Ophthalmic Research最新文献

{"title":"Characterization of Macular Fundus Autofluorescence Changes in Patients with Retinitis Pigmentosa.","authors":"Muhammad Jehanzeb Khan, Zainab Rustam, Faiqa Binte Aamir, Maria Chairez Miranda, Imad Shaikh, Anam Akhlaq, Jiawen Liu, Mandeep Singh, Xiangrong Kong, Peter A Campochiaro","doi":"10.1159/000543082","DOIUrl":"10.1159/000543082","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to characterized fundus autofluorescence (AF) changes that occur in the macula of patients with retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>We conducted a case series on 99 patients with RP. Features seen on fundus AF images were evaluated, organized into a grading scheme, and correlated with ellipsoid zone (EZ) width. Patterns of AF changes occurring in the macula and correlation with EZ width.</p><p><strong>Results: </strong>Four primary fundus AF phenotypes were identified: (1) hyperAF arc, (2) hyperAF ring, (3) hyperAF ring with abnormal hyperAF within the ring, and (4) central hyperAF. The second phenotype was most common and had 3 subgroups, hyperAF rings within the macula, those extending outside the macula, and incomplete rings. HyperAF rings were also characterized as narrow or wide with wide rings having a greater amount of hyperAF. Linear Mixed-Effects Model showed mean measured EZ width was significantly greater for phenotype 1 versus each of the other 3 phenotypes (p < 0.01) and for phenotype 2 versus phenotypes 3 and 4 (p < 0.05), and also differed among phenotype 2 subgroups (p < 0.05). Other AF characteristics identified were focal posterior distinct or indistinct hypoAF which sometimes formed complete or incomplete hypoAF rings surrounding a hyperAF ring, diffuse or focal hyperAF outside hyperAF rings, and the amount of encroachment of peripheral hypoAF.</p><p><strong>Conclusions: </strong>A grading scheme for macular AF features in patients with RP identified phenotypes that correlate with stage of disease based upon EZ width. Longitudinal studies are needed to test whether presumed early AF phenotypes evolve into later phenotypes. Use of the grading scheme for patient populations in interventional trials could help determine if any of the defined AF features provide predictive value for therapeutic responses.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"156-168"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Penetrating Canaloplasty versus Trabeculectomy in Patients with Bilateral Primary Glaucoma: A Self-Control Study.","authors":"Wenqing Ye, Xiaowei Xu, Haishuang Lin, Jinxin Li, Shuqing Zhu, Yanqian Xie, Shaodan Zhang, Yuanbo Liang","doi":"10.1159/000546133","DOIUrl":"10.1159/000546133","url":null,"abstract":"<p><strong>Introduction: </strong>Schlemm's canal-based minimally invasive glaucoma surgeries (MIGSs) are gaining increasing recognition and acceptance, but majority of these MIGSs are recommended in eyes with open angle. Bleb-independent penetrating canaloplasty (PCP) restores physiological aqueous outflow in eyes with both open and closed angles. We aimed to compare the efficacy, safety, and postoperative management of PCP versus trabeculectomy (TRAB) in patients with bilateral primary glaucoma.</p><p><strong>Methods: </strong>This study is prospective self-control case series in a tertiary hospital in China. A total of 54 eyes from 27 patients with bilateral primary open angle glaucoma (n = 18) or primary angle-closure glaucoma (n = 9) were included. TRAB with mitomycin C was performed in one eye, while PCP was performed in the contralateral fellow eye. Intraocular pressure (IOP), number of glaucoma medications, surgery-related complications, and postoperative interventions were compared between groups. Complete (without medication) and qualified success (with/without medication) were defined as IOP ≤21 mm Hg and ≥20% IOP reduction.</p><p><strong>Results: </strong>Mean IOP decreased from 32.5 ± 8.87 mm Hg on 2.3 ± 1.43 medications at baseline to 15.5 ± 5.02 mm Hg on 0.12 ± 0.33 medications at 24 months in TRAB group (both p < 0.0001) and from 30.0 ± 9.61 mm Hg on 2.7 ± 1.10 medications to 15.5 ± 4.36 mm Hg on 0.40 ± 0.82 medications in PCP group (both p < 0.0001). Equal complete success (12 months: 84.0%, p > 0.999; 24 months: 72.0%, p > 0.999) was achieved at both 12 and 24 months in two groups. Although not statistically significant, higher qualified success was observed in PCP (88.0%) than in TRAB group (80.0%, p = 0.702) at 24 months. However, 63.0% eyes (n = 17) in TRAB group needed bleb managements to maintain a lower IOP. Transient IOP spike (>25 mm Hg, 22.2%) and microhyphema (22.2%) were the most common complications for PCP, while hypotony (14.8%) and wound leakage (11.1%) were frequently seen after TRAB.