研究减肥手术对无代谢性疾病的肥胖者黄斑和毛细血管密度的影响。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-05-08 DOI:10.1159/000539103
Müslüm Toptan, Hasan Elkan
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引用次数: 0

摘要

导言:众所周知,患有代谢性疾病的肥胖者的微血管结构会受到影响。我们的目的是通过光学相干断层血管成像(OCTA)检查无代谢性疾病的肥胖者在减肥手术后黄斑和毛细血管密度,评估其对微血管结构的影响:这项前瞻性研究包括 48 名肥胖患者的 96 只眼睛。结果:体重指数(BMI)、浅层、中间层和深层毛细血管丛中的黄斑血管密度以及毛细血管周围的血管密度在减肥手术前和手术后 6 个月进行了测量:结果:与术前的 55.31±5.1 kg/m2 相比,术后体重指数明显降低至 43.75±4.4 kg/m2(p<0.05)。术后观察到深部毛细血管丛中的黄斑血管密度明显增加(p<0.01)。但是,浅层和中层毛细血管丛的黄斑血管密度在术后没有明显增加(p>0.05)。此外,毛细血管周围的血管密度也没有变化(p>0.05)。术后眼窝、眼底旁和眼底周围视网膜层明显增厚(p <0.001)。BMI变化与黄斑和视网膜周边血管密度变化之间无明显相关性(p>0.05):结论:对无代谢性疾病的肥胖者进行减肥手术后,可观察到黄斑部血管密度(尤其是深部毛细血管丛)和视网膜层厚度增加。这种增加可能表明,即使没有代谢性疾病,微血管结构也会受到影响,而且手术会改善微灌注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Impact of Bariatric Surgery on Macular and Peripapillary Vessel Density in Obese Individuals without Metabolic Disease.

Introduction: It is well established that microvascular structures are affected in obese people with metabolic disease. We aimed to evaluate the effect on microvascular structures by examining macular and peripapillary vessel density with optical coherence tomography angiography after bariatric surgery in obese individuals without metabolic disease.

Methods: This prospective study included 96 eyes of 48 obese patients. Body mass index (BMI), macular vessel density in the superficial, intermediate, and deep capillary plexus, and peripapillary vessel density were measured before and 6 months after bariatric surgery.

Results: BMI decreased significantly to 43.75 ± 4.4 kg/m2 postoperatively compared to 55.31 ± 5.1 kg/m2 preoperatively (p < 0.05). A significant increase was observed in macular vessel density in the deep capillary plexus postoperatively (p < 0.01). However, no significant postoperative increase occurred in macular vascular density in the superficial and intermediate capillary plexus (p > 0.05). Moreover, there was no change in peripapillary vascular density (p > 0.05). Postoperative thickening of the foveal, parafoveal, and perifoveal retinal layers was significant (p < 0.001). No significant correlation was detected between BMI change and macular and peripapillary vessel density changes (p > 0.05).

Conclusion: An increase in macular vascular density, particularly in the deep capillary plexus, and retinal layer thickness has been observed following bariatric surgery performed on obese individuals without metabolic disease. This increase may indicate that microvascular structures are affected even in the absence of metabolic disease and that microperfusion improves with surgery.

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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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