Ophthalmic epidemiologyPub Date : 2024-10-01Epub Date: 2024-02-05DOI: 10.1080/09286586.2023.2301572
Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar
{"title":"Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.","authors":"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar","doi":"10.1080/09286586.2023.2301572","DOIUrl":"10.1080/09286586.2023.2301572","url":null,"abstract":"<p><strong>Purpose: </strong>Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.</p><p><strong>Methods: </strong>A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.</p><p><strong>Results: </strong>47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.</p><p><strong>Conclusion: </strong>Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"439-447"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ophthalmic epidemiologyPub Date : 2024-10-01Epub Date: 2024-01-24DOI: 10.1080/09286586.2023.2301583
Yeji Kim, Mi Yeon Song, Kyungdo Han, Jae Hui Kim
{"title":"Bilateral Involvement of Age-Related Macular Degeneration in South Korea: Findings from the Korea National Health and Nutrition Examination Survey 2017-2020.","authors":"Yeji Kim, Mi Yeon Song, Kyungdo Han, Jae Hui Kim","doi":"10.1080/09286586.2023.2301583","DOIUrl":"10.1080/09286586.2023.2301583","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the bilateral involvement of age-related macular degeneration (AMD) in South Koreans.</p><p><strong>Methods: </strong>This was a cross-sectional study of the Korean National Health and Nutrition Examination Survey (2017-2020). This study included 13,737 participants aged 40 years or older. Participants were evaluated to determine the prevalence of bilateral early and late AMD. In cases in which exudative AMD or geographic atrophy (GA) was diagnosed in a single eye, the fellow eye was evaluated to determine the presence and type of late AMD.</p><p><strong>Results: </strong>The overall prevalence of bilateral AMD was 6.12% (95% confidence interval [CI], 5.63-6.61). The prevalence of bilateral early AMD was 5.71% (95% CI, 5.24-6.18), while that of late AMD was 0.14% (95% CI, 0.08-0.20). The prevalence of the bilateral involvement of late AMD increased with age. A 0.02% prevalence (95% CI, 0.00-0.06) of late AMD was observed in participants aged 50-59. The prevalence increased to 0.08% (95% CI, 0.00-0.18) in participants aged 60-69, while the prevalence in participants aged 70-79 and over 80 was 0.45% (95% CI, 0.12-0.78) and 1.97% (95% CI, 0.75-3.19), respectively. The prevalence of early AMD in one eye and late AMD in the fellow eye was 0.26% (95% CI, 0.16-0.36).</p><p><strong>Conclusions: </strong>An assessment of the incidence of AMD revealed that a significant number of persons had bilateral involvement. The treatment burden may significantly increase for participants with bilateral late AMD compared to those with unilateral involvement. Therefore, the study may be helpful with the establishment of private and national insurance policies.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"460-467"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ophthalmic epidemiologyPub Date : 2024-10-01Epub Date: 2023-11-16DOI: 10.1080/09286586.2023.2279113
Nathan C Grove, Victoria S Pelak, Karen L Christopher, Brandie D Wagner, Anne M Lynch, Jennifer L Patnaik
{"title":"Cataract Phacoemulsification in People with Dementia: Characterization and Outcomes.","authors":"Nathan C Grove, Victoria S Pelak, Karen L Christopher, Brandie D Wagner, Anne M Lynch, Jennifer L Patnaik","doi":"10.1080/09286586.2023.2279113","DOIUrl":"10.1080/09286586.2023.2279113","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize cataract surgery in people with dementia (PWD) using a cataract surgery outcomes database.</p><p><strong>Methods: </strong>Demographics, medical and ocular history, surgical characteristics, and postoperative measures were analyzed for differences between PWD and non-PWD cohorts. Patient-level data were analyzed with Fisher's Exact Test, and eye-level data were analyzed with logistic regression using generalized estimating equations to account for correlation of eyes from the same individual.