Ophthalmic Research最新文献

{"title":"Relationship of Retinal Zone and Plus Severity with the Requirement of Re-Treatment in Bevacizumab-Treated Eyes for Retinopathy of Prematurity.","authors":"Sadik Etka Bayramoglu, Nihat Sayin, Ibrahim Kocak","doi":"10.1159/000544710","DOIUrl":"10.1159/000544710","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the relationship between the location of retinal vascularization and plus severity with re-treatment rates in intravitreal bevacizumab (IVB)-treated eyes.</p><p><strong>Methods: </strong>For this retrospective, observational study, 200 eyes treated with IVB for type 1 retinopathy of prematurity (ROP) and aggressive-ROP were included. The pretreatment retinal vascularization was evaluated by analyzing quantitative measurements of optic disc-to-fovea distance (DFD), disc diameter, and shortest and longest distance between the optic disc and ridge of wide-field fundus photographs (WFPs). Plus severity was qualified in five grades such as normal, pre-plus, mild plus, moderate plus, and severe plus by evaluating WFPs. Re-treatments up to 60 weeks of postmenstrual age (PMA) were evaluated. Re-treated eyes up to first month after initial treatment were labeled as early re-treatment group and re-treated eyes after the first month of initial treatment up to 60 weeks of PMA were labeled as middle-term re-treated group.</p><p><strong>Results: </strong>Thirty-six percentage of eyes had zone I, 64% of eyes had zone II disease, and 42% eyes had mild plus disease. Forty-three (21.5%) eyes of 23 infants underwent re-treatment prior to 60 weeks of PMA. Thirteen eyes and 30 eyes were in the early- and middle-term re-treated groups, respectively. In middle-term re-treated group, 27 (13.5%) eyes re-treated for progressive reactivated disease, and 3 (1.5%) eyes re-treated for prophylactic purposes. Advanced pretreatment retinal vascularization and high birth weight were negatively associated with the re-treatment rate (p = 0.016, odds ratio = 0.774; p = 0.041, odds ratio = 0.999, respectively). There was a positive association between the re-treatment rate and pretreatment plus severity (p = 0.044, odds ratio = 1.449). The lower ratio of shortest distance between the optic disc and ridge to DFD was considered as an independent predictive variable for higher rate of re-treatment (p = 0.002; odds ratio: 0.450).</p><p><strong>Conclusion: </strong>The location of retinal vascularization and plus disease showed a wide distribution in bevacizumab-treated eyes. Graded evaluation of retinal vascularization and plus severity may help predict the need for additional treatment. Unresponsiveness to the initial treatment, increased fibrotic activity, progressive reactivated stage 2-3 ROP, extraretinal new vessels, and prophylactic purposes were the main re-treatment indications.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"195-209"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous versus Interrupted Sutures for Closure of Scleral Pocket and Conjunctiva after Evisceration and Placement of Acrylic Ocular Implant.","authors":"Ahmed Ali Amer, Hasan Naveed, Ibrahim Amer, Hamdy Osman Abdelrahman Osman, Mostafa Abdelrahman Ahmed Mohamed, Ashraf Mohammed GadElkareem, Ahmed Abdallah Elbarawy, Zisis Gatzioufas, Mohamed Elalfy, Mohamed A ElShafie","doi":"10.1159/000545331","DOIUrl":"10.1159/000545331","url":null,"abstract":"<p><strong>Introduction: </strong>Various methods of conjunctival closure have been described, with no consensus of preference. We designed this study to compare continuous versus interrupted sutures for closure of scleral pocket and conjunctiva after evisceration and acrylic ocular implant installation.</p><p><strong>Methods: </strong>This study was a retrospective comparative observational study conducted at South Valley University Hospital on all ocular evisceration cases with acrylic implants from 1 March 2019 to 31 March 2024. For each patient, clinical data were perused, including demographics, indications, clinical history, operative details, and postoperative follow-up data.</p><p><strong>Results: </strong>Forty-seven patients were included in this study. Twenty-seven were allocated to group A (continuous sutures) and 20 patients to group B (interrupted sutures). The mean age of patients was 38.52 ± 12.8 and 39.35 ± 14.5 in groups A and B, respectively (p value = 0.839). Males represented 51.9% (14/27) and 50% (10/20) of groups A and B, respectively (p value = 0.901). Absolute glaucoma was the indication in 5 (18.5%) and 3 (15%) patients in groups A and B, respectively; anterior staphyloma was the indication in 7 (25.9%) and 5 (25%) patients, respectively; and atrophia/phthisis was the indication in 6 (22.2%) and 5 (25%) patients, respectively, while old trauma was the indication in 9 (33.3%) and 7 (35%) patients, respectively, with p value = 0.769. The median size of the acrylic implant used was 20 mm in both groups. Patients were followed up on average in group A for 20.19 ± 3.2 months and in group B for 19.95 ± 3.4 months (p value = 0.812). No cases of infection or implant extrusion were observed in both groups. But in group B, there were 3 cases (15%) of wound dehiscence and implant exposure, while no reported cases in group A (0%) with clinically significant p value (0.029).