Ophthalmic epidemiology最新文献

{"title":"Diabetic Retinopathy Screening Rates at Student-Run Clinics in the United States: A Systematic Review and Meta-Analysis.","authors":"Nicholas Peoples, Dylan McBee, Shangzhi Xiong, Alexandra Alvarez, Emily Wang, Ashley Ricciardelli, Shiwei Wang, Dana L Clark, Tien Yin Wong","doi":"10.1080/09286586.2024.2378778","DOIUrl":"10.1080/09286586.2024.2378778","url":null,"abstract":"","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression in the Number of Cataract Surgeries in Brazil: 10 Years of Evolution.","authors":"Silvana Rossi, Priscilla A Jorge, Rafael Scherer, Newton Kara-Junior","doi":"10.1080/09286586.2024.2378770","DOIUrl":"https://doi.org/10.1080/09286586.2024.2378770","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the frequency of cataract surgery in Brazil between 2010 and 2019 and determine the impact of public policies on preventing blindness, thereby providing evidence to conduct healthcare programs.</p><p><strong>Methods: </strong>An analytical epidemiological approach was employed, which used data from public databases, specifically the Hospital Information System (SIH-SUS) and the Outpatient Information System (SIA-SUS). We focused on cataract surgeries conducted via phacoemulsification and extracapsular cataract extraction techniques between 2010 and 2019, mainly targeting senile cataracts within the Brazilian public health system. Data were analyzed on an annual basis and stratified by region. Trends over time were assessed using generalized additive models.</p><p><strong>Results: </strong>A statistically significant upward trend in cataract surgeries was observed both nationally and within the South region (<i>p</i> < 0.05). Nationally, there was a 40.22% increase in surgeries between 2010 and 2019. Furthermore, the surgery rate per 1000 individuals aged ≥50 years varied across regions: nationally, it was 10.85, with rates of 9.23 in the Southeast, 13.86 in the Northeast, 9.23 in the South, 11.94 in the Midwest, and 14.2 in the North.</p><p><strong>Conclusion: </strong>All regions of the country, a satisfactory number of cataract surgeries were performed at some point. Only the Southern region demonstrated a notable upward trend in the number of cataract surgeries. Conversely, the remaining regions failed to sustain surgical performance, hindering consistent improvement in cataract-related conditions. To accurately gauge the prevalence of blindness in Brazil, it is crucial to examine the population growth among individuals aged ≥50 years.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-Based Incidence and Clinical Characteristics of Ocular Adnexal Tumors in Olmsted County, Minnesota.","authors":"Kenny Y Wang, Timothy T Xu, Mihai G Dumbrava, Kafayat A Oyemade, Johanny Lopez Dominguez, David O Hodge, Launia J White, Andrea A Tooley, Lauren A Dalvin","doi":"10.1080/09286586.2024.2379971","DOIUrl":"10.1080/09286586.2024.2379971","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the incidence and clinical characteristics of ocular adnexaltumors in Olmsted County, Minnesota.</p><p><strong>Methods: </strong>Retrospective population-based cohort study of all patients residing in Olmsted County, Minnesota diagnosed with any ocular tumor from January 1, 2006, to December 31, 2015. The medical records of all patients with an incident diagnosis of any ocular adnexal tumor were reviewed using the Rochester Epidemiology Project medical record linkage system for patient demographics, tumor type, and histopathologic confirmation. Incidence rates were calculated per 100,000 person-years. Poisson regression analysis was used to analyze changes in incidence over time.</p><p><strong>Results: </strong>There were 717 patients diagnosed with ocular adnexal tumors during the 10-year study period, yielding an age- and sex-adjusted incidence rate of 59.7 per 100,000 (95% CI 55.4 to 64.0, <i>p</i> < 0.05) per year. In total, 764 tumors were diagnosed. Most tumors were eyelid lesions (<i>N</i> = 756, 99.0%), which were mostly benign (<i>N</i> = 512, 67.8%) with epidermal inclusion cysts (<i>N</i> = 275, 36.0%), hidrocystoma (<i>N</i> = 70, 9.2%), and eyelid sebaceous cysts (<i>N</i> = 46, 6.1%) accounting for the majority. Malignant eyelid lesions (<i>N</i> = 244, 31.9%) were relatively common with basal cell carcinoma (<i>N</i> = 184, 24.1%) and squamous cell carcinoma (<i>N</i> = 49, 6.4%) having the highest frequencies. Orbital tumors (<i>N</i> = 8, 1.0%) were infrequent. Of the orbital tumors, the most common was lacrimal gland adenoidcystic carcinoma (<i>N</i> = 2, 25.0%).</p><p><strong>Conclusions: </strong>In a population-based setting, most ocular adnexal tumors were benign eyelid lesions. Understanding the epidemiology of ocular adnexal tumors is important to aid providers in diagnosing and facilitating appropriate referrals of potentially vision- and life-threatening malignancies.