Ophthalmologica最新文献

{"title":"Patient-Reported Outcomes after Surgery for Proliferative Vitreoretinopathy: Post hoc Analysis of a Randomized Controlled Trial.","authors":"Rodrigo Anguita, Lorenzo Ferro Desideri, Janice Roth, Ines Schumacher, Philip Banerjee, Martin Zinkernagel, David G Charteris","doi":"10.1159/000550679","DOIUrl":"10.1159/000550679","url":null,"abstract":"<p><p><p>Introduction: Proliferative vitreoretinopathy (PVR) is the leading cause of surgical failure in rhegmatogenous retinal detachment (RRD) and is associated with poor visual prognosis. We aimed to report changes in VFQ-25 and SF-36 tests following surgery for PVR-RRD and identify clinical and demographic factors associated with recovery.</p><p><strong>Methods: </strong>This is a post hoc analysis of a phase IIIb randomized, participant-masked clinical trial evaluating slow-release dexamethasone in PVR-RRD. Patients underwent pars plana vitrectomy with silicone oil tamponade. Vision-related QOL was assessed using VFQ-25, and SF-36 test, at baseline, 6 months, and 12 months postoperatively. VFQ-25 subscales and SF-36 domains were analysed descriptively and with nonparametric paired tests; associations with best-corrected visual acuity (BCVA, logMAR) and other variables were assessed using Spearman correlation and nonparametric tests.</p><p><strong>Results: </strong>A total of 139 patients were included (mean age 61 years; 60% male). VFQ-25 total score improved from a median of 65.5 at baseline to 70 at 12 months (p = 0.0004). SF-36 total score improved from 68 to 77.5 at 12 months (p = 0.006). Worse 12-month BCVA correlated with lower VFQ-25 (p < 0.001) and showed a borderline association with SF-36 (p = 0.054). In univariable analyses, women reported lower 12-month QOL; however, gender associations were attenuated in multivariable models (VFQ-25: β = -4.39, p = 0.073; SF-36: β = -4.71, p = 0.199). Retinal anatomical status and number of surgeries were not associated with QOL outcomes. Subscale/domain analyses showed the largest improvements in psychosocial domains: VFQ-25 mental health increased from 50.0 to 68.8 (p = 3.35 × 10-5), and SF-36 mental health increased from 68.0 to 80.0 (p = 2.38 × 10-6), while most physical health domains were stable.</p><p><strong>Conclusions: </strong>Despite the complexity of PVR-RRD, significant improvements in both visual function and general QOL were observed postoperatively driven largely by psychosocial recovery. Final BCVA and baseline QOL had a greater influence on perceived recovery than anatomical success or number of surgeries. These findings highlight the importance of personalized care and rehabilitation in managing PVR-RRD patients. </p>.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"175-181"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers.","authors":"","doi":"10.1159/000549003","DOIUrl":"https://doi.org/10.1159/000549003","url":null,"abstract":"","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"1"},"PeriodicalIF":1.9,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary and Macular Optical Coherence Tomography Angiography Predictors of Visual Improvement in Patients Treated with Vitrectomy for Idiopathic Epiretinal Membrane.","authors":"Elvia Mastrogiuseppe, Giacomo Visioli, Giuseppe Maria Albanese, Ludovico Iannetti, Enrico Romano, Antonio Guillot, Luca Lucchino, Magda Gharbiya","doi":"10.1159/000542214","DOIUrl":"10.1159/000542214","url":null,"abstract":"<p><strong>Introduction: </strong>We investigated the changes of peripapillary and macular microvasculature in idiopathic macular epiretinal membrane (iERM) eyes before and after pars plana vitrectomy (PPV), aiming to identify potential optical coherence tomography angiography (OCTA) predictors of visual acuity improvement.</p><p><strong>Methods: </strong>Fifty-seven eyes diagnosed with iERM were enrolled and underwent PPV with ERM and internal limiting membrane (ILM) peeling. Data were collected before surgery and during the 12-month postoperative period. OCTA analysis focused on radial peripapillary capillary (RPC) vessel density (VD), superficial and deep capillary plexus (SCP and DCP, respectively). Functional and OCT structural outcomes, including best-corrected visual acuity (BCVA) and macular thickness, were also recorded.