One Health最新文献

{"title":"Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from companion animals and human infections in Europe","authors":"Adrien Biguenet ,&nbsp;Benoit Valot ,&nbsp;Farid El Garch ,&nbsp;Xavier Bertrand ,&nbsp;Didier Hocquet ,&nbsp;the ComPath Study Group","doi":"10.1016/j.onehlt.2025.100971","DOIUrl":"10.1016/j.onehlt.2025.100971","url":null,"abstract":"<div><div>In high-income countries, dogs and cats are often considered members of the family. Because of this proximity, it has been suggested that pets and humans might exchange bacterial species from their gut microbiota, with multidrug resistant bacteria being of particular concern. The aim of this study was to compare the genomes of third-generation cephalosporin-resistant (3GC-R) <em>Escherichia coli</em> responsible for human and pet infections in Europe.</div><div>Whole-genome sequencing data from 3GC-R <em>E. coli</em> isolated from clinical samples of humans, dogs and cats, and published in eight European studies were re-analyzed using bioinformatics tools. The acquired genes responsible for 3GC-R were identified. The sequence type (ST) of all genomes were assessed by multilocus sequence typing. Alpha and beta diversities were measured within and between the two populations.</div><div>We included genomes of 1327 3GC-R <em>E. coli</em> isolated from humans and animals with 109 (8.2 %) being responsible for infections in dogs and cat, and 1218 (91.8 %) responsible for human infections. Alpha diversity analysis suggested greater diversity within ST and 3GC-R genes in the animal population. Beta diversity analysis by principal coordinate analysis separated animal and human strains. ST131 was more abundant in human strains (43.4 %) than in animal strains (14.7 %) (<em>p</em> &lt; 0.001). Six STs, including ST372, were identified almost exclusively in 3GC-R <em>E. coli</em> from animal origin. The <em>bla</em>_CTX-M-15 gene was more frequent in humans (49.24 %) than in companion animals (17.9 %) (<em>p</em> &lt; 0.001). The resistance genes <em>bla</em>_CMY-2 (30.8 %) and <em>bla</em>_CTX-M-1 (15.4 %) were more frequent in <em>E. coli</em> isolated from pets (p &lt; 0.001).</div><div>We found that populations of 3GC-R <em>E. coli</em> responsible for human and pet infections in Europe do not overlap. Although it cannot rule out occasional transmission of bacteria between pets and humans within a household, it suggests that dogs and cats are not a major source of human infection with this antibiotic-resistant pathogen.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100971"},"PeriodicalIF":4.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One health agriculture: Heat stress mitigation dilemma in agriculture","authors":"Edit Mikó ,&nbsp;Gideon Adu Donyina ,&nbsp;Wissem Baccouri ,&nbsp;Violetta Tóth ,&nbsp;Kovács Flórián ,&nbsp;Ingrid Melinda Gyalai ,&nbsp;Gizem Yüksel ,&nbsp;Dávid Köteles ,&nbsp;Vineet Srivastava ,&nbsp;George Wanjala","doi":"10.1016/j.onehlt.2025.100966","DOIUrl":"10.1016/j.onehlt.2025.100966","url":null,"abstract":"<div><div>The concept of One Health was developed as a successful strategy for addressing global crises that impact the health of animals, humans, and plants. The agriculture industry is facing a huge dilemma due to climate change and the impacts of heat stress, which might pose a threat to mankind in the future. In order to enhance the management of heat stress in the agriculture sector (Agri-heat stress), we suggest implementing the One Health approach. This is because the existing methods employed to alleviate heat stress in both livestock and crop farming may have side-effects on the well-being of animals, plants, humans, and the ecosystem. This review article examines the “dilemma” of mitigating heat stress in animal and crop husbandry. It discusses the One Health approach to heat stress, including a recommended strategy for reducing Agri-heat stress using the One Health approach. The study also highlights the benefits of adopting the One Health approach in mitigating Agri-heat stress. In our opinion, the efficacy of the One Health Approach in reducing Agri-heat stress depends on the process of conceptualization. This process includes recognizing the issue or hypothesis, as well as incorporating cooperating teams in the creation of environmentally friendly approaches. The efficacy and challenges of implementing this notion arise from the precise coordination of resources and collaborators.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100966"},"PeriodicalIF":4.1,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Health interventions and challenges under rural African smallholder farmer settings: A scoping review","authors":"Evanson R. Omuse ,&nbsp;Honest Machekano ,&nbsp;Bonoukpoè M. Sokame ,&nbsp;Daniel M. Mutyambai ,&nbsp;Thomas Dubois ,&nbsp;Sevgan Subramanian ,&nbsp;Frank Chidawanyika","doi":"10.1016/j.onehlt.2024.100959","DOIUrl":"10.1016/j.onehlt.2024.100959","url":null,"abstract":"<div><div>The global human population is rapidly increasing, escalating interactions of people, animals and the environment. This has led to more convoluted health challenges, for which African smallholder farmers bear the brunt. The One Health (OH) approach recognises the interconnectedness of these health challenges and