</p><p><strong>Conclusion: </strong>PCP demonstrates comparable IOP-lowering effect with TRAB in eyes with primary glaucoma, but with less postoperative complications and interventions.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"310-319"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Specificity Rates of Clarus 500™ Ultra-Wide-Field Retinal Imaging for Detecting Peripheral Retinal Lesions in Medium-to-High Myopia Eyes.","authors":"Fangcheng Xu, Xiaojun Hu, Yunzhe Wang, Ruoyan Wei, Yongfu Yu, Yuwei Peng, Meiyan Li, Haixiang Wu","doi":"10.1159/000546494","DOIUrl":"10.1159/000546494","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to investigate the specificity of Clarus 500™, an ultra-wide-field (UWF) fundus camera, for detecting peripheral retinal lesions in myopic eyes.</p><p><strong>Methods: </strong>This diagnostic test included 436 eyes from 221 patients with myopia before refractive surgery. The mean age was 28.9 ± 6.0 years (18 to 49 years), with the average spherical equivalent refraction being -8.33 ± 2.81 diopters (D) (-20.63 D to -0.50 D). Images were captured using Clarus 500™ from the posterior pole and four UWF directions, including the superior temporal, superior nasal, inferior temporal, and inferior nasal gaze. A slit-lamp non-contact +120 D lens was used as the control. Sensitivity and specificity in detecting fundus lesions were compared between the images obtained by Clarus 500™ and slit-lamp examination. Statistical analysis was performed using version 4.3.0 of R software, and significance was set at p < 0.05.</p><p><strong>Results: </strong>Of the 436 eyes, 13 (2.98%) underwent slit-lamp examination, and 5 (1.15%) underwent Clarus 500™ examination, revealing retinal lesions. The sensitivity of Clarus 500™ for detecting peripheral retinal holes/tears was 50% (95% confidence interval [95% CI]: 1.26%, 98.74%). The specificity for peripheral lattice degeneration was 99.77% (95% CI: 98.70%, 99.99%). The agreement between the two methods for detecting peripheral reticular degeneration and retinal holes was moderate (kappa value: 0.42, 95% CI: 0.10-0.75, p < 0.01) and substantial (kappa value: 0.67, 95% CI: 0.05-1, p < 0.01), respectively.</p><p><strong>Conclusion: </strong>Clarus 500™ showed high specificity for detecting peripheral retinal holes and substantial agreement with the slit-lamp in identifying peripheral retinal degeneration and retinal holes.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"352-359"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Evaluation of Ocular Surface and Meibomian Gland Function after Laser-Assisted in situ Keratomileusis Surgery.","authors":"Kenneth Ka Hei Lai, Zhichao Hu, Jamie Tsun Chiu, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, George Pak Man Cheng, Wilson Wai Kuen Yip, Alvin Lerrmann Young, Clement Chee Yung Tham, Calvin Chi Pui Pang, Kelvin Kam Lung Chong","doi":"10.1159/000542985","DOIUrl":"10.1159/000542985","url":null,"abstract":"<p><strong>Introduction: </strong>Laser-assisted in situ keratomileusis (LASIK) is a common refractive surgery. But it may lead to temporary dry eye due to reversible damage to the corneal subbasal nerve plexus. However, evidence on chronic ocular surface changes are unclear. This study reports the ocular surface changes, partial blinking rates, and meibomian gland statuses in eyes that underwent LASIK for at least 48 months.</p><p><strong>Methods: </strong>Cross-sectional, matched case-control comparison study, including 48 post-LASIK patients and 48 sex-, age-, smoking-, and axial length-matched healthy controls, recruited from a community eye screening program. Outcome measures include anterior segment clinical findings, keratographic and meibographic imaging.</p><p><strong>Results: </strong>Totally, 48 right eyes of 48 post-LASIK Chinese patients (39 females, 2 smokers) were analyzed with 48 right eyes of 48 matched healthy controls. The mean age at the time of ocular surface examination was 50 ± 11 years, and the axial length 26±1 mm. Post-LASIK eyes had a lower quality of meibum (p = 0.008) compared to healthy controls. Post-LASIK eyes were associated with a shorter Schirmer's test (p = 0.03). The ocular surface disease index (OSDI) score was higher in post-LASIK patients (p = 0.00001). Other anterior segment examination parameters, partial blinking rate, meibomian gland dropout, lipid layer thickness, noninvasive tear break-up time, and tear meniscus height were comparable between the 2 groups.