</p><p><strong>Results: </strong>507 eyes from 296 PWD were identified using appropriate ICD codes and cross-referenced to a cataract surgery outcomes database containing 12,949 eyes from 7,853 patients who underwent cataract phacoemulsification at a single center between January 2014 and October 2019. PWD were older (<i>p</i> < .001), had shorter duration cataract surgeries (<i>p</i> = .006), and were more likely to have mature cataract (<i>p</i> = .017). The rate of general anesthesia was higher in PWD (<i>p</i> = .005). There were no differences in complication rates between PWD and non-PWD cohorts. Both preoperative best corrected LogMAR distance visual acuity (CDVA) (<i>p</i> < .001) and postoperative CDVA (<i>p</i> < .001) were worse in PWD. CDVA significantly improved in both groups (<i>p</i> < .001); however, the average magnitude of improvement in CDVA was not significantly different between groups (<i>p</i> = .169).</p><p><strong>Conclusions: </strong>PWD present for cataract surgery at a later age and were more likely to have mature cataracts and general anesthesia, but did not have higher rates of complication, and showed significant improvement in CDVA following surgery. These findings should be encouraging to PWD undergoing counseling for cataract surgery, and for the potential for improved function in PWD.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"400-408"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retinal Vascular Occlusions After COVID-19 Vaccination in South Korea: A Nation-Wide Population-Based Study.","authors":"Yeji Kim,Kyungdo Han,Jae Hui Kim","doi":"10.1080/09286586.2024.2399345","DOIUrl":"https://doi.org/10.1080/09286586.2024.2399345","url":null,"abstract":"PURPOSETo investigate the association between the retinal vascular occlusion and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).METHODSThis nationwide population-based cohort study included 2,742,065 individuals aged ≥ 20 years who were vaccinated against SARS-CoV-2 from March 1, 2021, to December 31, 2021, and unvaccinated individuals matched at a ratio of approximately 1:10 by gender and age, all without a history of retinal vascular occlusion. The occurrence of retinal vascular occlusion was observed up to 60 days after the 1st vaccination date in the vaccination group, while 60 days from January 1, 2021, in the non-vaccination group. The risk of developing retinal vascular occlusion was compared between vaccinated and unvaccinated subjects. Risks were also compared among the different types of vaccines.RESULTSVaccination lowered the risk of retinal vascular occlusion, with an odds ratio (OR) of 0.80 (95% confidence interval (CI), 0.64-0.99; p = 0.039). For individuals aged < 40 years, the vaccination lowered the risk of retinal vascular occlusion occurrence significantly compared with those over the age of 40 (OR, 0.35 for age 20-39, 0.83 for age 40-64, 0.81 for age ≥ 65; P for interaction = 0.028). There was a significant difference in the ORs for retinal vascular occlusion among the four vaccine types (p < 0.001).CONCLUSIONSSARS-CoV-2 vaccination did not increase the risk of retinal vascular occlusion. However, the risk levels differed depending on the type of vaccine used. Considering the ongoing evolution of SARS-CoV-2 vaccines, it is imperative to conduct additional assessments of the recently introduced vaccines.","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":"27 1","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cigarette Smoking and its Association with Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis","authors":"Hiromi Yee, Suzanne Adkins","doi":"10.1080/09286586.2024.2391028","DOIUrl":"https://doi.org/10.1080/09286586.2024.2391028","url":null,"abstract":"To systematically assess the association between cigarette smoking and development of Primary Open Angle Glaucoma (POAG) in the general adult population. Heterogeneity will be explored appropriatel...","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":"74 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poverty and Vision: The Effect of Title 1 Status on Vision Screening Referral Rates in School-Aged Children in Western South Dakota.","authors":"Brandon Vander Zee,Marilee Kneeland,Taylor Slingsby","doi":"10.1080/09286586.2024.2399348","DOIUrl":"https://doi.org/10.1080/09286586.2024.2399348","url":null,"abstract":"PURPOSEInterventions such as eye exams and glasses are used to correct visual problems that may lead to amblyopia, an irreversible decrease in visual acuity. Children with limited access to these interventions are more likely to have unaddressed visual problems that can lead to amblyopia or negatively impact school performance. This study