Ophthalmic Research最新文献

{"title":"Incremental Predictive Value of Month-1 OCT and OCT Angiography for Residual Exudative Activity After Anti-VEGF Loading in Treatment-Naive Neovascular Age-Related Macular Degeneration.","authors":"Ruilong Li, Ming Yan, Zhen Huang, Ya Ye, Xianggui Zhang, Yanping Song","doi":"10.1159/ore/aedag007","DOIUrl":"https://doi.org/10.1159/ore/aedag007","url":null,"abstract":"<p><strong>Introduction: </strong>During the anti-vascular endothelial growth factor (anti-VEGF) loading phase for neovascular age-related macular degeneration (nAMD), the month-1 follow-up visit represents the earliest standardized imaging time point, yet whether month-1 optical coherence tomography (OCT) and OCT angiography (OCTA) improve prediction of short-term anatomical outcome beyond baseline OCT has not been formally tested. This study quantified the incremental predictive value of month-1 imaging using a nested-model framework that mirrors the sequential clinical workflow.</p><p><strong>Methods: </strong>This retrospective, single-center cohort included 124 treatment-naive nAMD eyes from 105 patients that completed three monthly anti-VEGF injections and had evaluable baseline, month-1, and month-3 imaging. Poor anatomical outcome was defined as residual intraretinal fluid and/or subretinal fluid at month 3. Nested generalized estimating equation logistic models accounted for inclusion of bilateral eyes and evaluated baseline OCT variables, the incremental contribution of month-1 structural OCT, and the additional contribution of month-1 OCTA-derived macular neovascularization (MNV) area. Discrimination was assessed using area under the receiver operating characteristic curve (AUC), with ΔAUC confidence intervals estimated by patient-level cluster bootstrap.</p><p><strong>Results: </strong>At month 3, 47 of 124 eyes (37.9%) had residual exudative activity. In the final model, month-1 central subfield thickness (OR 2.065 per 100-µm increase, 95% CI 1.107-3.853), residual month-1 intraretinal fluid (OR 14.623, 95% CI 3.305-64.703), residual month-1 subretinal fluid (OR 6.975, 95% CI 1.963-24.785), and month-1 MNV area (OR 1.130 per 1-mm² increase, 95% CI 1.030-1.240) were associated with poor month-3 anatomical outcome. AUC improved from 0.742 (95% CI 0.658-0.822) with baseline OCT alone to 0.889 (95% CI 0.828-0.940) after adding month-1 structural OCT (ΔAUC 0.147, 95% CI 0.072-0.226), and to 0.908 (95% CI 0.853-0.952) after adding month-1 MNV area. Baseline-to-month-1 quantitative changes were not associated with outcome.</p><p><strong>Conclusion: </strong>Month-1 structural OCT substantially improved prediction of month-3 residual exudative activity beyond baseline OCT alone, whereas OCTA-derived MNV area contributed modest additional discrimination. These findings identify the first post-treatment imaging visit as an informative point for short-term anatomical risk assessment, but external validation is required before clinical application.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Pupil Constriction Latency in Immunoglobulin G4-related Ophthalmic Disease.","authors":"Kenneth Ka Hei Lai, Angus Pok Yiu Leung, Chen Hui Tang, Hanson Yiu Man Wong, Yifei Yang, Stephany Wing Lam Tai, Zhichao Hu, Andy Chi On Cheng, Joyce Kar Yee Chin, Chi Ho Kwong, Nelson Kwok Foo Yip, Wendy Pui Fan Lam, Kenneth Kai Wang Li, Andrew Kin Ting Kuk, Ngai Yang, Polin Leow, Alvin Lerrmann Young, Carmen Kar Mun Chan, Hunter Kwok Lai Yuen, Clement Chee Yung Tham, Chi Pui Pang, Kelvin Kam Lung Chong","doi":"10.1159/ore/aedag009","DOIUrl":"https://doi.org/10.1159/ore/aedag009","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the pupillary light reflex (PLR) in Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) compared with healthy controls using virtual reality-based infrared pupillometry.</p><p><strong>Design: </strong>Cross-sectional matched case-control study.</p><p><strong>Participants: </strong>Twenty-five eyes from 25 biopsy-proven IgG4-ROD patients without a history of optic neuropathy and 50 eyes from 50 age-, sex-, and smoking-matched healthy subjects were included.</p><p><strong>Methods: </strong>Participants underwent PLR assessment using a virtual reality head-mounted display with integrated infrared pupillometry. Pupillary responses to three progressively increasing white-light stimuli were recorded at 120 Hz. Twenty-seven PLR parameters were extracted across response latency, constriction, and redilation phases. Group differences were analyzed using paired t-tests, multinomial logistic regression, and backward stepwise variable selection. Machine learning classifiers were evaluated using accuracy and area under the receiver operating characteristic curve (AUC). Main Outcome Measures Pupil constriction latency, constriction amplitude, velocity, redilation parameters, and machine learning classification performance metrics.