Paediatric Respiratory Reviews最新文献_第7页

Interventions to improve lung growth in premature infants. 改善早产儿肺部生长的干预措施。

IF 3.4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-11-21 DOI: 10.1016/j.prrv.2025.11.007

Rachna R Mamidi, Kelvin D MacDonald, Eliot R Spindel, Cindy T McEvoy

{"title":"Interventions to improve lung growth in premature infants.","authors":"Rachna R Mamidi, Kelvin D MacDonald, Eliot R Spindel, Cindy T McEvoy","doi":"10.1016/j.prrv.2025.11.007","DOIUrl":"10.1016/j.prrv.2025.11.007","url":null,"abstract":"<p><p>Preterm birth, affecting approximately 10 % of live births worldwide, is the most common cause of altered lung development and can have lasting respiratory consequences, including the occurrence of bronchopulmonary dysplasia (BPD). This review summarizes prenatal and postnatal strategies to promote pulmonary growth and reduce morbidity in preterm infants. Prenatal interventions such as optimizing maternal health and antenatal corticosteroids improve foetal lung maturity. Postnatally, non-invasive respiratory support-particularly continuous positive airway pressure (CPAP)-both prevents injury and promotes alveolar and vascular growth. Lung-protective ventilation strategies, adequate nutrition, and pharmacologic agents like caffeine enhance outcomes. Experimental therapies, including mesenchymal stem cells, insulin-like growth factor-1 (IGF-1), and artificial placenta technology, show promise in restoring pulmonary growth and function. Despite advances, many preterm survivors exhibit persistent lung deficits into adulthood, underscoring the need for longitudinal monitoring and continued innovation to support lung growth and lifelong respiratory health.</p>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pressurised metered-dose inhalers: How do they work? A short guide for clinicians. 加压计量吸入器：它们是如何工作的？给临床医生的简短指南。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-11-19 DOI: 10.1016/j.prrv.2025.11.006

Robert S Beckett, Chloe B Fairbrother, Francis J Gilchrist, Bruce K Rubin, William D Carroll

引用次数: 0

Non-invasive ventilation in pediatrics: a narrative review. Part 1: conventional non-invasive ventilation. 儿科无创通气：叙述性回顾。第1部分：常规无创通气。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-11-19 DOI: 10.1016/j.prrv.2025.11.004

Agustin J Cabrera, Ignacio E Tapia

引用次数: 0

Non-invasive ventilation in pediatrics. A narrative review. Part 2: New and emerging modes of non-invasive ventilation. 儿科无创通气。叙述性评论第2部分：新的和新兴的无创通气模式。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-11-19 DOI: 10.1016/j.prrv.2025.11.003

Agustin J Cabrera, Ignacio E Tapia

引用次数: 0

Smart inhalers in paediatric asthma: bridging the gap between innovation and clinical practice. 儿童哮喘的智能吸入器：弥合创新与临床实践之间的差距。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-15 DOI: 10.1016/j.prrv.2025.07.002

David Drummond, Job F M van Boven, Boudewijn J H Dierick, Ireti Adejumo, William Carroll, Heather De Keyser, Erol A Gaillard, Amy Chan

{"title":"Smart inhalers in paediatric asthma: bridging the gap between innovation and clinical practice.","authors":"David Drummond, Job F M van Boven, Boudewijn J H Dierick, Ireti Adejumo, William Carroll, Heather De Keyser, Erol A Gaillard, Amy Chan","doi":"10.1016/j.prrv.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.prrv.2025.07.002","url":null,"abstract":"<p><p>Smart inhaler systems represent a major opportunity to transform paediatric asthma care by potentially addressing three fundamental problems affecting paediatric asthma outcomes: medication adherence, inhalation technique and reliever overuse. The data generated across these domains opens up multiple applications - from supporting patient self-management to enabling early detection of asthma deterioration. In this review, we outline the main categories of smart inhalers - including digital dose counters, smart spacers, and smart nebulisers - and summarise the current evidence surrounding their use in children. We discuss key obstacles to implementation, including technical limitations, behavioural factors, and health system-level challenges. Establishing clear smart inhaler systems quality standards, defining appropriate indications resulting in better asthma outcomes, achieving better integration of smart inhaler data into electronic health care records, and generating robust cost-effectiveness data will be essential to support the widespread clinical adoption of these technologies.</p>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addition of long‐acting beta‐agonists to inhaled corticosteroids for asthma in preschool children: A systematic review 在吸入皮质类固醇治疗学龄前儿童哮喘的基础上加用长效β-受体激动剂：系统综述。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-01 Epub Date: 2024-10-22 DOI: 10.1016/j.prrv.2024.09.002

