Ophthalmic Research最新文献

{"title":"Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.","authors":"Huangyang Shi, Yao Liu, Yanlin Li, Yingjie Li, Ling Jin, Yuan Liu, Ni Guo, Wei Huang, Zhihong Huang, Huishan Lin, Yue Dong, Nachuan Luo, Yuheng Tan, Xin Ma, Jian Ge, Mingkai Lin, Chengguo Zuo","doi":"10.1159/000546980","DOIUrl":"https://doi.org/10.1159/000546980","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.</p><p><strong>Methods: </strong>Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.</p><p><strong>Results: </strong>Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.</p><p><strong>Conclusions: </strong>In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-23"},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The specificity rates of Clarus 500™ ultra-wide-field retinal imaging for detecting peripheral retinal lesions in medium-to-high myopia eyes.","authors":"Fangcheng Xu, Xiaojun Hu, Yunzhe Wang, Ruoyan Wei, Yongfu Yu, Yuwei Peng, Meiyan Li, Haixiang Wu","doi":"10.1159/000546494","DOIUrl":"https://doi.org/10.1159/000546494","url":null,"abstract":"<p><strong>Background: </strong>To investigate the specificity of Clarus 500™, an ultra-wide-field (UWF) fundus camera, for detecting peripheral retinal lesions in myopic eyes.</p><p><strong>Methods: </strong>This diagnostic test included 436 eyes from 221 patients with myopia before refractive surgery. The mean age was 28.9 ± 6.0 years (18 to 49 years), with the average spherical equivalent refraction being -8.33 ± 2.81 diopters (D) (-20.63 D to -0.50 D). Images were captured using Clarus 500™ from the posterior pole and four UWF directions, including the superior temporal, superior nasal, inferior temporal, and inferior nasal gaze. A slit-lamp non-contact +120 D lens was used as the control. Sensitivity and specificity in detecting fundus lesions were compared between the images obtained by Clarus 500™ and slit-lamp examination. Statistical analysis was performed using version 4.3.0 of R software, and significance was set at P < 0.05.</p><p><strong>Results: </strong>Of the 436 eyes, 13 (2.98%) underwent slit-lamp examination, and 5 (1.15%) underwent Clarus 500™ examination, revealing retinal lesions. The sensitivity of Clarus 500™ for detecting peripheral retinal holes/tears was 50% (95% confidence interval (95% CI: 1.26%, 98.74%). The specificity for peripheral lattice degeneration was 99.77% (95% CI: 98.70%, 99.99%). The agreement between the two methods for detecting peripheral reticular degeneration and retinal holes was moderate (kappa value: 0.42, 95% CI: 0.10 - 0.75, P < 0.01) and substantial (kappa value: 0.67, 95% CI: 0.05 - 1, P < 0.01), respectively.</p><p><strong>Conclusions: </strong>Clarus 500™ showed high specificity for detecting peripheral retinal holes and substantial agreement with the slit-lamp in identifying peripheral retinal degeneration and retinal holes.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B7-H3 Exacerbates Laser-induced Choroidal Neovascularization by Promoting Macrophage Recruitment and Polarization via S100A8/A9.","authors":"Xianbin Yuan, Hongya Wu, Hang Ren, Bo Jiang, Weiming Liu, Qingying Yao, Jie Wu, Gaoqin Liu, Peirong Lu","doi":"10.1159/000546556","DOIUrl":"https://doi.org/10.1159/000546556","url":null,"abstract":"<p><p>Background This study investigates the role of the immune costimulatory factor B7-H3 in laser-induced choroidal neovascularization (CNV) and its underlying molecular mechanisms. Methods A CNV model was established in C57BL/6J mice to examine the temporal expression dynamics of B7-H3 in choroidal tissues. B7-H3 knockout (B7-H3-KO) mice were used to assess CNV lesion size compared to wild-type (WT) controls after laser induction. RNA sequencing and xCELL analysis were performed to identify differentially expressed genes and immune cell infiltration patterns. Additionally, in vitro experiments using culture supernatants from murine B7-H3+/- peritoneal macrophages were conducted to evaluate B7-H3's role in angiogenesis using bEnd.3 endothelial cells. Results B7-H3 expression in the CNV model