</p><p><strong>Results: </strong>Pupil constriction latency at the third (highest intensity) stimulus (LAT3rd) was significantly prolonged in IgG4-ROD eyes compared with controls (P < 0.05), while other PLR parameters were comparable between groups. LAT3rd remained a significant differentiating feature on multinomial logistic regression and backward stepwise selection. Machine learning models using all features showed good performance, with Random Forest achieving an accuracy/AUC of 0.875/0.900. When using bootstrapped LAT3rd-only data, K-nearest neighbors, decision tree, and random forest models also demonstrated good classification performance.</p><p><strong>Conclusion: </strong>IgG4-ROD eyes exhibit prolonged pupil constriction latency, suggesting subclinical involvement of the pupillary light reflex pathway. Virtual reality-based infrared pupillometry may serve as a useful non-invasive tool for detecting neural or autonomic dysfunction in IgG4-ROD.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Quality Assessment of Online Resources on Keratoconus using the Modified Ensuring Quality Information for Patients (mEQIP).","authors":"Antonio Cartabellotta, Andrea Taloni, Ginevra Giovanna Adamo, Marco Pellegrini, Vincenzo Scorcia, Marco Mura, Giuseppe Giannaccare","doi":"10.1159/ore/aedag008","DOIUrl":"https://doi.org/10.1159/ore/aedag008","url":null,"abstract":"<p><strong>Introduction: </strong>To systematically rate the quality of online educational websites focused on keratoconus.</p><p><strong>Methods: </strong>Google, Yahoo and Bing were queried for the keywords \"Keratoconus\", \"Keratoconus treatment\", \"Keratoconus surgery\". For each keyword, the first 50 websites were assessed for quality of information using the Modified Ensuring Quality Information for Patient (mEQIP) scale. English websites intended for non-professional public were included while forums, blogs and scientific articles were excluded. Websites with a score above the 75th percentile were labelled as high-score, while those below were classified as low-score. Statistically significant values were considered if p < 0.05.</p><p><strong>Results: </strong>Overall, 119 eligible websites were included and classified in 5 groups based on their source: healthcare portals (n=36, 30.25%), practitioners (n=48, 40.34%), hospitals (n=21, 17.65%), professional societies (n=13, 10.92%) and encyclopedias (n=1, 0.84%). The mean mEQIP score was 20.03 ŷ 4.13. Websites with a score of 23 or higher were labelled as high score, websites below 23 were classified as low score. High-score websites (27.73%) provided more comprehensive details about treatments, medical procedures, benefits, and risks, and were supported by scientific references. Conversely, low-score websites (72.27%) often lacked essential information and quantitative data. There was no significant difference in the quality of information for webpages published before and after COVID-19 pandemic (P = .79), or between different types of sources (P = .80).</p><p><strong>Conclusions: </strong>Overall, this study indicates moderate quality of online information regarding keratoconus and underscores the need for improvements of online health resources.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Beta Parapapillary Atrophy in Primary Angle-Closure Suspect: A 5-Year Follow-Up Study.","authors":"Fei Xiang, Ye Zhang, Qing Zhang, Mengyang Li, Xiaohua Pan, Hui Feng, Caixia Li, Meijuan Zhang, Liqin Song, Yi Wang, Junying Ren, Shuning Li","doi":"10.1159/ore/aedag004","DOIUrl":"https://doi.org/10.1159/ore/aedag004","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the changes in beta parapapillary atrophy (β-PPA) in eyes with primary angle-closure suspect (PACS) after 5 years.</p><p><strong>Methods: </strong>This longitudinal cohort study included participants aged ≥50 years with PACS at baseline, who participated in the 5-year follow-up examinations. β-PPA was characterized using stereoscopic fundus and optical coherence tomography. Logistic and linear regression analyses were performed to identify factors correlating with the presence of β-PPA enlargement and with the enlargement of β-PPA parameters, respectively.</p><p><strong>Results: </strong>A total of 83 participants with PACS (83 eyes) were included. The enlargement of β-PPA was found in 26.51% of PACS eyes during the 5-year follow-up period. The parameters of area, angular extent, and maximum radial length of β-PPA were significantly enlarged at the 5-year follow-up compared with those at baseline (P < 0.001, 0.027, and < 0.001, respectively). The presence of β-PPA enlargement was associated with a larger axial length (AL; odds ratio [OR] = 2.473, 95% confidence interval [CI]: 1.119-5.446, P = 0.025) and larger vertical cup-to-disc ratio (VCDR; OR = 1.066, 95% CI: 1.001-1.135, P = 0.048). The factor associated with the enlargement of area, angular extent, and maximum radial length of β-PPA was a longer AL (P = 0.016, 0.023, and 0.018, respectively).