Paediatric Respiratory Reviews最新文献_第10页

Cystic Fibrosis-Related Diabetes: Clinical approach and knowledge gaps 囊性纤维化相关糖尿病:临床方法和知识差距

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2022.10.001

Bernadette J. Prentice , Kathryn J. Potter , Adèle Coriati , Valérie Boudreau , Leah Rusnell , Tamizan Kherani , Peter A. Senior , Shihab Hameed , Rémi Rabasa-Lhoret

{"title":"Cystic Fibrosis-Related Diabetes: Clinical approach and knowledge gaps","authors":"Bernadette J. Prentice , Kathryn J. Potter , Adèle Coriati , Valérie Boudreau , Leah Rusnell , Tamizan Kherani , Peter A. Senior , Shihab Hameed , Rémi Rabasa-Lhoret","doi":"10.1016/j.prrv.2022.10.001","DOIUrl":"10.1016/j.prrv.2022.10.001","url":null,"abstract":"<div><p><span>Cystic Fibrosis-Related Diabetes (CFRD) is a unique type of diabetes mellitus that shares some features with both type 1 and type 2 diabetes. Yet, its distinguishing feature of acute pulmonary complications associated with hyperglycemia<span> and the catabolic metabolism associated with a relative insulin deficiency<span> poses challenges to the application of traditional definitions and treatments for diabetes mellitus. People with CF (pwCF) undergo rigorous annual screening starting at age 10, a process that is challenging for patients and limited by sensitivity, specificity, and reproducibility. As pwCF continue to live longer, over 50% are expected to develop CFRD over their lifetime, including up to 20% of adolescents. Increasing numbers of people with CFRD will make this disease increasingly relevant to diabetes practitioners. Evidence-guided practice in CFRD care is limited by small and short studies. Our current understanding of CFRD may change significantly with the recent introduction of CF Transmembrane Regulator (CFTR) modulator medications. This review will explore current challenges in the diagnosis and </span></span></span>management of CFRD<span>, specifically highlighting knowledge gaps in the pathophysiology of CFRD, optimal screening methods, priorities for research and provide guidance with regards to screening, diagnosis, and treatment.</span></p></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"46 ","pages":"Pages 3-11"},"PeriodicalIF":5.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Exercise induced laryngeal obstruction (EILO) in children and young people: Approaches to assessment and management 儿童和青少年运动性喉部梗阻(EILO):评估和管理方法

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2023.04.003

Charlotte Wells , Ioannis Makariou , Nicki Barker , Ravi Thevasagayam , Samatha Sonnappa

引用次数: 0

Psychosocial needs and interventions for young children with cystic fibrosis and their families 囊性纤维化幼儿及其家庭的心理社会需求和干预措施

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2023.04.002

Stella Li , Tonia Douglas , Dominic A. Fitzgerald

引用次数: 2

Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis 囊性纤维化患者非结核分枝杆菌呼吸道感染的系统基因组学研究

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2023.02.001

Nicholas Bolden , Joshua Chang Mell , Jennifer Bouso Logan , Paul J. Planet

引用次数: 0

Cystic fibrosis related diabetes (CFRD) in the era of modulators: A scoping review 调节剂时代的囊性纤维化相关性糖尿病(CFRD):范围综述

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2022.11.005

Bernadette Prentice , Michael Nicholson , Grace Y. Lam

引用次数: 8

Approaches to the management of haemoptysis in young people with cystic fibrosis 青年囊性纤维化患者咯血的治疗方法

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2022.10.002

Megan Sheppard , Hiran Selvadurai , Paul D. Robinson , Chetan Pandit , S. Murthy Chennapragada , Dominic A. Fitzgerald

{"title":"Approaches to the management of haemoptysis in young people with cystic fibrosis","authors":"Megan Sheppard , Hiran Selvadurai , Paul D. Robinson , Chetan Pandit , S. Murthy Chennapragada , Dominic A. Fitzgerald","doi":"10.1016/j.prrv.2022.10.002","DOIUrl":"10.1016/j.prrv.2022.10.002","url":null,"abstract":"<div><p><span><span>Haemoptysis occurs in up to 25 % of young people with </span>Cystic fibrosis<span> (CF) [1]. We undertook a literature review and described the management approach to haemoptysis in CF between 2010 and 2020 at an Australian tertiary paediatric centre, The Children’s Hospital Westmead, Sydney, New South Wales, using a retrospective review of the </span></span>medical records<span> which identified 67 episodes. Sixty episodes met inclusion criteria, including 31 patients. Using the US CF Foundation guidelines, episodes were classified as scant (53.3 %), moderate (38.3 %) or massive (8.3 %). Fifty-two percent of patients were female, mean age at presentation was 15.4 years (SD+/- 2.4) and 58 % were homozygous for the Fdel508 genotype. Twelve episodes (9 patients) required bronchial artery embolization (BAE). BAE was used in all cases of massive haemoptysis 5/5 (100 %), 6/23 (22 %) episodes of moderate and 1/32 (3 %) episode of scant haemoptysis as an elective procedure for recurrent haemoptysis. Our literature review and institutional experience highlights the need for up-to-date management guidelines in the management of haemoptysis in Cystic Fibrosis. Based on our experience, we provide a proposed algorithm to help guide the management of haemoptysis in CF.</span></p></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"46 ","pages":"Pages 17-22"},"PeriodicalIF":5.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9679227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sleep in children and young adults with cystic fibrosis 患有囊性纤维化的儿童和年轻人的睡眠