</p><p><strong>Results: </strong>Multivariate linear regression analysis revealed that higher preoperative RPC VD, lower SCP VD, and lower BCVA were predictors of postoperative BCVA improvement (p < 0.001, p = 0.047, and p < 0.001, respectively). Throughout the follow-up period, there was an observed increase in intradisc RPC VD, whole-disc VD, and parafoveal DCP VD (all p < 0.001). BCVA and central macular thickness demonstrated significant improvement (p < 0.001) within the first month following vitrectomy, which then stabilized from the third month onward.</p><p><strong>Conclusions: </strong>Preoperative microvascular measurements in iERM patients can forecast postoperative BCVA. OCTA findings reveal that both increased RPC density and reduced SCP density at baseline could serve as predictors of better visual outcomes after surgery. Enhanced RPC density may reflect a healthier optic nerve with greater potential for visual recovery, while a less dense SCP could indicate less iERM contraction, both contributing to more favorable postoperative visual results.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"54-66"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intraoperative Early Positioning on Anatomical Success after Inverted Flap Technique in Large Macular Holes: A Retrospective Comparative Study.","authors":"Fikret Ucar, Ekrem Kadıoğlu","doi":"10.1159/000547711","DOIUrl":"10.1159/000547711","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we wanted to evaluate the effect of intraoperative early positioning on anatomical success in patients with large macular holes undergoing the inverted flap (IF) technique.</p><p><strong>Methods: </strong>This retrospective, comparative study included 43 patients diagnosed with a macular hole ≥400 μm in minimum linear diameter who underwent pars plana vitrectomy using the IF technique. Patients were allocated chronologically into two groups: those operated on prior to February 2020 formed the standard positioning group (n = 23), and those treated thereafter composed the early positioning group (n = 20). In the early intraoperative positioning group, the patient's head was turned nasally immediately after the air-fluid exchange to stabilize the IF. In contrast, the standard group followed conventional postoperative prone positioning. The primary outcome was complete macular hole closure, assessed using optical coherence tomography. Secondary outcomes included IF stability, retinal layer integrity, and the need for additional postoperative surgical interventions.</p><p><strong>Results: </strong>At postoperative month 3, anatomical closure was achieved in all patients (100%) in the early positioning group, compared to 85% in the standard group (p = 0.05). Flap dislocation occurred in 15% of patients in the standard group, while none was observed in the early group (p = 0.05). Preoperative BCVA was 0.67 ± 0.28 logMAR in the early group and 0.65 ± 0.28 logMAR in the standard group (p = 0.74). Postoperative BCVA improved to 0.07 ± 0.08 logMAR and 0.16 ± 0.22 logMAR, respectively (p = 0.09).</p><p><strong>Conclusion: </strong>Intraoperative early positioning significantly improves anatomical outcomes in large macular hole surgery by enhancing flap stability and promoting successful closure.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"356-366"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Ectopic Inner Foveal Layer on Optical Coherence Tomography and Postoperative Quantitative Metamorphopsia in Patients Undergoing Epiretinal Membrane Surgery.","authors":"Lamberto La Franca, Micol Alkabes, Andrea Muraca, Lamberto La Franca, Alessandro Rabiolo, Paolo Fogagnolo, Stefano Ranno, Filippo Frerio, Mattia Marchetti, Davide Wild, Valentina Gatti, Stefano De Cillà","doi":"10.1159/000546248","DOIUrl":"10.1159/000546248","url":null,"abstract":"<p><strong>Introduction: </strong>Epiretinal membrane (ERM) is a condition that can lead to visual impairment and metamorphopsia. This study aimed to examine the correlation between metamorphopsia and foveal microstructure before and after macular surgery in a cohort of patients with advanced ERM.