</p><p><strong>Conclusions: </strong>The morphology parameters of β-PPA were enlarged in eyes with PACS during the 5-year follow-up period. The presence of β-PPA enlargement was associated with a longer AL and larger VCDR at baseline.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease.","authors":"Kenneth Ka Hei Lai, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Nicole Tsz Yan Wong, Kevin Ka Fai Yuen, Carly S K Yeung, George Pak Man Cheng, Winnie Chiu Wing Chu, Wilson Wai Kuen Yip, Alvin Lerrmann Young, Hunter Kwok Lai Yuen, Alan Chun Hong Lee, Chiu Ming Ng, Clement Chee Yung Tham, Chi Pui Pang, Kelvin Kam Lung Chong","doi":"10.1159/000553278","DOIUrl":"https://doi.org/10.1159/000553278","url":null,"abstract":"<p><strong>Purpose: </strong>Clinical activity score (CAS) is widely used to assess thyroid eye disease (TED) activity, but its predictive value in East Asian patients remains unclear. This study evaluated correlation between CAS and both radiological and serological markers in treatment-naïve ethnic Han Chinese TED patients.</p><p><strong>Methods: </strong>Cross-sectional study of treatment-naïve ethnic Han Chinese TED patients managed at The Chinese University of Hong Kong between January 2014 and May 2022. STIR signal intensity was quantified using signal intensity ratio (SIR), while disease activity was assessed clinically using CAS.</p><p><strong>Results: </strong>A total of 188 patients with a mean onset age of 50±14 years who underwent baseline MRI were included. The mean presenting CAS was 1.4±1.3. A weak positive correlation was observed between CAS and the SIR of the levator palpebral superioris/superior rectus complex (r=0.196, P=0.00709). Nominal positive correlations were observed between CAS and the SIRs of the inferior rectus (r=0.185, P=0.0112), and medial rectus (r=0.167, P=0.0224). In subgroup analysis of patients presenting with CAS ≥3, nominal positive correlations were observed between CAS and the SIRs of the lateral rectus (r=0.374, P=0.0416), medial rectus (r=0.351, P=0.0487), and inferior rectus (r=0.335, P=0.0348). No correlation was identified in patient with CAS <3. No significant correlation was found between CAS and serological markers.</p><p><strong>Conclusions: </strong>The correlation between CAS and STIR signals was generally weak, and no significant correlation was identified between CAS and serological markers. These findings suggest that orbital MRI may provide complementary information beyond clinical assessment in evaluating disease activity in Ethnic Chinese TED patients.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Keratitis in Southern Arizona.","authors":"Ahmed Abdelhady, Jonathan Han, Robert Wu, Max Coffeen, Zachary E Leibovit-Reiben, Meet Panjwani, Mingwu Wang, Ovette F Villavicencio, Xuemin Zhang, Jonathan M Holmes","doi":"10.1159/000551714","DOIUrl":"10.1159/000551714","url":null,"abstract":"<p><strong>Introduction: </strong>There is a paucity of data on microbial keratitis in the southwestern USA, specifically southern Arizona. Understanding demographic factors and causative organisms will help design future treatments and preventative measures.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on all cases (>17 years old) of microbial keratitis at Banner University Medical Center Tucson, Arizona, from September 1, 2017, to August 31, 2022. Frequencies of social, demographic, ocular factors, and isolated organisms were reported. We used Fisher's exact tests to compare findings with 2023 census data.</p><p><strong>Results: </strong>We identified 272 eyes in 268 patients. Compared with census data, demographic factors overrepresented in microbial keratitis were as follows: unemployment (50.4%) and homelessness (8.2%). Drug use was identified in 22.4% of patients. Associated factors were contact lens wear (33.1%) and preceding ocular trauma (14.7%). Among eyes associated with contact lens use, 49 (54.4%) were worn overnight. Of 203 eyes with culture results, 152 (74.9%) yielded a positive microbial culture; 96.5% were bacterial and 3.4% were fungal. Gram-positive bacteria were found in 54.7%, most commonly Staphylococcus epidermidis (16.7%). The most common gram-negative isolate was Pseudomonas aeruginosa (12.8%).</p><p><strong>Conclusion: </strong>In southern Arizona, microbial keratitis is particularly associated with drug use, unemployment, and homelessness. Contact lens use and overnight wear were common, warranting education on safe practices. Positive fungal cultures were rare. Each factor deserves consideration for societal intervention, to reduce the burden of microbial keratitis in southern Arizona, and should be evaluated as potential risk factors in other communities. Overall culture results may influence choice of initial therapy.