Organogenesis最新文献_第5页

The Influence Mechanism of Abnormal Immunophilin FKBP52 on the Expression Levels of PR-A and PR-B in Endometriosis Based on Endometrial Stromal Cell Model in Vitro. 基于子宫内膜基质细胞模型的子宫内膜异位症中异常免疫噬菌体 FKBP52 对 PR-A 和 PR-B 表达水平的影响机制研究

IF 2.3 4区生物学

Organogenesis Pub Date : 2021-04-03 Epub Date: 2021-01-19 DOI: 10.1080/15476278.2020.1860424

Liling Liu, Junping Cheng, Fu Wei, Lihong Pang, Zhifu Zhi, Wenmei Yang, Weihong Tan

{"title":"The Influence Mechanism of Abnormal Immunophilin FKBP52 on the Expression Levels of PR-A and PR-B in Endometriosis Based on Endometrial Stromal Cell Model in Vitro.","authors":"Liling Liu, Junping Cheng, Fu Wei, Lihong Pang, Zhifu Zhi, Wenmei Yang, Weihong Tan","doi":"10.1080/15476278.2020.1860424","DOIUrl":"10.1080/15476278.2020.1860424","url":null,"abstract":"As a chaperone protein of progesterone receptor (PR), FK-506 Binding Protein 52 (FKBP52) can enhance the activity of PR, but the mechanism of FKBP52 affecting PR expression levels is difficult to clarify. Here, we report a novel in vitro model of ectopic endometrial stromal cells (ESCM) established through the primary culture method of endometrial stromal cells, which is used to study the details of relationship between FKBP52 abnormality and PR expression level in endometriosis (Ems). At the same time, the clinical study of the relationship between FKBP52 and PR expression levels in endometriosis patients was used to verify our conclusions. The results showed that the expression levels of PR-A mRNA and protein in endometriosis are positively correlated with FKBP52 and the abnormality of FKBP52 leads to the decrease of PR-B mRNA and protein expression. When FKBP52 was deleted or reduced, the expression levels of m RNA and protein of PR-A and PR-B have decreased leading to the proliferation of ectopic endometrium cells (ESC) and the occurrence of endometriosis, which is consistent with the expression levels of clinical endometriosis patients and fully confirms our conclusions and reliability of the model, and has great guiding significance for the research of Ems disease occurrence mechanism and clinical treatment.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"17 1-2","pages":"1-13"},"PeriodicalIF":2.3,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162255/pdf/KOGG_17_1860424.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38768924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Evaluation of Wound Healing Efficacy of a Film Dressing Made from Polymer-integrated Amnion Membrane. 聚合物集成羊膜膜敷料创面愈合效果的评价。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-10-01 DOI: 10.1080/15476278.2020.1844507

Bo Wang, Wuwei Li, Justin Harrison

{"title":"An Evaluation of Wound Healing Efficacy of a Film Dressing Made from Polymer-integrated Amnion Membrane.","authors":"Bo Wang, Wuwei Li, Justin Harrison","doi":"10.1080/15476278.2020.1844507","DOIUrl":"https://doi.org/10.1080/15476278.2020.1844507","url":null,"abstract":"ABSTRACT A film dressing is an easy and common wound management, which is flexible to cover many types of superficial injuries. In a recent study, we developed a scaffold from poly (1,8-octanediolco-citrate) incorporated decellularized amnion membrane (DAM-POC). The DAM-POC scaffold was biocompatible and could enhance soft and hard tissue regeneration when applied to repair the cleft palate in rat. The efficacy of the DAM-POC scaffold in oral repair had led us to hypothesize that it could be employed extensively in the medical field as a wound dressing. This study aimed to investigate the feasibility and efficacy of the DAM-POC scaffold as a film dressing in accelerating wound healing when applied in multiple tissue injuries. Our results demonstrated that both the DAM and DAM-POC scaffolds were biocompatible and anti-adhesive without causing severe foreign body reactions when covering wounds in abdominal wall, back muscle, tibia bone, and liver. In addition, the DAM-POC scaffold was superior to the DAM scaffold in reducing inflammation, preventing fibrosis, and regenerating tissues. In conclusion, the DAM-POC scaffold might potentially be adopted as a film dressing in a wide range of therapeutic applications and healing situations to protect the damaged tissues from the external environment and prevent infections.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 4","pages":"126-136"},"PeriodicalIF":2.3,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1844507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Recent Advances in Biomaterials for the Treatment of Bone Defects. 骨缺损生物材料的研究进展。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-10-01 Epub Date: 2020-08-16 DOI: 10.1080/15476278.2020.1808428