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Carotid Artery Stenosis and the Development of Open-Angle Glaucoma: A Long-term Cohort Study in Taiwan.","authors":"Wen-Yun Lin, Jin-Jhe Wang, Chauyin-Yin Chen, Chia-Yen Liu, Meng-Hung Lin, Yao-Hsu Yang, Chien-Hsiung Lai","doi":"10.1080/09286586.2024.2371467","DOIUrl":"https://doi.org/10.1080/09286586.2024.2371467","url":null,"abstract":"<p><strong>Purposes: </strong>To determine the relationship between carotid artery stenosis (CAS) and the development of open-angle glaucoma (OAG) in the Taiwanese population.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted using Chang Gung Research Database. Cox-proportional hazards model was applied to calculate the hazard ratio for OAG between CAS and the control cohort.</p><p><strong>Results: </strong>Among 19,590 CAS patients, 17,238 had mild CAS (<50%), 1,895 had moderate CAS (50-69%), and 457 had severe CAS (≥70%). The CAS cohort had a higher proportion of several comorbidities. After adjusting for comorbidities, no significant difference in OAG development was found between CAS and control cohorts. Matching for key comorbidities, no significant differences in OAG incidence were found between matched cohorts (P = .869). Subdividing the matched CAS cohort by stenosis severity: mild (<50%), moderate (50-69%), and severe (≥70%), a statistically significantly lower OAG risk was observed in patients with mild CAS stenosis (HR: 1.12, 95% CI = 1.03-1.21, <i>P </i>= .006). Kaplan-Meier analysis revealed reduced OAG incidence in CAS patients who underwent surgical intervention, compared to the control cohort (<i>P</i> <.001). Subgroup analysis revealed that patients in the mild CAS stenosis group, those who underwent surgical intervention exhibited a reduced OAG risk (HR: 0.29, 95% CI = 0.15-0.58, <i>P </i>= .001).</p><p><strong>Conclusions: </strong>No statistically significant differences in OAG risk were observed between patients with CAS and the control cohort. The severity of CAS appears to influence OAG risk, with surgical intervention potentially offering protective effects, particularly in patients with mild CAS stenosis (<50%), suggesting that enhanced ocular perfusion post-surgery may act as a protective factor against OAG development.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Gaps in Medical Insurance Coverage with Vision Care Benefits Among US Adults.","authors":"Mufida Muhammad, Johnny Vang, Dmitry Tumin","doi":"10.1080/09286586.2024.2378757","DOIUrl":"https://doi.org/10.1080/09286586.2024.2378757","url":null,"abstract":"<p><strong>Background: </strong>In the US, routine vision care and medical services are often covered by separate insurance plans. Unmet needs for vision care are more common among adults with gaps in medical coverage, but it is unclear how gaps in medical coverage correlate with lack of vision benefits among currently insured adults. We hypothesized that gaps in medical coverage in the past 12 months would be associated with lack of coverage for vision care among US adults currently covered by commercial medical insurance.</p><p><strong>Methods: </strong>We included adults age 18-65 with private insurance who participated in the 2019-2022 National Health Interview Survey. The primary outcome was any coverage for vision care services, and the secondary outcome was a source of vision coverage (primary health insurance policy as compared to single-service plans only).</p><p><strong>Results: </strong>Based on a sample of 50,000 participants, we estimated 4% of commercially insured adults recently experienced coverage gaps, and 75% had coverage for vision care services. On multivariable analysis, commercially insured adults with recent gaps in medical coverage were more likely to lack coverage for vision care at the time of the survey, compared to adults with continuous medical coverage (odds ratio [OR], 0.77; 95% CI: 0.68, 0.86). However, medical coverage gaps were not associated with source of vision care coverage.</p><p><strong>Conclusions: </strong>Gaps in medical insurance coverage were associated with lower likelihood of vision care coverage compared to continuous medical coverage. Protecting continuity of health insurance may support access to vision benefits and reduce gaps in routine vision care.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Addressing Retinopathy of Prematurity in Rwanda.","authors":"Connor J Alder, Francis Mutangana, Victoria Phillips, Edmund R Becker, Neil S Fleming, Sherwin J Isenberg, Scott R Lambert, Tahvi D Frank","doi":"10.1080/09286586.2024.2372803","DOIUrl":"10.1080/09286586.2024.2372803","url":null,"abstract":"<p><strong>Purpose: </strong>With the expansion of neonatal care in sub-Saharan Africa (SSA), an increasing number of premature babies are at risk to develop retinopathy of prematurity (ROP). Previous studies have quantified the cost-effectiveness of addressing ROP in middle-income countries, but few have focused on SSA. This study estimates the cost of a national program for ROP screening and anti-VEGF injection treatment in Rwanda compared to the status quo.