exhibited an initial upregulation followed by a decline. CNV lesions were significantly smaller in B7-H3-KO mice (1.47 × 106 ± 0.21 × 106 µm2, P < 0.001) and in mice receiving intravitreal injections of B7-H3 monoclonal antibody (2.29 × 106 ± 0.21 × 106 µm2, P < 0.05) compared to WT controls (3.46 × 106 ± 0.41 × 106 µm2). Transcriptomic and xCELL analyses revealed reduced M2 macrophage infiltration and downregulation of the S100A8/A9 heterodimer in B7-H3-KO mice. In vitro, B7-H3-KO peritoneal macrophages and RAW264.7 cells treated with S100A8/A9-siRNA exhibited diminished proliferation, migration, and tube formation of bEnd.3 cells. These effects were reversed upon supplementation with exogenous S100A8/A9 heterodimer to B7-H3-KO peritoneal macrophages. Further mechanistic investigation demonstrated that B7-H3 modulates bEnd.3 proliferation and CNV progression via S100A8/A9-mediated activation of the TLR4-NF-κB-VEGFA signaling pathway. Conclusions The immune costimulatory molecule B7-H3 promotes CNV by modulating macrophage-mediated S100A8/A9 signaling, which activates the TLR4-NF-κB-VEGFA axis. These findings highlight B7-H3 as a potential therapeutic target in CNV-associated diseases.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-19"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early vs late switch to an intravitreal Dexamethasone implant after failed Anti-VEGF therapy for diabetic macular edema: A systematic review and meta-analysis.","authors":"Chanyuan Cao, Guoxiao Yu, Zhen Deng","doi":"10.1159/000546682","DOIUrl":"https://doi.org/10.1159/000546682","url":null,"abstract":"<p><strong>Introduction: </strong>Monthly anti-vascular endothelial growth factors (VEGF) are the primary line of management of diabetic macular edema (DME). However, a large number of patients do not respond to anti-VEGF and require Dexamethasone implants (DEXI) as a second line of therapy. There remains a clinical conundrum on the optimal timing of the switch to DEXI. We systematically reviewed the literature to assess outcomes after an early vs late switch to DEXI after failed anti-VEGF therapy in DME.</p><p><strong>Methods: </strong>Relevant studies were identified by searching PubMed, CENTRAL, Scopus, Web of Science, and Embase till 25th December 2024. We assessed changes in central retinal thickness (CRT), best-corrected visual acuity (BCVA), and risk of ocular hypertension between early vs late switch groups.</p><p><strong>Results: </strong>Six studies were included. Pooled analysis of all six studies showed that there was a tendency of improved CRT (MD: 19.01 95% CI: -27.29, 65.31 I2=85%) and BCVA (MD: 0.05 95% CI: -0.04, 0.14 I2=72%) with early switch as compared to late switch group but without statistical significance. Removing one outlier study showed statistically significant improvement in CRT (MD: 36.84 95% CI: 7.54, 66.14 I2=48%) and BCVA with early switch (MD: 0.09 95% CI: 0.08, 0.11 I2=0%). Subgroup analysis based on the definition of late switch indicated better outcomes with an early switch when the late switch was defined as after >6 anti-VEGF injections. No difference was noted in the risk of ocular hypertension between the two groups (OR: 0.81 95% CI: 0.38, 1.73 I2=30%).</p><p><strong>Conclusions: </strong>An early switch to DEXI may tend towards better outcomes as compared to a late switch in treatment-resistant DME patients. High heterogeneity of the meta-analysis and outlier studies are important limitations of present evidence which can only be resolved with high-quality randomized controlled trials.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-19"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bruch's membrane opening (BMO) based peripapillary OCT-A analysis.","authors":"Sebastian Fassihi Dehkordi, Julia Schottenhamml, Meike Müller, Sami Hosari, Robert Lämmer, Andreas Maier, Bettina Hohberger, Christian Mardin","doi":"10.1159/000545878","DOIUrl":"https://doi.org/10.1159/000545878","url":null,"abstract":"<p><strong>Purpose: </strong>Peripapillary OCT-A scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of BMO-based peripapillary OCT-A analysis with and without the implementation of the Anatomical Positioning System (APS) compared to manual analysis.