thus follows a transdisciplinary approach involving diverse stakeholders to address them. Although there have recently been global concerted efforts and studies on OH, an information gap exists in Africa, particularly regarding smallholder farmers and their needs. Additionally, evaluation frameworks and outcome metrics for OH initiatives are still unclear. Thus, this study was conducted to critically map the available evidence of OH initiatives in the lens of African smallholder settings and identify gaps and opportunities for optimally targeted interventions. An extensive article searches yielded 1479 references, with only 21 studies from 11 countries qualifying for this review. Implementation of OH initiatives involved the collaboration of diverse stakeholders at local, national, regional and global levels. Most of the reported stakeholders of the OH initiatives were largely UN agencies, CGIAR centres, non-governmental organizations and universities. More than half of the studies focused on zoonotic and human-animal shared diseases. Conversely, few studies focused on human or animal food and nutrition security; land degradations; livelihoods and well-being; antimicrobial resistance, water sanitation and hygiene; food safety; soil health; crop health; biodiversity loss; climate change and gender equity. Effective capacity building, risk mitigation, social benefits, economic benefits, improved animal health and welfare, improved human health and well-being and improved ecosystem health and resilience were identified as OH outcomes. Based on the many evidence gaps, the OH initiatives must address health challenges mostly encountered by smallholder farmers with an increased focus on food security and safety, especially under the ongoing climate change. However, the successful implementation of OH initiatives was constrained by weak governance and coordination structures, poor communication and information sharing, lack of integrated surveillance system, limited community engagement, lack of political will, inadequate resources and logistical support, limited multi-disciplinarity and divergent priorities. Additionally, the lack of consensus on evaluation framework and outcomes highlights the need for an integrated standard framework for developing and implementing OH initiatives and harmonised outcome evaluation metrics to avoid under- or over-estimation of OH benefits.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100959"},"PeriodicalIF":4.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putting one health to the test: Operational challenges and critical reflections from the global South","authors":"Mridula Mary Paul ,&nbsp;Sunita Pradhan ,&nbsp;Aarti Chettri ,&nbsp;Sarala Khaling ,&nbsp;Abi T. Vanak","doi":"10.1016/j.onehlt.2024.100963","DOIUrl":"10.1016/j.onehlt.2024.100963","url":null,"abstract":"<div><div>One Health as a policy framework to tackle zoonoses has gained wide-ranging validation with multiple international organizations throwing their collective might behind it. Such endorsement has convinced several governments to adopt One Health as a national strategy to address zoonoses. Although some argue that One Health is so many things that there are in fact multiple ‘One Healths’, others find that most international policy documents that use the One Health framing contain certain key recommendations, with intersectoral coordination and disease surveillance prominent among them. In this paper we examine whether and how One Health travels in a sub-national setting in a developing country context such as that of India, with particular focus on intersectoral coordination. We draw on documentary analysis, semi-structured interviews, and workshops with government officials across key sectoral agencies at the district level, to understand prevalent institutional mechanisms in place to address zoonoses in such a setting. We locate our study in the district of Gyalshing in the state of Sikkim in India, which is a potential zoonoses ‘hotspot’ given its location within the biodiverse Indian Himalayan Region, with numerous avenues for human-animal interactions, and burgeoning human population linked to its tourism-run economy. We outline successful cases where certain zoonotic diseases could be tackled, while also highlighting structural constraints that need to be borne in mind while planning or advocating One Health as a blanket policy prescription. In doing so, we draw attention to the political dimensions of global health policies, and question whether One Health can be uncritically deployed in developing country contexts.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100963"},"PeriodicalIF":4.1,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial biopesticides: A one health perspective on benefits and risks","authors":"Panqin Cai ,&nbsp;George Dimopoulos","doi":"10.1016/j.onehlt.2024.100962","DOIUrl":"10.1016/j.onehlt.2024.100962","url":null,"abstract":"<div><div>Controlling insect pests that destroy crop and spread diseases will become increasingly crucial for addressing the food demands of a growing global population and the expansion of vector-borne diseases. A key challenge is the development of a balanced approach for sustainable food production and disease control in 2050 and beyond. Microbial biopesticides, derived from bacteria, viruses, fungi, protozoa, or nematodes, offer potentially significant benefits for promoting One Health and contributing to several United Nations Sustainable Development Goals (SDGs). This narrative review examines the benefits and risks of microbial biopesticides from a One Health perspective, focusing on the Americas and Europe, and aligned with respective SDGs.