</p><p><strong>Methods: </strong>Medical cost data were collected from King Faisal Hospital in Rwanda (July 2022). Societal burden of vision loss included lost productivity and quality-adjusted life years (QALYs). Published data on epidemiology and natural history of ROP were used to estimate burden and sequelae of ROP in Rwanda. Cost of a national program for screening and treating a one-year birth cohort was compared to the status quo using a decision analysis model.</p><p><strong>Results: </strong>Cost of ROP screening and treatment was $738 per infant. The estimated equipment cost necessary for the startup of a national program was $58,667. We projected that a national program could avert 257 cases of blindness in the cohort and increase QALYs compared to the status quo. Screening and treatment for ROP would save an estimated $270,000 for the birth cohort from reductions in lost productivity.</p><p><strong>Conclusion: </strong>The cost of screening and anti-VEGF treatment for ROP is substantially less than the indirect cost of vision loss due to ROP. Allocating additional funding towards expansion of ROP screening and treatment is cost-saving from a societal perspective compared to current practice.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status, Hotspots, and Prospects of Artificial Intelligence in Ophthalmology: A Bibliometric Analysis (2003-2023).","authors":"Jie Deng, YuHui Qin","doi":"10.1080/09286586.2024.2373956","DOIUrl":"https://doi.org/10.1080/09286586.2024.2373956","url":null,"abstract":"<p><strong>Purpose: </strong>Artificial intelligence (AI) has gained significant attention in ophthalmology. This paper reviews, classifies, and summarizes the research literature in this field and aims to provide readers with a detailed understanding of the current status and future directions, laying a solid foundation for further research and decision-making.</p><p><strong>Methods: </strong>Literature was retrieved from the Web of Science database. Bibliometric analysis was performed using VOSviewer, CiteSpace, and the R package Bibliometrix.</p><p><strong>Results: </strong>The study included 3,377 publications from 4,035 institutions in 98 countries. China and the United States had the most publications. Sun Yat-sen University is a leading institution. Translational Vision Science & Technology\"published the most articles, while \"Ophthalmology\" had the most co-citations. Among 13,145 researchers, Ting DSW had the most publications and citations. Keywords included \"Deep learning,\" \"Diabetic retinopathy,\" \"Machine learning,\" and others.</p><p><strong>Conclusion: </strong>The study highlights the promising prospects of AI in ophthalmology. Automated eye disease screening, particularly its core technology of retinal image segmentation and recognition, has become a research hotspot. AI is also expanding to complex areas like surgical assistance, predictive models. Multimodal AI, Generative Adversarial Networks, and ChatGPT have driven further technological innovation. However, implementing AI in ophthalmology also faces many challenges, including technical, regulatory, and ethical issues, and others. As these challenges are overcome, we anticipate more innovative applications, paving the way for more effective and safer eye disease treatments.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-Year Trends in the Prevalence and Severity of Diabetic Retinopathy at the First Visit in Patients with Untreated Type 2 Diabetes Mellitus.","authors":"Tetsuya Kubota, Kikue Todoroki-Mori, Masahiko Iwamoto, Toshiko Kobori, Takako Kikuchi, Tazu Tahara, Yukiko Onishi, Michihiro Araki, Masato Kasuga, Yoko Yoshida","doi":"10.1080/09286586.2024.2383285","DOIUrl":"https://doi.org/10.1080/09286586.2024.2383285","url":null,"abstract":"<p><strong>Purpose: </strong>Although the rate of diabetic retinopathy (DR)-related blindness has decreased in developed countries in recent years, the reasons for this decrease have remained unclear. The prevalence/severity trends of DR at the first visit in patients with untreated type 2 diabetes mellitus (T2DM) patients seen between the1986s and 2018s were assessed.</p><p><strong>Methods: </strong>A total of 1979 Japanese T2DM patients diagnosed between 1986 and 2018 were divided into four groups by the decade of their first visit: the 1986 years (1986-1987), the 1996 years (1996-1997), the 2006 years (2006-2008), the 2016 years (2016-2018). The DR prevalence/severity trends were assessed.