</p><p><strong>Methods: </strong>Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analysed by the Erlangen Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (Fovea-to-Bruch's Membrane Opening-Center). Peripapillary OCT-A scans were analysed: (I) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (II) BMO-based, and (III) BMO-based with APS information. Coefficients of variation (CV) were calculated.</p><p><strong>Results: </strong>Peripapillary mean VD was 42.52±4 and 41.69±4 (manually), 50.29±4 and 48.8±4 (BMO-based), and 44.73±3 and 44.39±4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p=0.04), but not for BMO-based (p>0.05) and BMO-based and APSified analysis (p>0.05). CV were 10.0 (manually), 8.0 (BMO-based), and 8.0 (BMO-based and APSified).</p><p><strong>Conclusion: </strong>The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma.","authors":"Leyi Wang, Bozhao Wang, Ying Wang, Xin Wang, Hongling Yang, Ran Wu, Yan Cui","doi":"10.1159/000544002","DOIUrl":"10.1159/000544002","url":null,"abstract":"<p><strong>Introduction: </strong>Cataract may cause severe visual impairment in eyes with microphthalmos (MO) and uveal coloboma (UC). Despite their similarities, distinguishing between these conditions is crucial for cataract surgery. We aimed to compare complications, nucleus hardness, surgical strategies, and outcomes of cataract surgery between MO and UC.</p><p><strong>Methods: </strong>This retrospective comparative study included 19 eyes with MO and 20 with UC. Preoperative, intraoperative, and postoperative data of eyes that underwent cataract surgery were analysed.</p><p><strong>Results: </strong>MO eyes had lower high-hardness nucleus rates (p = 0.002) than UC. The most common preoperative complications in the MO and UC groups were glaucoma (37.5%) and retinal detachment (15.4%), respectively. No significant differences in the phacoemulsification (p = 0.45) or intraocular lens implantation (p > 0.99) rates between the two groups. Extracapsular cataract extraction was performed in five eyes (25%), and posterior capsular rupture was the most common surgical complication (15%) in the UC group. Combined surgery was mainly used to deal with high or unstable intraocular pressure (IOP; 77%) in the MO group versus posterior pars plana vitrectomy (85.71%) in the UC group to treat vitreoretinal pathologies. Corrected distance visual acuity was significantly improved in both MO (p = 0.0005) and UC (p < 0.001) groups, while IOP was decreased (p = 0.03) in the MO group.</p><p><strong>Conclusion: </strong>Eyes with MO and UC exhibited distinct cataract grades and complications, necessitating varied surgical strategies; while cataract surgery has proven to be effective in improving the visual acuity in both groups. Our findings hold significant value for guiding clinical treatment decision-making.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"147-155"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biometric Factors Associated with Prediction Errors Related to Lens Position in Vitrectomized Patients.","authors":"Eloi Debourdeau, Pierre Pineau, Chloe Chamard, Julien Plat, Didier Hoa, Frederico Manna, Sandrine Akouete, Thibault Mura, Max Villain, Nicolas Molinari, Vincent Daien","doi":"10.1159/000542358","DOIUrl":"10.1159/000542358","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate clinical and biometric factors leading to a prediction error related to lens position in pars plana vitrectomy.</p><p><strong>Methods: </strong>This study was conducted as a consecutive retrospective case series at the Department of Ophthalmology, Montpellier University Hospital. All medical files and PCI biometrical reports from a single surgeon were reviewed from 2017 to 2019. Patients who had phacoemulsification with the ASPHINA 509 MP® intraocular lens were selected and stratified into 3 groups: phacoemulsification alone (group 1), phacoemulsification and vitrectomy with gas tamponade (group 2), and phacoemulsification and vitrectomy without tamponade (group 3). Clinical factors and biometry factors from initial and final biometry were collected. Refractive error, actual lens position, C constant, axial length delta, and pre-operative and post-operative anterior and posterior segment variation parameters were calculated.