</p><p><strong>Conclusions: </strong>Up to 75% of post-LASIK patients complained of on-going, chronic dry eye symptoms. Post-LASIK eyes were associated with a reduced aqueous tear production. Post-LASIK patients with chronic dry eye symptoms are advised to have periodic ocular surface evaluation. Treatments might be considered in patients with poor tear film stability.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"84-89"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000543854","DOIUrl":"https://doi.org/10.1159/000543854","url":null,"abstract":"<p><p>The article \"Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress and Reduction of VEGF Expression\" [Ophthalmic Res. 2012;47:122-27; https://doi.org/10.1159/000329600] by Lina Huang, Shihong Zhao, John H. Zhang and Xuejun Sun has been retracted by the Publisher and the Editor.After the publication of this article, concerns were raised about the integrity of some of the data presented. Specifically, internal image duplications were found in areas of Figure 4a and 4b of this article. The authors responded to the above concerns and stated that they no longer have access to the original data supporting the figures. In addition, they have discussed this matter with several of their co-authors and acknowledge that there may have been errors during their processing of their figures. The authors requested to retract their above article. Given that the concerns in the above article cannot be addressed, this article is being retracted. The authors agree with this retraction.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":"68 1","pages":"146"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Outcomes and Cost-Utility Analyses of Toric Intraocular Lens Implantation in Cataract Patients over 80 with Corneal Astigmatism: A Retrospective Cohort Study.","authors":"Jiaqi Sun, Baojiang Li, Bijun Zhu, Yuyu Miao, Qian Sun, Huiyi Jin, Ying Zheng, Senlin Lin, Haidong Zou, Yingyan Ma","doi":"10.1159/000547708","DOIUrl":"10.1159/000547708","url":null,"abstract":"<p><p><p>Introduction: This study aimed to assess visual and refractive outcomes and cost-utility of toric intraocular lens (IOL) implantation in cataract patients over 80 with corneal astigmatism.</p><p><strong>Methods: </strong>Patients ≥80 years with corneal astigmatism ≥1.50 diopters (D) who underwent cataract surgery with toric or monofocal IOLs were enrolled. Uncorrected distance visual acuity (UDVA) and residual refractive astigmatism at the 3-month postoperative follow-up were compared between the toric and non-toric groups. Cost data were gathered, long-term quality-adjusted life years (QALYs) were calculated, and the incremental cost-effectiveness ratio (ICER) was determined.</p><p><strong>Results: </strong>The study included 50 eyes from 50 patients, with 25 eyes receiving toric IOLs and the remaining 25 receiving non-toric IOLs. Three months after surgery, both the mean UDVA (p < 0.0001) and the mean residual refractive astigmatism (p < 0.0001) in the toric group significantly outperformed those in the non-toric group. An average of 4.04 ± 0.25 QALYs were obtained in the toric group through cataract surgery, while 3.78 ± 0.26 QALYs were obtained in the non-toric group. The median ICER stood at CNY 11,222 (USD 1,753) per QALY (95% CI: CNY 5,840∼25,295 [USD 913∼3,952] per QALY), which was lower than the threshold of cost-effectiveness in China (CNY 80,976 [USD 12,653] per QALY).</p><p><strong>Conclusion: </strong>In cataract patients aged over 80 with corneal astigmatism and no complicating vision-threatening conditions, toric IOL implantation not only improved UDVA and reduced residual astigmatism but also emerged as a cost-effective intervention compared with non-toric IOL implantation. </p>.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"475-484"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Iris Vessel Density for Primary Glaucoma Diagnosis Using Anterior Segment Optical Coherence Tomography.","authors":"Qiang Li, Wenjuan Wu, Xiaofei Man, Cuixia Dai","doi":"10.1159/000545948","DOIUrl":"10.1159/000545948","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the iris vessel density within a 15 mm × 12 mm area in primary glaucoma using anterior segment optical coherence tomography (AS-OCT) and anterior segment optical coherence tomography angiography (AS-OCTA).