</p><p><strong>Conclusion: </strong>Continuous suturing for closure, as opposed to interrupted sutures, produces better wound outcomes when closing the scleral pocket and conjunctiva post evisceration and acrylic ocular implant installation.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"285-291"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Month Silicone Oil Tamponade Can Decrease Intraocular Complications via Reducing the Recruitment and Activation of Leukocytes in Patients with Rhegmatogenous Retinal Detachment.","authors":"Lan Jiang, Yuqing Wu, Baoyi Liu, Kunbei Lai, Yuan Ma, Ziye Chen, Zijian Qin, Zhuojun Xu, Zhuangling Lin, Zitong Chen, Chin-Ling Tsai, Tao Li","doi":"10.1159/000545211","DOIUrl":"10.1159/000545211","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to compare the effects of 1-month versus routine-duration silicone oil (SO) tamponade on intraocular inflammatory cytokine levels and clinical outcomes in patients undergoing vitrectomy for rhegmatogenous retinal detachment.</p><p><strong>Methods: </strong>A prospective study from May 2019 to March 2022 divided patients undergoing vitrectomy into routine and early groups. Aqueous humor was sampled before SO removal to measure cytokine levels, including granulocyte-macrophage colony-stimulating factor, interferon (IFN)-γ, interleukin (IL)-4, IL-8, IL-10, IL-13, IL-17, macrophage inflammatory protein (MIP)-1α, tumor necrosis factor (TNF)-α, and IL-1α. Clinical outcomes such as SO emulsification, cataract formation, recurrent retinal detachment, corneal endothelial cell (CEC) density, and intraocular pressure were assessed. Statistical analyses were performed to evaluate differences and correlations between cytokine levels and clinical characteristics.</p><p><strong>Results: </strong>The study analyzed 48 eyes, with 28 in the routine group and 20 in the early group. The early group had significantly lower IL-8 and TNF-α levels (p = 0.006 and p = 0.013) and reduced SO emulsification (p = 0.01). A significant trend toward fewer cataract cases and higher CEC density was observed in the early group (p = 0.019 and p = 0.015). IL-8 and TNF-α levels showed positive correlations with IL-10, MIP-1α.</p><p><strong>Conclusion: </strong>One-month SO tamponade significantly reduces intraocular inflammatory cytokine levels and associated complications by decreasing the recruitment and activation of leukocytes. These findings suggest that shorter SO placement durations can effectively minimize inflammation-related complications while maintaining therapeutic efficacy. Future research should focus on optimizing SO tamponade protocols and exploring the underlying mechanisms of inflammation and emulsification to enhance the safety and efficacy of vitreoretinal surgeries.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"292-300"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Anisometropic Amblyopia Associated with Unilateral High Myopia in Children with Modified Posterior Scleral Reinforcement.","authors":"Minshu Wang, Xuran Dong, Jing Liu, Juan Bu","doi":"10.1159/000546921","DOIUrl":"10.1159/000546921","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate the effect of modified posterior scleral reinforcement (PSR) surgery integrated with comprehensive amblyopia rehabilitation in children with high myopia-related anisometropic amblyopia.</p><p><strong>Methods: </strong>A retrospective cohort analysis was conducted, including 24 eyes treated with the modified PSR intervention and 20 nonsurgical controls. Baseline and 3-year postoperative assessments included best-corrected visual acuity (BCVA), cycloplegic spherical equivalent (SE), and axial length (AL).</p><p><strong>Results: </strong>At the 3-year follow-up, the PSR cohort exhibited significant BCVA enhancement (p < 0.001) alongside suppressed myopic progression, as evidenced by reduced SE deterioration (p < 0.001) and AL elongation (p < 0.001), compared to controls. Amblyopia treatment success rates were markedly higher in the surgical group (p < 0.001). Stratified analyses revealed greater BCVA gains in the PSR group across all amblyopia severities, with pronounced improvements in severe amblyopia cases. Age-specific outcomes demonstrated attenuated AL growth in both preschoolers (<6 years, p < 0.01) and school-aged children (≥6 years, p < 0.05). Notably, younger preschoolers in the PSR group achieved superior BCVA gains (p < 0.05), whereas older controls showed limited responsiveness.