环状 RNA 在视网膜母细胞瘤发病机制中的新作用。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2023-12-18 DOI:10.1159/000535329
Weizhen Wu, Youjing Zhang, Ming Yang
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引用次数: 0

摘要

视网膜母细胞瘤占所有儿童癌症的 3%。它是最常见的眼内恶性肿瘤,具有高度侵袭性和转移性。了解参与这些过程的分子机制将有助于设计治疗方法和鉴定新型肿瘤标志物。最近的研究表明,环状 RNA(circRNA)在视网膜母细胞瘤(Rb)的演化过程中起着重要作用。包括 circ_0000034、circ_0000527、circ_0075804、circ_0099198、circFAM158A 和 circVAPA 在内的一些 circRNA 促进了视网膜母细胞瘤的发展和转移。然而,一些 circRNAs,如 circ_0001649、circMKLN1 和 circTET1,则起着抑制肿瘤的作用。在这方面,circRNAs 可调控癌症发生过程,包括细胞增殖、凋亡、迁移、侵袭和肿瘤生长。本综述总结了 circRNAs 在视网膜母细胞瘤中的功能作用及其在诊断和预后方面的潜在临床应用,并对 circRNAs 在 Rb 病理生理学中的作用提供了一个全面的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Role of Circular RNAs in the Pathogenesis of Retinoblastoma.

Retinoblastoma (Rb) accounts for 3% of all childhood cancers. It is the most common intraocular malignant tumor with a highly aggressive and metastatic phenotype. Gaining a more comprehensive understanding of the molecular mechanisms underlying the proliferation, metastasis, migration, invasive apoptosis, and autophagy processes associated with this cancer would facilitate the design of therapeutic modalities and the identification of novel tumor markers. Recent investigations have shown the contribution of circular RNAs (circRNAs) in the evolution of Rb. Several circRNAs, including circ_0000034, circ_0000527, circ_0075804, circ_0099198, circFAM158A, and circVAPA, promote the progression and metastasis of Rb. However, some circRNAs, such as circ_0001649, circMKLN1, and circTET1, play a tumor suppressive role. In this regard, circRNAs can regulate cancer-developing processes including cell proliferation, apoptosis, migration, invasion, and tumor growth. This review summarizes the functional roles of circRNAs in Rb and their potential clinical applications for diagnosis and prognosis, and provides a comprehensive understanding of the role of circRNAs in the pathophysiology of Rb.

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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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