</p><p><strong>Methods: </strong>The study involved 30 normal eyes and 31 eyes with primary glaucoma, comprising 15 with primary open-angle glaucoma and 16 with primary angle-closure glaucoma. OCT/OCTA images of the iris obtained were evaluated and a univariate logistic regression model was used to assess the correlation between the iris vessel density and primary glaucoma, area under the receiver operating characteristic (AUROC), and clinically relevant performance metrics of different regions (superior, inferior, temporal, and nasal regions) were compared. Additionally, the trabecular iris angle (TIA) in both the nasal and temporal regions to elaborate the mechanism of using iris vessel density for primary glaucoma detection.</p><p><strong>Results: </strong>Across all regions, the vessel density in the glaucoma group was significantly lower than in the normal eyes. The nasal 6-12 mm annular region of the iris demonstrated the highest diagnostic ability (AUROC = 0.870, p < 0.001), followed by the temporal 3-6 mm annular region (AUROC = 0.837, p < 0.001). All AUROC exceeded 0.8, with p values below 0.01, indicating strong diagnostic accuracy. Furthermore, TIA in primary glaucoma was smaller than normal individuals. Compared with the nasal region, the temporal region exhibited higher correlation with TIA, where TIA500 demonstrated the largest diagnostic value in the temporal region (AUROC = 0.995, p < 0.001). Moreover, a strong correlation was observed between iris vessel density and TIA in the 6-12 mm region. Based on the clinical parameter metrics, the detection ability of iris vessel density in the nasal region and TIA in the temporal region are more significant.</p><p><strong>Conclusion: </strong>Iris vessel density is significantly reduced in primary glaucoma. The wide-field AS-OCTA of iris provides a comprehensive perspective of microvascular structures, facilitating precise comparison and evaluation of vessel changes in different regions associated with glaucoma. Specifically, the vessel density in the larger annular region on the nasal region has significant diagnostic value, enhancing understanding of disease mechanisms and progression.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"320-332"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bruch's Membrane Opening-Based Peripapillary Optical Coherence Tomography Angiography Analysis.","authors":"Sebastian Fassihi Dehkordi, Julia Schottenhamml, Meike Müller, Sami Hosari, Robert Lämmer, Andreas Maier, Bettina Hohberger, Christian Mardin","doi":"10.1159/000545878","DOIUrl":"10.1159/000545878","url":null,"abstract":"<p><strong>Introduction: </strong>Peripapillary optical coherence tomography angiography (OCT-A) scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of Bruch's membrane opening (BMO)-based peripapillary OCT-A analysis with and without the implementation of the anatomical positioning system (APS) compared to manual analysis.</p><p><strong>Methods: </strong>Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analyzed by the Erlangen-Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (fovea-to-Bruch's membrane opening center). Peripapillary OCT-A scans were analyzed: (1) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (2) BMO-based, and (3) BMO-based with APS information. Coefficients of variation (CVs) were calculated.</p><p><strong>Results: </strong>Peripapillary mean VD was 42.52 ± 4 and 41.69 ± 4 (manually), 50.29 ± 4 and 48.8 ± 4 (BMO-based), and 44.73 ± 3 and 44.39 ± 4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p = 0.04), but not for BMO-based (p > 0.05) and BMO-based and APSified analysis (p > 0.05). CVs were 10.0% (manually), 8.0% (BMO-based), and 8.0% (BMO-based and APSified).</p><p><strong>Conclusion: </strong>The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"372-380"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Coherence Tomography Measurements Alteration in Patients with End-Stage Renal Disease after Hemodialysis.","authors":"Sepehr Fekrazad, Golnar Hassanzadeh, Asma Mousavi, Shayan Shojaei, Mohammad Amin Salehi, Kian Najimi, Jay Chhablani, J Fernando Arevalo","doi":"10.1159/000548710","DOIUrl":"10.1159/000548710","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis aimed to evaluate the effects of hemodialysis (HD) on ocular parameters in patients with the end-stage renal disease (ESRD) using optical coherence tomography (OCT).