</p><p><strong>Conclusion: </strong>The combination of modified PSR surgery and multidisciplinary amblyopia rehabilitation represents a promising therapeutic approach for mitigating refractive error progression and enhancing visual outcomes in children with high myopia-associated anisometropic amblyopia.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"381-388"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-High-Density Lipoprotein-to-High-Density Lipoprotein Cholesterol Ratio as a Predictive Biomarker for Diabetic Retinopathy Risk: A Population-Based Analysis of US Adults.","authors":"Zhirui Zhang, Changxing Liu, Lingying Zhao, Xufang Tan, Ximing Yu, Jiadi Wang, Jing Yao","doi":"10.1159/000545816","DOIUrl":"10.1159/000545816","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy (DR) is a severe complication of diabetes, and lipid imbalances play a key role in its progression. The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has been identified as a predictor of cardiovascular diseases, but its link to DR remains unclear. This study aimed to assess the association between NHHR and DR risk in diabetic patients.</p><p><strong>Methods: </strong>Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate logistic regression models were used to evaluate the relationship between NHHR and DR. Nonlinear associations were assessed using restricted cubic spline analysis.</p><p><strong>Results: </strong>Of the 4,935 participants, 1,193 had DR. Higher NHHR was strongly associated with increased DR risk. Each unit rise in NHHR increased the risk by 19% (OR = 1.19, 95% CI: 1.07-1.31, p < 0.05). In quartile analysis, participants in the highest NHHR quartile had nearly double the risk of DR compared to those in the lowest quartile (OR = 1.84, 95% CI: 1.62-2.06, p < 0.001). Subgroup analysis showed this association was consistent across different demographic groups, including age, gender, BMI, and smoking status.</p><p><strong>Conclusion: </strong>NHHR is significantly linked to DR risk in diabetic patients and may be a valuable biomarker for early detection and prevention strategies in clinical settings.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"301-309"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Perfluorohexyloctane for the Treatment of Patients with Dry Eye Disease: A Meta-Analysis.","authors":"Andrea Taloni, Giulia Coco, Marco Pellegrini, Vincenzo Scorcia, Giuseppe Giannaccare","doi":"10.1159/000542149","DOIUrl":"10.1159/000542149","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to systematically review the evidence from randomized controlled trials that evaluate the efficacy and safety of perfluorohexyloctane in the treatment of dry eye disease.</p><p><strong>Methods: </strong>Literature search was conducted on PubMed and Scopus in April 2024 with the search strategy (\"perfluorohexyloctane\" or \"NOV03\" or \"semifluorinated alkane\") and \"dry eye.\" Extension and paired-eyes study were excluded. The risk of bias was assessed using the Cochrane risk-of-bias tool. Forest plots and a summary of findings were prepared for total corneal fluorescein staining (tCFS), tear film break-up time (TFBUT), eye dryness score (EDS), and Ocular Surface Disease Index (OSDI).</p><p><strong>Results: </strong>The pooled standardized mean difference (SMD) for tCFS after 8 weeks of treatment was -0.53 (95% CI: -0.68 to -0.38; p < 0.001), indicating a significant improvement in patients treated with perfluorohexyloctane. The between-study heterogeneity was moderately high (I2 = 52.0%). No significant differences in TFBUT were observed (SMD = 0.05; 95% CI: -0.16 to 0.25; p = 0.654). Regarding symptoms, patients treated with NOV03 had significantly lower EDS compared to controls (SMD = -0.49; 95% CI: -0.66 to -0.32; p < 0.001), with moderately high heterogeneity (I2 = 71.1%). Conversely, the pooled SMD of OSDI was -0.13 (95% CI: -0.43 to 0.17; p = 0.412), indicating no significant difference.</p><p><strong>Conclusion: </strong>Perfluorohexyloctane is an effective and safe alternative for the treatment of evaporative dry eye disease due to MGD that can significantly reduce tCFS and eye dryness symptoms. More well-designed non-sponsored randomized clinical trials are required to investigate the impact on other ocular surface parameters.