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2021.09.006

Brigitte Fauroux , Karen Waters , Joanna E. MacLean

{"title":"Sleep in children and young adults with cystic fibrosis","authors":"Brigitte Fauroux , Karen Waters , Joanna E. MacLean","doi":"10.1016/j.prrv.2021.09.006","DOIUrl":"10.1016/j.prrv.2021.09.006","url":null,"abstract":"<div><p><span><span><span><span>Large gains have been made in the management of respiratory diseases associated with cystic fibrosis (CF). Initial studies evaluating sleep issues in CF focused on respiratory problems of nocturnal </span>hypoxia<span>, alveolar hypoventilation and risk of airway obstruction from </span></span>nasal polyps<span> with treatment<span> evaluations including long term oxygen therapy or noninvasive ventilation in case of nocturnal </span></span></span>hypercapnia. More recent studies include patients whose lung function is better preserved, and have permitted more focus on sleep patterns and sleep quality. This literature identified that reduced sleep duration and poor sleep quality are common and may be explained by chronic pain and cough, frequent stools, gastro-oesophageal reflux, nasal obstruction or sinusitis, and </span>drugs<span><span> such as corticosteroids or beta-agonists. In the teenage years, poor sleep hygiene<span><span>, sleep debt and poor sleep quality are associated with depression, poor academic performance, less physical activity, and a decrease in quality of life. </span>Restless leg syndrome also seems to be common in adult patients with CF. These sleep problems seem more important </span></span>in patients<span> with a low lung function but may also be observed in patients with preserved lung function. The consequences of poor sleep may potentially exaggerate the multi-organ morbidity of CF, such as pain, inflammation, susceptibility to infection, and glucose intolerance, but these aspects are largely under-evaluated. Sleep should be evaluated on a routine basis in CF and prospective studies assessing the benefits of interventions aiming at improving sleep duration and sleep quality urgently needed.</span></span></p></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"46 ","pages":"Pages 12-16"},"PeriodicalIF":5.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10054562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Surgical treatment of non-cystic fibrosis bronchiectasis in children and adolescents: A review 儿童和青少年非囊性纤维化支气管扩张症的手术治疗:综述

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2022.11.003

Helena Teresinha Mocelin , Gilberto Bueno Fischer , Júlia Danezi Piccini , Renata Baú , Cristiano Feijó Andrade , Janice Luisa Lukrafka

{"title":"Surgical treatment of non-cystic fibrosis bronchiectasis in children and adolescents: A review","authors":"Helena Teresinha Mocelin , Gilberto Bueno Fischer , Júlia Danezi Piccini , Renata Baú , Cristiano Feijó Andrade , Janice Luisa Lukrafka","doi":"10.1016/j.prrv.2022.11.003","DOIUrl":"10.1016/j.prrv.2022.11.003","url":null,"abstract":"<div><h3>Objective</h3><p>To discuss surgery for non-cystic fibrosis [CF] bronchiectasis in children and adolescents.</p></div><div><h3>Sources</h3><p>Non-systematic review including articles in English, mainly from the last 5 years.</p></div><div><h3>Summary of findings</h3><p>In this review, we present that in low- and middle-income countries [LMIC] clinical treatment fails in around 20% of cases due to low socioeconomic status and poor adherence. This causes the disease to progress and require surgery. We emphasize that the indications for surgery are not well defined and must be considered on an individual basis. The surgical treatment of bronchiectasis in children may be indicated in selected cases; especially in localized disease with frequent exacerbations despite an optimized clinical approach. Surgery can improve quality of life [QoL] and reduce exacerbations. It has few postoperative complications and low morbidity and mortality. Finally, we propose an algorithm for managing bronchiectasis, which takes into account LMIC settings with limited resources.</p></div><div><h3>Conclusion</h3><p>We conclude that in LMICs, surgery is a treatment strategy for selected children/adolescents with bronchiectasis.</p></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":"46 ","pages":"Pages 57-62"},"PeriodicalIF":5.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Optimism grows after 10 years of modulator therapies in Cystic Fibrosis 编辑:10年来囊性纤维化调节剂治疗的前景越来越乐观

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-06-01 DOI: 10.1016/j.prrv.2023.05.004

Dominic A. Fitzgerald

引用次数: 0

Race, bias, disparities, and pulmonary medicine 种族、偏见、差异和肺部医学

IF 5.8 3区医学

Paediatric Respiratory Reviews Pub Date : 2023-03-01 DOI: 10.1016/j.prrv.2022.12.003

Bruce K. Rubin

引用次数: 0