</p><p><strong>Results: </strong>A total of 140 eyes were analyzed, 90 in group 1, and 25 in group 2 and 3. The mean prediction error was 0.10 ± 0.55 D (group 1); -0.36 ± 0.74 D (group 2); and -0.12 ± 0.54 D (group 3) with p < 0.05 for group 1 vs. group 2. The mean actual lens position was 5.25 ± 0.29 mm; 5.66 ± 0.60 mm; and 5.50 ± 0.43 mm for the 3 groups, respectively (p < 0.001). Axial length delta was -0.10 ± 0.13 mm in group 1, -0.062 ± 0.20 mm in group 2, and -0.022 ± 0.17 mm in group 3 (p = 0.015). Multilinear regression analysis found a significant and independent influence of vitrectomy and gas tamponade on prediction error.</p><p><strong>Conclusion: </strong>Myopic shift in the case of vitrectomy is multifactorial, effective lens position is modified by vitrectomy and vitreous refractive index is changing. The integration of these data in formulas may improve refractive outcome after cataract and vitrectomy surgery.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"52-60"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Factors behind Patient Nonadherence to Intravitreal Anti-Vascular Endothelial Growth Factor Injections in Macular Diseases.","authors":"Efrat Naaman, Noa Yanir-Prat, Diana Shair-Nakhleh, Nitai Bar, Beata Miller, Anna Fishman, Shiri Zayit-Soudry","doi":"10.1159/000543352","DOIUrl":"10.1159/000543352","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, intravitreal injections (IVTs) of vascular endothelial growth factor (VEGF) inhibitors have become the standard of care for several macular disorders. Frequently, the therapeutic course requires numerous injections, posing a burden on patients. Nonadherence to treatment may result in reduced visual outcomes, therefore understanding and addressing the underlying causes is imperative.</p><p><strong>Methods: </strong>A cross-sectional study of patients who missed their scheduled appointment for anti-VEGF IVT as part of the routine management of their macular disease at a single tertiary center between November 2020 and February 2021. A telephone survey was conducted and patient medical charts were reviewed for ophthalmological data.</p><p><strong>Results: </strong>A total of 100/556 (18%) patients who failed to attend their scheduled anti-VEGF IVT appointments were documented. Among these subjects, the average age was 66 (SD ± 14) years with a nearly equal gender distribution of 49:51 F:M ratio. Reported no-show reasons included concurrent illness (39%), administrative issues such as missing financial coverage forms or scheduling problems (28%), and lack of motivation (11%). Additionally, 73% of patients who missed appointments expressed a need for accompaniment, and 74% resided outside the hospital city.</p><p><strong>Conclusions: </strong>Study results highlight modifiable factors contributing to no-shows to anti-VEGF IVT, such as poor transportation access, complicated administrative processes, and difficulty rescheduling missed appointments. Understanding potential obstacles to anti-VEGF IVT therapy, particularly those that are preventable, can enhance adherence and potentially improve the clinical outcome.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"221-227"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Outcomes of 1-Month Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment: A Multicenter Study.","authors":"Jingyi Li, Wei Wu, Chunling Huang, Yulin Ma, Pengtao Gu, Qiuxia Lin, Jiaqi Liu, Porpor Kea, Yonggang Yuan, Ling Lin, Peiyang Shen, Jiali Li, Songfu Feng","doi":"10.1159/000546255","DOIUrl":"10.1159/000546255","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of study was to investigate postoperative outcomes in patients who underwent rhegmatogenous retinal detachment (RRD) surgery.