Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2025-06-23 DOI:10.1159/000546980

Huangyang Shi, Yao Liu, Yanlin Li, Yingjie Li, Ling Jin, Yuan Liu, Ni Guo, Wei Huang, Zhihong Huang, Huishan Lin, Yue Dong, Nachuan Luo, Yuheng Tan, Xin Ma, Jian Ge, Mingkai Lin, Chengguo Zuo

{"title":"Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.","authors":"Huangyang Shi, Yao Liu, Yanlin Li, Yingjie Li, Ling Jin, Yuan Liu, Ni Guo, Wei Huang, Zhihong Huang, Huishan Lin, Yue Dong, Nachuan Luo, Yuheng Tan, Xin Ma, Jian Ge, Mingkai Lin, Chengguo Zuo","doi":"10.1159/000546980","DOIUrl":null,"url":null,"abstract":"Purpose: To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.Methods: Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.Results: Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.Conclusions: In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-23"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546980","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.

Methods: Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.

Results: Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.

Conclusions: In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.

查看原文本刊更多论文

房水细胞因子水平作为原发性青光眼超声睫状体成形术预后的影响因素。

目的：评价原发性青光眼患者房水（AH）中40种细胞因子水平及其与超声睫状体成形术（UCP）预后的相关性。方法：收集38例原发性青光眼UCP术后房水标本。通过抗体阵列测量细胞因子，并通过Cox比例风险回归评估以确定UCP结果。分别于术后1天、1周、1个月和3个月进行随访。研究对象根据手术结果被分为成功组和失败组。结果：失败组MCP-1 （P=0.034）、TGF-β1 （P=0.041）水平显著升高。单因素和多因素分析均表明，高MCP-1 （P=0.040， P=0.018）和TGF-β1 （P=0.049， P=0.041）水平是UCP失败的显著危险因素。术后1天（r=0.416， P=0.010）和3个月（r=0.329， P=0.044） MCP-1水平与眼内压（IOP）呈正相关。结论：原发性青光眼患者术后高水平MCP-1和TGF-β1是UCP失败的重要危险因素。AH中MCP-1水平可能是预测术后IOP的一个潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.