聚合物集成羊膜膜敷料创面愈合效果的评价。

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2020-10-01 DOI:10.1080/15476278.2020.1844507

Bo Wang, Wuwei Li, Justin Harrison

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引用次数: 6

摘要

薄膜敷料是一种简单而常见的伤口处理方法，它灵活地覆盖了许多类型的表面损伤。在最近的研究中，我们开发了一种由聚(1,8-辛烷二醇-柠檬酸酯)结合脱细胞羊膜(DAM-POC)的支架。DAM-POC支架具有良好的生物相容性，可促进大鼠腭裂的软硬组织再生。DAM-POC支架在口腔修复中的效果使我们设想其作为伤口敷料在医学领域的广泛应用。本研究旨在探讨DAM-POC支架作为膜敷料在多组织损伤中加速伤口愈合的可行性和有效性。我们的研究结果表明，DAM和DAM- poc支架在覆盖腹壁、背部肌肉、胫骨和肝脏伤口时均具有生物相容性和抗粘连性，且不会引起严重的异物反应。此外，DAM- poc支架在减轻炎症、防止纤维化和组织再生方面优于DAM支架。综上所述，DAM-POC支架有可能作为膜敷料广泛应用于治疗和愈合情况，以保护受损组织免受外界环境的影响，防止感染。

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An Evaluation of Wound Healing Efficacy of a Film Dressing Made from Polymer-integrated Amnion Membrane.

ABSTRACT A film dressing is an easy and common wound management, which is flexible to cover many types of superficial injuries. In a recent study, we developed a scaffold from poly (1,8-octanediolco-citrate) incorporated decellularized amnion membrane (DAM-POC). The DAM-POC scaffold was biocompatible and could enhance soft and hard tissue regeneration when applied to repair the cleft palate in rat. The efficacy of the DAM-POC scaffold in oral repair had led us to hypothesize that it could be employed extensively in the medical field as a wound dressing. This study aimed to investigate the feasibility and efficacy of the DAM-POC scaffold as a film dressing in accelerating wound healing when applied in multiple tissue injuries. Our results demonstrated that both the DAM and DAM-POC scaffolds were biocompatible and anti-adhesive without causing severe foreign body reactions when covering wounds in abdominal wall, back muscle, tibia bone, and liver. In addition, the DAM-POC scaffold was superior to the DAM scaffold in reducing inflammation, preventing fibrosis, and regenerating tissues. In conclusion, the DAM-POC scaffold might potentially be adopted as a film dressing in a wide range of therapeutic applications and healing situations to protect the damaged tissues from the external environment and prevent infections.

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.