Effect of Estimated Individual Vitreous Volume on Intraocular Pressure Spikes after Intravitreal Anti-Vascular Endothelial Growth Factors Injection.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2025-01-01 Epub Date: 2024-12-18 DOI:10.1159/000543071

Nurullah Koçak, Abdülcemal Gürpınar, Volkan Yeter

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引用次数: 0

Abstract

Introduction: The present study aimed to evaluate the effect of estimated individual vitreous volume (VV) on intraocular pressure (IOP) spikes after intravitreal anti-vascular endothelial growth factor injections (IVIs).

Methods: VVs of eyes were calculated using an axial length (AL)-based formula AL3 × (π/6) × 0.76 + 0.012 × (AL - 24), and study eyes were divided into four groups according to their VVs; <4.5 cm3 (Group 1, n = 52), 4.5-5.0 cm3 (Group 2, n = 60), 5.0-5.50 cm3 (Group 3, n = 60), and >5.50 cm3 (Group 4, n = 35). IOP measurements were taken Pre-IVI, immediately after (Post-IVI-0), 5 min (Post-IVI-5), 15 min (Post-IVI-15), and 30 min after the IVI.

Results: A significant IOP change was found between the five-time points in all groups (p < 0.001 for all). Regarding the same time point measurement comparison between the groups, only a statistically significant change was found in the Post-IVI-0 point (p = 0.001). In a post hoc analysis, Group 1, Group 2, and Group 3 had significantly higher IOP values when compared to Group 4 (p < 0.05 for all). Patients treated with prefilled ranibizumab syringes exhibited lower IOP increases than vial-prepared aflibercept injection at the Post-IVI-0 time point (p = 0.042).

Conclusions: A similar increase in IOP was observed in eyes with low and intermediate volumes, but the increase was less pronounced in those with high volumes after the IVI. Prefilled syringe form showed a lower IOP increase tendency in comparison with vial-prepared forms of the molecules.

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估计个体玻璃体体积对玻璃体内注射抗血管内皮生长因子后眼压峰值的影响。

摘要：本研究旨在评价玻璃体内注射抗血管内皮生长因子（VEGF）（IVI）后估计的个体玻璃体体积对眼内眼压（IOP）峰值的影响。方法：采用基于轴向长度（AL）的公式AL3 × （π/6） × 0.76+0.012 × （AL-24）计算眼的玻璃体体积（VV），并根据其VV分为四组；5.50 cm3（第四组，n=35）。分别在玻璃体注射前（IVI）、注射后立即（IVI -0）、5分钟（IVI -5）、15分钟（IVI -15）和IVI后30分钟测量IOP。结果：各组患者IOP在5个时间点间均有明显变化(p结论：IVI后低、中容积眼的IOP升高相似，而高容积眼的IOP升高不明显。与小瓶制备的分子相比，PFS形式的IOP增加趋势较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.