Effect of Estimated Individual Vitreous Volume on Intraocular Pressure Spikes After Intravitreal Anti-Vascular Endothelial Growth Factors Injection.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2024-12-18 DOI:10.1159/000543071

Nurullah Koçak, Abdülcemal Gürpınar, Volkan Yeter

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引用次数: 0

Abstract

Introduction: The present study aimed to evaluate the effect of estimated individual vitreous volume on intraocular pressure (IOP) spikes after intravitreal anti-vascular endothelial growth factor (VEGF) injections (IVI).

Methods: Vitreous volumes (VV) of eyes were calculated using an axial length (AL) based formula AL3 x (π/6) x 0.76+0.012 x (AL-24) and study eyes divided into four groups according to their VV; <4.5 cm3 (Group 1, n=52), 4.5-5.0 cm3 (Group 2, n=60), 5.0-5.50 cm3 (Group 3, n=60), and >5.50 cm3 (Group 4, n=35). IOP measurements were taken at pre-intravitreal injection (IVI), immediately after (Post-IVI-0), 5 minutes (Post-IVI-5), 15 minutes (Post-IVI-15), and 30 minutes after the IVI.

Results: A significant IOP change was found between the five time points in all groups (p<0.001 for all). Regarding the same time point measurement comparison between the groups, only a statistically significant change was found in the Post-IVI-0 point (p=0.001). In posthoc analysis, Group 1, Group 2, and Group 3 had significantly higher IOP values when compared to Group 4 (p<0.05 for all). Patients treated with prefilled Ranibizumab syringes exhibited lower IOP increases than vial-prepared Aflibercept injection at the post-IVI-0 time point (p=0.042).

Conclusions: A similar increase in IOP was observed in eyes with low and intermediate volumes, but the increase was less pronounced in those with high volumes after the IVI. PFS form showed a lower IOP increase tendency in comparison with vial-prepared forms of the molecules.

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.