</p><p><strong>Results: </strong>A significant decrease in the rate of prevalence of DR from the 1986s to 2016s was observed among previously untreated T2DM patients visiting our hospital for the first time (1986s: 25.5%; 1996s: 26.2%; 2006s: 22.2%; and 2016s: 15.6%). The prevalence was significantly higher in females (30.2%) than in males (21.3%). Although the severity trend of DR did not differ significantly among the four measurement years, the rate of simple DR was the highest in the 2016s.</p><p><strong>Conclusion: </strong>We found, for the first time, a significant decrease in the rate of prevalence of DR from the 1986s to 2016s in patients with untreated T2DM visiting our hospital for the first time. A decrease in the rate of DR prevalence could explain, at least in part, the observed reduction in the rate of blindness in patients with T2DM.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Intraoperative Cataract Surgical Complications and Mortality.","authors":"Sophia Sidhu, Nathan C Grove, Jennifer L Patnaik, Anne M Lynch, Karen L Christopher","doi":"10.1080/09286586.2024.2382155","DOIUrl":"https://doi.org/10.1080/09286586.2024.2382155","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association between intraoperative complications of cataract surgery and postoperative mortality.</p><p><strong>Methods: </strong>A retrospective review of patients who underwent cataract surgery at our institution from 2014 to 2020 was conducted. Intraoperative complications included choroidal hemorrhage, posterior capsule rupture, vitreous loss, retained lens, and/or severe zonular dialysis in either eye. All-cause mortality statistics were obtained through a collaborative agreement with the Colorado Department of Public Health and Environment. Hazard ratios (HRs) from Cox proportional hazard models were used to estimate survival following cataract surgery.</p><p><strong>Results: </strong>Among 8,054 patients, the mean follow-up time was 4.4 (SD = 2.3) years and the mortality rate was 15% (<i>n</i> = 1,175). The overall complication rate was 2.2% (<i>n</i> = 181), and the rate of retained lens was 0.7% (<i>n</i> = 58). In univariate analysis, retained lens (HR: 1.86, 95% CI: 1.08-3.21, <i>p</i> = 0.026), severe zonular dialysis (HR: 2.00, 95% CI: 1.29-3.12, <i>p</i> = 0.002), and any intraoperative complication (HR: 1.51, 95% CI: 1.09-2.11, <i>p</i> = 0.015) were associated with higher hazard of mortality. When adjusted for demographic factors, comorbid medical conditions, and pre-operative visual acuity, intraoperative complications were not associated with mortality.</p><p><strong>Conclusion: </strong>Intraoperative cataract surgery complications were associated with mortality in univariate analysis. However, this association was not significant in the multivariable analysis as it is confounded by other factors such as pre-operative visual acuity.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Multimorbidity and Presence of Diagnosed Vision Problems Among the Middle-Aged and Older Population in India.","authors":"Trupti Meher, T Muhammad, Waquar Ahmed","doi":"10.1080/09286586.2024.2384061","DOIUrl":"https://doi.org/10.1080/09286586.2024.2384061","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to estimate the prevalence of diagnosed vision problems and to examine the association of single and multiple chronic conditions with vision problems among middle-aged and older adults in India.</p><p><strong>Methods: </strong>The study utilized data from the Longitudinal Ageing Study in India (LASI) Wave 1, (2017-18). Descriptive statistics along with bivariate and multivariable analyses were conducted to achieve the study objectives.</p><p><strong>Results: </strong>The prevalence of diagnosed vision problems in the sampled population was 48.2%. The older adults (60+ years) (55.3%) had shown a greater prevalence of vision problems than the middle-aged individuals (41%). Among chronic conditions, hypertension, diabetes, chronic lung diseases, chronic heart diseases, bone related diseases, psychiatric disorders, and high cholesterol were significantly associated with vision problems in the case of both middle-aged and older adults. Furthermore, odds of experiencing vision problems according to the presence of multimorbidity were higher in the middle-aged population [adjusted odds ratio (AOR) = 1.986; confidence interval (CI):1.855-2.126] than in the older population [AOR = 1.746; CI:1.644-1.854].</p><p><strong>Conclusions: </strong>Middle-aged and older adults with chronic illnesses and multimorbidity were at greater risk of vision problems. Due to the high prevalence of vision problem, interventions aimed at prevention or early detection are warranted.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}