</p><p><strong>Methods: </strong>Adhering to PRISMA guidelines, we conducted a comprehensive search of PubMed, Scopus, and Embase databases up to June 26, 2023. Eligible studies included original research investigating retinal and choroidal OCT measurements before and after HD in human subjects. Meta-analyses were conducted using Stata 16, calculating weighted mean differences and standardized mean differences (SMDs) with 95% confidence. Meta-regression and subgroup meta-analysis were carried out for suitable parameters.</p><p><strong>Results: </strong>Twenty-six studies on 1,430 participants were included. Meta-analysis revealed a significant reduction in subfoveal choroidal thickness post-HD in diabetic and mixed patient groups (SMD = -0.24, p < 0.0001) but not in nondiabetic patients. No significant changes were observed in average choroidal thickness, foveal retinal thickness, peripapillary retinal nerve fiber layer thickness, or macular volume across all groups. Subgroup analyses based on OCT models, eye selection, etc., largely mirrored overall findings, with some variations. Sensitivity analyses were generally consistent, and quality assessment indicated satisfactory to excellent study quality.</p><p><strong>Conclusion: </strong>HD generally exerts minimal effects on various ocular parameters. However, a notable reduction in subfoveal choroidal thickness was observed in diabetic and mixed ESRD populations, suggesting increased vulnerability of choroidal tissues in these groups. These findings underscore the importance of regular ophthalmologic monitoring for ESRD patients undergoing HD, particularly those with diabetes. Future research should address existing heterogeneities and explore the long-term ocular implications of repeated HD sessions.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"503-520"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Change of Ciliary Muscle-Trabecular Meshwork-Schlemm Canal Complex after Phacoemulsification using Swept-Source-Optical Coherence Tomography.","authors":"Zhangliang Li, Xueer Wu, Xinpei Ji, Zehui Zhu, Nan Zhe, Yun-E Zhao","doi":"10.1159/000543303","DOIUrl":"10.1159/000543303","url":null,"abstract":"<p><strong>Introduction: </strong>Cataract surgery has been reported to have a reducing effect on intraocular pressure (IOP) in glaucomatous and non-glaucomatous eyes. This effect seems to be more noticeable in eyes with narrow angles (NAs) than in eyes with open angles (OAs). Decrease in IOP may be a result of the increase in anterior chamber angle and Schlemm canal (SC) after cataract surgery. The purpose of this paper was to evaluate the relationship between Schlemm canal-cross-sectional area (SC-CSA) changes and trabecular meshwork, ciliary muscle changes after cataract surgery and the difference in non-glaucomatous eyes with NAs and OAs.</p><p><strong>Methods: </strong>IOP, SC-CSA, Schlemm canal diameter (SCD), trabecular meshwork width (TMW) and thickness (TMT), trabecular-iris angle at 500 µm from the scleral spur (TIA500), and the distance between the inner apex of the ciliary muscle and scleral spur (IA-SS) were measured by swept-source-optical coherence tomography preoperatively and 1-week post-surgery. Patients were divided into NA and OA groups according to the degree of TIA500, and SC-CSA-related parameters were compared.</p><p><strong>Results: </strong>Seventy-five patients (89 eyes) were included. IOP significantly decreased, SC-CSA, SCD, TMW, TMT, and TIA500 significantly increased post-surgery (p < 0.001). Changes in nasal SC-CSA were associated with TMW (p = 0.003) and TIA500 (p < 0.001) changes; changes in temporal SC-CSA were associated with TMW (p = 0.001) and TMT (p < 0.001) changes. SC-CSA expansion was correlated with changes in TMW (β3.726 ± 1.085, p = 0.001 nasally; β3.405 ± 0.945, p = 0.001 temporally), TMT (β5.224 ± 2.033, p = 0.012 nasally; β11.853 ± 3.059, p < 0.001 temporally), and TIA500 (β40.330 ± 15.100, p = 0.009 nasally; β35.453 ± 17.527, p = 0.047 temporally). There was no association between SC-CSA expansion and IA-SS changes. SC-CSA expansion was greater in the NAs than in the OAs group (p < 0.001).</p><p><strong>Conclusion: </strong>Cataract surgery results in IOP reduction and SC-CSA expansion. Increased SC-CSA correlates with increases in TMW, TMT, and TIA500. SC-CSA increased more in NAs than in OAs group post-surgery, which may explain the greater decrease in IOP in eyes with NAs.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"100-107"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}