{"title":"房水细胞因子水平作为原发性青光眼超声睫状体成形术预后的影响因素。","authors":"Huangyang Shi, Yao Liu, Yanlin Li, Yingjie Li, Ling Jin, Yuan Liu, Ni Guo, Wei Huang, Zhihong Huang, Huishan Lin, Yue Dong, Nachuan Luo, Yuheng Tan, Xin Ma, Jian Ge, Mingkai Lin, Chengguo Zuo","doi":"10.1159/000546980","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.</p><p><strong>Methods: </strong>Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.</p><p><strong>Results: </strong>Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.</p><p><strong>Conclusions: </strong>In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-23"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.\",\"authors\":\"Huangyang Shi, Yao Liu, Yanlin Li, Yingjie Li, Ling Jin, Yuan Liu, Ni Guo, Wei Huang, Zhihong Huang, Huishan Lin, Yue Dong, Nachuan Luo, Yuheng Tan, Xin Ma, Jian Ge, Mingkai Lin, Chengguo Zuo\",\"doi\":\"10.1159/000546980\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.</p><p><strong>Methods: </strong>Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.</p><p><strong>Results: </strong>Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.</p><p><strong>Conclusions: </strong>In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.</p>\",\"PeriodicalId\":19662,\"journal\":{\"name\":\"Ophthalmic Research\",\"volume\":\" \",\"pages\":\"1-23\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000546980\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546980","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Aqueous Humor Cytokine Levels as Prognostic Factors for Ultrasound Cycloplasty Outcomes in Primary Glaucoma Patients.
Purpose: To evaluate the levels of 40 cytokines in the aqueous humor (AH) and their correlation with ultrasound cycloplasty (UCP) outcomes in patients with primary glaucoma.
Methods: Aqueous humor samples were collected from 38 primary glaucoma patients after UCP procedure. The cytokines were measured via antibody arrays and evaluated via Cox proportional hazards regression to determine the UCP outcomes. Follow-up visits were performed at 1 day, 1 week, and 1 and 3 months postoperatively. The study subjects were allocated into success and failure groups based on surgical results.
Results: Significantly high MCP-1 (P=0.034) and TGF-β1 levels (P=0.041) were observed in the failure group. Both univariate and multivariate analyses indicated that high MCP-1 (P=0.040, P=0.018) and TGF-β1 (P=0.049, P=0.041) levels were significant risk factors for UCP failure. The levels of MCP-1 were positively correlated with intraocular pressure (IOP) at 1 day (r=0.416, P=0.010) and 3 months (r=0.329, P=0.044) postoperatively.
Conclusions: In primary glaucoma patients, high postoperative levels of MCP-1 and TGF-β1 were significant risk factors for UCP failure. MCP-1 levels in the AH could be a potential indicator for predicting postoperative IOP.
期刊介绍：
''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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