Dominika Ambrożej , Maja Cieślik , Wojciech Feleszko , Carlos E. Rodriguez-Martinez , Jose A. Castro-Rodriguez

{"title":"Addition of long‐acting beta‐agonists to inhaled corticosteroids for asthma in preschool children: A systematic review","authors":"Dominika Ambrożej , Maja Cieślik , Wojciech Feleszko , Carlos E. Rodriguez-Martinez , Jose A. Castro-Rodriguez","doi":"10.1016/j.prrv.2024.09.002","DOIUrl":"10.1016/j.prrv.2024.09.002","url":null,"abstract":"<div><div><span><span>Inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) are essential in asthma management, but the guidelines for treatment in preschool children remain heterogeneous worldwide. This </span>systematic review<span><span><span> evaluates the efficacy and safety of LABA + ICS therapy in asthmatic children under six years. We searched four databases, identifying six eligible studies (n = 1415 preschoolers), and in all the LABA used was </span>salmeterol. Due to high heterogeneity, quantitative analysis was not feasible. Three before-and-after studies demonstrated significant reductions in unscheduled visits and hospitalizations due to </span>asthma exacerbations with LABA + ICS. One </span></span>RCT<span> showed fewer exacerbations in the LABA + ICS group compared to ICS alone. Night-time awakenings decreased significantly in two studies but not in one RCT<span><span>. Improvements in lung function using impulse oscillometry and </span>FeNO<span> levels were noted with LABA+ICS in one RCT. No significant adverse effects were reported. Despite positive findings, high-quality trials are needed to confirm these results, particularly using formoterol as LABA, aligning with the recommendations. Further research is imperative to optimize asthma management in preschool children.</span></span></span></div></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"55 ","pages":"Pages 23-29"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chest and spinal disease in patients with progressive neuromuscular disease 进行性神经肌肉疾病患者的胸部和脊柱疾病。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-01 Epub Date: 2024-10-11 DOI: 10.1016/j.prrv.2024.10.001

Oscar Henry Mayer , Greg Redding

{"title":"Chest and spinal disease in patients with progressive neuromuscular disease","authors":"Oscar Henry Mayer , Greg Redding","doi":"10.1016/j.prrv.2024.10.001","DOIUrl":"10.1016/j.prrv.2024.10.001","url":null,"abstract":"<div><div>The chest and spine deformity in neuromuscular disease (NMDz) can impact respiratory mechanics and pulmonary function by changing the orientation of the muscles and joints of the respiratory system and placing them in a mechanically unfavorable position. This increases mechanical load on weak respiratory muscles and eventually can cause respiratory failure. Therefore, chest and spine deformity in NMDz will both lead to increased respiratory “load” and decreased respiratory muscle “pump”, an exceptionally bad combination.</div><div>While the current pharmacotherapies used for progressive neuromuscular disease focus on slowing progression, a similar approach has been used for decades in managing chest and spine deformity in patients with NMDz. There are, however, variable approaches to doing so and a recognition that not all “neuromuscular scoliosis” is the same and that each patient type (i.e. hypotonic vs. hypertonic) requires a different approach. Figuring out what approach to use requires both an understanding of the underlying pathophysiology of a particular neuromuscular condition and considering available options for and timing of surgical interventions. The remaining discussion will focus on hypotonic neuromuscular scoliosis.</div></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"55 ","pages":"Pages 30-49"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise capacity and the psychosocial effect in preterm born infants – Should we do more? 早产儿的运动能力和心理社会影响——我们应该做更多吗？

