The Epidemiology and Survival Outcomes of Adult Conjunctival Malignancies in Germany: A Decade-Long Population-Based Analysis (2009-2019).

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2024-07-05 DOI:10.1080/09286586.2024.2361170

Piotr Chlad, Vinodh Kakkassery, Armin Wolf, Christina V Miller, Olaf Strauss, Ahmad Samir Alfaar

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引用次数: 0

Abstract

Purpose: This study aims to evaluate the epidemiological patterns, treatment strategies, and survival outcomes of conjunctival malignancies in Germany between 2009 and 2019.

Methods: A total of 1,532 cases were analyzed, with the crude incidence rate calculated. The survival rates were investigated using life tables and Cox regression analysis.

Results: The overall incidence rate was 1.7 per million. Incidence rates varied across age groups, peaking in the 75+ age group. Carcinomas (43%), melanomas (30%), and lymphomas (20%), were the most prevalent malignancies. Of the total cases with reported treatment, surgical intervention was undertaken in 64.5% of the patients. The 5-year overall survival rates were 90.4% for lymphomas, 73.8% for melanomas, and 72.9% for carcinomas. Age at diagnosis emerged as a significant prognostic factor in the Cox regression analysis.

Conclusions: This study provides the first population-based incidence data on conjunctival malignancies in Germany, noting a generally low incidence with survival rates comparable to other regions. The findings underscore the importance of consistent reporting and further research into risk factors for a deeper understanding of these malignancies. The study calls for improved reporting systems and further investigations into genetic factors and targeted prevention strategies for high-risk groups.

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德国成人结膜恶性肿瘤的流行病学和生存结果：长达十年的人口分析（2009-2019 年）》。

目的：本研究旨在评估2009年至2019年间德国结膜恶性肿瘤的流行病学模式、治疗策略和生存结果：方法：共分析了 1,532 个病例，并计算了粗发病率。采用生命表和 Cox 回归分析法研究了存活率：结果：总发病率为 1.7/百万。不同年龄组的发病率各不相同，75 岁以上年龄组的发病率最高。癌症（43%）、黑色素瘤（30%）和淋巴瘤（20%）是最常见的恶性肿瘤。在所有报告治疗的病例中，64.5%的患者接受了手术治疗。淋巴瘤的 5 年总生存率为 90.4%，黑色素瘤为 73.8%，癌为 72.9%。在考克斯回归分析中，确诊年龄是一个重要的预后因素：这项研究首次提供了德国结膜恶性肿瘤的人群发病率数据，指出德国结膜恶性肿瘤的发病率普遍较低，存活率与其他地区相当。研究结果强调了持续报告和进一步研究风险因素对深入了解这些恶性肿瘤的重要性。研究呼吁改进报告系统，进一步调查遗传因素，并为高危人群制定有针对性的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.