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The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice. 锌离子刺激小鼠软骨发育过程中 SOX9 的 SUMO1 修饰作用
IF 1.6 4区 生物学
Organogenesis Pub Date : 2025-12-01 Epub Date: 2025-02-04 DOI: 10.1080/15476278.2025.2460269
Na Xue, Jing Zhao, Jing Yin, Liang Liu, Zhong Yang, Shuchao Zhai, Xiyun Bian, Xiang Gao
{"title":"The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice.","authors":"Na Xue, Jing Zhao, Jing Yin, Liang Liu, Zhong Yang, Shuchao Zhai, Xiyun Bian, Xiang Gao","doi":"10.1080/15476278.2025.2460269","DOIUrl":"10.1080/15476278.2025.2460269","url":null,"abstract":"<p><p>Zinc ions play a pivotal role in facilitating the development of cartilage in mice. Nevertheless, the precise underlying mechanism remains elusive. Our investigation was centered on elucidating the impact of zinc deficiency on cartilage maturation by modulating SUMO1 and UBC9 at both the protein and mRNA levels. We administered a regimen inducing zinc deficiency to gravid mice from E0.5 until euthanasia. Subsequently, we subjected the embryos to scrutiny employing HE, Safranin O staining and IHC. Primary chondrocytes were isolated from fetal mouse femoral condyles and utilized for Western blot analysis to discern the expression profiles of SUMO1, SUMO2/3, UBC9, SOX9, MMP13, Collagen II, RUNX2, and aggrecan. Furthermore, ATDC5 murine chondrocytes were subjected to treatment with ZnCl<sub>2</sub>, followed by RT-PCR assessment to scrutinize the expression levels of MMP13, Collagen II, RUNX2, and aggrecan. Additionally, we conducted Co-IP assays on ZnCl<sub>2</sub>-treated ATDC5 cells to explore the interaction between SOX9 and SUMO1. Our investigation unveiled that zinc deficiency led to a reduction in cartilage development, as evidenced by the HE results in fetal murine femur. Moreover, diminished expression levels of SUMO1 and UBC9 were observed in the IHC and Western blot results. Furthermore, Western blot and Co-IP assays revealed an augmented interaction between SOX9 and SUMO1, which was potentiated by ZnCl<sub>2</sub> treatment. Significantly, mutations at the SUMOylation site of SOX9 resulted in alterations in the expression patterns of crucial chondrogenesis factors. This research underscores how zinc ions promote cartilage development through the modification of SOX9 by SUMO1.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"21 1","pages":"2460269"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives. 用于肝细胞癌精准医学治疗的脂质纳米囊平台：进展与展望》。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-02-15 DOI: 10.1080/15476278.2024.2313696
Brandon M Lehrich, Evan R Delgado
{"title":"Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives.","authors":"Brandon M Lehrich, Evan R Delgado","doi":"10.1080/15476278.2024.2313696","DOIUrl":"10.1080/15476278.2024.2313696","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including immune checkpoint inhibitors and combinations, have achieved limited objective response rates for the majority of patients. Thus, a precision medicine approach is needed to tailor specific treatment options for molecular subsets of HCC patients. Lipid nanovesicle platforms, either liposome- (synthetic) or extracellular vesicle (natural)-derived present are improved drug delivery vehicles which may be modified to contain specific cargos for targeting specific tumor sites, with a natural affinity for liver with limited toxicity. This mini-review provides updates on the applications of novel lipid nanovesicle-based therapeutics for HCC precision medicine and the challenges associated with translating this therapeutic subclass from preclinical models to the clinic.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2313696"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation. 肝移植期间再灌注后综合征的风险因素和预防方法综述。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-08-04 DOI: 10.1080/15476278.2024.2386730
Qian Gao, Jin-Zhen Cai, He Dong
{"title":"A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation.","authors":"Qian Gao, Jin-Zhen Cai, He Dong","doi":"10.1080/15476278.2024.2386730","DOIUrl":"10.1080/15476278.2024.2386730","url":null,"abstract":"<p><p>Post-reperfusion syndrome (PRS) is a severe and highly lethal syndrome that occurs after declamping the portal vein forceps during liver transplantation. It is marked by severe hemodynamic disturbances manifested by decreased mean arterial pressure, increased heart rate and elevated pulmonary artery pressure. The complex pathogenesis of PRS remains understudied. It is generally believed to be related to the large amount of acidic, cold blood that enters the circulation after release of the portal clamp. This blood is rich in oxygen-free radicals and metabolic toxins, which not only aggravate the ischemia-reperfusion injury of the liver but also further attack the systemic organs indiscriminately. Considering the range of possible adverse prognoses including acute kidney injury, delirium and graft nonfunction, it is imperative that clinicians increase their awareness and prevention of PRS. The aim of this article is to review the current risk factors, pathophysiological mechanisms and prevention strategies for PRS.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2386730"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes derived from TNF-α-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice. 从经 TNF-α 处理的骨髓间充质干细胞中提取的外泌体可改善小鼠心肌梗死损伤。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-05-20 DOI: 10.1080/15476278.2024.2356341