</p><p><strong>Methods: </strong>The severity of metamorphopsia was quantified using M-CHARTS, and foveal microstructure was evaluated via two optical coherence tomography (OCT) measures: central foveal thickness and ectopic inner foveal layer (EIFL). Assessments were performed pre- and post-surgery with an average follow-up of 1 year. Correlations between morphological and functional parameters pre- and post-surgery were explored by means of regression analysis.</p><p><strong>Results: </strong>Sixty eyes of 57 patients diagnosed with advanced ERM and surgically treated were included in the study. Our findings showed a significant correlation between postoperative metamorphopsia and both pre- (R2 = 0.431) and postoperative (R2 = 0.300) EIFL thickness. Disparities were observed in metamorphopsia scores between patients with ERM stages 3 and 4, both pre- (0.46 ± 0.31 and 0.84 ± 0.32, respectively, p < 0.01) and post-surgery (0.18 ± 0.21 and 0.46 ± 0.28, respectively, p < 0.01). Postoperative EIFL thickness was the only variable significantly associated with postoperative metamorphopsia scores according to multiple regression analysis.</p><p><strong>Conclusion: </strong>EIFL thickness emerges as a critical determinant of postoperative metamorphopsia severity, underscoring its importance in predicting functional outcomes after ERM surgery. Although surgery improved metamorphopsia across stages, patients with more advanced ERM experienced less favorable outcomes, stressing the importance of a timely surgical intervention.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"239-248"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Progression of Nuclear Sclerosis after Lens-Sparing Vitrectomy in Proliferative Diabetic Retinopathy Eyes: A Real-World Investigation with Scheimpflug Lens Densitometry.","authors":"Luca Mautone, Patrick Fisel, Vasyl Druchkiv, Nefeli Eleni Kounatidou, Philipp Schindler, Martin Stephan Spitzer, Christos Skevas","doi":"10.1159/000546292","DOIUrl":"10.1159/000546292","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to objectively investigate the progression of lens nuclear sclerosis after lens spearing pars plana vitrectomy (PPV) in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>Comparison of Pentacam HR® Scheimpflug imaging-based lens densitometry (LD) of eyes with PDR-associated tractive retinal detachment (study group) and nondiabetic eyes with rhegmatogenous retinal detachment (control group) after lens-sparing PPV.</p><p><strong>Results: </strong>Fifty-nine eyes of 55 subjects treated with gas (GT; 29 eyes in the study and 30 in the control group; mean follow-up: 381.41 [±309.17] days) and 42 eyes of 41 subjects treated with silicone oil tamponade (SOT; 10 eyes in the Study and 32 in the control group; mean follow-up: 326.50 [±239.59] days) were included. The prediction model for postoperative LD progression indicated that the increase in LD was lower in the study group than in the control group, regardless of the type of tamponade used. A second adjusted prediction model, including only age and baseline LD-matched eyes, further confirmed that the study group experienced a lower increase in LD in both SOT and GT cases than the control group.</p><p><strong>Conclusion: </strong>The increase in lens nuclear sclerosis is more pronounced in nondiabetic eyes than in those with PDR after lens-sparing vitrectomy. These findings support the hypothesis that ischemia in PDR may protect against the development of nuclear cataracts following PPV.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"284-293"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Intravitreal Aflibercept 2 mg Treatment of Macular Oedema Secondary to Retinal Vein Occlusion in Italy: 24-Month Results from the AURIGA Observational Study.","authors":"Maria Oliva Grassi, Andrea Russo, Maria Vadalà, Helmut Allmeier, Tobias Machewitz, Monica Varano","doi":"10.1159/000545534","DOIUrl":"10.1159/000545534","url":null,"abstract":"<p><p><p>Introduction: This subgroup analysis of the global AURIGA study evaluated intravitreal aflibercept 2 mg (IVT-AFL) effectiveness and treatment patterns in routine practice in Italy in patients with macular oedema secondary to branch or central retinal vein occlusion (BRVO/CRVO).