Le-Yi Zhang, Qing Bi, Chen Zhao, Jin-Yang Chen, Mao-Hua Cai, Xiao-Yi Chen

{"title":"Recent Advances in Biomaterials for the Treatment of Bone Defects.","authors":"Le-Yi Zhang, Qing Bi, Chen Zhao, Jin-Yang Chen, Mao-Hua Cai, Xiao-Yi Chen","doi":"10.1080/15476278.2020.1808428","DOIUrl":"https://doi.org/10.1080/15476278.2020.1808428","url":null,"abstract":"Bone defects or fractures generally heal in the absence of major interventions due to the high regenerative capacity of bone tissue. However, in situations of severe/large bone defects, these orchestrated regeneration mechanisms are impaired. With advances in modern medicine, natural and synthetic bio-scaffolds from bioceramics and polymers that support bone growth have emerged and gained intense research interest. In particular, scaffolds that recapitulate the molecular cues of extracellular signals, particularly growth factors, offer potential as therapeutic bone biomaterials. The current challenges for these therapies include the ability to engineer materials that mimic the biological and mechanical properties of the real bone tissue matrix, whilst simultaneously supporting bone vascularization. In this review, we discuss the very recent innovative strategies in bone biomaterial technology, including those of endogenous biomaterials and cell/drug delivery systems that promote bone regeneration. We present our understanding of their current value and efficacy, and the future perspectives for bone regenerative medicine.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":" ","pages":"113-125"},"PeriodicalIF":2.3,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1808428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38268347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Differentiation of Human Parthenogenetic Embryonic Stem Cells into Functional Hepatocyte-like Cells. 人孤雌胚胎干细胞向功能性肝细胞样细胞的分化。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-10-01 Epub Date: 2020-11-25 DOI: 10.1080/15476278.2020.1848237

Rui Liang, Zhiqiang Wang, Xiangyang Kong, Xiaoxiao Xiao, Tianxing Chen, Hui Yang, Ying Li, Xingqi Zhao

{"title":"Differentiation of Human Parthenogenetic Embryonic Stem Cells into Functional Hepatocyte-like Cells.","authors":"Rui Liang, Zhiqiang Wang, Xiangyang Kong, Xiaoxiao Xiao, Tianxing Chen, Hui Yang, Ying Li, Xingqi Zhao","doi":"10.1080/15476278.2020.1848237","DOIUrl":"https://doi.org/10.1080/15476278.2020.1848237","url":null,"abstract":"Stem cell and tissue engineering-based therapies for acute liver failure (ALF) have been limited by the lack of an optimal cell source. We aimed to determine the suitability of human parthenogenetic embryonic stem cells (hPESCs) for the development of strategies to treat ALF. We studied the ability of human parthenogenetic embryonic stem cells (hPESCs) with high whole-genome SNP homozygosity, which were obtained by natural activation during in vitro fertilization (IVF), to differentiate into functional hepatocyte-like cells in vitro by monolayer plane orientation. hPESCs were induced on a single-layer flat plate for 21 d in complete medium with the inducers activin A, FGF-4, BMP-2, HGF, OSM, DEX, and B27. Polygonal cell morphology and binuclear cells were observed after 21 d of induction by using an inverted microscope. RT-qPCR results showed that the levels of hepatocyte-specific genes such as AFP, ALB, HNF4a, CYP3A4, SLCO1B3, and ABCC2 significantly increased after induction. Immunocytochemical assay showed CK18 and Hepa expression in the induced cells. Indocyanine green (ICG) staining showed that the cells had the ability to absorb and metabolize dyes. Detection of marker proteins and urea in cell culture supernatants showed that the cells obtained after 21 d of induction had synthetic and secretory functions. The typical ultrastructure of liver cells was observed using TEM after 21 d of induction. The results indicate that naturally activated hPESCs can be induced to differentiate into hepatocellular cells by monolayer planar induction.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":" ","pages":"137-148"},"PeriodicalIF":2.3,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1848237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38651044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Airway reconstruction using decellularized aortic xenografts in a dog model. 犬脱细胞主动脉异种移植气道重建的研究。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-07-02 Epub Date: 2020-07-16 DOI: 10.1080/15476278.2020.1790273