Shuo Wang, Rubin Wu, Qincong Chen, Tao Liu, Liu Li
{"title":"Exosomes derived from TNF-α-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice.","authors":"Shuo Wang, Rubin Wu, Qincong Chen, Tao Liu, Liu Li","doi":"10.1080/15476278.2024.2356341","DOIUrl":"10.1080/15476278.2024.2356341","url":null,"abstract":"<p><p>Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) exhibit considerable therapeutic potential for myocardial regeneration. In our investigation, we delved into their impact on various aspects of myocardial infarction (MI), including cardiac function, tissue damage, inflammation, and macrophage polarization in a murine model. We meticulously isolated the exosomes from TNF-α-treated BMSCs and evaluated their therapeutic efficacy in a mouse MI model induced by coronary artery ligation surgery. Our comprehensive analysis, incorporating ultrasound, serum assessment, Western blot, and qRT-PCR, revealed that exosomes from TNF-α-treated BMSCs demonstrated significant therapeutic potential in reducing MI-induced injury. Treatment with these exosomes resulted in improved cardiac function, reduced infarct area, and increased left ventricular wall thickness in MI mice. On a mechanistic level, exosome treatment fostered M2 macrophage polarization while concurrently suppressing M1 polarization. Hence, exosomes derived from TNF-α-treated BMSCs emerge as a promising therapeutic strategy for alleviating MI injury in a mouse model.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2356341"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Adipose Tissue-Derived Stromal Cells Ameliorate Adriamycin-Induced Nephropathy by Promoting Angiogenesis. 人脂肪组织衍生基质细胞通过促进血管生成改善阿霉素诱发的肾病
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-05-26 DOI: 10.1080/15476278.2024.2356339
Xiaodi Zhao, Chengyan Ma, Lijie Li, Yuemei Yang, Sen Zhang, Xiaoli Wang
{"title":"Human Adipose Tissue-Derived Stromal Cells Ameliorate Adriamycin-Induced Nephropathy by Promoting Angiogenesis.","authors":"Xiaodi Zhao, Chengyan Ma, Lijie Li, Yuemei Yang, Sen Zhang, Xiaoli Wang","doi":"10.1080/15476278.2024.2356339","DOIUrl":"10.1080/15476278.2024.2356339","url":null,"abstract":"<p><p>This study is to investigate the therapeutical effect and mechanisms of human-derived adipose mesenchymal stem cells (ADSC) in relieving adriamycin (ADR)-induced nephropathy (AN). SD rats were separated into normal group, ADR group, ADR+Losartan group (20 mg/kg), and ADR + ADSC group. AN rats were induced by intravenous injection with adriamycin (8 mg/kg), and 4 d later, ADSC (2 × 10<sup>5</sup> cells/mouse) were administrated twice with 2 weeks interval time (i.v.). The rats were euthanized after the 6 weeks' treatment. Biochemical indicators reflecting renal injury, such as blood urea nitrogen (BUN), neutrophil gelatinase alpha (NGAL), serum creatinine (Scr), inflammation, oxidative stress, and pro-fibrosis molecules, were evaluated. Results demonstrated that we obtained high qualified ADSCs for treatment determined by flow cytometry, and ADSCs treatment significantly ameliorated renal injuries in DN rats by decreasing BUN, Scr and NGAL in peripheral blood, as well as renal histopathological injuries, especially protecting the integrity of podocytes by immunofluorescence. Furthermore, ADSCs treatment also remarkably reduced the renal inflammation, oxidative stress, and fibrosis in DN rats. Preliminary mechanism study suggested that the ADSCs treatment significantly increased renal neovascularization via enhancing proangiogenic VEGF production. Pharmacodynamics study using in vivo imaging confirmed that ADSCs via intravenous injection could accumulate into the kidneys and be alive at least 2 weeks. In a conclusion, ADSC can significantly alleviate ADR-induced nephropathy, and mainly through reducing oxidative stress, inflammation and fibrosis, as well as enhancing VEGF production.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2356339"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the Application of Organoids-On-A-Chip in Diseases. 器官芯片在疾病中的应用进展。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-08-10 DOI: 10.1080/15476278.2024.2386727
Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong
{"title":"Progress in the Application of Organoids-On-A-Chip in Diseases.","authors":"Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong","doi":"10.1080/15476278.2024.2386727","DOIUrl":"10.1080/15476278.2024.2386727","url":null,"abstract":"<p><p>With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development. Establishing a new generation of experimental models and research models is of great significance for deeply understanding human health and disease processes, and developing effective treatment measures. As is well known, long research and development cycles, high risks, and high costs are the \"three mountains\" facing the development of new drugs today. Organoids and organ-on-chips technology can highly simulate and reproduce the human physiological environment and complex reactions in <i>vitro</i>, greatly improving the accuracy of drug clinical efficacy prediction, reducing drug development costs, and avoiding the defects of drug testing animal models. Therefore, organ-on-chips have enormous potential in medical diagnosis and treatment.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2386727"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Therapy Approaches for Articular Cartilage Regeneration. 关节软骨再生的细胞治疗方法。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-14 DOI: 10.1080/15476278.2023.2278235