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"41-51"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Preferences with Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Multinational Discrete Choice Experiment Study.","authors":"Alfredo García-Layana, Gloria C Chi, Laurent Kodjikian, Mariacristina Parravano, David Chow, Timothy L Jackson, Carl Danzig, Liliana P Paris, Mirela Mirt, Mickael Henry-Szatkowski, Hannah B Lewis, Brittany Gentile","doi":"10.1159/000541349","DOIUrl":"10.1159/000541349","url":null,"abstract":"<p><strong>Introduction: </strong>New anti-vascular endothelial growth factor (VEGF) treatments are emerging for the treatment of diabetic macular edema (DME)/neovascular age-related macular degeneration (nAMD). This study aimed to explore the treatment attributes patients find important when deciding on treatment options.</p><p><strong>Methods: </strong>This noninterventional survey study assessed treatment preferences through a discrete choice experiment (DCE) among patients with DME/nAMD in the USA, Canada, France, Italy, Spain, and the UK. The DCE design was informed by a targeted literature review and qualitative interview research and included five treatment attributes: mode of administration, frequency of examinations, frequency of injections or refills, likely change in visual acuity, and eye-related side effects. Conditional logit models were used to analyze the choice data.</p><p><strong>Results: </strong>Overall, 537 patients completed the DCE (DME, n = 173; nAMD, n = 364). Patients reported preferring \"injection\" over \"implant surgery and refills\" and better visual outcomes over \"stabilization,\" which were also the most important attributes driving preference (35.1% and 31.5%, respectively). They also showed a preference for less-frequent treatment and examinations and for \"mild-moderate, frequent\" over \"severe, rare\" side effects. These findings were generally consistent across the two conditions, although significant differences were found depending on anti-VEGF treatment duration (nAMD, DME) and number of reported barriers (nAMD).</p><p><strong>Conclusion: </strong>Patient preferences for treatment are driven by several factors. Considering these preferences is essential when designing/introducing new therapies. Individual treatment preferences should be identified and given key consideration when helping patients select from an expanding array of treatment options.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"13-22"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Macular Fundus Autofluorescence Changes in Patients with Retinitis Pigmentosa.","authors":"Muhammad Jehanzeb Khan, Zainab Rustam, Faiqa Binte Aamir, Maria Chairez Miranda, Imad Shaikh, Anam Akhlaq, Jiawen Liu, Mandeep Singh, Xiangrong Kong, Peter A Campochiaro","doi":"10.1159/000543082","DOIUrl":"10.1159/000543082","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to characterized fundus autofluorescence (AF) changes that occur in the macula of patients with retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>We conducted a case series on 99 patients with RP. Features seen on fundus AF images were evaluated, organized into a grading scheme, and correlated with ellipsoid zone (EZ) width. Patterns of AF changes occurring in the macula and correlation with EZ width.</p><p><strong>Results: </strong>Four primary fundus AF phenotypes were identified: (1) hyperAF arc, (2) hyperAF ring, (3) hyperAF ring with abnormal hyperAF within the ring, and (4) central hyperAF. The second phenotype was most common and had 3 subgroups, hyperAF rings within the macula, those extending outside the macula, and incomplete rings. HyperAF rings were also characterized as narrow or wide with wide rings having a greater amount of hyperAF. Linear Mixed-Effects Model showed mean measured EZ width was significantly greater for phenotype 1 versus each of the other 3 phenotypes (p < 0.01) and for phenotype 2 versus phenotypes 3 and 4 (p < 0.05), and also differed among phenotype 2 subgroups (p < 0.05). Other AF characteristics identified were focal posterior distinct or indistinct hypoAF which sometimes formed complete or incomplete hypoAF rings surrounding a hyperAF ring, diffuse or focal hyperAF outside hyperAF rings, and the amount of encroachment of peripheral hypoAF.</p><p><strong>Conclusions: </strong>A grading scheme for macular AF features in patients with RP identified phenotypes that correlate with stage of disease based upon EZ width. Longitudinal studies are needed to test whether presumed early AF phenotypes evolve into later phenotypes. Use of the grading scheme for patient populations in interventional trials could help determine if any of the defined AF features provide predictive value for therapeutic responses.