</p><p><strong>Methods: </strong>AURIGA (NCT03161912) was a 24-month, prospective observational study in patients for whom IVT-AFL treatment had already been prescribed by their physician. All clinical decisions were according to physician discretion and local practice. Statistical analyses were descriptive only.</p><p><strong>Results: </strong>In Italy, 152 treatment-naïve and 50 pretreated patients participated across 27 centres. Mean (95% confidence interval) change in visual acuity (VA) from baseline to month 12 in treatment-naïve patients was +10.3 (7.0, 13.6) and +12.2 (5.6, 18.8) letters for BRVO and CRVO (baseline: 55.3 ± 20.3 and 44.5 ± 25.5 letters), and pretreated patients gained +6.6 (0.3, 13.0) and +14.6 (5.5, 23.8) letters for BRVO and CRVO (baseline: 56.0 ± 15.9 and 42.2 ± 23.5 letters). In treatment-naïve patients, VA gains by M12 after a mean of 4.8 injections were maintained through M24 after a mean of 5.7 injections from baseline; in pretreated patients, M12 gains were not maintained, despite a similar mean of 5.8 injections by M24. Most injections were received within the first 6 months, with a marked reduction in injection frequency thereafter.</p><p><strong>Conclusion: </strong>Robust VA improvements were observed in treatment-naïve patients with RVO in Italy following IVT-AFL treatment for up to 24 months in routine practice, despite a low injection frequency. However, guidelines indicate that regular, proactive treatment beyond the acute stage is required to improve long-term outcomes. </p>.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"270-283"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brolucizumab for Wet Age-Related Macular Degeneration in Switch Patients: Long-Term Real-World Experience from a Tertiary Center.","authors":"Andrea Scupola, Lorenzo Hu, Mattia Cusato, Claudia Fossataro, Marzia Michieletto, Maria Grazia Sammarco, Stanislao Rizzo, Gustavo Savino","doi":"10.1159/000547471","DOIUrl":"10.1159/000547471","url":null,"abstract":"<p><strong>Introduction: </strong>This retrospective, single-center, observational cohort study evaluated the 3-year real-world efficacy and safety of intravitreal brolucizumab injections in patients with neovascular age-related macular degeneration (nAMD) who had previously been treated with other anti-vascular endothelial growth factor (VEGF) agents. A total of 97 eyes from 91 patients were included, all of whom completed 3 years of follow-up after switching to brolucizumab.</p><p><strong>Methods: </strong>Patients received intravitreal injections of 6 mg brolucizumab. Data on best-corrected visual acuity (BCVA), central subfield thickness (CST), intraretinal fluid (IRF), subretinal fluid (SRF), subretinal pigment epithelium fluid (sRPEF), treatment intervals, and adverse events were collected over a 3-year follow-up period.</p><p><strong>Results: </strong>The mean age of patients was 78.9 ± 8.2 years, with a mean follow-up of 161.3 weeks. At 3-year follow-up, mean BCVA significantly improved, from 41.1 ± 6.5 at baseline to 50.7 ± 7.5 ETDRS letters (p < 0.001), and mean CST significantly decreased from 371.3 ± 136.7 to 299.1 ± 137.81 (p < 0.001). Significant reductions were observed in IRF (p < 0.001), SRF (p < 0.001), and sRPEF (p = 0.004). Mean injections per year were 4.7 ± 1.9, 3.9 ± 1.7, and 3.6 ± 1.9 in the first, second, and third years, respectively. Adverse events were noted in 4 patients after either the first or second injection, with no further events reported.</p><p><strong>Conclusion: </strong>This study reports that brolucizumab provides favorable anatomical and functional outcomes and can reduce treatment burden in patients with nAMD due to its rapid and sustained efficacy and favorable safety profile.