</div><div>The value of biopesticides in sustainable agriculture and integrated pest management (IPM) approaches for food security, particularly SDG 2 (Zero Hunger) and SDG 1 (No Poverty) has been widely recognized, with relatively fewer adverse effects to people and the environment than synthetic pesticides. With increased demand and usage, microbial biopesticides can be expected to contribute further to additional SDGs such as SDG 12 (responsible consumption and production) through waste recycling for biopesticide production and remediation of polluted ecosystems, and by reducing vector-borne disease burdens such as malaria and dengue. Nevertheless, the prudent and judicious application of microbial biopesticides is crucial to ensuring their effectiveness and maximizing their One Health benefits while minimizing pest resistance and unintended impacts. From a One Health perspective, this goal involves incorporating microbial biopesticides into a comprehensive biological control strategy within an IPM framework for sustainable agriculture and for controlling vector-borne diseases.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100962"},"PeriodicalIF":4.1,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering topics and trends in biosecurity law research: A machine learning approach","authors":"Yang Liu","doi":"10.1016/j.onehlt.2024.100964","DOIUrl":"10.1016/j.onehlt.2024.100964","url":null,"abstract":"<div><div>This study employed machine learning techniques, specifically Latent Dirichlet Allocation (LDA), to analyze 559 articles on biosecurity legislation from 1996 to 2023. The LDA model identified nine key research topics, including Agricultural Management and Production, Biosafety and Environmental Impact, Biological Invasion and Regulation, Biosecurity Legislation and Prevention, Agriculture and Environmental Relations, Virus Infection and Governance, Health Risk Assessment and Detection, Disease Prevention and Biotechnology, and Policy Control and Research. The findings reveal significant trends: an increasing focus on Biosecurity Legislation and Prevention and a declining interest in Agricultural Management and Production. Geographically, Australia, Canada, and the United States lead in biosecurity research, exhibiting diverse research topics. Journal-level analysis highlights central topics such as Agricultural Management and Production, Biosecurity Legislation and Prevention, and Health Risk Assessment and Detection. This study's use of LDA reduces subjective bias, providing a more objective analysis of global biosecurity legislation literature. The research underscores the importance of expanding geographical scope, integrating advanced machine learning models, adopting interdisciplinary approaches, and assessing policy impacts to enhance biosecurity strategies globally.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100964"},"PeriodicalIF":4.1,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effect of acute versus persistent insect-specific flavivirus infection on superinfection exclusion of West Nile, Zika and chikungunya viruses in RNAi-competent and -deficient mosquito cells","authors":"Wessel Willemsen ,&nbsp;Nick Helmes ,&nbsp;Gijs J. Overheul ,&nbsp;Marleen Henkens ,&nbsp;Ruben Spruijt ,&nbsp;Ronald P. van Rij ,&nbsp;Monique M. van Oers ,&nbsp;Gorben P. Pijlman ,&nbsp;Jelke J. Fros","doi":"10.1016/j.onehlt.2024.100960","DOIUrl":"10.1016/j.onehlt.2024.100960","url":null,"abstract":"<div><div>Millions of people are annually infected by mosquito-transmitted arboviruses including dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV) and chikungunya virus (CHIKV). Insect-specific flaviviruses (ISFs), which only infect mosquitoes and cannot replicate in vertebrates, can offer a potential one health strategy to block the transmission of arboviruses by reducing the mosquito's susceptibility for subsequent arbovirus infections through superinfection exclusion (SIE). Most SIE studies focus on acute ISF infections in RNAi-deficient <em>Aedes albopictus</em> C6/36 cells. Because ISFs are known to persistently infect mosquitoes, acute infections in C6/36 cells may not accurately reflect natural interactions between ISFs and arboviruses. To study the underlying mechanisms for SIE, we persistently infected C6/36 and RNAi-competent <em>Aedes aegypti</em> Aag2 cells with the ISF Binjari virus (BinJV) and a BinJ-ZIKV chimera that contains the ZIKV prME structural genes. SIE of WNV, ZIKV and CHIKV by BinJV was more pronounced in acute than in persistently infected cells and much stronger in acutely infected C6/36 cells compared to Aag2 cells. The viability of RNAi-deficient mosquito cells was severely reduced upon acute ISF infection, which correlated to the observed SIE. However, persistently infected mosquito cells still inhibited subsequent arbovirus replication. Moreover, RNAi-competent Aag2 cells were better protected against ZIKV superinfection when they were pre-infected with BinJ-ZIKV as compared to BinJV. Therefore, acute ISF infections and strong cytopathic effects in RNAi-deficient cells augment SIE, while in persistently infected cells SIE is established through RNAi-dependent and independent mechanisms. This highlight the importance of using more representative <em>in vitro</em> models.