Shao-Fei Cheng, Song Wu, Qian-Ping Li, Hong-Yang Sang, Zheng-Yang Fan

{"title":"Airway reconstruction using decellularized aortic xenografts in a dog model.","authors":"Shao-Fei Cheng, Song Wu, Qian-Ping Li, Hong-Yang Sang, Zheng-Yang Fan","doi":"10.1080/15476278.2020.1790273","DOIUrl":"https://doi.org/10.1080/15476278.2020.1790273","url":null,"abstract":"Tracheal reconstruction after extensive resection remains a challenge in thoracic surgery. Aortic allograft has been proposed to be a potential tracheal substitute. However, clinically, its application is limited for the shortage of autologous aortic segment. Whether xenogeneic aortic biosheets can be used as tracheal substitutes remains unknown. In the present study, we investigated the possibility in dog model. The results show that all dogs were survived without airway symptoms at 6 months after tracheal reconstruction with gently decellularized bovine carotid arteries. In the interior of engrafted areas, grafted patch integrated tightly with the residual native tracheal tissues and tracheal defects in the lumen were repaired smoothly without obvious inflammation, granulation, anastomotic leakage, or stenosis. In addition, histological and scanning electron microscopy examination showed that grafted patches were covered with ciliated columnar epithelium similar to epithelium in native trachea, which indicated successfully re-epithelialization of decellularized bovine carotid arteries in dogs. These findings provide preclinical investigation of xenogeneic aortic biosheets in serving as tracheal substitute in a dog model, which proposes that decellularized biosheets of bovine carotid may be a potential material for bioartificial tracheal graft.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 3","pages":"73-82"},"PeriodicalIF":2.3,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1790273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38160388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle. 缺血和高氧对头发生长和周期的影响。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-07-02 Epub Date: 2020-07-30 DOI: 10.1080/15476278.2020.1794271

Harunosuke Kato, Kahori Kinoshita, Natsumi Saito, Koji Kanayama, Masanori Mori, Natsumi Asahi, Ataru Sunaga, Katsutoshi Yoshizato, Satoshi Itami, Kotaro Yoshimura

