Kenneth Ka Hei Lai, Zhichao Hu, Jamie Tsun Chiu, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, George Pak Man Cheng, Wilson Wai Kuen Yip, Alvin Lerrmann Young, Clement Tham, Calvin Pang, Kelvin Kam Lung Chong
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引用次数: 0
Abstract
Introduction: Laser-assisted in Situ Keratomileusis (LASIK) is a common refractive surgery. But it may lead to temporary dry eye due to reversible damage to the corneal sub-basal nerve plexus. However, chronic ocular surface changes are unclear. This study reports the ocular surface changes, partial blinking rate, and meibomian gland status in eyes that underwent LASIK for at least 48 months.
Methods: Cross-sectional, matched case-control comparison study, including 48 post-LASIK patients and 48 sex-, age-, smoking-, and axial length-matched healthy controls, recruited from a community eye screening program. Outcome measures include anterior segment clinical findings, keratographic and meibographic imagings.
Results: Totally 48 right eyes of 48 post-LASIK Chinese patients (39 females, 2 smokers) were analyzed with 48 right eyes of 48 matched healthy controls. The age on ocular surface examination was 50±11 years, and the axial length 26±1mm. Post-LASIK eyes had a lower quality of meibum (P=0.008) compared to healthy controls. Post-LASIK eyes were associated with a shorter Schimer test (P=0.03). The ocular surface disease index (OSDI) score was higher in post-LASIK patients (P=0.00001). Other anterior segment examination parameters, partial blinking rate, meibomian gland dropout, lipid layer thickness, non-invasive tear break-up time, and tear meniscus height were comparable between the 2 groups.
Conclusions: Up to 75% of post-LASIK patients complained of chronic dry eye symptoms. Post-LASIK eyes were associated with a reduced aqueous tear production. Post-LASIK patients with chronic dry eye symptoms should have comprehensive ocular surface evaluation. Treatment should be commenced in patients with poor tear film stability.
期刊介绍:
''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.