Meagan J Makarczyk
{"title":"Cell Therapy Approaches for Articular Cartilage Regeneration.","authors":"Meagan J Makarczyk","doi":"10.1080/15476278.2023.2278235","DOIUrl":"10.1080/15476278.2023.2278235","url":null,"abstract":"<p><p>Articular cartilage is a common cartilage type found in a multitude of joints throughout the human body. However, cartilage is limited in its regenerative capacity. A range of methods have been employed to aid adults under the age of 45 with cartilage defects, but other cartilage pathologies such as osteoarthritis are limited to non-steroidal anti-inflammatory drugs and total joint arthroplasty. Cell therapies and synthetic biology can be utilized to assist not only cartilage defects but have the potential as a therapeutic approach for osteoarthritis as well. In this review, we will cover current cell therapy approaches for cartilage defect regeneration with a focus on autologous chondrocyte implantation and matrix autologous chondrocyte implantation. We will then discuss the potential of stem cells for cartilage repair in osteoarthritis and the use of synthetic biology to genetically engineer cells to promote cartilage regeneration and potentially reverse osteoarthritis.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2278235"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ-On-A-Chip: An Emerging Research Platform. 器官芯片:一个新兴的研究平台。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-15 DOI: 10.1080/15476278.2023.2278236
Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya, Shaila Lewis
{"title":"Organ-On-A-Chip: An Emerging Research Platform.","authors":"Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya, Shaila Lewis","doi":"10.1080/15476278.2023.2278236","DOIUrl":"10.1080/15476278.2023.2278236","url":null,"abstract":"<p><p>In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2278236"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells. 干扰素β修饰的人脐带间充质干细胞来源的外泌体在前列腺癌细胞增殖和凋亡中的调控作用。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-30 DOI: 10.1080/15476278.2023.2285836
Haichao Yuan, Senmao Li, Zhengping Zhao, Yan Wang
{"title":"Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells.","authors":"Haichao Yuan, Senmao Li, Zhengping Zhao, Yan Wang","doi":"10.1080/15476278.2023.2285836","DOIUrl":"10.1080/15476278.2023.2285836","url":null,"abstract":"<p><p>Prostate cancer (PCa) poses a serious burden to men. Interferon-β (IFN-β) is implicated in cancer cell growth. This study hence explored the regulation of IFN-β-modified human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) in PCa cells. <i>In vitro-</i>cultured hUCMSCs were transfected with pcDNA3.1-IFN-β plasmid or IFN-β siRNA. hUCMSC-Exos were extracted by ultracentrifugation and identified. PCa cells (PC3 and LNCap) were treated with Exos. Cellular internalization of Exos by cells was detected by uptake assay. Cell proliferation, cycle, and apoptosis were evaluated by CCK-8, EdU staining, and flow cytometry. Levels of cell cycle-related proteins (cyclin D/cyclin E) were determined by Western blot. The effect of IFN-β-modified hUCMSC-Exos <i>in vivo</i> was analyzed. IFN-β-modified hUCMSC-Exos (Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup> or Exo<sup>si-</sup><sup>IFN</sup><sup>-β</sup>) were successfully isolated. IFN-β was encapsulated in Exos, and PCa cells could uptake Exos. After treating with Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup>, PCa cell proliferation was impeded, the percentage of cells in the G0/G1 phase, cyclin D/cyclin E levels, and cell apoptotic rate were elevated, while cells treated with Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup> exhibited contrary trends. IFN-β-modified hUCMSC-Exos reduced PCa tumor size and weight <i>in vivo</i>. Conjointly, IFN-β-modified hUCMSC-Exos suppress PCa cell proliferation and facilitate apoptosis.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2285836"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications. Gasdermin-D介导的Pyroposis在器官损伤中的作用及其治疗意义。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2023-12-31 DOI: 10.1080/15476278.2023.2177484
Joud Mulla, Rohan Katti, Melanie J Scott
{"title":"The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications.","authors":"Joud Mulla, Rohan Katti, Melanie J Scott","doi":"10.1080/15476278.2023.2177484","DOIUrl":"10.1080/15476278.2023.2177484","url":null,"abstract":"<p><p>Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2177484"},"PeriodicalIF":1.6,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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