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-01 Epub Date: 2025-01-08 DOI: 10.1016/j.prrv.2025.01.001

H.T. Fitzgerald , T. Halvorsen , M. Engan , S. Li , H. Selvadurai

{"title":"Exercise capacity and the psychosocial effect in preterm born infants – Should we do more?","authors":"H.T. Fitzgerald , T. Halvorsen , M. Engan , S. Li , H. Selvadurai","doi":"10.1016/j.prrv.2025.01.001","DOIUrl":"10.1016/j.prrv.2025.01.001","url":null,"abstract":"<div><div><span><span>Physical activity is crucial for children’s physical, cognitive, and social development, reducing the risk of non-communicable diseases and improving overall well-being. A major legacy of extremely preterm delivery is respiratory limitation with reduced lung function and decreased exercise capacity which can be further exacerbated by inactivity and deconditioning. Strategies to increase incidental physical activities in early childhood and participation in sport and more formal exercise programmes in middle childhood have the potential to optimize </span>cardiopulmonary function, improve </span>quality of life, and foster social interactions in childhood and beyond, thereby providing benefits that extend far beyond the physical domain.</div><div>Intervention strategies such as supervised aerobic and resistance training, and incorporation of physical activity into daily routines have shown promise in increasing activity levels and improving exercise capacity in this population. Engaging families and tailoring programs to individual needs are crucial for the success of these interventions.</div><div>Overall, a holistic approach that promotes increased physical activity and addresses psychosocial barriers is essential for optimizing the health, well-being, and quality of life of preterm-born children. Further research and development of effective, long-term intervention programs are needed to support these vulnerable individuals throughout childhood and into adulthood.</div></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"55 ","pages":"Pages 10-16"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of paediatric obstructive sleep apnoea assessment: Integrating artificial intelligence, biomarkers, and more 儿科阻塞性睡眠呼吸暂停评估的未来：整合人工智能、生物标志物等。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-01 Epub Date: 2025-01-19 DOI: 10.1016/j.prrv.2025.01.004

Mon Ohn , Kathleen J. Maddison , Jennifer H. Walsh , Britta S. von Ungern-Sternberg

{"title":"The future of paediatric obstructive sleep apnoea assessment: Integrating artificial intelligence, biomarkers, and more","authors":"Mon Ohn , Kathleen J. Maddison , Jennifer H. Walsh , Britta S. von Ungern-Sternberg","doi":"10.1016/j.prrv.2025.01.004","DOIUrl":"10.1016/j.prrv.2025.01.004","url":null,"abstract":"<div><div><span>Assessing obstructive sleep apnoea (OSA) in children involves various methodologies, including sleep studies, nocturnal </span>oximetry<span><span>, and clinical evaluations. Previous literature has extensively discussed these traditional methods. Despite this, there is no consensus on the optimal screening method for childhood OSA, further complicated by the complexity and limited availability of diagnostic </span>polysomnography (PSG). Recent advancements, such as the integration of artificial intelligence, biomarkers, 3D facial photography, and wearable technology, offer promising alternatives for early detection and more accurate diagnosis of OSA in children. This article provides a comprehensive review of these innovative techniques, highlighting their potential to enhance diagnostic accuracy and overcome the limitations of current methods. With an emphasis on cutting-edge technologies and emerging biomarkers, we discuss the future directions for paediatric OSA assessments and their potential to revolutionise clinical practice.</span></div></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"55 ","pages":"Pages 68-74"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential effects of climate change on non-cystic fibrosis bronchiectasis in children 气候变化对儿童非囊性纤维化支气管扩张症的潜在影响。

IF 4 3区医学

Paediatric Respiratory Reviews Pub Date : 2025-09-01 Epub Date: 2024-10-18 DOI: 10.1016/j.prrv.2024.10.002

Grigorios Chatziparasidis , Ahmad Kantar , Maria Rafailia Chatziparasidi , Sotirios Fouzas , Andrew Bush , Anne Chang

引用次数: 0