Risk Factors for Developing Neovascular Glaucoma in Central Retinal Vein Occlusion: Two-Year Real-World Study.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Yu-Bai Chou, Hsin-Ho Chang, Hsun-I Chiu, Yiing-Jenq Chou, Christy Pu
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Abstract

Purpose: To explore potential risk factors for the development of neovascular glaucoma (NVG) in central retinal vein occlusion (CRVO) over a two-year intensive follow-up period.

Methods: This study reviewed 1545 patients with CRVO between 2005 and 2019 at Taipei Veterans General Hospital. Inclusion was restricted to (1) patients with acute CRVO within 3 months; (2) patients with ocular neovascularization at initial presentation (3) patients had not received any treatment at the time of CRVO; (4) at least bimonthly follow-up schedule over the course of 2 years. The included patients were screened for potential risk factors for developing NVG and assessed with Kaplan-Meier survival analysis and Cox regression model.

Results: Among the included 123 patients, the cumulative probability of developing NVG was 26.8% (33/123 cases) in overall follow-up period. The mean interval between the onset of CRVO and NVG was 507 days. Neither macular edema nor central macular thickness at baseline was correlated with the development of NVG (p =.104 and .25, respectively). Patients with diabetes mellitus (DM), older age, and poor vision independently played significant risk factors for developing NVG after controlling other covariates. (p =.034, .001, and .013, respectively).

Conclusions: Patients presenting with CRVO who have comorbidities such as DM, older age, and worse VA warrant closer attention and intensive follow-up for the development of NVG. Additionally, the statistical analysis indicated that the presence of macular edema, increased central macular thickness, CV events, history of glaucoma, and early PRP within 3 months had no significant impact on the likelihood of developing NVG.

中央视网膜静脉闭塞发生新生血管性青光眼的风险因素:两年真实世界研究
目的:探讨视网膜中央静脉闭塞(CRVO)患者在两年强化随访期间发生新生血管性青光眼(NVG)的潜在风险因素:本研究回顾了 2005 年至 2019 年期间在台北荣民总医院就诊的 1545 名 CRVO 患者。纳入患者仅限于:(1)3 个月内患有急性 CRVO 的患者;(2)初次发病时有眼部新生血管的患者;(3)在 CRVO 发生时未接受任何治疗的患者;(4)在两年内至少每两个月随访一次的患者。对纳入的患者进行了NVG潜在风险因素筛查,并采用Kaplan-Meier生存分析和Cox回归模型进行了评估:结果:在纳入的 123 例患者中,在整个随访期间发生 NVG 的累积概率为 26.8%(33/123 例)。CRVO 和 NVG 发病的平均间隔时间为 507 天。基线时的黄斑水肿和黄斑中心厚度均与 NVG 的发生无关(p =.104 和 .25)。在控制了其他协变量之后,糖尿病(DM)患者、高龄患者和视力不佳的患者都是发生 NVG 的重要风险因素。(结论:结论:合并有 DM、高龄和视力减退等并发症的 CRVO 患者应密切关注并加强随访,以防发生 NVG。此外,统计分析表明,黄斑水肿、黄斑中心厚度增加、CV 事件、青光眼病史以及 3 个月内的早期 PRP 对罹患 NVG 的可能性没有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ophthalmic epidemiology
Ophthalmic epidemiology 医学-眼科学
CiteScore
3.70
自引率
5.60%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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