compared vision screening results of children in schools with Title 1 or Non-Title 1 designation to investigate the link between poverty and vision.METHODSData from KidsFIRST vision screenings conducted with the SPOTTM photoscreener performed in Rapid City Area elementary schools were compared across multiple parameters. Students were referred for eye examinations based on identifying the following problems: anisometropia, anisocoria, astigmatism, myopia, hyperopia, gaze misalignment, or a combination.RESULTSOverall, eye exam referral rates have increased since 2012 (11.9% in 2012, 19.7% in 2023), with a disproportionate increase in referrals from Title 1 schools (25.2% in 2023) vs. Non-Title 1 schools (11.9% in 2023) (p < 0.001). This is largely due to a significantly higher prevalence of astigmatism referrals in Title 1 students (20.9%) compared to Non-Title 1 students (7.5%). Although a higher percentage of Title 1 students are reported to have eye correction (24.4% vs 16.6%), only a slightly higher percentage of Title 1 students wore eye correction during screening (11.5% vs 10.5%).CONCLUSIONStudents at Title 1 schools may have a higher rate of amblyopia risk factors. Additional eye care-based interventions should be taken to reduce the risk of amblyopia in this population.","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":"54 1","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Sociomedical Factors on Corneal Donor Recovery Using Machine Learning.","authors":"Wuqaas M Munir,Saleha Z Munir","doi":"10.1080/09286586.2024.2399350","DOIUrl":"https://doi.org/10.1080/09286586.2024.2399350","url":null,"abstract":"PURPOSETo evaluate co-morbid sociomedical conditions affecting corneal donor endothelial cell density and transplant suitability.METHOD(S)Corneal donor transplant information was collected from the CorneaGen eye bank between June 1, 2012 and June 30, 2016. A natural language processing algorithm was applied to generate co-morbid sociomedical conditions for each donor. Variables of importance were identified using four machine learning models (random forest, Glmnet, Earth, nnet), for the outcomes of transplant suitability and endothelial cell density. SHAP (SHapley Additive exPlanations) values were generated, with beeswarm and box plots to visualize the contribution of each feature to the models.RESULTSWith a total of 23,522 unique donors, natural language processing generated 30,573 indices, which were reduced to 41 most common co-morbid sociomedical conditions. For transplant suitability, hypertension ranked the top overall variable of importance in two models. Hypertension, chronic obstructive pulmonary disease, history of smoking, and alcohol use appeared consistently in the top variables of importance. By SHAP feature importance, hypertension (0.042), alcohol use (0.017), ventilation of donor (0.011), and history of smoking (0.010) contributed the most to the transplant suitability model. For endothelial cell density, hypertension was the sociomedical condition of highest importance in three models. SHAP scores were highest among the sociomedical conditions of hypertension (0.037), alcohol use (0.013), myocardial infarction (0.012), and history of smoking (0.011).CONCLUSIONIn a large cohort of corneal donor eyes, hypertension was identified as the most common contributor to machine learning models examining sociomedical conditions for corneal donor transplant suitability and endothelial cell density.","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":"17 1","pages":"1-8"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan-Lin Li, Yu Qin, Ya-Jie Zheng, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Gang Liang, Chen-Wei Pan
{"title":"Distribution and Determinants of Anterior Chamber Angle and Anterior Chamber Volume in Young Chinese Adults","authors":"Dan-Lin Li, Yu Qin, Ya-Jie Zheng, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Gang Liang, Chen-Wei Pan","doi":"10.1080/09286586.2024.2390425","DOIUrl":"https://doi.org/10.1080/09286586.2024.2390425","url":null,"abstract":"Current study aimed to understand the distribution and determinants of anterior chamber angle (ACA) and anterior chamber volume (ACV) in Chinese young adults, which can help fill current data gaps ...","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":"44 1","pages":"1-8"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyra Singh, Roozbeh Akhtari, Arnold Prywes, Craig Marcus, Robert Rothman, Daniel Hayes, Allison Angelilli