{"title":"The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle.","authors":"Harunosuke Kato, Kahori Kinoshita, Natsumi Saito, Koji Kanayama, Masanori Mori, Natsumi Asahi, Ataru Sunaga, Katsutoshi Yoshizato, Satoshi Itami, Kotaro Yoshimura","doi":"10.1080/15476278.2020.1794271","DOIUrl":"https://doi.org/10.1080/15476278.2020.1794271","url":null,"abstract":"Alopecia has several causes, but its relationship with ischemia/hypoxia has not yet been investigated in detail. In this study, we studied the changes of hair follicles induced by ischemia and potential effects of normobaric hyperoxygenation (NBO) on the hair cycle and growth. We found that skin ischemia reduced hair growth rate, hair shaft size, and its pigmentation in the anagen phase of mice, which may reflect an aspect of pathophysiology of hair loss (alopecia) and depigmentation (gray/white hairs). Hyperoxygenation increased hair growth rate in organ culture of both human and murine hair follicles. Systemic NBO promoted hair growth in early anagen and mid-anagen, and delayed catagen onset in mice. However, telogen-to-anagen transition was not affected by NBO as far as non-ischemic skin is concerned. The results of this study indicated that the hair follicle is very sensitive to oxygen tension and oxygen tension affects the regulation of hair growth and cycle in vitro and in vivo. It was suggested that systemic NBO can be safely applied for a long period and can be a noninvasive therapeutic approach to alter hair growth and cycle by manipulating the microenvironment of hair follicles.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 3","pages":"83-94"},"PeriodicalIF":2.3,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1794271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38205861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Surgical Models to Explore Acellular Liver Scaffold Transplantation: Step-by-Step. 探索脱细胞肝支架移植的外科模型:一步一步。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-07-02 Epub Date: 2020-08-15 DOI: 10.1080/15476278.2020.1801273

Marlon L Dias, Cíntia M P Batista, Victor J K Secomandi, Alexandre C Silva, Victoria R S Monteiro, Lanuza A Faccioli, Regina C S Goldenberg

{"title":"Surgical Models to Explore Acellular Liver Scaffold Transplantation: Step-by-Step.","authors":"Marlon L Dias, Cíntia M P Batista, Victor J K Secomandi, Alexandre C Silva, Victoria R S Monteiro, Lanuza A Faccioli, Regina C S Goldenberg","doi":"10.1080/15476278.2020.1801273","DOIUrl":"https://doi.org/10.1080/15476278.2020.1801273","url":null,"abstract":"Acellular liver scaffolds (ALS) have arisen as potential candidates for transplantation. Until now, all reports involving ALS transplantation failed in surgical method descriptions and do not offer support to scientists to reproduce the procedures used in experimental microsurgery to make the results comparable to literature. To overcome the lack of detail information, we described surgical steps details to perform heterotopic and partial orthotopic surgical models to promote ALS transplantation. After preservation and vessel cannulation steps, the liver grafts were decellularized. In addition, ex vivo blood perfusion tests were performed to obtain a successful anticoagulation treatment prior in vivo transplantation. Then, methods of partial liver resection, combination of hand-suture and cuff techniques to complete end-to-end anastomosis between the scaffold and the recipient animal were performed. These procedures which take 30-60 min and were efficient to allow acellular liver scaffold viability and recellularization of different types of cell post-surgery. In conclusion, our methods are practical and simple promising approach that provides the opportunity to investigate ways to achieve sufficient liver function post-transplantation in vivo.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 3","pages":"95-112"},"PeriodicalIF":2.3,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1801273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38268335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Extracellular Matrix Remodeling During Palate Development. 腭发育过程中的细胞外基质重塑。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-04-02 Epub Date: 2020-03-31 DOI: 10.1080/15476278.2020.1735239

Xia Wang, Chunman Li, Zeyao Zhu, Li Yuan, Wood Yee Chan, Ou Sha

引用次数: 8

Development of Bioengineered Organ Using Biological Acellular Rat Liver Scaffold and Hepatocytes. 利用生物脱细胞大鼠肝支架和肝细胞制备生物工程器官。

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-04-02 Epub Date: 2020-05-03 DOI: 10.1080/15476278.2020.1742534