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"120-128"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Tissue Impact on Descemet Membrane Endothelial Keratoplasty Graft Preparation and Clinical Outcome.","authors":"Silvia Schrittenlocher, Jithmi Weliwitage, Mara Serban, Aline Woitas, Mario Matthaei, Björn Bachmann, Claus Cursiefen","doi":"10.1159/000551253","DOIUrl":"10.1159/000551253","url":null,"abstract":"<p><strong>Introduction: </strong>Aims of the study were to determine which donor characteristics, like previous diseases and surgeries, influence the graft preparation difficulty of the Descemet membrane/endothelial lamella in DMEK surgery and to analyze the impact on the 1-year clinical outcome.</p><p><strong>Methods: </strong>Overall, 1,051 eyes with DMEK surgery between January, 2018, and January, 2021, performed at the University Hospital Cologne, Germany, were included in this single-center and retrospective study. Information regarding the donors' previous diseases and surgeries were provided by a large database of a cornea bank (Multi Tissue Bank Mecklenburg-Vorpommern) and merged with the Cologne DMEK database that contains information regarding preparation characteristics of the surgeon-prepared graft directly preoperatively and postoperative clinical follow-up. Three preparation groups (easy, difficult, and very difficult) were correlated to the donors' previous disease and surgeries. Also, outcome parameters, like visual acuity, endothelial cell density, and graft survival, were correlated to the graft preparation group.</p><p><strong>Results: </strong>Donor diabetes was found as significant predictor for central adhesions (p < 0.001). Diabetes patients are 2 times more likely to have central adhesions complicating preparation than non-diabetes patients (OR = 2.2). Previous cataract surgery was significantly associated with difficult stripping and preparation (p < 0.001), with an estimated 1.07-fold increase in stripping difficulty (95% CI: 0.80-1.34) and overall 1.99-fold increase in preparation difficulty (95% CI: 1.71-2.29). Chronic kidney disease (p = 0.012) and previous cataract surgery (p = 0.005) show significant associations to tissue loss. Donor diagnosis such as diabetes mellitus type 2, chronic ischemic heart disease, and respiratory insufficiency has a significant association with the preparation group (p = 0.001; p = 0.004; and p = 0.032, respectively). No interactions were found between preparation difficulties and visual acuity (p = 0.122), rebubbling rate (p = 0.780), or endothelial cell density (p = 0.886) nor graft survival (p value = 0.157) 1 year postoperatively.</p><p><strong>Conclusions: </strong>Donor diabetes mellitus, heart failure, hypertension, respiratory insufficiency, kidney disease, and previous cataract surgery are associated with difficult DMEK graft preparation, the latter two also with tissue loss. No impact of donor factors on clinical outcome was found.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"98-104"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AROMA Dataset for Automatic Detection of Artifact Type and Severity in Retinal Optical Coherence Tomography Angiography.","authors":"Lucas Szwarcberg, Atif Anwer, Alexandre Gozlan, Paul Drouard, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Fabrice Mériaudeau, Louis Arnould","doi":"10.1159/000551126","DOIUrl":"10.1159/000551126","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, retinal vascular imaging has attracted growing interest and is experiencing rapid technological advancements in imaging modalities such as swept-source optical coherence tomography angiography (SS OCT-A). OCT-A enables precise, noninvasive, quantitative measurements of retinal vascularization. However, it is also prone to artifacts that are challenging to detect and can significantly limit diagnostic accuracy and biomarker reliability.</p><p><strong>Methods: </strong>We present a dataset of en face retinal SS OCT-A images, labeled by artifact type and severity. Each patient's OCT-A scan consists of 14 images that are graded by multiple experts and assigned corresponding artifact labels with an overall quality grade. We also report results for two deep-learning binary classification models trained on the dataset: one based on image compression via principal component analysis (PCA) and the other using a six-channel tensor.</p><p><strong>Results: </strong>The dataset comprised 281 OCT-A scans from 115 anonymized patients. The PCA-based model achieved a precision of 87% for image quality classification, while the six-channel model achieved 97%.