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Progress in the Application of Organoids-On-A-Chip in Diseases. 器官芯片在疾病中的应用进展。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-08-10 DOI: 10.1080/15476278.2024.2386727
Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong
{"title":"Progress in the Application of Organoids-On-A-Chip in Diseases.","authors":"Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong","doi":"10.1080/15476278.2024.2386727","DOIUrl":"10.1080/15476278.2024.2386727","url":null,"abstract":"<p><p>With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development. Establishing a new generation of experimental models and research models is of great significance for deeply understanding human health and disease processes, and developing effective treatment measures. As is well known, long research and development cycles, high risks, and high costs are the \"three mountains\" facing the development of new drugs today. Organoids and organ-on-chips technology can highly simulate and reproduce the human physiological environment and complex reactions in <i>vitro</i>, greatly improving the accuracy of drug clinical efficacy prediction, reducing drug development costs, and avoiding the defects of drug testing animal models. Therefore, organ-on-chips have enormous potential in medical diagnosis and treatment.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"20 1","pages":"2386727"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Therapy Approaches for Articular Cartilage Regeneration. 关节软骨再生的细胞治疗方法。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-14 DOI: 10.1080/15476278.2023.2278235
Meagan J Makarczyk
{"title":"Cell Therapy Approaches for Articular Cartilage Regeneration.","authors":"Meagan J Makarczyk","doi":"10.1080/15476278.2023.2278235","DOIUrl":"10.1080/15476278.2023.2278235","url":null,"abstract":"<p><p>Articular cartilage is a common cartilage type found in a multitude of joints throughout the human body. However, cartilage is limited in its regenerative capacity. A range of methods have been employed to aid adults under the age of 45 with cartilage defects, but other cartilage pathologies such as osteoarthritis are limited to non-steroidal anti-inflammatory drugs and total joint arthroplasty. Cell therapies and synthetic biology can be utilized to assist not only cartilage defects but have the potential as a therapeutic approach for osteoarthritis as well. In this review, we will cover current cell therapy approaches for cartilage defect regeneration with a focus on autologous chondrocyte implantation and matrix autologous chondrocyte implantation. We will then discuss the potential of stem cells for cartilage repair in osteoarthritis and the use of synthetic biology to genetically engineer cells to promote cartilage regeneration and potentially reverse osteoarthritis.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2278235"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ-On-A-Chip: An Emerging Research Platform. 器官芯片:一个新兴的研究平台。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-15 DOI: 10.1080/15476278.2023.2278236
Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya, Shaila Lewis
{"title":"Organ-On-A-Chip: An Emerging Research Platform.","authors":"Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya, Shaila Lewis","doi":"10.1080/15476278.2023.2278236","DOIUrl":"10.1080/15476278.2023.2278236","url":null,"abstract":"<p><p>In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2278236"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells. 干扰素β修饰的人脐带间充质干细胞来源的外泌体在前列腺癌细胞增殖和凋亡中的调控作用。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2023-12-31 Epub Date: 2023-11-30 DOI: 10.1080/15476278.2023.2285836
Haichao Yuan, Senmao Li, Zhengping Zhao, Yan Wang
{"title":"Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells.","authors":"Haichao Yuan, Senmao Li, Zhengping Zhao, Yan Wang","doi":"10.1080/15476278.2023.2285836","DOIUrl":"10.1080/15476278.2023.2285836","url":null,"abstract":"<p><p>Prostate cancer (PCa) poses a serious burden to men. Interferon-β (IFN-β) is implicated in cancer cell growth. This study hence explored the regulation of IFN-β-modified human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) in PCa cells. <i>In vitro-</i>cultured hUCMSCs were transfected with pcDNA3.1-IFN-β plasmid or IFN-β siRNA. hUCMSC-Exos were extracted by ultracentrifugation and identified. PCa cells (PC3 and LNCap) were treated with Exos. Cellular internalization of Exos by cells was detected by uptake assay. Cell proliferation, cycle, and apoptosis were evaluated by CCK-8, EdU staining, and flow cytometry. Levels of cell cycle-related proteins (cyclin D/cyclin E) were determined by Western blot. The effect of IFN-β-modified hUCMSC-Exos <i>in vivo</i> was analyzed. IFN-β-modified hUCMSC-Exos (Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup> or Exo<sup>si-</sup><sup>IFN</sup><sup>-β</sup>) were successfully isolated. IFN-β was encapsulated in Exos, and PCa cells could uptake Exos. After treating with Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup>, PCa cell proliferation was impeded, the percentage of cells in the G0/G1 phase, cyclin D/cyclin E levels, and cell apoptotic rate were elevated, while cells treated with Exo<sup>oe-</sup><sup>IFN</sup><sup>-β</sup> exhibited contrary trends. IFN-β-modified hUCMSC-Exos reduced PCa tumor size and weight <i>in vivo</i>. Conjointly, IFN-β-modified hUCMSC-Exos suppress PCa cell proliferation and facilitate apoptosis.