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100960"},"PeriodicalIF":4.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication channel preference for raising rabies awareness among dog owners in Thailand: A nationwide study","authors":"Wagee Worrawattanatam ,&nbsp;Wongsaton Ektasaeng ,&nbsp;Phakwat Pornsuksant ,&nbsp;Sarin Suwanpakdee ,&nbsp;Sith Premashthira ,&nbsp;Anuwat Wiratsudakul","doi":"10.1016/j.onehlt.2024.100955","DOIUrl":"10.1016/j.onehlt.2024.100955","url":null,"abstract":"<div><div>Rabies is a severe zoonotic disease with potentially fatal consequences. Effective communication channels are crucial for disseminating key rabies prevention and control messages to target populations. This study examined how dog owners' demographic factors influenced communication channels in Thailand. We distributed a questionnaire survey to retrieve general demographic data of participants and the ranks of their communication channels. We used the mean ranking score to assess the most accessible and commonly used platforms. Univariate and multiple logistic regression methods were used to determine the association between each demographic feature and the preference for communication. In total, 476 participants were involved across all regions of Thailand. Village health volunteers represented the most selected channel, as identified by the mean ranking (3.32), followed by public loudspeaker (3.30) and television (2.93). Age, occupation, region, and cat ownership significantly influenced how people chose the channels. Moreover, farmers likely received information from various sources, and elderly individuals generally preferred to receive information about rabies from administrative authorities, such as village heads. These results can benefit policymakers aiming to enhance communication strategies in public health. This study enhances rabies risk communication and aligns with global health initiatives to eliminate dog-mediated rabies by 2030.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100955"},"PeriodicalIF":4.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bat predation by domestic cats: A neglected rabies-risk in Ecuador","authors":"Eduardo A. Díaz ,&nbsp;Carolina Sáenz ,&nbsp;Rebecca Zug","doi":"10.1016/j.onehlt.2024.100958","DOIUrl":"10.1016/j.onehlt.2024.100958","url":null,"abstract":"","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100958"},"PeriodicalIF":4.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A one health approach for integrated vector management monitoring and evaluation","authors":"Johanna Fite ,&nbsp;Thierry Baldet ,&nbsp;Antoinette Ludwig ,&nbsp;Sylvie Manguin ,&nbsp;Claude Saegerman ,&nbsp;Frédéric Simard ,&nbsp;Philippe Quénel","doi":"10.1016/j.onehlt.2024.100954","DOIUrl":"10.1016/j.onehlt.2024.100954","url":null,"abstract":"<div><div>The French Agency for Food, Environmental and Occupational Health &amp; Safety (Anses) has set up a multidisciplinary working group (WG) to develop an innovative One Health approach for the monitoring and evaluation of an integrated vector management system (IVMS) on a territorial scale. Four existing evaluation guidelines and methods have been combined into a semi-quantitative evaluation approach that takes into account all the dimensions of an integrated process. We propose a set of 34 criteria divided into three sections (objectives and management, implementation, integration) that correspond to the main functional components of an IVMS. Each criterion is assigned a score based on the results of a scoring questionnaire completed by the system's stakeholders, and two graphical outputs are generated using a specific combination of these scores. An overview of the system's performance is provided through a series of pie charts synthesizing the scores for each of the three sections and the corresponding eleven subsections. A radar chart further combines the results according to eight attributes chosen to characterize the qualities of the system. Our approach was tested for the invasive mosquito <em>Aedes albopictus,</em> a main vector of arboviruses, in two French territories with contrasting dengue epidemiology. This approach is intended to be generic and usable in all territories that are at risk of being affected by arboviruses, whether in tropical or temperate regions. Beyond a conventional assessment of the various components of an IVMS, our interdisciplinary and multisectoral approach aims to gain a better understanding of such a system in its environment, its overall functioning and its mechanisms for adapting to contextual change. It also aims to identify avenues for improvement as part of a continuous quality process, and to facilitate comparisons between territories and the cross-fertilization of knowledge between stakeholders.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100954"},"PeriodicalIF":4.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}