</p><p><strong>Conclusion: </strong>Using a curated dataset of en face SS OCT-A images with detailed artifact annotations, we trained a deep-learning model capable of high-precision image quality classification. These results demonstrate the feasibility of using task-specific artificial intelligence for quality assessment based on artifact detection in retinal imaging.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"105-119"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Neighborhood Factors Influencing Participation in a Personalized Glaucoma Coaching Program.","authors":"Stephanie Lee, Patrice M Hicks, Justus N Dobson, Jamie Mitchell, Deborah Darnley-Fisch, Michele Heisler, Nauman R Imami, Paula Anne Newman-Casey","doi":"10.1159/ore/aedag001","DOIUrl":"10.1159/ore/aedag001","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess barriers and facilitators to program engagement for participants in the Support, Educate, Empower (SEE) Personalized Glaucoma Coaching Pilot Program and identify differences by demographics or neighborhood area deprivation.</p><p><strong>Methods: </strong>This mixed-methods study analyzed SEE glaucoma coaching program participants. Patient characteristics included age, sex, race, and neighborhood socioeconomic status (area deprivation index [ADI]). Interview transcripts were coded using the adapted Penchansky and Thomas framework, which defines healthcare access through access dimensions: availability (supply of services), accessibility (location), accommodation (organization of services), affordability (cost), awareness (communication/information), and acceptability (attitudes and comfort), to categorize barriers and facilitators. Thematic frequencies were calculated and stratified by participant characteristics.</p><p><strong>Results: </strong>The 44 participants in the SEE pilot program were 52% ≥ 65 years old, 55% male, 46% White, and 34% lived in high ADI neighborhoods. Awareness (100%) and acceptability (66%) were the most cited themes. Low-ADI participants experienced more acceptability (79% vs. 39% high ADI) and awareness barriers (79% vs. 43% mid ADI). Mid-ADI participants had more accessibility barriers (71% vs. 13% low ADI) and accommodation facilitators (43% vs. 8% low ADI). High-ADI participants reported more patient-level facilitators (44% vs. 14% mid ADI). No differences emerged by other demographics.</p><p><strong>Conclusion: </strong>Among SEE pilot program participants, acceptability barriers and awareness facilitators were the most frequently cited. There were ADI differences for barriers and facilitators. Neighborhood factors should be considered when implementing glaucoma coaching programs, as program interaction varies by these characteristics. The SEE pilot program facilitated glaucoma medication adherence through educational resources and adherence monitoring tools.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"276-285"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Intraocular Lens Power Calculation Formulas in Cataract Eyes after Vitrectomy with Silicone Oil Tamponade: A Network Meta-Analysis.","authors":"Peng Zhao, Meng Li, Zhao-Xing Guo, Zhi-Yong Tian, Jing-Shang Zhang, Ying-Yan Mao, Zheng Xin, Zhong-Yan Li, Xiu-Hua Wan","doi":"10.1159/000551331","DOIUrl":"10.1159/000551331","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to systematically compare the accuracy of artificial intelligence and traditional intraocular lens (IOL) calculation formulas in cataract eyes after vitrectomy with silicone oil tamponade.</p><p><strong>Methods: </strong>PubMed, Cochrane, Embase, and Web of Science databases were searched to select relevant studies published up to October 29, 2025. A total of 12 formulas (SRK/T, Hoffer Q, Hoffer QST, Haigis, Barrett Universal II, Holladay I, Holladay II, RBF, LSF, EVO, Kane, and Pearl-DGS) were included for final comparison. The primary outcomes were the percentage of eyes with prediction errors (PE) within ± 0.50 D and ± 1.00 D.</p><p><strong>Results: </strong>This meta-analysis included 7 studies comprising 1,060 eyes. Overall, compared to traditional formulas, newer formulas demonstrated relatively higher accuracy. The results indicated that among all the formulas being compared, the optimal formula was Kane. For the percentage of eyes with PE within ± 0.50 D, Kane had the highest precision. For the IOL power percentage within ± 1.00 D, EVO performed the best, with Kane also ranking highly. Furthermore, RBF also performed very well.</p><p><strong>Conclusion: </strong>Kane and EVO appear to be better choices for silicone oil-filled eyes after vitrectomy.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"85-97"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}