</p><p><strong>Methods: </strong>This was a multicenter retrospective study involving 263 patients who underwent silicone oil (SiO) tamponade for RRD. Patients were divided into three groups based on the SiO tamponade: 1 month (group 1, n = 55), 3 months (group 2, n = 176), and 6 months (group 3, n = 32). The main outcomes were best-corrected visual acuity (BCVA), intraocular pressure (IOP), and retinal structure 1 month after silicone oil removal (SOR).</p><p><strong>Results: </strong>In the analysis of retinal structure in post-SOR, the median central macular thickness (CMT) in groups 1, 2, and 3 was 182.5 μm (IQR: 156.0-214.0), 170.0 μm (IQR: 140.3-211.5), and 152.0 μm (IQR: 92.3-195.3), and the median ganglion cell layer-inner plexiform layer (GCL-IPL) in groups 1, 2, and 3 was 80.5 μm (IQR: 70.0-92.3), 73.0 μm (IQR: 65.0-81.3), and 65.0 μm (IQR: 56.3-79.0), respectively. Both CMT and GCL-IPL differed significantly with the group 1 exhibiting the thickest retinal structure (p = 0.03 and p = 0.006). IOP differed significantly across groups, with group 3 showing the highest IOP in post-SOR (p = 0.015). However, there were no significant differences in BCVA, inner retinal layer thickness, outer retinal layer thickness, or submacular fluid among the groups.</p><p><strong>Conclusions: </strong>Prolonged SiO tamponade is correlated with increased IOP and the thinning of the CMT and GCL-IPL over time, with favorable postoperative outcomes for 1-month SiO tamponade. Given the potential risks of extended tamponade, it is advisable to remove SiO as soon as anatomically feasible.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"333-341"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combined Index of Steady-State Pattern Electroretinogram and Optical Coherence Tomography Improved the Detection of Early Glaucoma.","authors":"Hwayeong Kim, Sangwoo Moon, EunAh Kim, Jinmi Kim, Jiwoong Lee","doi":"10.1159/000545094","DOIUrl":"10.1159/000545094","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of the study were to evaluate the structure-function relationship between steady-state pattern electroretinogram (ssPERG), optical coherence tomography (OCT), and visual field (VF) tests and to investigate indicators that enhance the detection of preperimetric and early-stage primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>In this retrospective cohort study, patients with POAG and normal subjects who underwent ssPERG, OCT, and VF tests were included. We defined the ratio of the amplitudes from 0.8° checks to 16° checks as the pattern electroretinogram ratio (PERGratio). The thickness of the macular ganglion cell inner plexiform layer and the circumpapillary retinal nerve fiber layer (cpRNFL) were measured using spectral-domain OCT. We compared the areas under the receiver operating characteristic curves (AUCs) for ssPERG, OCT, and VF test parameters. A combined index using structural and functional measures was generated using logistic regression models to improve diagnostic accuracy.</p><p><strong>Results: </strong>Four parameters had AUCs higher than 0.8; PERGratio (AUC = 0.890), average cpRNFL thickness (AUC = 0.827), 7 o'clock cpRNFL thickness (AUC = 0.844), and inferior quadrant cpRNFL thickness (AUC = 0.830). The new index, which combines the PERGratio and 7 o'clock cpRNFL thickness, significantly improved diagnostic accuracy (AUC = 0.951), outperforming the best four parameters (all p ≤ 0.004). Furthermore, the combined index of PERGratio and 7 o'clock cpRNFL thickness showed significantly higher diagnostic accuracy compared to those combining the 7 o'clock cpRNFL thickness with VF mean deviation, pattern standard deviation, and VF index.</p><p><strong>Conclusion: </strong>The combined index of ssPERG, indicative of retinal ganglion cell dysfunction, and the OCT test, indicative of focal structural damage, improved the detection of patients with POAG in its early stage.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"252-262"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}