Multilinear regression analysis found a significant and independent influence of vitrectomy and gas tamponade on prediction error.</p><p><strong>Conclusion: </strong>Myopic shift in the case of vitrectomy is multifactorial, effective lens position is modified by vitrectomy and vitreous refractive index is changing. The integration of these data in formulas may improve refractive outcome after cataract and vitrectomy surgery.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"52-60"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Factors behind Patient Nonadherence to Intravitreal Anti-Vascular Endothelial Growth Factor Injections in Macular Diseases.","authors":"Efrat Naaman, Noa Yanir-Prat, Diana Shair-Nakhleh, Nitai Bar, Beata Miller, Anna Fishman, Shiri Zayit-Soudry","doi":"10.1159/000543352","DOIUrl":"10.1159/000543352","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, intravitreal injections (IVTs) of vascular endothelial growth factor (VEGF) inhibitors have become the standard of care for several macular disorders. Frequently, the therapeutic course requires numerous injections, posing a burden on patients. Nonadherence to treatment may result in reduced visual outcomes, therefore understanding and addressing the underlying causes is imperative.</p><p><strong>Methods: </strong>A cross-sectional study of patients who missed their scheduled appointment for anti-VEGF IVT as part of the routine management of their macular disease at a single tertiary center between November 2020 and February 2021. A telephone survey was conducted and patient medical charts were reviewed for ophthalmological data.</p><p><strong>Results: </strong>A total of 100/556 (18%) patients who failed to attend their scheduled anti-VEGF IVT appointments were documented. Among these subjects, the average age was 66 (SD ± 14) years with a nearly equal gender distribution of 49:51 F:M ratio. Reported no-show reasons included concurrent illness (39%), administrative issues such as missing financial coverage forms or scheduling problems (28%), and lack of motivation (11%). Additionally, 73% of patients who missed appointments expressed a need for accompaniment, and 74% resided outside the hospital city.</p><p><strong>Conclusions: </strong>Study results highlight modifiable factors contributing to no-shows to anti-VEGF IVT, such as poor transportation access, complicated administrative processes, and difficulty rescheduling missed appointments. Understanding potential obstacles to anti-VEGF IVT therapy, particularly those that are preventable, can enhance adherence and potentially improve the clinical outcome.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"221-227"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combined Index of Steady-State Pattern Electroretinogram and Optical Coherence Tomography Improved the Detection of Early Glaucoma.","authors":"Hwayeong Kim, Sangwoo Moon, EunAh Kim, Jinmi Kim, Jiwoong Lee","doi":"10.1159/000545094","DOIUrl":"10.1159/000545094","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of the study were to evaluate the structure-function relationship between steady-state pattern electroretinogram (ssPERG), optical coherence tomography (OCT), and visual field (VF) tests and to investigate indicators that enhance the detection of preperimetric and early-stage primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>In this retrospective cohort study, patients with POAG and normal subjects who underwent ssPERG, OCT, and VF tests were included. We defined the ratio of the amplitudes from 0.8° checks to 16° checks as the pattern electroretinogram ratio (PERGratio). The thickness of the macular ganglion cell inner plexiform layer and the circumpapillary retinal nerve fiber layer (cpRNFL) were measured using spectral-domain OCT. We compared the areas under the receiver operating characteristic curves (AUCs) for ssPERG, OCT, and VF test parameters. A combined index using structural and functional measures was generated using logistic regression models to improve diagnostic accuracy.</p><p><strong>Results: </strong>Four parameters had AUCs higher than 0.8; PERGratio (AUC = 0.890), average cpRNFL thickness (AUC = 0.827), 7 o'clock cpRNFL thickness (AUC = 0.844), and inferior quadrant cpRNFL thickness (AUC = 0.830). The new index, which combines the PERGratio and 7 o'clock cpRNFL thickness, significantly improved diagnostic accuracy (AUC = 0.951), outperforming the best four parameters (all p ≤ 0.004). Furthermore, the combined index of PERGratio and 7 o'clock cpRNFL thickness showed significantly higher diagnostic accuracy compared to those combining the 7 o'clock cpRNFL thickness with VF mean deviation, pattern standard deviation, and VF index.</p><p><strong>Conclusion: </strong>The combined index of ssPERG, indicative of retinal ganglion cell dysfunction, and the OCT test, indicative of focal structural damage, improved the detection of patients with POAG in its early stage.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"252-262"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Intraocular Lens Power Calculation in Microspherophakia Patients: Comparison of 7 Formulas.","authors":"Yang Sun, Tianhui Chen, Zexu Chen, Wannan Jia, Zhennan Zhao, Yongxiang Jiang","doi":"10.1159/000545050","DOIUrl":"10.1159/000545050","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to compare the accuracy of seven formulas for intraocular lens power calculation in patients with microspherophakia (MSP).</p><p><strong>Methods: </strong>A retrospective case series included 44 eyes from 28 patients with MSP. The mean prediction error (PE) was calculated, and the accuracy was determined by formula performance index (FPI), median absolute error (MedAE), and percentage of eyes with a PE within ±0.25 diopters (D), ±0.50 D, ±0.75 D, and ±1.00 D. Depending on whether the patients had Marfan syndrome (MFS), MSP patients 36 were sub-divided into MFS and non-MFS group.</p><p><strong>Results: </strong>In the non-MFS subgroup, the performance of formulas ranked by FPI from highest to lowest was BUII, Emmetropia Verifying Optical (EVO), Kane, Haigis, Sanders-Retzlaff-Kraff/Theoretical (SRK/T), Holladay 1, and Hoffer Q. In the MFS subgroup, Kane achieved the best accuracy regarding the lowest MedAE and the largest percentage of PE in the range of ±0.50 D. Similar results were obtained in eyes with shallow anterior chamber depth (ACD). In the regular ACD subgroup, the EVO provided the highest prediction accuracy and SRK/T took the second place. In the deep ACD subgroup, Holladay 1 performed superiorly presenting the lowest standard deviation values, mean absolute error and MedAE.</p><p><strong>Conclusions: </strong>Overall, new generation formulas showed a better trend of refractive outcomes in MSP patients. The Holladay 1 formula was suggested for eyes with deep ACD, while Haigis was not recommended.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"237-251"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}