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"156-168"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early High Postoperative Intraocular Pressure Improved the Predictability of Trabeculectomy in Patients with Primary Open-Angle Glaucoma: A Retrospective Cohort Study.","authors":"Yao Liu, Huangyang Shi, Xinbo Gao, Wei Huang, Huishan Lin, Weng Ian Tam, Zhuoyi Wu, Chengguo Zuo, Mingkai Lin","doi":"10.1159/000543420","DOIUrl":"10.1159/000543420","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the effect of different levels of early intraocular pressure (IOP) on long-term outcomes of patients with primary open-angle glaucoma (POAG) who were treated with primary trabeculectomy.</p><p><strong>Methods: </strong>This was a retrospective cohort study, with a total of 74 patients (90 eyes) with POAG who were treated with trabeculectomy surgery at a single center from 2021 to 2022. Based on IOP at 1 day after surgery, they were divided into the high IOP group (≥15 mm Hg) and the low IOP group (<15 mm Hg). The Student's t test and a chi-square test were used to compare the differences between the two groups. The generalized estimating equation model compared the included binocular data to adjust for internal correlations between the two eyes of the same subject. The Kaplan-Meier method compared the surgical success rates of the two groups. Besides, to identify the relationship between IOP at different postoperative time points and IOP at 1-year follow-up, the Spearman correlation analysis was established.</p><p><strong>Results: </strong>A total of 90 eyes (74 patients) with POAG were included in this investigation. After a 1-year follow-up, both the qualified surgical success rates in the high IOP group and the low IOP group were 92.3% and 92.2%, respectively, and there was no statistically significant difference between them (p = 0.890). The rate of bleb massage in the high IOP group was 82.1% (32 eyes) which was significantly higher than in the low IOP group (19.6%, 10 eyes) (p < 0.001). In the Spearman correlation analysis, it was observed that in the high IOP group, the significant correlation with IOP at 1 year emerged at 1 week after surgery (r = 0.496, p = 0.002) and a higher correlation at 1 month after surgery (r = 0.515, p = 0.002). In the low IOP group, the significant correlation with IOP at 1 year emerged at 3 month after surgery (r = 0.314, p = 0.038) and a higher correlation at 6 month after surgery (r = 0.592, p < 0.001).</p><p><strong>Conclusion: </strong>In the POAG patients with primary trabeculectomy, we demonstrated that compared with the low IOP group, the high IOP group could provide a similar surgical success rate while requiring a higher frequency of bleb massage. In addition, in the high IOP group, IOP at 1 month after surgery predicted long-term IOP control outcomes.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"210-220"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Estimated Individual Vitreous Volume on Intraocular Pressure Spikes after Intravitreal Anti-Vascular Endothelial Growth Factors Injection.","authors":"Nurullah Koçak, Abdülcemal Gürpınar, Volkan Yeter","doi":"10.1159/000543071","DOIUrl":"10.1159/000543071","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to evaluate the effect of estimated individual vitreous volume (VV) on intraocular pressure (IOP) spikes after intravitreal anti-vascular endothelial growth factor injections (IVIs).</p><p><strong>Methods: </strong>VVs of eyes were calculated using an axial length (AL)-based formula AL3 × (π/6) × 0.76 + 0.012 × (AL - 24), and study eyes were divided into four groups according to their VVs; <4.5 cm3 (Group 1, n = 52), 4.5-5.0 cm3 (Group 2, n = 60), 5.0-5.50 cm3 (Group 3, n = 60), and >5.50 cm3 (Group 4, n = 35). IOP measurements were taken Pre-IVI, immediately after (Post-IVI-0), 5 min (Post-IVI-5), 15 min (Post-IVI-15), and 30 min after the IVI.</p><p><strong>Results: </strong>A significant IOP change was found between the five-time points in all groups (p < 0.001 for all). Regarding the same time point measurement comparison between the groups, only a statistically significant change was found in the Post-IVI-0 point (p = 0.001). In a post hoc analysis, Group 1, Group 2, and Group 3 had significantly higher IOP values when compared to Group 4 (p < 0.05 for all). Patients treated with prefilled ranibizumab syringes exhibited lower IOP increases than vial-prepared aflibercept injection at the Post-IVI-0 time point (p = 0.042).</p><p><strong>Conclusions: </strong>A similar increase in IOP was observed in eyes with low and intermediate volumes, but the increase was less pronounced in those with high volumes after the IVI. Prefilled syringe form showed a lower IOP increase tendency in comparison with vial-prepared forms of the molecules.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"108-116"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}