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2285836"},"PeriodicalIF":2.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications. Gasdermin-D介导的Pyroposis在器官损伤中的作用及其治疗意义。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2023-12-31 DOI: 10.1080/15476278.2023.2177484
Joud Mulla, Rohan Katti, Melanie J Scott
{"title":"The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications.","authors":"Joud Mulla, Rohan Katti, Melanie J Scott","doi":"10.1080/15476278.2023.2177484","DOIUrl":"10.1080/15476278.2023.2177484","url":null,"abstract":"<p><p>Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2177484"},"PeriodicalIF":1.6,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Hepatocellular response in Cholestatic Liver Diseases. 胆固醇性肝病中的人肝细胞反应。
IF 1.6 4区 生物学
Organogenesis Pub Date : 2023-12-31 DOI: 10.1080/15476278.2023.2247576
Kimberly Ortiz, Zeliha Cetin, Yiyue Sun, Zhiping Hu, Takeshi Kurihara, Edgar N Tafaleng, Rodrigo M Florentino, Alina Ostrowska, Alejandro Soto-Gutierrez, Lanuza A P Faccioli
{"title":"Human Hepatocellular response in Cholestatic Liver Diseases.","authors":"Kimberly Ortiz, Zeliha Cetin, Yiyue Sun, Zhiping Hu, Takeshi Kurihara, Edgar N Tafaleng, Rodrigo M Florentino, Alina Ostrowska, Alejandro Soto-Gutierrez, Lanuza A P Faccioli","doi":"10.1080/15476278.2023.2247576","DOIUrl":"10.1080/15476278.2023.2247576","url":null,"abstract":"<p><p>Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the most common types of cholestatic liver disease (CLD), result in enterohepatic obstruction, bile acid accumulation, and hepatotoxicity. The mechanisms by which hepatocytes respond to and cope with CLD remain largely unexplored. This study includes the characterization of hepatocytes isolated from explanted livers of patients with PBC and PSC. We examined the expression of hepatocyte-specific genes, intracellular bile acid (BA) levels, and oxidative stress in primary-human-hepatocytes (PHHs) isolated from explanted livers of patients with PBC and PSC and compared them with control normal human hepatocytes. Our findings provide valuable initial insights into the hepatocellular response to cholestasis in CLD and help support the use of PHHs as an experimental tool for these diseases.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"19 1","pages":"2247576"},"PeriodicalIF":1.6,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focusing on Hippo Pathway in Stem Cells of Oral Origin, Enamel Formation and Periodontium Regeneration. 重点研究口腔起源干细胞、牙釉质形成和牙周组织再生中的Hippo通路。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2022-12-31 DOI: 10.1080/15476278.2022.2082236
Tianyi Wang, Kehan Li, Hanghang Liu, En Luo
{"title":"Focusing on Hippo Pathway in Stem Cells of Oral Origin, Enamel Formation and Periodontium Regeneration.","authors":"Tianyi Wang,&nbsp;Kehan Li,&nbsp;Hanghang Liu,&nbsp;En Luo","doi":"10.1080/15476278.2022.2082236","DOIUrl":"https://doi.org/10.1080/15476278.2022.2082236","url":null,"abstract":"<p><p>Hippo pathway is a cellular regulatory pathway composed of core molecules such as MST1/2, LATS1/2, SAV1, MOB1A/B and downstream YAP/TAZ. Fully involved in regulating cell proliferation, differentiation, migration and apoptosis, the Hippo pathway is critical in regulating stem cells of oral origin, for instance, DPSCs and PDLSCs, enamel formation and periodontium regeneration. Here, we summarized the Hippo pathway involved in these progresses and concluded crosstalks of the Hippo pathway with BCL-2, ERK1/2, ROCK, TGF-β/BMP and Wnt/β-catenin pathways, hoping to provide foundation for further clinical therapy.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"18 1","pages":"2082236"},"PeriodicalIF":2.3,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/a2/KOGG_18_2082236.PMC9897286.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10662921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Applications of Transcriptomics in the Research of Antibody-Mediated Rejection in Kidney Transplantation: Progress and Perspectives. 转录组学在肾移植抗体介导排斥反应研究中的应用:进展与展望。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2022-12-31 DOI: 10.1080/15476278.2022.2131357
Hsuan Yeh