Tanya Debnath, Chandra Shekar Mallarpu, Lakshmi Kiran Chelluri

{"title":"Development of Bioengineered Organ Using Biological Acellular Rat Liver Scaffold and Hepatocytes.","authors":"Tanya Debnath, Chandra Shekar Mallarpu, Lakshmi Kiran Chelluri","doi":"10.1080/15476278.2020.1742534","DOIUrl":"https://doi.org/10.1080/15476278.2020.1742534","url":null,"abstract":"The increasing demand for organs for transplantation necessitates the development of substitutes to meet the structural and physiological functions. Tissue decellularization and recellularization aids in retaining the three-dimensional integrity, biochemical composition, tissue ultra-structure, and mechanical behavior, which makes them functionally suitable for organ transplantation. Herein, we attempted to rebuild functional liver grafts in small animal model (Wistar rat) with a potential of translation. A soft approach was adopted using 0.1% SDS (Sodium Dodecyl Sulfate) for decellularization and primary hepatocytes were used as a potential cell source for recellularization. The decellularization process was evaluated and confirmed using histology, DNA content, ultra-structure analysis. The resultant scaffold was re-seeded with the rat hepatocytes and their biocompatibility was assessed by its metabolic functions and gene expression. The structural components of the Extracellular matrix (ECM) (Laminins, Collagen type I, Reticulins) were conserved and the liver cell-specific proteins like CK-18, alpha-fetoprotein, albumin were expressed in the recellularized scaffold. The functionality and metabolic activity of the repopulated scaffold were evident from the albumin and urea production. Expression of Cytokeratin-19 (CK-19), Glucose 6-Phosphatase (G6P), Albumin, Gamma Glutamyl Transferase (GGT) genes has distinctly confirmed the translational signals after the repopulation process. Our study clearly elucidates that the native extracellular matrix of rat liver can be utilized as a scaffold for effective recellularization for whole organ regeneration.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 2","pages":"61-72"},"PeriodicalIF":2.3,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2020.1742534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37896381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Development of Small-diameter Polyester Vascular Grafts Coated with Silk Fibroin Sponge 丝素海绵包覆小直径聚酯血管移植物的研制

IF 2.3 4区生物学

Organogenesis Pub Date : 2020-01-02 DOI: 10.1080/15476278.2019.1686295

Takashi Tanaka, R. Tanaka, Yoko Ogawa, Yoshihide Takagi, T. Asakura

{"title":"Development of Small-diameter Polyester Vascular Grafts Coated with Silk Fibroin Sponge","authors":"Takashi Tanaka, R. Tanaka, Yoko Ogawa, Yoshihide Takagi, T. Asakura","doi":"10.1080/15476278.2019.1686295","DOIUrl":"https://doi.org/10.1080/15476278.2019.1686295","url":null,"abstract":"ABSTRACT In recent years, the demand for functional small-diameter (< 6 mm) artificial vascular grafts has greatly increased due to an increase in the number of patients with vascular heart disease. However, currently, there are no available commercial small-diameter grafts. The objective of this research was to develop a porous silk fibroin (SF)-coated poly(ethylene terephthalate) (PET) graft with a diameter < 6 mm. The graft was compared with a gelatin-coated PET graft because the latter PET graft with a diameter ~ 6 mm was widely used as a commercial vascular graft. Initially, porous SF was prepared using Glyc as the porogen [termed SF(Glyc)] and the PET grafts were prepared through the double-Raschel knitting method. Subsequently, the degradation of the SF coating was monitored using protease XIV in vitro and was compared with that observed in gelatin-coated PET grafts. Finally, these grafts were also implanted into rats for an in vivo comparison. In degradation experiments, after 7 days, the SF was clearly digested by protease XIV, but the gelatin on the graft was still remained at the outer surface. In implantation experiments in rats, the SF(Glyc)-coated PET graft was rapidly degraded in vivo and remodeling to self-tissues was promoted compared with the gelatin-coated PET graft. Thrombus formation and intimal hyperplasia were observed in the gelatin-coated PET graft; however, such side reactions were not observed in the SF(Glyc)-coated PET graft. Thus, the porous SF(Glyc)-coated PET graft with a small diameter < 6 mm may be useful as a commercial vascular graft.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"16 1","pages":"1 - 13"},"PeriodicalIF":2.3,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15476278.2019.1686295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44443539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11