{"title":"Superior Laser Peripheral Iridotomy Confers Greater Risk of Negative Dysphotopsias than Temporal Laser Peripheral Iridotomy.","authors":"Kyra Singh, Roozbeh Akhtari, Arnold Prywes, Craig Marcus, Robert Rothman, Daniel Hayes, Allison Angelilli","doi":"10.1080/09286586.2024.2390422","DOIUrl":"https://doi.org/10.1080/09286586.2024.2390422","url":null,"abstract":"<p><strong>Purpose: </strong>Laser peripheral iridotomy (LPI) is largely used as the first course of action to treat primary angle-closure (PAC). Previous literature has long been divided on the relationship between iridotomy position and dysphotopsia onset. The current study investigates whether there is a correlation between iridotomy position, temporal versus superior, and new onset post-operative dysphotopsia rates.</p><p><strong>Methods: </strong>The project involves a retrospective chart review of 2,385 lasered eyes. Demographic data and iridotomy-specific data including laterality, iridotomy position, and new onset post- operative dysphotopsias were recorded.</p><p><strong>Results: </strong>Of 2385 eyes with LPIs, 217 (9.10%) experienced postoperative dysphotopsia. Superior and temporal LPIs were associated with total dysphotopsia rates of 11.20% and 8.01%, respectively. The percentage distribution of dysphotopsias among negative, positive, and non-specific categories were 2.81%, 4.99%, and 1.26%, respectively. Superior LPIs are associated with a greater risk of new onset dysphotopsia than temporal LPI (<i>p</i> = 0.0107), specifically negative dysphotopsia (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Patients with superior LPI were more likely to experience negative dysphotopsia onset than those with temporal LPI. Among negative dysphotopsias, positive dysphotopsias, and non-specific symptoms, only negative dysphotopsias were significantly impacted by iridotomy position. Results may influence providers to perform LPI temporally to prevent negative dysphotopsia. Further research into the etiology of dysphotopsia may elucidate further clinical decisions to protect patients from dysphotopsia onset.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Jiemin Ong, David A Mackey Ao, Michael Hunter, Samantha Sze-Yee Lee
{"title":"Exploring the Effects of Age at Menarche and Pregnancy on Myopia.","authors":"Nicholas Jiemin Ong, David A Mackey Ao, Michael Hunter, Samantha Sze-Yee Lee","doi":"10.1080/09286586.2024.2379973","DOIUrl":"https://doi.org/10.1080/09286586.2024.2379973","url":null,"abstract":"<p><strong>Purpose: </strong>Associations between age at menarche and myopia have been observed in studies that included older women. Furthermore, pregnancy-related hormone surges in young women are associated with short-term changes in refractive error, although the long-term effects are less known. This study explored associations of age at menarche and parity with refractive error and ocular biometry in young women, and the relationship between age at menarche and refractive error in middle-aged adults for comparison.</p><p><strong>Methods: </strong>Community-based young women underwent eye examinations at 20 and 28 years old. Information on age at menarche and parity were collected prospectively. The older cohort underwent an eye examination and information on age at menarche was self-reported retrospectively. Cross-sectional associations between age at menarche and myopia were explored in both cohorts. Associations between parity and 8-year longitudinal change in refractive error measures were explored in the young cohort.</p><p><strong>Results: </strong>The cross-sectional analyses comprised 429 young (age 18-22) and 1,818 older (age 46-69) women. No associations were found between age at menarche and myopia or ocular biometry measures in either cohort. The longitudinal analysis (<i>n</i> = 269 women) revealed that for each pregnancy carried to full term, there rate of lens thickening increased by 0.004 mm/year (95% CI = 0.002-0.007). No other associations between parity and refractive error or ocular biometry were found.</p><p><strong>Conclusion: </strong>There is no association between age at menarche and myopia or its related measures. While pregnancy was associated with thicker lens in the long term, there is no lasting effect on refractive error.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}