{"title":"Applications of Transcriptomics in the Research of Antibody-Mediated Rejection in Kidney Transplantation: Progress and Perspectives.","authors":"Hsuan Yeh","doi":"10.1080/15476278.2022.2131357","DOIUrl":"https://doi.org/10.1080/15476278.2022.2131357","url":null,"abstract":"<p><p>Antibody-mediated rejection (ABMR) is the major cause of chronic allograft dysfunction and loss in kidney transplantation. The immunological mechanisms of ABMR that have been featured in the latest studies indicate a highly complex interplay between various immune and nonimmune cell types. Clinical diagnostic standards have long been criticized for being arbitrary and the lack of accuracy. Transcriptomic approaches, including microarray and RNA sequencing of allograft biopsies, enable the identification of differential gene expression and the continuous improvement of diagnostics. Given that conventional bulk transcriptomic approaches only reflect the average gene expression but not the status at the single-cell level, thereby ignoring the heterogeneity of the transcriptome across individual cells, single-cell RNA sequencing is rising as a powerful tool to provide a high-resolution transcriptome map of immune cells, which allows the elucidation of the pathogenesis and may facilitate the development of novel strategies for clinical treatment of ABMR.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"18 1","pages":"2131357"},"PeriodicalIF":2.3,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Approach of the Intrauterine Morphogenesis of the Human Palpebral Apparatus. 人眼睑器官宫内形态发生的系统研究。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2022-12-31 DOI: 10.1080/15476278.2022.2066453
Octavian Munteanu, Florin-Mihail Filipoiu, Monica Mihaela Cirstoiu, Roxana Elena Bohiltea, Tiberiu Augustin Georgescu, Adrian Dumitru, Andra-Ioana Băloiu, Mihai-Alin Publik, Ioan-Andrei Petrescu
{"title":"A Systematic Approach of the Intrauterine Morphogenesis of the Human Palpebral Apparatus.","authors":"Octavian Munteanu,&nbsp;Florin-Mihail Filipoiu,&nbsp;Monica Mihaela Cirstoiu,&nbsp;Roxana Elena Bohiltea,&nbsp;Tiberiu Augustin Georgescu,&nbsp;Adrian Dumitru,&nbsp;Andra-Ioana Băloiu,&nbsp;Mihai-Alin Publik,&nbsp;Ioan-Andrei Petrescu","doi":"10.1080/15476278.2022.2066453","DOIUrl":"https://doi.org/10.1080/15476278.2022.2066453","url":null,"abstract":"<p><p>The human eyelid embodies a vast diversity of functions. Acting as a protective shield for the ocular apparatus and as a light regulator in the sight process, eyelids stand a fascinating - yet omitted - role in facial aesthetics, serving as a racial trait by which humankind succeeded to manifest heterogeneity as a species. These assumptions are precisely forecasted right from in-utero life through intricate processes of growth and cell differentiation. In the Department of Anatomy of \"Carol Davila\" University of Medicine and Pharmacy, we performed morphological assessments on 41 embryos and fetuses with gestational ages ranging from 6 to 29 weeks. This study aims to illustrate the morphogenesis of eyelids in human embryos and fetuses and highlight macroscopic features which could potentially have significant clinical implications in ophthalmic pathology.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"18 1","pages":"2066453"},"PeriodicalIF":2.3,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10687259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Genes Involved in Dentinogenesis. 与牙本质形成有关的基因。
IF 2.3 4区 生物学
Organogenesis Pub Date : 2022-12-31 Epub Date: 2022-01-13 DOI: 10.1080/15476278.2021.2022373
Shuang Chen, Han Xie, Shouliang Zhao, Shuai Wang, Xiaoling Wei, Shangfeng Liu
{"title":"The Genes Involved in Dentinogenesis.","authors":"Shuang Chen,&nbsp;Han Xie,&nbsp;Shouliang Zhao,&nbsp;Shuai Wang,&nbsp;Xiaoling Wei,&nbsp;Shangfeng Liu","doi":"10.1080/15476278.2021.2022373","DOIUrl":"https://doi.org/10.1080/15476278.2021.2022373","url":null,"abstract":"<p><p>The development and repair of dentin are strictly regulated by hundreds of genes. Abnormal dentin development is directly caused by gene mutations and dysregulation. Understanding and mastering this signal network is of great significance to the study of tooth development, tissue regeneration, aging, and repair and the treatment of dental diseases. It is necessary to understand the formation and repair mechanism of dentin in order to better treat the dentin lesions caused by various abnormal properties, whether it is to explore the reasons for the formation of dentin defects or to develop clinical drugs to strengthen the method of repairing dentin. Molecular biology of genes related to dentin development and repair are the most important basis for future research.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":" ","pages":"1-19"},"PeriodicalIF":2.3,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39815878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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