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"367-377"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Anatomically Defined Retinal Zones on Ultrawide-Field Fluorescein Angiography Nonperfusion Measurements in Diabetic Retinopathy.","authors":"Mohamed Ashraf, Abdulrahman Rageh, Michael J Gilbert, Paolo S Silva","doi":"10.1159/000545754","DOIUrl":"10.1159/000545754","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of the study were to determine the effect of retinal zone placement on nonperfusion index (NPI) measurements using ultrawide-field fluorescein angiography (FA) in eyes with diabetic retinopathy (DR) and assess its association with disease progression.</p><p><strong>Methods: </strong>The study analyzed retinal periphery zones based on FA findings in 18 eyes without DR to standardize anatomical boundaries. NPI measurements were then conducted on a separate set of 285 eyes with DR. Eyes were grouped by NPI levels, and Cox regression was used to examine the association between nonperfusion in the mid-peripheral and far peripheral retina and progression to proliferative diabetic retinopathy (PDR).</p><p><strong>Results: </strong>The retinal zones defined by FA (FA-defined zones) were similar in size to a standard 15-mm radius circle centered on the optic disk (14.98 ± 1.40 mm). However, when compared to circles centered on the fovea, the fovea-centered circles were displaced temporally by an average of 3.94 mm, leading to a significant overestimation of the anatomic nasal far periphery (79.10 ± 13.60 mm2 vs. 36.91 ± 10.52 mm2, p < 0.001). Among the eyes with at least 1 year of follow-up (N = 121, 42.5%), those with medium and high mid-peripheral NPI had a significantly higher risk of progression to PDR (HR, 3.44; 95% CI, 1.36-8.70; p = 0.009) when using FA-defined zones. No significant association was found when using fovea-centered zones (HR, 1.39; 95% CI, 0.56-3.46; p = 0.476).</p><p><strong>Conclusion: </strong>While the diameter of the retinal measurement zones did not differ significantly, the location of the zone center had a substantial impact on NPI measurements. Using FA-defined zones centered on the optic disk led to lower mid-peripheral and higher far peripheral NPI measurements, providing a more accurate prediction of progression to PDR compared to fovea-centered zone.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"194-201"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Traumatic Macular Hole and Orbital Fracture.","authors":"Jonnah Kristina Teope, Mayari Ito, Jose Miguel Ambat, Yasuhiro Takahashi","doi":"10.1159/000543232","DOIUrl":"10.1159/000543232","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to report 5 cases of concomitant traumatic macular hole (TMH) and orbital fracture and discuss its incidence.</p><p><strong>Methods: </strong>This was a retrospective, observational study including all patients with orbital fracture who were referred to us from May 2013 to December 2023. Axial and coronal orbital computed tomographic images with bone and soft tissue window algorithms and optical coherence tomographic images were obtained from all patients.</p><p><strong>Results: </strong>Among 1,171 sides from 1,152 patients with pure orbital blowout fractures, we found 5 sides from 5 patients (0.4%) with concomitant TMH. All trauma was caused by baseball/softball injury. One patient had a medial orbital wall fracture with TMH stage 1b. Two had orbital floor fracture with TMH stages 2 and 3. The other two had both orbital floor and medial orbital wall fractures with TMH stages 3 and 4. Orbital fracture was reduced in 3 patients. Two had spontaneous closure of TMH with no improvement in visual acuity, while one improved with pars plans vitrectomy and internal limiting membrane peeling.</p><p><strong>Conclusion: </strong>The incidence of concomitant TMH and orbital fracture is only 0.4%. The rarity of this association supports the protective role of orbital fractures in blunt trauma. Specific mechanisms of trauma, such as impacts from baseballs and softballs, may increase the risk of such injuries.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":" ","pages":"67-72"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}